Article
Environmental Sciences
Peixian Luan, Yue Sun, Yue Zhu, Senqiu Qiao, Guo Hu, Qi Liu, Ziwei Zhang
Summary: Exposure to cadmium resulted in brain and cerebellum damage in pigs, with decreased antioxidant capacity and increased oxidative stress. The findings indicated that cadmium exposure can activate necrosis and ferroptosis pathways through increased oxidative stress.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Yafei Duan, Yun Wang, Jianhua Huang, Hua Li, Hongbiao Dong, Jiasong Zhang
Summary: After exposure to cadmium and lead, the intestines of shrimp showed significant damage and changes in microbiota composition. The exposure to Cd and Pb had negative effects on the intestinal health of shrimp.
MARINE POLLUTION BULLETIN
(2021)
Article
Biochemistry & Molecular Biology
Sushweta Mahalanobish, Sukanya Saha, Sayanta Dutta, Sumit Ghosh, Parames C. Sil
Summary: The study demonstrates the efficacy of melatonin in controlling the renin-angiotensin system (RAS) in the context of chronic lung injury induced by cadmium (Cd) exposure. Melatonin treatment effectively inhibits inflammatory responses and necroptotic cell death mediated by Angiotensin-II (Ang-II), thereby protecting the alveolar-capillary barrier from Cd toxicity.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wenyue Zhang, Xinyue Sun, Xu Shi, Xue Qi, Shaoqian Shang, Hongjin Lin
Summary: This study reveals that subacute Cd exposure is closely associated with necroptosis in swine lung. The mechanisms may involve Th1/Th2 imbalance, down-regulation of miR-181-5p, increased TNF-alpha expression, and activation of the NF-kappa B/NLRP3 and JAK/STAT pathways and RIPK1/RIPK3/MLKL axis.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Environmental Sciences
Xinyu Tang, Xue Fan, Tong Xu, Yujiao He, Qianru Chi, Zhe Li, Shu Li
Summary: The study found that polystyrene nanoplastics (PS-NPs) exacerbated LPS-induced spleen necroptosis and inflammation in mice by inducing oxidative stress, activating the MAPK pathway in both mouse spleen and RAW264.7 cells.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Immunology
Zhen Cao, Silong Mu, Maihuan Wang, Yun Zhang, Guijun Zou, Xinpu Yuan, Yun Huang, Siwang Yu, Jinming Zhang, Chaojun Zhang
Summary: Intestinal ischemia-reperfusion (I/R) injury disrupts the intestinal barrier composed of tight junction proteins, leading to the entry of bacteria and endotoxins into the bloodstream and causing distant organ damage. This study investigated the role of succinate, an intermediate product of the tricarboxylic acid cycle, in intestinal I/R injury, and found that pretreatment with succinate reduced tissue damage, necroptosis, and inflammation. The protective effect of succinate was associated with the upregulation of the inflammatory protein KLF4 and was diminished after inhibition of KLF4.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Xintong Zhang, Lihua Xu, Wenxue Ma, Bendong Shi, Qiaohan Liu, Yinghao Song, Cheng Fang, Pinnan Liu, Senqiu Qiao, Jingzeng Cai, Ziwei Zhang
Summary: Nickel (Ni) is widely used due to its excellent physical and chemical properties, but it can harm animals' immune system. This study investigates the effects of different concentrations of NiCl2 exposure and intervention with antioxidants on spleen lymphocytes to better understand the damage mechanism. The findings demonstrate that NiCl2 can cause oxidative stress, inflammation, and necroptosis, but these effects can be mitigated by antioxidants.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Food Science & Technology
Janaina Trindade Piagette, Jose Eudes Gomes Pinheiro Junior, Samia Hassan Husein Kanaan, Camila Teixeira Herrera, Leandro Ortiz Bastilhos, Franck Maciel Pecanha, Dalton Valentim Vassallo, Marta Miguel-Castro, Giulia Alessandra Wiggers
Summary: In this study, we investigated the protective effects of pretreatment with egg white hydrolysate (EWH) on the cardiovascular system, especially resistance vessels, against damage caused by high levels of Cd exposure. The results showed that EWH pretreatment reduced the increased vascular contractile response and protected mesenteric resistance arteries (MRA) from vascular damage induced by Cd exposure. EWH pretreatment also maintained normal blood pressure, reduced oxidative stress through the NOX1 pathway, prevented inflammatory cascades (COX-2, TNF alpha, NF-kappa B), and protected MRA from Caspase-3 activation induced by Cd.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biochemistry & Molecular Biology
Lei Lei, Mu Jing, Zheng Yingce, Zhang Pei, Liu Yun
Summary: This study investigates the effects of selenium deficiency on the intestines of weaned calves, revealing that selenium deficiency can cause oxidative stress, inflammation, apoptosis, and necroptosis in the intestines. The study suggests that weaned calves' intestines are severely damaged by selenium deficiency.
Article
Pharmacology & Pharmacy
Xia Zhao, Shengchen Wang, Xiaojing Li, Honggui Liu, Shiwen Xu
Summary: Cadmium exposure induced necrotic cell death and ion homeostasis imbalance in swine myocardium. Furthermore, Cd exposure increased LXA4 content, inhibited FPR2 expression, activated TGF-beta pathway, suppressed Nrf2 pathway, and activated NF-kappa B pathway. Cd exposure also increased the expressions of necroptosis-related genes.
Article
Plant Sciences
Yan-Ru Cui, Fei Qu, Wen-Jing Zhong, Hui-Hui Yang, Jie Zeng, Jun-Hao Huang, Jie Liu, Ming-Yue Zhang, Yong Zhou, Cha-Xiang Guan
Summary: This study validated the beneficial effects of Alo in LPS-induced acute lung injury (ALI), suggesting that Alo may be a new drug candidate against ALI. Alo attenuated lung injuries, reduced inflammation and oxidative stress, and reversed LPS-induced necroptosis.
Article
Food Science & Technology
Qingfeng He, Yunjing Luo, Ziqi Xie
Summary: This study demonstrated the antioxidant and anti-inflammatory effects of SFN against Cd-induced liver damage, which were associated with the modulation of the intrinsic Nrf2/ARE and NF-kappa B pathway.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Jinxi Zhang, Yue Zhang, Xue Qi, Yuan Cui, Xiaoming Chen, Hongjin Lin
Summary: Cadmium exposure induces lung cell apoptosis and oxidative stress in swine, activating the mitochondrial apoptosis pathway via the TRAF2/ASK1/JNK signaling pathway.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Environmental Sciences
Haoran Zhang, Jiaqiang Huang, Jie Yang, Jingzeng Cai, Qi Liu, Xintong Zhang, Jun Bao, Ziwei Zhang
Summary: Cadmium (Cd) is an environmental contaminant known for its potential toxicity, particularly in accumulating in the liver and kidney and causing serious damage. In this study, Cd-induced intestinal damage in swine was investigated through in vivo and in vitro models. The research found that Cd treatment induced ileal apoptosis and autophagy in cells, activating the PI3K/Akt pathway, and altering expression levels of apoptosis and autophagy-related proteins. Furthermore, the study showed that treatment with a PI3K activator could mitigate the effects of Cd-induced apoptosis and autophagy.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Victor Enrique Sarmiento-Ortega, Diana Moroni-Gonzalez, Alfonso Diaz, Eduardo Brambila, Samuel Trevino
Summary: This study aimed to monitor whether chronic oral exposure to cadmium NOAEL dose induces insulin resistance in Wistar rats and investigate if oxidative stress and/or inflammation are related. The results showed that a cadmium NOAEL dose after 15 days of exposure causes ROS and mitogenic arm of insulin signaling to increase while hepatic glycogen diminishes. At 30 days, Cd accumulation accentuates ROS production, hepatic triglyceride overaccumulation, and mitogenic signals that develop insulin resistance. In conclusion, environmental exposure to cadmium NAOEL dose causes hepatic Cd accumulation and ROS overproduction that chronically declines the antioxidant defense, deteriorates metabolic homeostasis associated with the mitogenic pathway of insulin signaling, and induces insulin resistance.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Jingzeng Cai, Jie Yang, Xiaoming Chen, Haoran Zhang, Yue Zhu, Qi Liu, Ziwei Zhang
Summary: TMT induces cardiac damage, inflammation, and oxidative stress, while MT mitigates these adverse changes.
Article
Biochemistry & Molecular Biology
Qi Liu, Pengyue Du, Yue Zhu, Xintong Zhang, Jingzeng Cai, Ziwei Zhang
Summary: Txnrd3 overexpression leads to intracellular calcium outflow and increased ROS, which eventually leads to necrosis and focal death of colon cancer cells, while causing Txnrd3-/- mice depth of the crypt deeper, weakened intestinal secretion and immune function and aggravate the occurrence of ulcerative colitis.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Environmental Sciences
Haoran Zhang, Jiaqiang Huang, Jie Yang, Jingzeng Cai, Qi Liu, Xintong Zhang, Jun Bao, Ziwei Zhang
Summary: Cadmium (Cd) is an environmental contaminant known for its potential toxicity, particularly in accumulating in the liver and kidney and causing serious damage. In this study, Cd-induced intestinal damage in swine was investigated through in vivo and in vitro models. The research found that Cd treatment induced ileal apoptosis and autophagy in cells, activating the PI3K/Akt pathway, and altering expression levels of apoptosis and autophagy-related proteins. Furthermore, the study showed that treatment with a PI3K activator could mitigate the effects of Cd-induced apoptosis and autophagy.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Fisheries
Peixian Luan, Haoran Zhang, Xiaofeng Zhang, Guo Hu, Ziwei Zhang
Summary: The study revealed that cadmium induces carp head kidney lymphocyte damage through the regulatory pathway involving miR-9-5p and its target gene FKBP5.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Fisheries
Haoran Zhang, Fuqing Zhao, Xiaoxue Gai, Jingzeng Cai, Xintong Zhang, Xiaoming Chen, Yue Zhu, Ziwei Zhang
Summary: Cadmium is a common environmental pollutant that has toxic effects on fish head kidney lymphocytes. This study utilized an in vitro Cd exposure model and antioxidant treatment to demonstrate that Cd induced lymphocyte apoptosis, which could be alleviated by antioxidants.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Senqiu Qiao, Yue Sun, Yangyang Jiang, Xiaoming Chen, Jingzeng Cai, Qi Liu, Ziwei Zhang
Summary: This study found that oxidative stress is the main mechanism behind nickel neurotoxicity. Nickel induced oxidative stress damage and autophagy in the mouse brain, but melatonin was able to intervene and protect the nervous system.
Article
Biochemistry & Molecular Biology
Jingzeng Cai, Jiaqiang Huang, Jie Yang, Xiaoming Chen, Haoran Zhang, Yue Zhu, Qi Liu, Ziwei Zhang
Summary: This study reveals the role of selenoprotein M (SELENOM) in maintaining mitophagy in high-fat diet-induced non-alcoholic fatty liver disease (NAFLD). SELENOM downregulation aggravates hepatic steatosis, inflammation, and fibrosis, while reducing mitophagy and increasing mitochondrial apoptosis. SELENOM overexpression activates Parkin-mediated mitophagy, reducing mitochondrial apoptosis and removing damaged mitochondria.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Medicine, Research & Experimental
Qi Liu, Yue Sun, Yue Zhu, Senqiu Qiao, Jingzeng Cai, Ziwei Zhang
Summary: Nickel exposure leads to liver dysfunction and fibrosis, which is exacerbated by Txnrd3 knockout. Melatonin, with its antioxidant effects, can mitigate oxidative damage caused by nickel exposure.
Article
Environmental Sciences
Lihua Xu, Haoyue Guan, Xintong Zhang, Senqiu Qiao, Wenxue Ma, Pinnan Liu, Qiaohan Liu, Yue Sun, Yue Liu, Jingzeng Cai, Ziwei Zhang
Summary: This study investigates the roles of Melatonin (Mel) and Thioredoxin reductase 3 (Txnrd3) in the treatment of nickel-induced renal injury. The results suggest that Mel improves oxidative stress and apoptosis induced by nickel by regulating Txnrd3 expression, thus reducing kidney damage.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Fisheries
Jingzeng Cai, Haoyue Guan, Di Li, Bendong Shi, Yangyang Jiang, Senqiu Qiao, Qiaohan Liu, Cheng Fang, Ziwei Zhang
Summary: This study investigated the immunotoxicity of Lambda-cyhalothrin (LC), a widely used insecticide, on lymphocytes and the potential protective effect of Microalgal astaxanthin (MA). The results showed that MA attenuated LC-induced lymphocyte death and improved mitochondrial damage caused by LC exposure. MA also upregulated mitophagy-related factors and decreased pyroptosis-related gene expression. These findings suggest that MA can enhance damaged mitochondrial elimination, reduce mtROS accumulation, and alleviate pyroptosis in lymphocytes. Hence, the application of MA in aquaculture and the defense against agrobiological hazards are of great importance.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Food Science & Technology
Pinnan Liu, Yue Sun, Senqiu Qiao, Wenxue Ma, Lihua Xu, Yue Liu, Xiaoxue Gai, Qiaohan Liu, Jingzeng Cai, Ziwei Zhang
Summary: Exposure to nickel can cause respiratory diseases in mice. Melatonin has been shown to have a protective effect on lung tissue by regulating inflammation-related factors and activating the VEGF signaling pathway.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Di Li, Kaixuan Zhang, Chenchen Xu, Yangyang Jiang, Jianhua Shan, Ziwei Zhang, Jingzeng Cai
Summary: This study found that CYP exposure caused endoplasmic reticulum stress in carp hepatocytes, resulting in apoptosis, autophagy, and inflammation. The expression levels of related genes also showed dose-dependent changes.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Article
Engineering, Environmental
Shun-Shun Chen, Xu-Xiu Chen, Tian-Yu Yang, Li Chen, Zheng Guo, Xing-Jiu Huang
Summary: A temperature-modulated sensing strategy was proposed to identify and determine BTEX compounds. Highly effective identification of BTEX was achieved using linear discrimination and convolutional neural network analyses. Additionally, quantitative analysis of concentration was accomplished by establishing the relationship between concentration and response.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Engineering, Environmental
Myungkyung Noh, Jeong Yeon Sim, Jisung Kim, Jee Hwan Ahn, Hye-Young Min, Jong-Uk Lee, Jong-Sook Park, Ji Yun Jeong, Jae Young Lee, Shin Yup Lee, Hyo-Jong Lee, Choon-Sik Park, Ho-Young Lee
Summary: This study reveals that chronic exposure to PM induces chronic inflammation and development of COPD by dysregulating NAD+ metabolism and subsequent SIRT1 deficiency in pulmonary macrophages. Activation of SIRT1 by resveratrol effectively mitigates PM-induced inflammation and COPD development. Targeting metabolic and epigenetic reprogramming in macrophages induced by PM is a promising strategy for COPD treatment.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Engineering, Environmental
Yu Liu, Linlin Qin, Yiming Qin, Tong Yang, Haoran Lu, Yulong Liu, Qiqi Zhang, Wenyan Liang
Summary: Co/NC/PAC electrode was prepared by compounding ZIF-67 with powder-activated carbon for the electrocatalytic treatment of nitrogen-containing heterocyclic compounds. The degradation efficiency of the four compounds reached 90.2-93.7% under optimal conditions, and the degradation order was pyridazine < pyrimidine < pyrazine < pyridine.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Engineering, Environmental
Julien Couturier, Pierre Tamba Oulare, Blanche Collin, Claire Lallemand, Isabelle Kieffer, Julien Longerey, Perrine Chaurand, Jerome Rose, Daniel Borschneck, Bernard Angeletti, Steven Criquet, Renaud Podor, Hamed Pourkhorsandi, Guilhem Arrachart, Clement Levard
Summary: This study analyzes the properties of bauxite residue samples and explores the influence of bauxite ore origin, storage conditions, and storage time. The results show that the speciation of yttrium is related to the origin of bauxite ore, while no significant variation was observed with storage conditions or aging of the residues.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Engineering, Environmental
Sakthinarenderan Saikumar, Ravi Mani, Mirunalini Ganesan, Inbakandan Dhinakarasamy, Thavamani Palanisami, Dharani Gopal
Summary: Microplastic contamination in marine ecosystems poses a growing concern due to its trophic transfer and negative effects on marine organisms. This study investigates the transfer and impacts of polystyrene microplastics in an estuarine food chain. The results show that microplastics can be transferred through the food chain, although the transfer rates are low. The exposed organisms exhibit stress responses, suggesting the potential risk of microplastics reaching humans through the food chain.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Review
Engineering, Environmental
Yan-Jiao Li, Ying Yuan, Wen-Bing Tan, Bei-Dou Xi, Hui Wang, Kun-Long Hui, Jia-Bao Chen, Yi-Fan Zhang, Lian-Feng Wang, Ren-Fei Li
Summary: This review investigated and analyzed the distribution, composition, and abundance of heavy metals and antibiotic resistance genes (ARGs) in landfill. The results showed that heavy metals have lasting effects on ARGs, and complexes of heavy metals and organic matter are common in landfill. This study provides a new basis to better understand the horizontal gene transfer (HGT) of ARGs in landfill.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Engineering, Environmental
Jessy Joseph, Ari Vaisanen, Ajay B. Patil, Manu Lahtinen
Summary: Efficient and environmentally friendly porous hybrid adsorbent beads have been developed for the removal of arsenic from drinking water. The structural tuning of the adsorbents has been shown to have a significant impact on their adsorption performance, with high crystallinity leading to increased adsorption capacity and selectivity towards As5+.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Engineering, Environmental
Yangyang Liu, Minhua Xiao, Kaiqin Huang, Juntao Cui, Hongli Liu, Yingxin Yu, Shengtao Ma, Xihong Liu, Meiqing Lin
Summary: This study measured the levels of phthalate metabolites in breast milk collected from mothers in southern China. The results showed that phthalates are still prevalent in the region, and breastfeeding contributes to phthalate intake in infants. However, the levels detected do not pose significant health risks to infants based on dietary exposure. The increasing exposure to certain phthalates calls for further research into their sources and potential risks.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Engineering, Environmental
Zhiqiang Wu, Jianxing Sun, Liting Xu, Hongbo Zhou, Haina Cheng, Zhu Chen, Yuguang Wang, Jichao Yang
Summary: Ocean depth affects microbial diversity, composition, and co-occurrence patterns of microplastic microbial communities. Deterministic processes dominate the assembly of mesopelagic plastisphere microbial communities, while stochastic processes shape the assembly of bathypelagic microbial communities. The relationships between microorganisms in the mesopelagic layer are more complex and stable, with Proteobacteria and Actinobacteriota playing important roles.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Engineering, Environmental
Tingting Xiao, Renjie Chen, Chen Cai, Shijie Yuan, Xiaohu Dai, Bin Dong, Zuxin Xu
Summary: Based on the efficiency of catalytic ozonation techniques in enhancing sludge dewaterability, this study investigated its effectiveness in simultaneous reduction of antibiotics and antibiotic resistance genes. The results showed that catalytic ozonation conditioning changed the distribution of antibiotics and achieved high degradation rates. It also significantly reduced the abundance of ARGs, inhibited horizontal gene transfer, and decreased the signal transduction of typical ARGs host bacteria.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Engineering, Environmental
Yang Deng, Xiaohong Guan
Summary: This article discusses two different development approaches for ferrate(VI) technology in water treatment, arguing that process integration is a promising method that can drive technological innovation and revolution in water treatment, achieving higher treatment efficiency, reduced costs and energy consumption, and a smaller physical footprint.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Engineering, Environmental
Zhe Zhang, Lu Zhang, Zhihao Huang, Yuxin Xu, Qingqing Zhao, Hongju Wang, Meiqing Shi, Xiangnan Li, Kai Jiang, Dapeng Wu
Summary: In this study, a floating catalytic foam was designed and prepared to enhance the mass transfer in immobilized photocatalysts for wastewater treatment. The floating catalytic foam could float on the water surface and establish a temperature gradient, effectively promoting the diffusion and adsorption of target molecules during the photocatalytic process.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Engineering, Environmental
Muhammad Nafees, Adiba Khan Sehrish, Sarah Owdah Alomrani, Linlin Qiu, Aasim Saeed, Shoaib Ahmad, Shafaqat Ali, Hongyan Guo
Summary: The accumulation of cadmium and antibiotics in edible plants and fertile soil is a worldwide problem. This study investigated the potential of zinc oxide nanoparticles to alleviate the toxicity of both cadmium and antibiotics and promote spinach growth.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Engineering, Environmental
Lurui Wan, Kai Wang, Yuan Chen, Zhiyong Xu, Wenbo Zhao
Summary: In this study, a low viscosity and high thermal stability SO2 absorbent with dual interacting sites was successfully synthesized. The absorbent showed the highest absorption enthalpy change and entropy change values among reported SO2 absorbents, and exhibited lower viscosity and comparable thermal stability to ILs.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Engineering, Environmental
Zhengwei Zhou, Guojie Ye, Yang Zong, Zhenyu Zhao, Deli Wu
Summary: This study utilized Mo powder and STPP to enhance the performance of the sodium percarbonate system in pollutant degradation. The presence of Mo and STPP resulted in a higher degradation rate of the model pollutant SMX, with low oxidant consumption. The system generated multiple active species through a series of chain reactions at different pH values, exhibiting excellent performance towards electron-rich pollutants. Furthermore, Mo demonstrated excellent stability and reusability.
JOURNAL OF HAZARDOUS MATERIALS
(2024)