Cadmium exposure induces pyroptosis in testicular tissue by increasing oxidative stress and activating the AIM2 inflammasome pathway

Joint approaches to reduce cadmium exposure risk from rice consumption

(2022) Peng Mao et al.   JOURNAL OF HAZARDOUS MATERIALS

NLRP3 inflammasome mediated pyroptosis is involved in cadmium exposure-induced neuroinflammation through the IL-1β/IkB-α-NF-κB-NLRP3 feedback loop in swine

(2021) Jingzeng Cai et al.   TOXICOLOGY

Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome

(2021) Li-Qiu Wang et al.   Nature Communications

Toxic Mechanisms of Five Heavy Metals: Mercury, Lead, Chromium, Cadmium, and Arsenic

(2021) Mahdi Balali-Mood et al.   Frontiers in Pharmacology

Cadmium induces renal inflammation by activating the NLRP3 inflammasome through ROS/MAPK/NF-κB pathway in vitro and in vivo

(2021) Ziyin Li et al.   ARCHIVES OF TOXICOLOGY

NLRP3 inflammasome activation and cell death

(2021) Yi Huang et al.   Cellular & Molecular Immunology

AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence

(2021) SangJoon Lee et al.   NATURE

Punching Holes in Cellular Membranes: Biology and Evolution of Gasdermins

(2021) Elke De Schutter et al.   TRENDS IN CELL BIOLOGY

Acute cadmium exposure induces GSDME-mediated pyroptosis in triple-negative breast cancer cells through ROS generation and NLRP3 inflammasome pathway activation

(2021) Jie Tang et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Cadmium attenuates testosterone synthesis by promoting ferroptosis and blocking autophagosome-lysosome fusion

(2021) Ling Zeng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cross-talk between autophagy and apoptosis regulates testicular injury/recovery induced by cadmium via PI3K with mTOR-independent pathway

(2020) Mei Wang et al.   Cell Death & Disease

Toxicological Effects of Cadmium on Mammalian Testis

(2020) Qiqi Zhu et al.   Frontiers in Genetics

Hypomethylation of LINE-1 retrotransposons is associated with cadmium-induced testicular injury

(2020) Xiaofei Wang et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

AIM2 in health and disease: Inflammasome and beyond

(2020) Puja Kumari et al.   IMMUNOLOGICAL REVIEWS

Downregulation of vdac2 inhibits spermatogenesis via JNK and P53 signalling in mice exposed to cadmium

(2020) Yu Fang et al.   TOXICOLOGY LETTERS

Cadmium exposure induces pyroptosis of lymphocytes in carp pronephros and spleens by activating NLRP3

(2020) Yiming Zhang et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Cadmium mediated redox modulation in germline stem cells homeostasis affects reproductive health of Drosophila males

(2020) Abik Nandi et al.   JOURNAL OF HAZARDOUS MATERIALS

Protective role of microglial HO-1 blockade in aging: Implication of iron metabolism

(2020) Cristina Fernández-Mendívil et al.   Redox Biology

Cadmium and molybdenum co-induce pyroptosis via ROS/PTEN/PI3K/AKT axis in duck renal tubular epithelial cells

(2020) Caiying Zhang et al.   ENVIRONMENTAL POLLUTION

Chronic oral exposure to cadmium causes liver inflammation by NLRP3 inflammasome activation in pubertal mice

(2020) Xusheng Li et al.   FOOD AND CHEMICAL TOXICOLOGY

Cadmium toxicity: effects on human reproduction and fertility

(2019) Sunil Kumar et al.   REVIEWS ON ENVIRONMENTAL HEALTH

Cadmium exposure in living organisms: A short review

(2019) Hao Zhang et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Cyanidin-3-O-glucoside restores spermatogenic dysfunction in cadmium-exposed pubertal mice via histone ubiquitination and mitigating oxidative damage

(2019) Xusheng Li et al.   JOURNAL OF HAZARDOUS MATERIALS

Molybdenum and cadmium co-induce oxidative stress and apoptosis through mitochondria-mediated pathway in duck renal tubular epithelial cells

(2019) Chang Wang et al.   JOURNAL OF HAZARDOUS MATERIALS

A multi-medium chain modeling approach to estimate the cumulative effects of cadmium pollution on human health

(2018) Xingmei Liu et al.   ENVIRONMENTAL POLLUTION

Ascorbic acid inhibits cadmium-induced disruption of the blood-testis barrier by regulating oxidative stress-mediated p38 MAPK pathways

(2018) Na Chen et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Mercury and arsenic attenuate canonical and non-canonical NLRP3 inflammasome activation

(2018) Huijeong Ahn et al.   Scientific Reports

Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis 

(2018) Bo Zhou et al.   CELL RESEARCH

Trehalose prevents cadmium-induced hepatotoxicity by blocking Nrf2 pathway, restoring autophagy and inhibiting apoptosis

(2018) Zhong-Gui Gong et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

The AIM2 inflammasome: Sensor of pathogens and cellular perturbations

(2017) Jérôme Lugrin et al.   IMMUNOLOGICAL REVIEWS

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity

(2017) Katharina S. Schneider et al.   Cell Reports

Mitochondrial ROS induced by chronic ethanol exposure promote hyper-activation of the NLRP3 inflammasome

(2017) Laura R. Hoyt et al.   Redox Biology

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

Programmed necrosis in inflammation: Toward identification of the effector molecules

(2016) D. Wallach et al.   SCIENCE

Low-level environmental arsenic exposure correlates with unexplained male infertility risk

(2016) Xiaofei Wang et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Cadmium induces NLRP3 inflammasome-dependent pyroptosis in vascular endothelial cells

(2016) Haiyan Chen et al.   TOXICOLOGY LETTERS

DNA damage foci: Meaning and significance

(2015) Kai Rothkamm et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

HISAT: a fast spliced aligner with low memory requirements

(2015) Daehwan Kim et al.   NATURE METHODS

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Environmentally induced epigenetic transgenerational inheritance of male infertility

(2014) Carlos Guerrero-Bosagna et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Low-level cadmium exposure and effects on kidney function

(2014) Maria Wallin et al.   OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

Mitochondrial ROS potentiates indirect activation of the AIM2 inflammasome

(2014) Deborah D. Crane et al.   Frontiers in Microbiology

ROS-induced DNA damage and PARP-1 are required for optimal induction of starvation-induced autophagy

(2012) José Manuel Rodríguez-Vargas et al.   CELL RESEARCH

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Proliferative and Nonproliferative Lesions of the Rat and Mouse Male Reproductive System

(2012) Dianne Creasy et al.   TOXICOLOGIC PATHOLOGY

Cadmium levels in Europe: implications for human health

(2009) Jilang Pan et al.   ENVIRONMENTAL GEOCHEMISTRY AND HEALTH

Cadmium Increases Human Fetal Germ Cell Apoptosis

(2009) Gaëlle Angenard et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

(2009) Teresa Fernandes-Alnemri et al.   NATURE

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

(2009) Tilmann Bürckstümmer et al.   NATURE IMMUNOLOGY