Epigenetic regulator BRD4 is involved in cadmium-induced acute kidney injury via contributing to lysosomal dysfunction, autophagy blockade and oxidative stress

Targeting Autophagy to Counteract Obesity-Associated Oxidative Stress

(2021) Federico Pietrocola et al.   Antioxidants

Yeast β-D-glucan exerts anti-tumour activity in liver cancer through impairing autophagy and lysosomal function, promoting reactive oxygen species production and apoptosis

(2020) Ningning Wang et al.   Redox Biology

BRD4 Inhibition Protects Against Acute Pancreatitis Through Restoring Impaired Autophagic Flux

(2020) Shuangjun Shen et al.   Frontiers in Pharmacology

Quercetin alleviates Cadmium-induced autophagy inhibition via TFEB-dependent lysosomal restoration in primary proximal tubular cells

(2020) Yuan Zhao et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

BETs inhibition attenuates oxidative stress and preserves muscle integrity in Duchenne muscular dystrophy

(2020) Marco Segatto et al.   Nature Communications

Cadmium effects on superoxide dismutase 1 in human cells revealed by NMR

(2019) Panagis Polykretis et al.   Redox Biology

GORASP2/GRASP55 collaborates with the PtdIns3K UVRAG complex to facilitate autophagosome-lysosome fusion

(2019) Xiaoyan Zhang et al.   Autophagy

BRD4 inhibition regulates MAPK, NF-κB signals, and autophagy to suppress MMP-13 expression in diabetic intervertebral disc degeneration

(2019) Jianle Wang et al.   FASEB JOURNAL

Inhibition of Brd4 alleviates renal ischemia/reperfusion injury-induced apoptosis and endoplasmic reticulum stress by blocking FoxO4-mediated oxidative stress

(2019) Hao Liu et al.   Redox Biology

Toxicity of cadmium in musculoskeletal diseases

(2019) D. Reyes-Hinojosa et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Cyanidin-3-O-glucoside restores spermatogenic dysfunction in cadmium-exposed pubertal mice via histone ubiquitination and mitigating oxidative damage

(2019) Xusheng Li et al.   JOURNAL OF HAZARDOUS MATERIALS

Bromodomain and Extraterminal Proteins as Novel Epigenetic Targets for Renal Diseases

(2019) Jose Luis Morgado-Pascual et al.   Frontiers in Pharmacology

BRD4 blockage alleviates pathological cardiac hypertrophy through the suppression of fibrosis and inflammation via reducing ROS generation

(2019) Wen Zhu et al.   BIOMEDICINE & PHARMACOTHERAPY

Disrupting Acetyl-lysine Interactions: Recent Advance in the Development of BET Inhibitors

(2018) Fa Zhang et al.   CURRENT DRUG TARGETS

Puerarin reverses cadmium-induced lysosomal dysfunction in primary rat proximal tubular cells via inhibiting Nrf2 pathway

(2018) Li-Yuan Wang et al.   BIOCHEMICAL PHARMACOLOGY

Impaired endothelial autophagy promotes liver fibrosis by aggravating the oxidative stress response during acute liver injury

(2018) Maria Ruart et al.   JOURNAL OF HEPATOLOGY

Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function

(2017) Jun-ichi Sakamaki et al.   MOLECULAR CELL

Chromatin dependencies in cancer and inflammation

(2017) Ivan Marazzi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cadmium disrupts autophagic flux by inhibiting cytosolic Ca 2+ -dependent autophagosome-lysosome fusion in primary rat proximal tubular cells

(2017) Fei Liu et al.   TOXICOLOGY

Trehalose protects against cadmium-induced cytotoxicity in primary rat proximal tubular cells via inhibiting apoptosis and restoring autophagic flux

(2017) Xin-Yu Wang et al.   Cell Death & Disease

Autophagy blockade and lysosomal membrane permeabilization contribute to lead-induced nephrotoxicity in primary rat proximal tubular cells

(2017) Xiang-Bin Song et al.   Cell Death & Disease

Identification of modulators of autophagic flux in an image-based high content siRNA screen

(2016) Christopher M. Hale et al.   Autophagy

Inhibition of Bromodomain and Extraterminal Domain Family Proteins Ameliorates Experimental Renal Damage

(2016) Beatriz Suarez-Alvarez et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Autophagy in acute kidney injury

(2016) Gur P. Kaushal et al.   KIDNEY INTERNATIONAL

Signal-Dependent Recruitment of BRD4 to Cardiomyocyte Super-Enhancers Is Suppressed by a MicroRNA

(2016) Matthew S. Stratton et al.   Cell Reports

Mitochondrial permeability transition and its regulatory components are implicated in apoptosis of primary cultures of rat proximal tubular cells exposed to lead

(2015) Gang Liu et al.   ARCHIVES OF TOXICOLOGY

Beating the odds: BETs in disease

(2015) Chen-Yi Wang et al.   TRENDS IN BIOCHEMICAL SCIENCES

Glutathione and mitochondria determine acute defense responses and adaptive processes in cadmium-induced oxidative stress and toxicity of the kidney

(2014) Ambily Ravindran Nair et al.   ARCHIVES OF TOXICOLOGY

Oxidative stress and autophagy: the clash between damage and metabolic needs

(2014) G Filomeni et al.   CELL DEATH AND DIFFERENTIATION

The Mechanisms behind the Therapeutic Activity of BET Bromodomain Inhibition

(2014) Junwei Shi et al.   MOLECULAR CELL

Epigenetic therapy in non-small-cell lung cancer: targeting DNA methyltransferases and histone deacetylases

(2013) Frank P Vendetti et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy

(2013) Jens Füllgrabe et al.   NATURE

Autophagy

(2012) Ricky H. Bhogal et al.   Autophagy

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

The cadmium-induced death of mesangial cells results in nephrotoxicity

(2009) Liang-Yo Yang et al.   Autophagy