Investigating the shared genetic architecture of post-traumatic stress disorder and gastrointestinal tract disorders: a genome-wide cross-trait analysis

Using phenotype risk scores to enhance gene discovery for generalized anxiety disorder and posttraumatic stress disorder

(2022) Frank R. Wendt et al.   MOLECULAR PSYCHIATRY

Sleep and Late-Onset Alzheimer’s Disease: Shared Genetic Risk Factors, Drug Targets, Molecular Mechanisms, and Causal Effects

(2022) Dongze Chen et al.   Frontiers in Genetics

Pinpointing novel risk loci for Lewy body dementia and the shared genetic etiology with Alzheimer’s disease and Parkinson’s disease: a large-scale multi-trait association analysis

(2022) Ping Guo et al.   BMC Medicine

Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect

(2021) Rafik Tadros et al.   NATURE GENETICS

GWAS of peptic ulcer disease implicates Helicobacter pylori infection, other gastrointestinal disorders and depression

(2021) Yeda Wu et al.   Nature Communications

Schizophrenia-associated SLC39A8 polymorphism is a loss-of-function allele altering glutamate receptor and innate immune signaling

(2021) Wei Chou Tseng et al.   Translational Psychiatry

Tryptophan Metabolism and Gut-Brain Homeostasis

(2021) William Roth et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MAD1L1 and TSNARE gene polymorphisms are associated with schizophrenia susceptibility in the Han Chinese population

(2021) Xianglai Liu et al.   BMC Medical Genomics

Pleiotropy method reveals genetic overlap between orofacial clefts at multiple novel loci from GWAS of multi-ethnic trios

(2021) Debashree Ray et al.   PLoS Genetics

Investigating the shared genetic architecture between multiple sclerosis and inflammatory bowel diseases

(2021) Yuanhao Yang et al.   Nature Communications

Chemerin in immune response and gastrointestinal pathophysiology

(2020) Damian Jacenik et al.   CLINICA CHIMICA ACTA

VARAdb: a comprehensive variation annotation database for human

(2020) Qi Pan et al.   NUCLEIC ACIDS RESEARCH

A powerful method for pleiotropic analysis under composite null hypothesis identifies novel shared loci between Type 2 Diabetes and Prostate Cancer

(2020) Debashree Ray et al.   PLoS Genetics

Association of a Schizophrenia-Risk Nonsynonymous Variant With Putamen Volume in Adolescents

(2019) Qiang Luo et al.   JAMA Psychiatry

Using phenome-wide association to investigate the function of a schizophrenia risk locus at SLC39A8

(2019) Thomas H. McCoy et al.   Translational Psychiatry

A statistical framework for cross-tissue transcriptome-wide association analysis

(2019) Yiming Hu et al.   NATURE GENETICS

Induction of the metal transporter ZIP8 by interferon gamma in intestinal epithelial cells: Potential role of metal dyshomeostasis in Crohn's disease

(2019) Joanna M.P. Melia et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of the primate-specific gene BTN3A2 as an additional schizophrenia risk gene in the MHC loci

(2019) Yong Wu et al.   EBioMedicine

A global overview of pleiotropy and genetic architecture in complex traits

(2019) Kyoko Watanabe et al.   NATURE GENETICS

International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci

(2019) Caroline M. Nievergelt et al.   Nature Communications

Gastroesophageal reflux GWAS identifies risk loci that also associate with subsequent severe esophageal diseases

(2019) Jiyuan An et al.   Nature Communications

Neuromodulators for Functional Gastrointestinal Disorders (Disorders of Gut−Brain Interaction): A Rome Foundation Working Team Report

(2018) Douglas A. Drossman et al.   GASTROENTEROLOGY

Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases

(2018) Marie Verbanck et al.   NATURE GENETICS

Multi-trait analysis of genome-wide association summary statistics using MTAG

(2018) Patrick Turley et al.   NATURE GENETICS

Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types

(2018) Hilary K. Finucane et al.   NATURE GENETICS

Experimental Models of Irritable Bowel Syndrome and the Role of the Enteric Neurotransmission

(2018) et al.   Journal of Clinical Medicine

The UK Biobank resource with deep phenotyping and genomic data

(2018) Clare Bycroft et al.   NATURE

Interpreting findings from Mendelian randomization using the MR-Egger method

(2017) Stephen Burgess et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Exome Array Analysis Identifies Variants in SPOCD1 and BTN3A2 That Affect Risk for Gastric Cancer

(2017) Meng Zhu et al.   GASTROENTEROLOGY

Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption

(2017) Fernando Pires Hartwig et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability

(2017) L E Duncan et al.   MOLECULAR PSYCHIATRY

Genetic effects on gene expression across human tissues

(2017) François Aguet et al.   NATURE

Ensembl 2018

(2017) Daniel R Zerbino et al.   NUCLEIC ACIDS RESEARCH

Functional mapping and annotation of genetic associations with FUMA

(2017) Kyoko Watanabe et al.   Nature Communications

Relationships between psychological state, abuse, somatization and visceral pain sensitivity in irritable bowel syndrome

(2017) Cecilia Grinsvall et al.   United European Gastroenterology Journal

A Pleiotropic Missense Variant in SLC39A8 Is Associated With Crohn’s Disease and Human Gut Microbiome Composition

(2016) Dalin Li et al.   GASTROENTEROLOGY

Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator

(2016) Jack Bowden et al.   GENETIC EPIDEMIOLOGY

Exercise-induced stress behavior, gut-microbiota-brain axis and diet: a systematic review for athletes

(2016) Allison Clark et al.   Journal of the International Society of Sports Nutrition

Detection and interpretation of shared genetic influences on 42 human traits

(2016) Joseph K Pickrell et al.   NATURE GENETICS

Fast set-based association analysis using summary data from GWAS identifies novel gene loci for human complex traits

(2016) Andrew Bakshi et al.   Scientific Reports

Using published data in Mendelian randomization: a blueprint for efficient identification of causal risk factors

(2015) Stephen Burgess et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Partitioning heritability by functional annotation using genome-wide association summary statistics

(2015) Hilary K Finucane et al.   NATURE GENETICS

An atlas of genetic correlations across human diseases and traits

(2015) Brendan Bulik-Sullivan et al.   NATURE GENETICS

AMPA receptor inhibition by synaptically released zinc

(2015) Bopanna I. Kalappa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MAGMA: Generalized Gene-Set Analysis of GWAS Data

(2015) Christiaan A. de Leeuw et al.   PLoS Computational Biology

Rumination Syndrome: A Review of Current Concepts and Treatments

(2014) Reza A. Hejazi et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Biological insights from 108 schizophrenia-associated genetic loci

(2014)   NATURE

Mendelian Randomization Analysis With Multiple Genetic Variants Using Summarized Data

(2013) Stephen Burgess et al.   GENETIC EPIDEMIOLOGY

ZIP8 Regulates Host Defense through Zinc-Mediated Inhibition of NF-κB

(2013) Ming-Jie Liu et al.   Cell Reports

Maternal separation as a model of brain–gut axis dysfunction

(2010) Siobhain M. O’Mahony et al.   PSYCHOPHARMACOLOGY

Depression and anxiety in inflammatory bowel disease: A review of comorbidity and management

(2009) Lesley A. Graff et al.   INFLAMMATORY BOWEL DISEASES