Pinpointing novel risk loci for Lewy body dementia and the shared genetic etiology with Alzheimer’s disease and Parkinson’s disease: a large-scale multi-trait association analysis

Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture

(2021) Ruth Chia et al.   NATURE GENETICS

rMVP: A Memory-efficient, Visualization-enhanced, and Parallel-accelerated tool for Genome-Wide Association Study

(2021) Lilin Yin et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Therapeutic Opportunities of Interleukin-33 in the Central Nervous System

(2021) Yun Sun et al.   Frontiers in Immunology

Templated α-synuclein inclusion formation is independent of endogenous tau

(2021) Lindsay E Stoyka et al.   eNeuro

A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease

(2021) Douglas P. Wightman et al.   NATURE GENETICS

Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression

(2021) Urmo Võsa et al.   NATURE GENETICS

Systematic review of genetic association studies in people with Lewy body dementia

(2020) Hazel Sanghvi et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

MAPT haplotype–stratified GWAS reveals differential association for AD risk variants

(2020) Samantha L. Strickland et al.   Alzheimers & Dementia

Polygenic risk and pleiotropy in neurodegenerative diseases

(2020) Eftychia Bellou et al.   NEUROBIOLOGY OF DISEASE

Extracellular clusterin limits the uptake of α‐synuclein fibrils by murine and human astrocytes

(2020) Alice Filippini et al.   GLIA

A unified framework for joint-tissue transcriptome-wide association and Mendelian randomization analysis

(2020) Dan Zhou et al.   NATURE GENETICS

Prevalence and clinical associations of tau in Lewy body dementias: A systematic review and meta-analysis

(2020) Kai Sin Chin et al.   PARKINSONISM & RELATED DISORDERS

Clusterin in Alzheimer’s Disease: Mechanisms, Genetics, and Lessons From Other Pathologies

(2019) Evangeline M. Foster et al.   Frontiers in Neuroscience

GARFIELD classifies disease-relevant genomic features through integration of functional annotations with association signals

(2019) Valentina Iotchkova et al.   NATURE GENETICS

g:Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update)

(2019) Uku Raudvere et al.   NUCLEIC ACIDS RESEARCH

SNCA rs11931074 polymorphism correlates with spontaneous brain activity and motor symptoms in Chinese patients with Parkinson’s disease

(2019) Qian-Qian Si et al.   JOURNAL OF NEURAL TRANSMISSION

Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson’s Disease

(2019) Sangjune Kim et al.   NEURON

GBA and APOE ε4 associate with sporadic dementia with Lewy bodies in European genome wide association study

(2019) Arvid Rongve et al.   Scientific Reports

Unique α-synuclein pathology within the amygdala in Lewy body dementia: implications for disease initiation and progression

(2019) Zachary A. Sorrentino et al.   Acta Neuropathologica Communications

Association between alpha-synuclein (SNCA) rs11931074 variability and susceptibility to Parkinson’s disease: an updated meta-analysis of 41,811 patients

(2019) Bingying Du et al.   NEUROLOGICAL SCIENCES

Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies

(2019) Mike A Nalls et al.   LANCET NEUROLOGY

Lewy Body Disease: Clinical and Pathological “Overlap Syndrome” Between Synucleinopathies (Parkinson Disease) and Tauopathies (Alzheimer Disease)

(2018) Clovis Foguem et al.   Current Neurology and Neuroscience Reports

Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study

(2018) Rita Guerreiro et al.   LANCET NEUROLOGY

Tau oligomers mediate α-synuclein toxicity and can be targeted by immunotherapy

(2018) Julia E. Gerson et al.   Molecular Neurodegeneration

Multi-trait analysis of genome-wide association summary statistics using MTAG

(2018) Patrick Turley et al.   NATURE GENETICS

Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics

(2018) Alvaro N. Barbeira et al.   Nature Communications

Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines

(2018) Irene Maeve Rea et al.   Frontiers in Immunology

Lewy Body Dementia

(2018) Angela M. Sanford   CLINICS IN GERIATRIC MEDICINE

SEdb: a comprehensive human super-enhancer database

(2018) Yong Jiang et al.   NUCLEIC ACIDS RESEARCH

The prognosis of dementia with Lewy bodies

(2017) Christoph Mueller et al.   LANCET NEUROLOGY

Diagnosis and management of dementia with Lewy bodies

(2017) Ian G. McKeith et al.   NEUROLOGY

Functional mapping and annotation of genetic associations with FUMA

(2017) Kyoko Watanabe et al.   Nature Communications

Brain-to-stomach transfer of α-synuclein via vagal preganglionic projections

(2016) Ayse Ulusoy et al.   ACTA NEUROPATHOLOGICA

MAPT haplotype H1G is associated with increased risk of dementia with Lewy bodies

(2016) Catherine Labbé et al.   Alzheimers & Dementia

The Prevalence and Incidence of Dementia with Lewy Bodies: a Systematic Review

(2016) David B. Hogan et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets

(2016) Zhihong Zhu et al.   NATURE GENETICS

Integrative approaches for large-scale transcriptome-wide association studies

(2016) Alexander Gusev et al.   NATURE GENETICS

Fast set-based association analysis using summary data from GWAS identifies novel gene loci for human complex traits

(2016) Andrew Bakshi et al.   Scientific Reports

Lewy body dementias

(2015) Zuzana Walker et al.   LANCET

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

A gene-based association method for mapping traits using reference transcriptome data

(2015) Eric R Gamazon et al.   NATURE GENETICS

Long-Term Mortality in a Cohort of Home-Dwelling Elderly with Mild Alzheimer's Disease and Lewy Body Dementia

(2014) Ragnhild Oesterhus et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Alpha-synuclein and tau: teammates in neurodegeneration?

(2014) Simon Moussaud et al.   Molecular Neurodegeneration

Multiple organ involvement by alpha-synuclein pathology in Lewy body disorders

(2014) Ellen Gelpi et al.   MOVEMENT DISORDERS

A general framework for estimating the relative pathogenicity of human genetic variants

(2014) Martin Kircher et al.   NATURE GENETICS

Association of MAPT haplotypes with Alzheimer’s disease risk and MAPT brain gene expression levels

(2014) Mariet Allen et al.   Alzheimers Research & Therapy

Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics

(2014) Claudia Giambartolomei et al.   PLoS Genetics

CrossMap: a versatile tool for coordinate conversion between genome assemblies

(2013) Hao Zhao et al.   BIOINFORMATICS

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

A Subset-Based Approach Improves Power and Interpretation for the Combined Analysis of Genetic Association Studies of Heterogeneous Traits

(2012) Samsiddhi Bhattacharjee et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Genetics of Dementia With Lewy Bodies

(2012) Bram Meeus et al.   ARCHIVES OF NEUROLOGY

Annotation of functional variation in personal genomes using RegulomeDB

(2012) A. P. Boyle et al.   GENOME RESEARCH

Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits

(2012) Jian Yang et al.   NATURE GENETICS

F-box protein FBXL19–mediated ubiquitination and degradation of the receptor for IL-33 limits pulmonary inflammation

(2012) Jing Zhao et al.   NATURE IMMUNOLOGY

View point: Etiology in Parkinson's disease. Dual hit or spreading intoxication

(2011) Heinz Reichmann   JOURNAL OF THE NEUROLOGICAL SCIENCES

GCTA: A Tool for Genome-wide Complex Trait Analysis

(2010) Jian Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

LocusZoom: regional visualization of genome-wide association scan results

(2010) R. J. Pruim et al.   BIOINFORMATICS

Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis

(2010) Venu M. Nemani et al.   NEURON

ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data

(2010) K. Wang et al.   NUCLEIC ACIDS RESEARCH

1000 Genomes project

(2008) Nayanah Siva   NATURE BIOTECHNOLOGY