Schizophrenia-associated SLC39A8 polymorphism is a loss-of-function allele altering glutamate receptor and innate immune signaling

Using phenome-wide association to investigate the function of a schizophrenia risk locus at SLC39A8

(2019) Thomas H. McCoy et al.   Translational Psychiatry

Induction of the metal transporter ZIP8 by interferon gamma in intestinal epithelial cells: Potential role of metal dyshomeostasis in Crohn's disease

(2019) Joanna M.P. Melia et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pharmacological evaluation of clinically relevant concentrations of (2R,6R)-hydroxynorketamine

(2019) Christopher L. Shaffer et al.   NEUROPHARMACOLOGY

Multiple long-range inputs evoke NMDA currents in prefrontal cortex fast-spiking interneurons

(2018) Luke Joseph Bogart et al.   NEUROPSYCHOPHARMACOLOGY

Neurovascular Unit Dysfunction and Blood–Brain Barrier Hyperpermeability Contribute to Schizophrenia Neurobiology: A Theoretical Integration of Clinical and Experimental Evidence

(2017) Souhel Najjar et al.   Frontiers in Psychiatry

Zinc Modulates Endotoxin-Induced Human Macrophage Inflammation through ZIP8 Induction and C/EBPβ Inhibition

(2017) Charlie J. Pyle et al.   PLoS One

Mismatch negativity: A simple and useful biomarker of N-methyl-d-aspartate receptor (NMDAR)-type glutamate dysfunction in schizophrenia

(2017) Michael Avissar et al.   SCHIZOPHRENIA RESEARCH

Chelation of hippocampal zinc enhances long-term potentiation and synaptic tagging/capture in CA1 pyramidal neurons of aged rats: implications to aging and memory

(2016) Mahesh Shivarama Shetty et al.   AGING CELL

Transcriptome-wide mega-analyses reveal joint dysregulation of immunologic genes and transcription regulators in brain and blood in schizophrenia

(2016) Jonathan L. Hess et al.   SCHIZOPHRENIA RESEARCH

North American Prodrome Longitudinal Study (NAPLS 2)

(2015) Jean Addington et al.   JOURNAL OF NERVOUS AND MENTAL DISEASE

Glutamate and dopamine in schizophrenia: An update for the 21st century

(2015) Oliver Howes et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Evaluating historical candidate genes for schizophrenia

(2015) M S Farrell et al.   MOLECULAR PSYCHIATRY

Inflammation in schizophrenia: A question of balance

(2015) Juan C. Leza et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Modulation of extrasynaptic NMDA receptors by synaptic and tonic zinc

(2015) Charles T. Anderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMPA receptor inhibition by synaptically released zinc

(2015) Bopanna I. Kalappa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of inflammation in schizophrenia

(2015) Norbert Müller et al.   Frontiers in Neuroscience

Evidence for an Immune Role on Cognition in Schizophrenia: A Systematic Review

(2014) Rafael Ribeiro-Santos et al.   Current Neuropharmacology

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Biological insights from 108 schizophrenia-associated genetic loci

(2014)   NATURE

Zinc Dynamics and Action at Excitatory Synapses

(2014) Angela Maria Vergnano et al.   NEURON

Genome-wide DNA methylation analysis of human brain tissue from schizophrenia patients

(2014) L F Wockner et al.   Translational Psychiatry

Tris(2-pyridylmethyl)amine (TPA) as a membrane-permeable chelator for interception of biological mobile zinc

(2013) Zhen Huang et al.   Metallomics

NMDA hypofunction as a convergence point for progression and symptoms of schizophrenia

(2013) Melissa A. Snyder et al.   Frontiers in Cellular Neuroscience

ZIP8 Regulates Host Defense through Zinc-Mediated Inhibition of NF-κB

(2013) Ming-Jie Liu et al.   Cell Reports

ZIP8 Zinc Transporter: Indispensable Role for Both Multiple-Organ Organogenesis and Hematopoiesis In Utero

(2012) Marina Gálvez-Peralta et al.   PLoS One

Chronic Zinc Exposure Decreases the Surface Expression of NR2A-Containing NMDA Receptors in Cultured Hippocampal Neurons

(2012) Jia Zhu et al.   PLoS One

Immuno-inflammatory, oxidative and nitrosative stress, and neuroprogressive pathways in the etiology, course and treatment of schizophrenia

(2012) George Anderson et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Association Study of Nonsynonymous Single Nucleotide Polymorphisms in Schizophrenia

(2011) Noa Carrera et al.   BIOLOGICAL PSYCHIATRY

Zinc alleviates pain through high-affinity binding to the NMDA receptor NR2A subunit

(2011) Chihiro Nozaki et al.   NATURE NEUROSCIENCE

Vesicular Zinc Promotes Presynaptic and Inhibits Postsynaptic Long-Term Potentiation of Mossy Fiber-CA3 Synapse

(2011) Enhui Pan et al.   NEURON

NMDA GluN2A and GluN2B receptors play separate roles in the induction of LTP and LTD in the amygdala and in the acquisition and extinction of conditioned fear

(2011) Gemma L. Dalton et al.   NEUROPHARMACOLOGY

GluN2B subunits of the NMDA receptor contribute to the AMPA receptor internalization during long-term depression in the lateral amygdala of juvenile rats

(2010) S.Y. Yu et al.   NEUROSCIENCE

Structure of the zinc-bound amino-terminal domain of the NMDA receptor NR2B subunit

(2009) Erkan Karakas et al.   EMBO JOURNAL

Synaptically Released Zinc Triggers Metabotropic Signaling via a Zinc-Sensing Receptor in the Hippocampus

(2009) L. Besser et al.   JOURNAL OF NEUROSCIENCE

Zinc in the physiology and pathology of the CNS

(2009) Stefano L. Sensi et al.   NATURE REVIEWS NEUROSCIENCE

Zinc: The brain's dark horse

(2009) Byron K.Y. Bitanihirwe et al.   SYNAPSE

Zinc and cortical plasticity

(2008) Amy S. Nakashima et al.   BRAIN RESEARCH REVIEWS

Inflammation and the glutamate system in schizophrenia: implications for therapeutic targets and drug development

(2008) Norbert Müller   EXPERT OPINION ON THERAPEUTIC TARGETS