A powerful method for pleiotropic analysis under composite null hypothesis identifies novel shared loci between Type 2 Diabetes and Prostate Cancer
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
A powerful method for pleiotropic analysis under composite null hypothesis identifies novel shared loci between Type 2 Diabetes and Prostate Cancer
Authors
Keywords
Genetics, Genome-wide association studies, Genetic loci, Single nucleotide polymorphisms, Genetics of disease, Research errors, Case-control studies, Prostate cancer
Journal
PLoS Genetics
Volume 16, Issue 12, Pages e1009218
Publisher
Public Library of Science (PLoS)
Online
2020-12-09
DOI
10.1371/journal.pgen.1009218
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Multivariate genome-wide analyses of the well-being spectrum
- (2019) Bart M. L. Baselmans et al. NATURE GENETICS
- Genome-wide analyses of sparse mediation effects under composite null hypotheses
- (2019) Yen-Tsung Huang Annals of Applied Statistics
- A global overview of pleiotropy and genetic architecture in complex traits
- (2019) Kyoko Watanabe et al. NATURE GENETICS
- Effect of non-normality and low count variants on cross-phenotype association tests in GWAS
- (2019) Debashree Ray et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- Multivariate Genome-wide Association Analysis of a Cytokine Network Reveals Variants with Widespread Immune, Haematological, and Cardiometabolic Pleiotropy
- (2019) Artika P. Nath et al. AMERICAN JOURNAL OF HUMAN GENETICS
- LPM: a latent probit model to characterize the relationship among complex traits using summary statistics from multiple GWASs and functional annotations
- (2019) Jingsi Ming et al. BIOINFORMATICS
- Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci
- (2018) Fredrick R. Schumacher et al. NATURE GENETICS
- Functional variants in the LRRK2 gene confer shared effects on risk for Crohn’s disease and Parkinson’s disease
- (2018) Ken Y. Hui et al. Science Translational Medicine
- Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes
- (2018) Angli Xue et al. Nature Communications
- The UK Biobank resource with deep phenotyping and genomic data
- (2018) Clare Bycroft et al. NATURE
- Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps
- (2018) Anubha Mahajan et al. NATURE GENETICS
- The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019
- (2018) Annalisa Buniello et al. NUCLEIC ACIDS RESEARCH
- Methods for meta-analysis of multiple traits using GWAS summary statistics
- (2017) Debashree Ray et al. GENETIC EPIDEMIOLOGY
- Genetic effects on gene expression across human tissues
- (2017) François Aguet et al. NATURE
- A multitrait GWAS sheds light on insulin resistance
- (2017) Iris M Heid et al. NATURE GENETICS
- Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease
- (2017) Wei Zhao et al. NATURE GENETICS
- Functional mapping and annotation of genetic associations with FUMA
- (2017) Kyoko Watanabe et al. Nature Communications
- Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus
- (2017) Carolina Medina-Gomez et al. Nature Communications
- Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation
- (2017) Xia Shen et al. Nature Communications
- Statistical methods to detect pleiotropy in human complex traits
- (2017) Sophie Hackinger et al. Open Biology
- A Statistical Approach for Testing Cross-Phenotype Effects of Rare Variants
- (2016) K. Alaine Broadaway et al. AMERICAN JOURNAL OF HUMAN GENETICS
- LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis
- (2016) Jie Zheng et al. BIOINFORMATICS
- A general approach to testing for pleiotropy with rare and common variants
- (2016) Sharon M. Lutz et al. GENETIC EPIDEMIOLOGY
- Statistical Methods for Testing Genetic Pleiotropy
- (2016) D. J. Schaid et al. GENETICS
- Detection and interpretation of shared genetic influences on 42 human traits
- (2016) Joseph K Pickrell et al. NATURE GENETICS
- Open Targets: a platform for therapeutic target identification and validation
- (2016) Gautier Koscielny et al. NUCLEIC ACIDS RESEARCH
- Genetic pleiotropy in complex traits and diseases: implications for genomic medicine
- (2016) Jacob Gratten et al. Genome Medicine
- Characterizing Race/Ethnicity and Genetic Ancestry for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort
- (2015) Yambazi Banda et al. GENETICS
- A Bayesian Partitioning Model for the Detection of Multilocus Effects in Case-Control Studies
- (2015) Debashree Ray et al. HUMAN HEREDITY
- Integration of disease association and eQTL data using a Bayesian colocalisation approach highlights six candidate causal genes in immune-mediated diseases
- (2015) H. Guo et al. HUMAN MOLECULAR GENETICS
- An atlas of genetic correlations across human diseases and traits
- (2015) Brendan Bulik-Sullivan et al. NATURE GENETICS
- LD Score regression distinguishes confounding from polygenicity in genome-wide association studies
- (2015) Brendan K Bulik-Sullivan et al. NATURE GENETICS
- WikiPathways: capturing the full diversity of pathway knowledge
- (2015) Martina Kutmon et al. NUCLEIC ACIDS RESEARCH
- A Pleiotropy-Informed Bayesian False Discovery Rate Adapted to a Shared Control Design Finds New Disease Associations From GWAS Summary Statistics
- (2015) James Liley et al. PLoS Genetics
- Characterizing Race/Ethnicity and Genetic Ancestry for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort
- (2015) Yambazi Banda et al. GENETICS
- Implications of pleiotropy: challenges and opportunities for mining Big Data in biomedicine
- (2015) Can Yang et al. Frontiers in Genetics
- Estimating and Testing Pleiotropy of Single Genetic Variant for Two Quantitative Traits
- (2014) Qunyuan Zhang et al. GENETIC EPIDEMIOLOGY
- GPA: A Statistical Approach to Prioritizing GWAS Results by Integrating Pleiotropy and Annotation
- (2014) Dongjun Chung et al. PLoS Genetics
- Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics
- (2014) Claudia Giambartolomei et al. PLoS Genetics
- Using previously genotyped controls in genome-wide association studies (GWAS): application to the Stroke Genetics Network (SiGN)
- (2014) Braxton D. Mitchell et al. Frontiers in Genetics
- An Assessment of the Shared Allelic Architecture between Type II Diabetes and Prostate Cancer
- (2013) O. H. Y. Yu et al. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- Epidemiology and Molecular Mechanisms Tying Obesity, Diabetes, and the Metabolic Syndrome With Cancer
- (2013) E. J. Gallagher et al. DIABETES CARE
- Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis
- (2013) LANCET
- Pleiotropy in complex traits: challenges and strategies
- (2013) Nadia Solovieff et al. NATURE REVIEWS GENETICS
- Improved Detection of Common Variants Associated with Schizophrenia and Bipolar Disorder Using Pleiotropy-Informed Conditional False Discovery Rate
- (2013) Ole A. Andreassen et al. PLoS Genetics
- Association of Type 2 Diabetes Susceptibility Variants With Advanced Prostate Cancer Risk in the Breast and Prostate Cancer Cohort Consortium
- (2012) M. J. Machiela et al. AMERICAN JOURNAL OF EPIDEMIOLOGY
- Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
- (2012) NATURE GENETICS
- Novel Loci for Metabolic Networks and Multi-Tissue Expression Studies Reveal Genes for Atherosclerosis
- (2012) Michael Inouye et al. PLoS Genetics
- Six Novel Susceptibility Loci for Early-Onset Androgenetic Alopecia and Their Unexpected Association with Common Diseases
- (2012) Rui Li et al. PLoS Genetics
- Abundant Pleiotropy in Human Complex Diseases and Traits
- (2011) Shanya Sivakumaran et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Molecular signatures database (MSigDB) 3.0
- (2011) A. Liberzon et al. BIOINFORMATICS
- Comparison of statistical tests for disease association with rare variants
- (2011) Saonli Basu et al. GENETIC EPIDEMIOLOGY
- Pervasive Sharing of Genetic Effects in Autoimmune Disease
- (2011) Chris Cotsapas et al. PLoS Genetics
- Diabetes Genes and Prostate Cancer in the Atherosclerosis Risk in Communities Study
- (2010) T. E. Meyer et al. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- Genetic Susceptibility to Type 2 Diabetes Is Associated with Reduced Prostate Cancer Risk
- (2010) Brandon L. Pierce et al. HUMAN HEREDITY
- Variance component model to account for sample structure in genome-wide association studies
- (2010) Hyun Min Kang et al. NATURE GENETICS
- Association of Diabetes With Prostate Cancer Risk in the Multiethnic Cohort
- (2009) K. M. Waters et al. AMERICAN JOURNAL OF EPIDEMIOLOGY
- Meta-Analysis of Genome-wide Association Studies with Overlapping Subjects
- (2009) Dan-Yu Lin et al. AMERICAN JOURNAL OF HUMAN GENETICS
- A genetic link between type 2 diabetes and prostate cancer
- (2008) T. M. Frayling et al. DIABETOLOGIA
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search