Tryptophan Metabolism and Gut-Brain Homeostasis

Gut-brain Axis and migraine headache: a comprehensive review

(2020) Mahsa Arzani et al.   JOURNAL OF HEADACHE AND PAIN

Structural and Functional Characterization of the Gut Microbiota in Elderly Women With Migraine

(2020) Juanjuan Chen et al.   Frontiers in Cellular and Infection Microbiology

Dietary Proteins Regulate Serotonin Biosynthesis and Catabolism by Specific Gut Microbes

(2020) Yunting Xie et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Composition of Gut Microbiota in Children with Autism Spectrum Disorder: A Systematic Review and Meta-Analysis

(2020) Lucía Iglesias-Vázquez et al.   Nutrients

Possibility of Amino Acid Treatment to Prevent the Psychiatric Disorders via Modulation of the Production of Tryptophan Metabolite Kynurenic Acid

(2020) Tsutomu Fukuwatari   Nutrients

Kynurenic Acid Levels are Increased in the CSF of Alzheimer’s Disease Patients

(2020) Marta González-Sánchez et al.   Biomolecules

Tryptophan Metabolism, Inflammation, and Oxidative Stress in Patients with Neurovascular Disease

(2020) Martin Hajsl et al.   Metabolites

The microbiota and the hypothalamus-pituitary-adrenocortical (HPA) axis, implications for anxiety and stress disorders

(2020) Linoy Mia Frankiensztajn et al.   CURRENT OPINION IN NEUROBIOLOGY

Kynurenine pathway modulation reverses the experimental autoimmune encephalomyelitis mouse disease progression

(2020) Gayathri Sundaram et al.   Journal of Neuroinflammation

Tryptophan Metabolites Are Associated With Symptoms and Nigral Pathology in Parkinson's Disease

(2020) Patrick L. Heilman et al.   MOVEMENT DISORDERS

Gut microbiota dysbiosis and altered tryptophan catabolism contribute to autoimmunity in lupus-susceptible mice

(2020) Seung-Chul Choi et al.   Science Translational Medicine

Gut Microbiota: Implications in Alzheimer’s Disease

(2020) Yixi He et al.   Journal of Clinical Medicine

Cyproheptadine in the treatment of reversible cerebral vasoconstriction syndrome

(2020) Jennifer Chima et al.   ACTA NEUROLOGICA BELGICA

Associations between gut microbiota and Alzheimer’s disease, major depressive disorder, and schizophrenia

(2020) Zhenhuang Zhuang et al.   Journal of Neuroinflammation

The role of peripheral monocytes and macrophages in ischemic stroke

(2020) Dong Han et al.   NEUROLOGICAL SCIENCES

Gastrointestinal Disorders and Risk of First-Ever Ischemic Stroke

(2020) William H. Roth et al.   STROKE

Young versus aged microbiota transplants to germ-free mice: increased short-chain fatty acids and improved cognitive performance

(2020) Juneyoung Lee et al.   Gut Microbes

Maternal separation induces changes in TREK-1 and 5HT1A expression in brain areas involved in the stress response in a sex-dependent way

(2020) J. Francis-Oliveira et al.   BEHAVIOURAL BRAIN RESEARCH

Indole-3-lactic acid associated with Bifidobacterium-dominated microbiota significantly decreases inflammation in intestinal epithelial cells

(2020) Amy M. Ehrlich et al.   BMC MICROBIOLOGY

International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function

(2020) Nicholas M. Barnes et al.   PHARMACOLOGICAL REVIEWS

Indole-3-Propionic Acid, a Tryptophan-Derived Bacterial Metabolite, Reduces Weight Gain in Rats

(2019) Piotr Konopelski et al.   Nutrients

Potential Influences of Gut Microbiota on the Formation of Intracranial Aneurysm

(2019) Fumiaki Shikata et al.   HYPERTENSION

Parkinson’s disease and the gastrointestinal microbiome

(2019) Michal Lubomski et al.   JOURNAL OF NEUROLOGY

Altered gut microbiota and inflammatory cytokine responses in patients with Parkinson’s disease

(2019) Chin-Hsien Lin et al.   Journal of Neuroinflammation

The Relationship Between the Serotonin Metabolism, Gut-Microbiota and the Gut-Brain Axis

(2019) Cristina Stasi et al.   CURRENT DRUG METABOLISM

Indole-3-propionic acid inhibits gut dysbiosis and endotoxin leakage to attenuate steatohepatitis in rats

(2019) Ze-Hua Zhao et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Examining the Role of the Microbiota-Gut-Brain Axis in Stroke

(2019) David J. Durgan et al.   STROKE

Effects of maternal separation on serotonergic systems in the dorsal and median raphe nuclei of adult male Tph2-deficient mice

(2019) Margaret W. Lieb et al.   BEHAVIOURAL BRAIN RESEARCH

Tryptophan Metabolism: A Link Between the Gut Microbiota and Brain

(2019) Kan Gao et al.   Advances in Nutrition

Tryptophan Metabolism by Gut Microbiome and Gut-Brain-Axis: An in silico Analysis

(2019) Harrisham Kaur et al.   Frontiers in Neuroscience

Variation of Genes Encoding Tryptophan Catabolites Pathway Enzymes in Stroke

(2019) Paulina Wigner et al.   Journal of Clinical Medicine

Gut bacteria interaction with vagal afferents

(2018) Carolina R. Cawthon et al.   BRAIN RESEARCH

Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease

(2018) Allison Agus et al.   Cell Host & Microbe

Traumatic injury leads to inflammation and altered tryptophan metabolism in the juvenile rabbit brain

(2018) Zhi Zhang et al.   JOURNAL OF NEUROTRAUMA

Kynurenine pathway metabolic balance influences microglia activity: Targeting kynurenine monooxygenase to dampen neuroinflammation

(2018) Allison M. Garrison et al.   PSYCHONEUROENDOCRINOLOGY

Increased complement component 4 (C4) gene expression in the cingulate cortex of rats exposed to late gestation immune activation

(2018) Ryan J. Duchatel et al.   SCHIZOPHRENIA RESEARCH

Microbial tryptophan catabolites in health and disease

(2018) Henrik M. Roager et al.   Nature Communications

Gut microbiota modulation accounts for the neuroprotective properties of anthocyanins

(2018) Cláudia Marques et al.   Scientific Reports

The Role of the Aryl Hydrocarbon Receptor (AHR) in Immune and Inflammatory Diseases

(2018) Drew Neavin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery

(2018) Minako Ito et al.   NATURE

Probiotics and Prebiotics as a Therapeutic Strategy to Improve Memory in a Model of Middle-Aged Rats

(2018) Alejandra Romo-Araiza et al.   Frontiers in Aging Neuroscience

Protective roles of intestinal microbiota derived short chain fatty acids in Alzheimer’s disease-type beta-amyloid neuropathological mechanisms

(2017) Lap Ho et al.   Expert Review of Neurotherapeutics

Commensal Propionibacterium strain UF1 mitigates intestinal inflammation via Th17 cell regulation

(2017) Natacha Colliou et al.   JOURNAL OF CLINICAL INVESTIGATION

Increases in Plasma Tryptophan Are Inversely Associated with Incident Cardiovascular Disease in the Prevención con Dieta Mediterránea (PREDIMED) Study

(2017) Edward Yu et al.   JOURNAL OF NUTRITION

Tryptophan status in autism spectrum disorder and the influence of supplementation on its level

(2017) Joanna Kałużna-Czaplińska et al.   METABOLIC BRAIN DISEASE

Kynurenine pathway metabolism and the microbiota-gut-brain axis

(2017) P.J. Kennedy et al.   NEUROPHARMACOLOGY

Regulation of gut luminal serotonin by commensal microbiota in mice

(2017) Tomokazu Hata et al.   PLoS One

Involvement of the kynurenine pathway in the pathogenesis of Parkinson’s disease

(2017) Chai K. Lim et al.   PROGRESS IN NEUROBIOLOGY

The Gut Microbiota and Autism Spectrum Disorders

(2017) Qinrui Li et al.   Frontiers in Cellular Neuroscience

Protective roles of intestinal microbiota derived short chain fatty acids in Alzheimer’s disease-type beta-amyloid neuropathological mechanisms

(2017) Lap Ho et al.   Expert Review of Neurotherapeutics

Microbial regulation of microRNA expression in the amygdala and prefrontal cortex

(2017) Alan E. Hoban et al.   Microbiome

Gut microbiota dysbiosis contributes to the development of hypertension

(2017) Jing Li et al.   Microbiome

Gut microbiome alterations in Alzheimer’s disease

(2017) Nicholas M. Vogt et al.   Scientific Reports

Mood, food, and cognition

(2016) Barbara Strasser et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Microbiota Dysbiosis Controls the Neuroinflammatory Response after Stroke

(2016) V. Singh et al.   JOURNAL OF NEUROSCIENCE

Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat

(2016) John R. Kelly et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Schizophrenia risk from complex variation of complement component 4

(2016) Aswin Sekar et al.   NATURE

The Gut Microbiome as Therapeutic Target in Central Nervous System Diseases: Implications for Stroke

(2016) Katarzyna Winek et al.   Neurotherapeutics

Alterations of the human gut microbiome in multiple sclerosis

(2016) Sushrut Jangi et al.   Nature Communications

Current Evidence for a Role of the Kynurenine Pathway of Tryptophan Metabolism in Multiple Sclerosis

(2016) Michael D. Lovelace et al.   Frontiers in Immunology

Serotonin, tryptophan metabolism and the brain-gut-microbiome axis

(2015) S.M. O’Mahony et al.   BEHAVIOURAL BRAIN RESEARCH

Adult Hippocampal Neurogenesis Is Regulated by the Microbiome

(2015) Ebere S. Ogbonnaya et al.   BIOLOGICAL PSYCHIATRY

Gut microbiota depletion from early adolescence in mice: Implications for brain and behaviour

(2015) Lieve Desbonnet et al.   BRAIN BEHAVIOR AND IMMUNITY

The contribution of astrocytes and microglia to traumatic brain injury

(2015) Ila P Karve et al.   BRITISH JOURNAL OF PHARMACOLOGY

Disease-modifying treatments for multiple sclerosis - a review of approved medications

(2015) Ø. Torkildsen et al.   EUROPEAN JOURNAL OF NEUROLOGY

Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells

(2015) Christopher S. Reigstad et al.   FASEB JOURNAL

Aryl hydrocarbon receptor mediates both proinflammatory and anti-inflammatory effects in lipopolysaccharide-activated microglia

(2015) Yi-Hsuan Lee et al.   GLIA

Clinical evidence of inflammation driving secondary brain injury

(2015) Holly E. Hinson et al.   Journal of Trauma and Acute Care Surgery

Functional MRI of migraine

(2015) Todd J Schwedt et al.   LANCET NEUROLOGY

α7 Nicotinic Acetylcholine Receptor is a Novel Mediator of Sinomenine Anti-Inflammation Effect in Macrophages Stimulated by Lipopolysaccharide

(2015) Lang Yi et al.   SHOCK

Clinical evidence of inflammation driving secondary brain injury

(2015) Holly E. Hinson et al.   Journal of Trauma and Acute Care Surgery

Role of central vagal 5-HT3 receptors in gastrointestinal physiology and pathophysiology

(2015) Kirsteen N. Browning   Frontiers in Neuroscience

Antidepressant-Like Effect of Sodium Butyrate is Associated with an Increase in TET1 and in 5-Hydroxymethylation Levels in the Bdnf Gene

(2015) Y. B. Wei et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Lactobacillus reuteri DSM 17938 differentially modulates effector memory T cells and Foxp3+ regulatory T cells in a mouse model of necrotizing enterocolitis

(2014) Yuying Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Discovery and Characterization of Gut Microbiota Decarboxylases that Can Produce the Neurotransmitter Tryptamine

(2014) Brianna B. Williams et al.   Cell Host & Microbe

Microbiota control of a tryptophan-AhR pathway in disease tolerance to fungi

(2014) Luigina Romani et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Association of SLC18A1, TPH1, and RELN gene polymorphisms with risk of paranoid schizophrenia

(2014) D. Yu. Galaktionova et al.   MOLECULAR BIOLOGY

A role for the gut microbiota in IBS

(2014) Stephen M. Collins   Nature Reviews Gastroenterology & Hepatology

Bone Marrow-Derived Mesenchymal Stem Cells Maintain the Resting Phenotype of Microglia and Inhibit Microglial Activation

(2014) Ke Yan et al.   PLoS One

Role of Melatonin in Traumatic Brain Injury and Spinal Cord Injury

(2014) Mehar Naseem et al.   TheScientificWorldJOURNAL

The 5-hydroxytryptamine 4 Receptor Agonist-induced Actions and Enteric Neurogenesis in the Gut

(2014) Miyako Takaki et al.   Journal of Neurogastroenterology and Motility

Serotonin and cholecystokinin mediate nutrient-induced segmentation in guinea pig small intestine

(2013) Melina Ellis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Maternal separation alters serotonergic and HPA axis gene expression independent of separation duration in c57bl/6 mice

(2013) Lawrence S. Own et al.   BRAIN RESEARCH

Indoles mitigate the development of experimental autoimmune encephalomyelitis by induction of reciprocal differentiation of regulatory T cells and Th17 cells

(2013) Michael Rouse et al.   BRITISH JOURNAL OF PHARMACOLOGY

Minocycline: far beyond an antibiotic

(2013) N Garrido-Mesa et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Human Gut Microbiome and Body Metabolism: Implications for Obesity and Diabetes

(2013) S. Devaraj et al.   CLINICAL CHEMISTRY

Lactobacillus johnsonii inhibits indoleamine 2,3-dioxygenase and alters tryptophan metabolite levels in BioBreeding rats

(2013) Ricardo Valladares et al.   FASEB JOURNAL

Role of probiotics as memory enhancer

(2013) Bikash Medhi et al.   INDIAN JOURNAL OF PHARMACOLOGY

Important role of mucosal serotonin in colonic propulsion and peristaltic reflexes:in vitroanalyses in mice lacking tryptophan hydroxylase 1

(2013) Dante J. Heredia et al.   JOURNAL OF PHYSIOLOGY-LONDON

Sodium butyrate inhibits interferon-gamma induced indoleamine 2,3-dioxygenase expression via STAT1 in nasopharyngeal carcinoma cells

(2013) Yu-Wen He et al.   LIFE SCIENCES

Serotonin signalling in the gut—functions, dysfunctions and therapeutic targets

(2013) Gary M. Mawe et al.   Nature Reviews Gastroenterology & Hepatology

Effect of diet on serotonergic neurotransmission in depression

(2013) Faisal Shabbir et al.   NEUROCHEMISTRY INTERNATIONAL

GABA concentration and GABAergic neuron populations in limbic areas are differentially altered by brain serotonin deficiency in Tph2 knockout mice

(2012) Jonas Waider et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Deletion or activation of the aryl hydrocarbon receptor alters adult hippocampal neurogenesis and contextual fear memory

(2012) Sarah E. Latchney et al.   JOURNAL OF NEUROCHEMISTRY

The α7 nicotinic acetylcholine receptor ligands methyllycaconitine, NS6740 and GTS-21 reduce lipopolysaccharide-induced TNF-α release from microglia

(2012) Morten S. Thomsen et al.   JOURNAL OF NEUROIMMUNOLOGY

Identification of 5-HT Receptor Subtypes Enhancing Inhibitory Transmission in the Rat Spinal Dorsal Horn in vitro

(2012) Du-Jie Xie et al.   Molecular Pain

The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner

(2012) G Clarke et al.   MOLECULAR PSYCHIATRY

Prenatal infection, maternal immune activation, and risk for schizophrenia

(2012) Sarah Canetta et al.   Translational Neuroscience

A Distinct Profile of Tryptophan Metabolism along the Kynurenine Pathway Downstream of Toll-Like Receptor Activation in Irritable Bowel Syndrome

(2012) Gerard Clarke et al.   Frontiers in Pharmacology

Essential Roles of Enteric Neuronal Serotonin in Gastrointestinal Motility and the Development/Survival of Enteric Dopaminergic Neurons

(2011) Z. Li et al.   JOURNAL OF NEUROSCIENCE

Fluctuations in Endogenous Kynurenic Acid Control Hippocampal Glutamate and Memory

(2011) Ana Pocivavsek et al.   NEUROPSYCHOPHARMACOLOGY

Kynurenine and its metabolites in Alzheimer's disease patients

(2010) E Gulaj et al.   Advances in Medical Sciences

Kynurenine metabolism in health and disease

(2010) Lukasz R. Kolodziej et al.   AMINO ACIDS

Prospects for Minocycline Neuroprotection

(2010) Jennifer M. Plane et al.   ARCHIVES OF NEUROLOGY

Assessment of psychotropic-like properties of a probiotic formulation ( Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects

(2010) Michaël Messaoudi et al.   BRITISH JOURNAL OF NUTRITION

The Cytokine Response to Human Traumatic Brain Injury: Temporal Profiles and Evidence for Cerebral Parenchymal Production

(2010) Adel Helmy et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The Role of Tryptophan Catabolism along the Kynurenine Pathway in Acute Ischemic Stroke

(2010) Raf Brouns et al.   NEUROCHEMICAL RESEARCH

The probiotic Bifidobacterium infantis 35624 displays visceral antinociceptive effects in the rat

(2010) D. P Mckernan et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Reduced anxiety-like behavior and central neurochemical change in germ-free mice

(2010) K. M. Neufeld et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Tryptophan degradation in irritable bowel syndrome: evidence of indoleamine 2,3-dioxygenase activation in a male cohort

(2009) Gerard Clarke et al.   BMC GASTROENTEROLOGY

The Serotonin Transporter Polymorphism rs25531 Is Associated with Irritable Bowel Syndrome

(2009) Ruth Kohen et al.   DIGESTIVE DISEASES AND SCIENCES

Cellular and mitochondrial glutathione redox imbalance in lymphoblastoid cells derived from children with autism

(2009) S. Jill James et al.   FASEB JOURNAL

Serotonin Has a Key Role in Pathogenesis of Experimental Colitis

(2009) Jean–Eric Ghia et al.   GASTROENTEROLOGY

5-HT4 Receptor-Mediated Neuroprotection and Neurogenesis in the Enteric Nervous System of Adult Mice

(2009) M.-T. Liu et al.   JOURNAL OF NEUROSCIENCE

Understanding the role of tryptophan and serotonin metabolism in gastrointestinal function

(2009) d. keszthelyi et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites

(2009) W. R. Wikoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The aryl hydrocarbon receptor in immunity

(2009) Charlotte Esser et al.   TRENDS IN IMMUNOLOGY

Serotonin: a review

(2008) L. F. MOHAMMAD-ZADEH et al.   JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS