Pharmacologically targeting transient receptor potential channels for seizures and epilepsy: Emerging preclinical evidence of druggability

Neuroinflammatory mediators in acquired epilepsy: an update

(2023) Yu Chen et al.   INFLAMMATION RESEARCH

Inhibition of TRPC3 channels by a novel pyrazole compound confers antiseizure effects

(2022) Marwa M. Nagib et al.   EPILEPSIA

Inhibition of Transient Receptor Potential Vanilloid 4 (TRPV4) Mitigates Seizures

(2022) Meng-liu Zeng et al.   Neurotherapeutics

Menthol exerts TRPM8-independent antiepileptic effects in prefrontal cortex pyramidal neurons

(2022) Bartłomiej Szulczyk et al.   BRAIN RESEARCH

Transient Receptor Potential Vanilloid 1 Function at Central Synapses in Health and Disease

(2022) Rodrigo C. Meza et al.   Frontiers in Cellular Neuroscience

TRPC channels as emerging targets for seizure disorders

(2022) Ying Yu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Transient Receptor Potential Vanilloid 4: a Double-Edged Sword in the Central Nervous System

(2022) Meng-liu Zeng et al.   MOLECULAR NEUROBIOLOGY

Ganaxolone for management of seizures associated with CDKL5 deficiency disorder

(2022) Nelufar Yasmen et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Editorial: Neuroinflammation in acquired epilepsy

(2022) Jianxiong Jiang et al.   Frontiers in Cell and Developmental Biology

Discovery of a Highly Selective and Potent TRPC3 Inhibitor with High Metabolic Stability and Low Toxicity

(2021) Sicheng Zhang et al.   ACS Medicinal Chemistry Letters

A Chinese patient with developmental and epileptic encephalopathies (DEE) carrying a TRPM3 gene mutation: a paediatric case report

(2021) Qingyun Kang et al.   BMC Pediatrics

Involvement of TRPV4 in changes in rapidly inactivating potassium channels in the early stage of pilocarpine‐induced status epilepticus in mice

(2021) Weixing Xu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Advances in TRP channel drug discovery: from target validation to clinical studies

(2021) Ari-Pekka Koivisto et al.   NATURE REVIEWS DRUG DISCOVERY

Contribution of non-selective membrane channels and receptors in epilepsy

(2021) Claudia García-Rodríguez et al.   PHARMACOLOGY & THERAPEUTICS

Blockade of TRPC Channels Limits Cholinergic-Driven Hyperexcitability and Seizure Susceptibility After Traumatic Brain Injury

(2021) Chase M. Carver et al.   Frontiers in Neuroscience

Description of a novel patient with the TRPM3 recurrent p.Val837Met variant

(2021) Lucas W Gauthier et al.   European Journal of Medical Genetics

Suppressive Effects of Transient Receptor Potential Melastatin 8 Agonist on Epileptiform Discharges and Epileptic Seizures

(2021) Hiroshi Moriyama et al.   Frontiers in Pharmacology

TRPC channels: Structure, function, regulation and recent advances in small molecular probes

(2020) Hongbo Wang et al.   PHARMACOLOGY & THERAPEUTICS

Mechanisms of action of currently used antiseizure drugs

(2020) Graeme J. Sills et al.   NEUROPHARMACOLOGY

TRPV1 Contributes to the Neuroprotective Effect of Dexmedetomidine in Pilocarpine-Induced Status Epilepticus Juvenile Rats

(2020) Xingqin Tan et al.   Biomed Research International

Disease-associated mutations in the human TRPM3 render the channel overactive via two distinct mechanisms

(2020) Siyuan Zhao et al.   eLife

Gain of channel function and modified gating properties in TRPM3 mutants causing intellectual disability and epilepsy

(2020) Evelien Van Hoeymissen et al.   eLife

The feast and famine: Epilepsy treatment and treatment gaps in early 21st century

(2020) Wolfgang Löscher et al.   NEUROPHARMACOLOGY

Sex Differences in the Epilepsies and Associated Comorbidities: Implications for Use and Development of Pharmacotherapies

(2020) Catherine A. Christian et al.   PHARMACOLOGICAL REVIEWS

The holy grail of epilepsy prevention: Preclinical approaches to antiepileptogenic treatments

(2019) Wolfgang Löscher   NEUROPHARMACOLOGY

TRPV4-induced inflammatory response is involved in neuronal death in pilocarpine model of temporal lobe epilepsy in mice

(2019) Zhouqing Wang et al.   Cell Death & Disease

De novo substitutions of TRPM3 cause intellectual disability and epilepsy

(2019) David A. Dyment et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

The path from scientific discovery to cures for epilepsy

(2019) Gemma L. Carvill et al.   NEUROPHARMACOLOGY

Pharmacoresistance – Epidemiology, mechanisms, and impact on epilepsy treatment

(2019) Mubeen Janmohamed et al.   NEUROPHARMACOLOGY

G protein-coupled receptors in acquired epilepsy: Druggability and translatability

(2019) Ying Yu et al.   PROGRESS IN NEUROBIOLOGY

Transient receptor potential vanilloid 4 is involved in the upregulation of connexin expression following pilocarpine-induced status epilepticus in mice

(2019) Chen Men et al.   BRAIN RESEARCH BULLETIN

Temperature elevation in epileptogenic foci exacerbates epileptic discharge through TRPV4 activation

(2019) Koji Shibasaki et al.   LABORATORY INVESTIGATION

Activation of TRPV1 Contributes to Recurrent Febrile Seizures via Inhibiting the Microglial M2 Phenotype in the Immature Brain

(2019) Weilin Kong et al.   Frontiers in Cellular Neuroscience

TRPM2 ion channel is involved in the aggravation of cognitive impairment and down regulation of epilepsy threshold in pentylenetetrazole-induced kindling mice

(2019) Qianqian Zheng et al.   BRAIN RESEARCH BULLETIN

TRPM2: a candidate therapeutic target for treating neurological diseases

(2018) Jillian Corinne Belrose et al.   ACTA PHARMACOLOGICA SINICA

Canonical Transient Receptor Potential Channel 3 Contributes to Febrile Seizure Inducing Neuronal Cell Death and Neuroinflammation

(2018) Dan Sun et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

TRPV1 mediates the anticonvulsant effects of acetaminophen in mice

(2018) Katsuya Suemaru et al.   EPILEPSY RESEARCH

Questioning the Effectiveness of Newer Antiseizure Medications

(2018) W. Allen Hauser   JAMA Neurology

Treatment Outcomes in Patients With Newly Diagnosed Epilepsy Treated With Established and New Antiepileptic Drugs

(2018) Zhibin Chen et al.   JAMA Neurology

Epilepsy

(2018) Orrin Devinsky et al.   Nature Reviews Disease Primers

Ca2+ Signals in Astrocytes Facilitate Spread of Epileptiform Activity

(2018) Kjell Heuser et al.   CEREBRAL CORTEX

Contribution of Zinc-Dependent Delayed Calcium Influx via TRPC5 in Oxidative Neuronal Death and its Prevention by Novel TRPC Antagonist

(2018) Sang Eun Park et al.   MOLECULAR NEUROBIOLOGY

Instruction manual for the ILAE 2017 operational classification of seizure types

(2017) Robert S. Fisher et al.   EPILEPSIA

Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology

(2017) Robert S. Fisher et al.   EPILEPSIA

Staining of HLA-DR, Iba1 and CD68 in human microglia reveals partially overlapping expression depending on cellular morphology and pathology

(2017) Debbie A.E. Hendrickx et al.   JOURNAL OF NEUROIMMUNOLOGY

Primidone inhibits TRPM3 and attenuates thermal nociception in vivo

(2017) Ute Krügel et al.   PAIN

TRPC3 channels play a critical role in the theta component of pilocarpine-induced status epilepticus in mice

(2016) Kevin D. Phelan et al.   EPILEPSIA

Involvement of TRPV1 channels in the activity of the cannabinoid WIN 55,212-2 in an acute rat model of temporal lobe epilepsy

(2016) Fabio Carletti et al.   EPILEPSY RESEARCH

Network synchronization in hippocampal neurons

(2016) Yaron Penn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-Inflammatory Small Molecules To Treat Seizures and Epilepsy: From Bench to Bedside

(2016) Avijit Dey et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Candidate Drug Targets for Prevention or Modification of Epilepsy

(2015) Nicholas H. Varvel et al.   Annual Review of Pharmacology and Toxicology

The role of TRPC6 in seizure susceptibility and seizure-related neuronal damage in the rat dentate gyrus

(2015) Y.-J. Kim et al.   NEUROSCIENCE

Store-Operated Calcium Channels

(2015) Murali Prakriya et al.   PHYSIOLOGICAL REVIEWS

Interference of TRPV1 function altered the susceptibility of PTZ-induced seizures

(2015) Yun-Fang Jia et al.   Frontiers in Cellular Neuroscience

Neuronal calcium signaling: function and dysfunction

(2014) Marisa Brini et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A Novel Subtype of Astrocytes Expressing TRPV4 (Transient Receptor Potential Vanilloid 4) Regulates Neuronal Excitability via Release of Gliotransmitters

(2014) Koji Shibasaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Astrocyte calcium signalling orchestrates neuronal synchronization in organotypic hippocampal slices

(2014) Takuya Sasaki et al.   JOURNAL OF PHYSIOLOGY-LONDON

Upregulation and Diverse Roles of TRPC3 and TRPC6 in Synaptic Reorganization of the Mossy Fiber Pathway in Temporal Lobe Epilepsy

(2014) Chang Zeng et al.   MOLECULAR NEUROBIOLOGY

Involvement of central TRPV1 receptors in pentylenetetrazole and amygdala-induced kindling in male rats

(2014) Mohsen Shirazi et al.   NEUROLOGICAL SCIENCES

Critical role of canonical transient receptor potential channel 7 in initiation of seizures

(2014) K. D. Phelan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of TRPV1 in susceptibility to PTZ-induced seizure following repeated hyperthermia challenges in neonatal mice

(2013) Wei-Lin Kong et al.   EPILEPSY & BEHAVIOR

The juvenile myoclonic epilepsy-related protein EFHC1 interacts with the redox-sensitive TRPM2 channel linked to cell death

(2012) Masahiro Katano et al.   CELL CALCIUM

The Reverse Roles of Transient Receptor Potential Canonical Channel-3 and -6 in Neuronal Death Following Pilocarpine-Induced Status Epilepticus

(2012) Duk-Soo Kim et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

A novel zebrafish model of hyperthermia-induced seizures reveals a role for TRPV4 channels and NMDA-type glutamate receptors

(2012) Robert F. Hunt et al.   EXPERIMENTAL NEUROLOGY

Increased Expression of TRPV1 in the Cortex and Hippocampus from Patients with Mesial Temporal Lobe Epilepsy

(2012) Fei-Ji Sun et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Physiology and Pathology of Calcium Signaling in the Brain

(2012) Elisa Mitiko Kawamoto et al.   Frontiers in Pharmacology

Disruption of metabotropic glutamate receptor signalling is a major defect at cerebellar parallel fibre-Purkinje cell synapses instaggerermutant mice

(2011) Kazuhiro Mitsumura et al.   JOURNAL OF PHYSIOLOGY-LONDON

Intrinsic and integrative properties of substantia nigra pars reticulata neurons

(2011) F.-M. Zhou et al.   NEUROSCIENCE

Activity-Dependent Release of Endogenous BDNF From Mossy Fibers Evokes a TRPC3 Current and Ca2+ Elevations in CA3 Pyramidal Neurons

(2010) Yong Li et al.   JOURNAL OF NEUROPHYSIOLOGY

International Union of Basic and Clinical Pharmacology. LXXVI. Current Progress in the Mammalian TRP Ion Channel Family

(2010) L.-J. Wu et al.   PHARMACOLOGICAL REVIEWS

Identification and characterization of novel TRPV4 modulators

(2009) Fabien Vincent et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TRPC3 protein is expressed across the lifespan in human prefrontal cortex and cerebellum

(2009) Angela S. Roedding et al.   BRAIN RESEARCH

Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound

(2009) S. Kiyonaka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRPC3 Channels Are Required for Synaptic Transmission and Motor Coordination

(2008) Jana Hartmann et al.   NEURON

A-Type GABA Receptor as a Central Target of TRPM8 Agonist Menthol

(2008) Xiao-Bing Zhang et al.   PLoS One