Article
Clinical Neurology
Soheila Rezakhani, Mahmood Amiri, Sarah Weckhuysen, Georgios A. Keliris
Summary: This study investigates the efficacy of cathodal high-definition tDCS as a noninvasive treatment for drug-resistant focal epilepsy. The results demonstrate that cathodal HD-tDCS significantly reduces seizure frequency and interictal epileptiform discharges, improves quality of life, and holds promise as a treatment modality for patients with drug-resistant focal epilepsy. Further research is needed to define the optimal stimulation parameters.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Clinical Neurology
Anca A. Arbune, Pirgit Meritam Larsen, Stephan Wustenhagen, Daniella Terney, Elena Gardella, Sandor Beniczky
Summary: The study found that more than one third of epileptiform EEG discharges showed a decrease in spiking patterns during seizures, suggesting a potential anticonvulsive function, while the majority of discharges increased in association with seizures.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Clinical Neurology
Karin Westin, Gerald Cooray, Sandor Beniczky, Daniel Lundqvist
Summary: Low-frequency oscillations prior to interictal epileptiform discharges (IEDs) indicate the presence of focal inhibition before hypersynchronization.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Clinical Neurology
Radek Janca, Petr Jezdik, Matyas Ebel, Adam Kalina, Martin Kudr, Alena Jahodova, David Krysl, Katerina Mackova, Barbora Straka, Petr Marusic, Pavel Krsek
Summary: This study demonstrates that electrophysiological patterns can accurately differentiate FCD types and help predict presurgical MRI findings, providing more precise surgical plans for patients.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Neurosciences
Alexandru Calin, Andrei S. Ilie, Colin J. Akerman
Summary: In this study, it was found that depolarization block in PV interneurons plays a significant role during the loss of inhibitory restraint, and that depolarization block in feedforward inhibitory synaptic mechanisms is a point of weakness.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Francesco Turco, Enrica Bonanni, Chiara Milano, Chiara Pizzanelli, Cecilia Steinwurzel, Riccardo Morganti, Francesco Fornai, Michelangelo Maestri, Gabriele Siciliano, Filippo Sean Giorgi
Summary: Prolonged epileptiform discharges (EDs) in EEG recordings may indicate antiepileptic drug failure in patients with Juvenile Myoclonic Epilepsy (JME). The maximum length and mean duration of EDs recorded during prolonged ambulatory EEG (paEEG) significantly differed between patients with seizure recurrence and those with sustained seizure freedom.
Review
Behavioral Sciences
Rene Andrade-Machado, Vanesa Benjumea Cuartas, Irshad Khan Muhammad
Summary: The article reviewed EEG findings in patients with focal epilepsy, highlighting the characteristics of discharges during the interictal period and the differences from generalized epilepsy. It discussed the coexistence of focal and generalized epilepsy, as well as methods for correctly diagnosing focal epilepsy.
EPILEPSY & BEHAVIOR
(2021)
Article
Neurosciences
Adam Gorlewicz, Barbara Pijet, Kristina Orlova, Leszek Kaczmarek, Ewelina Knapska
Summary: This study investigates the role of GluN2B in the pathophysiology of temporal lobe epilepsy and suggests the potential therapeutic use of ifenprodil, a GluN2B selective NMDAR antagonist. The findings provide insights into the factors contributing to recurrent seizures and propose a new candidate treatment for temporal lobe epilepsy.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Clinical Neurology
Gareth Morris, Mona Heiland, Kai Lamottke, Haifeng Guan, Thomas D. M. Hill, Yijun Zhou, Qianjin Zhu, Stephanie Schorge, David C. Henshall
Summary: Drug-resistant epilepsy is still a major clinical and societal burden. This study evaluated the potential of BICS01, a synthetic compound, as a new anti-seizure drug. The results showed that BICS01 rapidly reduced the frequency of epileptiform bursting without affecting network excitability or short-term synaptic facilitation. It was well tolerated at high doses in animal models. However, it did not have a protective effect against acute seizures. Further studies are needed to improve its pharmacokinetics, brain accumulation, and understand its mechanism of action.
FRONTIERS IN NEUROLOGY
(2022)
Article
Biology
Elliot H. Smith, Jyun-You Liou, Edward M. Merricks, Tyler Davis, Kyle Thomson, Bradley Greger, Paul House, Ronald G. Emerson, Robert Goodman, Guy M. McKhann, Sameer Sheth, Catherine Schevon, John D. Rolston
Summary: This study investigates the relationship between interictal epileptiform discharges (IEDs) and seizures. The findings demonstrate a spatiotemporal similarity between IEDs and ictal discharges, suggesting that the propagation of IEDs can provide useful information for localizing the seizure focus.
Article
Clinical Neurology
Louise Linka, Benedikt Magnus, Lena Habermehl, Panagiota-Eleni Tsalouchidou, Felix Zahnert, Leona Moeeller, Kristina Krause, Susanne Knake, Katja Menzler
Summary: This study evaluated the impact of the new definition of epilepsy on treatment decisions, seizure recurrence rates, and risk factors associated with epilepsy. The results showed that the new definition led to an increase in the use of antiseizure medication, but did not reduce the recurrence rates. The study also confirmed the relationship between seizure recurrence and interictal epileptiform discharges, as well as the protective effect of antiseizure medication, but could not confirm the impact of imaging findings on the new definition of epilepsy.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Joshua M. Diamond, Benjamin E. Diamond, Michael S. Trotta, Kate Dembny, Sara K. Inati, Kareem A. Zaghloul
Summary: Our study suggests that ictal activity observed by intracranial EEG may reflect propagated activity from a relatively focal seizure source, even during later time points when ictal activity is more widespread. By analyzing the time differences between ictal discharges in adjacent electrodes, we were able to estimate the location of the hypothesized focal source, which was found to closely match the clinically and neurophysiologically determined brain region giving rise to seizures. Furthermore, we found that this focal source is a dynamic entity that moves and evolves over the time course of a seizure, challenging the traditional conceptualization of the seizure source.
Article
Clinical Neurology
Simon Henin, Anita Shankar, Helen Borges, Adeen Flinker, Werner Doyle, Daniel Friedman, Orrin Devinsky, Gyorgy Buzsaki, Anli Liu
Summary: The spatiotemporal characteristics of cortical high-gamma activity, hippocampal ripple activity, and interictal epileptiform discharges have a significant impact on memory performance during an associative memory task, particularly in the hippocampal region. Interictal epileptiform discharges may impair associative memory by disrupting physiological activity, making them a promising therapeutic target for memory remediation in patients with epilepsy.
Article
Neurosciences
Anna Witkowska-Wrobel, Kirill Aristovich, Abbe Crawford, Justin D. Perkins, David Holder
Summary: The study successfully reconstructed slow impedance changes evoked by cell swelling using Electrical Impedance Tomography (EIT) in a swine model of epilepsy, demonstrating the potential of combining EIT with intracranial EEG monitoring to improve diagnostic yield in epileptic patients.
Article
Clinical Neurology
Sulaiman I. Abuhaiba, Isabel C. Duarte, Joo Castelhano, Ana Dionisio, Francisco Sales, Richard Edden, Miguel Castelo-Branco
Summary: This study investigated the antiepileptic effects of cathodal transcranial direct current stimulation (c-tDCS) and its mechanisms of action on neurotransmitters and brain metabolites. The results showed that real c-tDCS decreased the number of epileptiform discharges and reduced GABA concentration in the epileptogenic zone. These findings provide insights into the mechanisms of action of tDCS for epilepsy treatment.
FRONTIERS IN NEUROLOGY
(2022)