Journal
MOLECULAR NEUROBIOLOGY
Volume 60, Issue 3, Pages 1232-1249Publisher
SPRINGER
DOI: 10.1007/s12035-022-03141-6
Keywords
Transient receptor potential vanilloid 4; Central nervous system; Physiological function; Pathological function
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This review summarizes the known features of transient receptor potential vanilloid 4 (TRPV4) channel, including its expression, structure, and its physiological and pathological roles in the central nervous system (CNS), proposing an emerging therapeutic strategy for CNS diseases.
Transient receptor potential vanilloid 4 (TRPV4) is a nonselective cation channel that can be activated by diverse stimuli, such as heat, mechanical force, hypo-osmolarity, and arachidonic acid metabolites. TRPV4 is widely expressed in the central nervous system (CNS) and participates in many significant physiological processes. However, accumulative evidence has suggested that deficiency, abnormal expression or distribution, and overactivation of TRPV4 are involved in pathological processes of multiple neurological diseases. Here, we review the latest studies concerning the known features of this channel, including its expression, structure, and its physiological and pathological roles in the CNS, proposing an emerging therapeutic strategy for CNS diseases.
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