Review
Pediatrics
Christopher Henry, Chelsea Cockburn, Mary Helen Simpson, Serenity Budd, Chen Wang, Darina Dinov
Summary: This study provides estimates for the risk of multiple febrile seizures in the same febrile illness. The estimated baseline risk is 17%.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Cell Biology
Yeon Hee Yu, Seong-Wook Kim, Hyuna Im, Yu Ran Lee, Gun Woo Kim, Seongho Ryu, Dae-Kyoon Park, Duk-Soo Kim
Summary: Research suggests a link between febrile seizures and the development of autism spectrum disorder (ASD), with the inflammatory response triggered by febrile seizures potentially contributing to social cognitive impairments.
Article
Behavioral Sciences
Nosaibeh Riahi Zaniani, Ali Roohbakhsh, Ali Moghimi, Soghra Mehri
Summary: This study evaluates the neuroprotective effect of inhibiting Toll-like receptor 4 (TLR4), a prominent inflammatory axis, on the consequences of febrile seizures (FS) and adulthood. The results show that the inflammatory response is associated with increased cytokine levels and TLR4 expression, as well as memory deficits. Pretreatment with TAK-242, a specific TLR4 inhibitor, reduces inflammation and improves memory deficits.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Plant Sciences
Baohua Jin, Wanjun Bai, Jiaojiao Zhao, Xia Qin, Han Guo, Yahui Li, Jie Hao, Siruan Chen, Zuxiao Yang, Hui Bai, Zongmao Zhao, Qingzhong Jia, Changzheng Dong, Zhuo Huang, Dezhi Kong, Wei Zhang
Summary: This study found that Jujuboside B (JuB) can suppress febrile seizures by inhibiting the activity of AMPA receptors and reducing intracellular calcium levels, thereby relieving seizure symptoms.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Marwa M. Nagib, Sicheng Zhang, Nelufar Yasmen, Lexiao Li, Ruida Hou, Ying Yu, Vijay K. Boda, Zhongzhi Wu, Wei Li, Jianxiong Jiang
Summary: Pharmacological inhibition of TRPC3 channels by JW-65 represents a new antiseizure strategy with potential therapeutic benefits. JW-65 can impair the initiation of seizures, reduce susceptibility to epileptic seizures, and decrease sensitivity to antiepileptic drugs.
Review
Pediatrics
Rana Sawires, Jim Buttery, Michael Fahey
Summary: This article provides an overview of febrile seizures in young children, including their pathophysiology and risk factors. It also outlines the appropriate clinical approach for this condition.
FRONTIERS IN PEDIATRICS
(2022)
Article
Medicine, General & Internal
Fan Yang, Lichao Sun, Jing Li, Weihong Lin
Summary: This study aims to investigate the relationship between acute repetitive seizures and claustrum damage by analyzing the cases of 5 patients with exclusive involvement of bilateral claustrum. The patients, all young women with unremarkable medical history, presented with similar symptoms and showed good outcomes after empirical treatment with anti-viral and anti-seizure drugs. Despite characteristic clinical and imaging findings, the etiology remains unclear, but all patients had a favorable prognosis contrary to previous studies.
Article
Biochemistry & Molecular Biology
Javier Casas, Clara Meana, Jose Ramon Lopez-Lopez, Jesus Balsinde, Maria A. Balboa
Summary: This study reveals the activation of the TRPC3 channel during macrophage exposure to LPS, which is essential for intracellular Ca2+ release. TRPC3 participates in cytosolic Ca2+ elevations, NF-kappa B activation, and cytokine upregulation. Pharmacological inhibition of TRPC3 reduces LPS-induced systemic inflammation in mice.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Medicine, General & Internal
Min Jeong Han, Jun Ho Heo, Ji Seong Hwang, Young-Taek Jang, Min Lee, Sun Jun Kim
Summary: During the study period from January 2020 to June 2022, a total of 33,457 children under the age of 5 in Jeonbuk province, South Korea were diagnosed with COVID-19, and 64 of them (44 boys, 20 girls) developed febrile seizures.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Elham Bakhtiari, Farhad Heydarian, Maryam Khalesi, Fatemeh Jafarian, Mohammad Heidarian
Summary: In this study, the serum selenium levels were compared in febrile children aged 6-60 months with and without febrile seizures. There was no significant difference in selenium levels between the two groups overall, but in children over 1 year old, those with febrile seizures had lower selenium levels compared to those without seizures.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Behavioral Sciences
Kerstin Alexandra Klotz, Jasmin Oezcan, Yusuf Sag, Jan Schoenberger, Klaus Kaier, Julia Jacobs
Summary: The study aimed to evaluate anxiety levels of parents and children after a first unprovoked seizure, and found that a semi-structured follow-up in a first seizure clinic (FSC) can effectively and sustainably reduce anxiety levels. In contrast, anxiety after a first febrile seizure decreases over time without additional intervention.
EPILEPSY & BEHAVIOR
(2021)
Article
Cell Biology
Yeon Hee Yu, Seong-Wook Kim, Hyuna Im, Yejin Song, Seo Jeong Kim, Yu Ran Lee, Gun Woo Kim, Changmin Hwang, Dae-Kyoon Park, Duk-Soo Kim
Summary: This study investigates the causal relationship between febrile seizures in infancy and increased levels of anxiety-related behaviors and depression-like symptoms in juvenile and adult rodents using an FS rat model.
Article
Pediatrics
Ozlem Erdede, Erdal Sari, Emek Uyur, Rabia Gonul Sezer Yamanel
Summary: By evaluating complete blood count (CBC)-associated biomarkers, including osmolarity, this study provides a comprehensive understanding of their diagnostic value in febrile seizures (FS). The results show that osmolarity can be a useful tool in distinguishing complex FS cases, with better predictive utility compared to other markers.
Article
Pediatrics
Lingling Shao, Youna Yu
Summary: The study aimed to develop a prediction nomogram for recurrent febrile seizures in pediatric children based on identified predictors. The medical records of 320 children with febrile seizures were retrospectively reviewed, and predictors were identified through analyses. A prediction nomogram was developed and validated for clinical utility. The nomogram demonstrated good performance and clinical utility, serving as a convenient tool for detecting high-risk recurrent febrile seizures in pediatric patients and providing early interventions and counseling.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Pediatrics
Anna Loussouarn, Anita Devlin, Thomas Bast, Gregoire Benoist, Francois Corrard, Helen Cross, Alessandro Ferretti, Fernando Garcia-Sala Viguer, Renzo Guerrini, Joerg Klepper, Thomas Meissner, Mathieu Milh, Violeta Poltorak, Umberto Raucci, Victoria San Antonio-Arce, Adrian Sie, Patricia Smeyers, Nicola Specchio, Alastair Sutcliffe, Adeline Trauffler, Blandine Dozieres-Puyravel, Stephane Auvin
Summary: Febrile seizures are often traumatic for families, but a consensus statement on delivering information to families following a febrile seizure has been established through a Delphi process involving child neurologists and pediatricians, aiming to reassure caregivers and prevent inappropriate anxiety-driven behaviors.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)