LRRK2 Knockout Confers Resistance in HEK-293 Cells to Rotenone-Induced Oxidative Stress, Mitochondrial Damage, and Apoptosis

Role of Astrocytes in Parkinson’s Disease Associated with Genetic Mutations and Neurotoxicants

(2023) Sanghoon Kim et al.   Cells

Inference of CRISPR Edits from Sanger Trace Data

(2022) David Conant et al.   CRISPR Journal

BH3-Only Proteins Noxa and Puma Are Key Regulators of Induced Apoptosis

(2022) Rabih Roufayel et al.   Life-Basel

Functional Analyses of Two Novel LRRK2 Pathogenic Variants in Familial Parkinson′s Disease

(2022) Ilda Coku et al.   MOVEMENT DISORDERS

A step forward for LRRK2 inhibitors in Parkinson’s disease

(2022) Patrick A. Lewis   Science Translational Medicine

Omarigliptin Mitigates 6-Hydroxydopamine- or Rotenone-Induced Oxidative Toxicity in PC12 Cells by Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Actions

(2022) Noha A. Gouda et al.   Antioxidants

Multitasking guardian of mitochondrial quality: Parkin function and Parkinson’s disease

(2021) Iryna Kamienieva et al.   Translational Neurodegeneration

The Cell Biology of LRRK2 in Parkinson’s Disease

(2021) Ahsan Usmani et al.   MOLECULAR AND CELLULAR BIOLOGY

The development of inhibitors of leucine‐rich repeat kinase 2 (LRRK2) as a therapeutic strategy for Parkinson's disease: the current state of play

(2021) Sonia Azeggagh et al.   BRITISH JOURNAL OF PHARMACOLOGY

In vitro genome editing rescues parkinsonism phenotypes in induced pluripotent stem cells-derived dopaminergic neurons carrying LRRK2 p.G2019S mutation

(2021) Kuo-Hsuan Chang et al.   Stem Cell Research & Therapy

Chemically induced models of Parkinson's disease

(2021) Thilaga Thirugnanam et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

Phenolic‐rich extract of avocado Persea americana (var. Colinred) peel blunts paraquat/maneb‐induced apoptosis through blocking phosphorylation of LRRK2 kinase in human nerve‐like cells

(2021) Diana A. Quintero‐Espinosa et al.   ENVIRONMENTAL TOXICOLOGY

PINK1/Parkin Mediated Mitophagy, Ca2+ Signalling, and ER–Mitochondria Contacts in Parkinson’s Disease

(2020) Lucia Barazzuol et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

In Vitro CRISPR/Cas9-Directed Gene Editing to Model LRRK2 G2019S Parkinson’s Disease in Common Marmosets

(2020) Scott C. Vermilyea et al.   Scientific Reports

PINK1 and Parkin mitochondrial quality control: a source of regional vulnerability in Parkinson’s disease

(2020) Preston Ge et al.   Molecular Neurodegeneration

Protein synthesis is suppressed in sporadic and familial Parkinson’s disease by LRRK2

(2020) Prasannakumar Deshpande et al.   FASEB JOURNAL

Current and emerging therapeutic targets for Parkinson’s disease

(2020) Tanvi Pingale et al.   METABOLIC BRAIN DISEASE

LRRK2 impairs PINK1/Parkin-dependent mitophagy via its kinase activity: pathologic insights into Parkinson’s disease

(2019) Fiona Bonello et al.   HUMAN MOLECULAR GENETICS

Roco Proteins: GTPases with a Baroque Structure and Mechanism

(2019) Lina Wauters et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondria as multifaceted regulators of cell death

(2019) Florian J. Bock et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Neuroprotective effects of mitoquinone and oleandrin on Parkinson’s disease model in zebrafish

(2019) İsmail Ünal et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

LRRK2 Biology from structure to dysfunction: research progresses, but the themes remain the same

(2019) Daniel C. Berwick et al.   Molecular Neurodegeneration

LRRK2 and mitochondria: Recent advances and current views

(2018) Alpana Singh et al.   BRAIN RESEARCH

Building and decoding ubiquitin chains for mitophagy

(2018) J. Wade Harper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

What exactly is ‘N’ in cell culture and animal experiments?

(2018) Stanley E. Lazic et al.   PLOS BIOLOGY

SIRT3 Protects Rotenone-induced Injury in SH-SY5Y Cells by Promoting Autophagy through the LKB1-AMPK-mTOR Pathway

(2018) Meng Zhang et al.   Aging and Disease

LRRK2 activation in idiopathic Parkinson’s disease

(2018) Roberto Di Maio et al.   Science Translational Medicine

Wild-type and mutant (G2019S) leucine-rich repeat kinase 2 (LRRK2) associate with subunits of the translocase of outer mitochondrial membrane (TOM) complex

(2018) Annika Neethling et al.   EXPERIMENTAL CELL RESEARCH

Direct transdifferentiation of human Wharton’s jelly mesenchymal stromal cells into cholinergic-like neurons

(2018) Miguel Mendivil-Perez et al.   JOURNAL OF NEUROSCIENCE METHODS

From the Cover: Manganese and Rotenone-Induced Oxidative Stress Signatures Differ in iPSC-Derived Human Dopamine Neurons

(2017) M. Diana Neely et al.   TOXICOLOGICAL SCIENCES

Comparison of different in vitro cell models for the assessment of pesticide-induced dopaminergic neurotoxicity

(2017) Harm J. Heusinkveld et al.   TOXICOLOGY IN VITRO

Current understanding of the molecular mechanisms in Parkinson's disease: Targets for potential treatments

(2017) Panchanan Maiti et al.   Translational Neurodegeneration

Neuroprotective Effect of the LRRK2 Kinase Inhibitor PF-06447475 in Human Nerve-Like Differentiated Cells Exposed to Oxidative Stress Stimuli: Implications for Parkinson’s Disease

(2016) Miguel Mendivil-Perez et al.   NEUROCHEMICAL RESEARCH

CRISPR-Cas: biology, mechanisms and relevance

(2016) Frank Hille et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases

(2016) Martin Steger et al.   eLife

A LUHMES 3D dopaminergic neuronal model for neurotoxicity testing allowing long-term exposure and cellular resilience analysis

(2015) L. Smirnova et al.   ARCHIVES OF TOXICOLOGY

Rotenone exerts similar stimulatory effects on H2O2 production by isolated brain mitochondria from young–adult and old rats

(2015) Luiz G.B. Michelini et al.   NEUROSCIENCE LETTERS

Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21WAF1/CIP1 expression

(2015) Dong Hwan Ho et al.   Molecular Brain

c-Jun transactivates Puma gene expression to promote osteoarthritis

(2014) HUADING LU et al.   Molecular Medicine Reports

Characteristics and requirements of basal autophagy in HEK 293 cells

(2013) Patience Musiwaro et al.   Autophagy

Inhibition of excessive mitochondrial fission reduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutation

(2013) Yu-Chin Su et al.   HUMAN MOLECULAR GENETICS

(G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD

(2012) C-Y Chen et al.   CELL DEATH AND DIFFERENTIATION

Classification of mitocans, anti-cancer drugs acting on mitochondria

(2012) Jiri Neuzil et al.   MITOCHONDRION

The IkappaB Kinase Family Phosphorylates the Parkinson’s Disease Kinase LRRK2 at Ser935 and Ser910 during Toll-Like Receptor Signaling

(2012) Nicolas Dzamko et al.   PLoS One

PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy

(2012) Kahori Shiba-Fukushima et al.   Scientific Reports

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

(2012) C. Kondapalli et al.   Open Biology

LRRK2 Mutant iPSC-Derived DA Neurons Demonstrate Increased Susceptibility to Oxidative Stress

(2011) Ha Nam Nguyen et al.   Cell Stem Cell

Mutations inLRRK2increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death

(2011) Dario C. Angeles et al.   HUMAN MUTATION

Reevaluation of Phosphorylation Sites in the Parkinson Disease-associated Leucine-rich Repeat Kinase 2

(2010) Xiaojie Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

JNK3 Mediates Paraquat- and Rotenone-Induced Dopaminergic Neuron Death

(2010) Won-Seok Choi et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

LRRK2 enhances oxidative stress-induced neurotoxicity via its kinase activity

(2009) Hye Young Heo et al.   EXPERIMENTAL CELL RESEARCH

Novel imine antioxidants at low nanomolar concentrations protect dopaminergic cells from oxidative neurotoxicity

(2009) Parvana Hajieva et al.   JOURNAL OF NEUROCHEMISTRY

A Chemical Inhibitor of DRP1 Uncouples Mitochondrial Fission and Apoptosis

(2008) Atsushi Tanaka et al.   MOLECULAR CELL