(G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD

Polyglutamine-expanded ataxin-7 upregulates Bax expression by activating p53 in cerebellar and inferior olivary neurons

(2010) Hung-Li Wang et al.   EXPERIMENTAL NEUROLOGY

MKK6 binds and regulates expression of Parkinson’s disease-related protein LRRK2

(2010) Cindy H. Hsu et al.   JOURNAL OF NEUROCHEMISTRY

The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease

(2010) Mark R. Cookson   NATURE REVIEWS NEUROSCIENCE

Leucine-Rich Repeat Kinase 2 Gene-Associated Disease: Redefining Genotype-Phenotype Correlation

(2010) Christian Wider et al.   Neurodegenerative Diseases

The genetics of Parkinson's syndromes: a critical review

(2009) John Hardy et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Parkinson's disease: from monogenic forms to genetic susceptibility factors

(2009) S. Lesage et al.   HUMAN MOLECULAR GENETICS

The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7,in vitro

(2009) Christian Johannes Gloeckner et al.   JOURNAL OF NEUROCHEMISTRY

The Parkinson Disease Protein Leucine-Rich Repeat Kinase 2 Transduces Death Signals via Fas-Associated Protein with Death Domain and Caspase-8 in a Cellular Model of Neurodegeneration

(2009) C. C.-Y. Ho et al.   JOURNAL OF NEUROSCIENCE

Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria

(2009) Dennis W Dickson et al.   LANCET NEUROLOGY

Mutant LRRK2 R1441G BAC transgenic mice recapitulate cardinal features of Parkinson's disease

(2009) Yanping Li et al.   NATURE NEUROSCIENCE

Polyglutamine-expanded ataxin-7 causes cerebellar dysfunction by inducing transcriptional dysregulation

(2009) An-Hsun Chou et al.   NEUROCHEMISTRY INTERNATIONAL

Quantitative micro-SPECT/CT for detecting focused ultrasound-induced blood–brain barrier opening in the rat

(2009) Kun-Ju Lin et al.   NUCLEAR MEDICINE AND BIOLOGY

JNK2 and JNK3 combined are essential for apoptosis in dopamine neurons of the substantia nigra, but are not required for axon degeneration

(2008) Vincent Ries et al.   JOURNAL OF NEUROCHEMISTRY

Developmental regulation of leucine-rich repeat kinase 1 and 2 expression in the brain and other rodent and human organs: Implications for Parkinson’s disease

(2008) M. Westerlund et al.   NEUROSCIENCE