In vitro genome editing rescues parkinsonism phenotypes in induced pluripotent stem cells-derived dopaminergic neurons carrying LRRK2 p.G2019S mutation

Comprehensive metabolic profiling of Parkinson’s disease by liquid chromatography-mass spectrometry

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An old weapon with a new function: PIWI-interacting RNAs in neurodegenerative diseases

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LRRK2 in Parkinson disease: challenges of clinical trials

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Transcriptomic profiling of microglia and astrocytes throughout aging

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Modeling G2019S-LRRK2 Sporadic Parkinson's Disease in 3D Midbrain Organoids

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LRRK2 regulation of immune-pathways and inflammatory disease

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Generation of genetically modified mice using SpCas9-NG engineered nuclease

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LRRK2 Biology from structure to dysfunction: research progresses, but the themes remain the same

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Widespread bacterial protein histidine phosphorylation revealed by mass spectrometry-based proteomics

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How to create state-of-the-art genetic model systems: strategies for optimal CRISPR-mediated genome editing

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OUP accepted manuscript

(2018)   NUCLEIC ACIDS RESEARCH

The genetic landscape of Parkinson's disease

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Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage

(2017) Nicole M. Gaudelli et al.   NATURE

RNA editing with CRISPR-Cas13

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Generation of induced pluripotent stem cells from a patient with Parkinson's disease carrying LRRK2 p.I2012T mutation

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Gaining comprehensive biological insight into the transcriptome by performing a broad-spectrum RNA-seq analysis

(2017) Sayed Mohammad Ebrahim Sahraeian et al.   Nature Communications

Oxidative stress and cellular pathologies in Parkinson’s disease

(2017) Lesly Puspita et al.   Molecular Brain

Optimizing the DNA Donor Template for Homology-Directed Repair of Double-Strand Breaks

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Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity

(2017) Alexis C. Komor et al.   Science Advances

MultiQC: summarize analysis results for multiple tools and samples in a single report

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PPARγ as a therapeutic target to rescue mitochondrial function in neurological disease

(2016) Juan Carlos Corona et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Perseus computational platform for comprehensive analysis of (prote)omics data

(2016) Stefka Tyanova et al.   NATURE METHODS

Knock-in of large reporter genes in human cells via CRISPR/Cas9-induced homology-dependent and independent DNA repair

(2016) Xiangjun He et al.   NUCLEIC ACIDS RESEARCH

Dopaminergic neurons differentiating from LRRK2 G2019S induced pluripotent stem cells show early neuritic branching defects

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Effects of Serine 129 Phosphorylation on α-Synuclein Aggregation, Membrane Association, and Internalization

(2015) Filsy Samuel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gene Expression Analyses Identify Narp Contribution in the Development of L-DOPA-Induced Dyskinesia

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HISAT: a fast spliced aligner with low memory requirements

(2015) Daehwan Kim et al.   NATURE METHODS

Trimmomatic: a flexible trimmer for Illumina sequence data

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Multi-kilobase homozygous targeted gene replacement in human induced pluripotent stem cells

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The new frontier of genome engineering with CRISPR-Cas9

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PPAR Agonists as Therapeutics for CNS Trauma and Neurological Diseases

(2013) Shweta Mandrekar-Colucci et al.   ASN Neuro

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

Genetic Correction of a LRRK2 Mutation in Human iPSCs Links Parkinsonian Neurodegeneration to ERK-Dependent Changes in Gene Expression

(2013) Peter Reinhardt et al.   Cell Stem Cell

LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: Reversal by gene correction

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An Inhibitor of Nonhomologous End-Joining Abrogates Double-Strand Break Repair and Impedes Cancer Progression

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LRRK2 Mutant iPSC-Derived DA Neurons Demonstrate Increased Susceptibility to Oxidative Stress

(2011) Ha Nam Nguyen et al.   Cell Stem Cell

LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice

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Genetic characteristics of leucine-rich repeat kinase 2 (LRRK2) associated Parkinson’s disease

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Allelic imbalance sequencing reveals that single-nucleotide polymorphisms frequently alter microRNA-directed repression

(2009) Jinkuk Kim et al.   NATURE BIOTECHNOLOGY

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

(2009) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY

Comparison of nonhomologous end joining and homologous recombination in human cells

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PPAR: a therapeutic target in Parkinsons disease

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A chemical compound that stimulates the human homologous recombination protein RAD51

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