Effects of Ruxolitinib on fibrosis in preclinical models of systemic sclerosis

Arsenic trioxide inhibits the functions of lung fibroblasts derived from patients with idiopathic pulmonary fibrosis

(2022) Audrey Joannes et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Disparate Interferon Signaling and Shared Aberrant Basaloid Cells in Single-Cell Profiling of Idiopathic Pulmonary Fibrosis and Systemic Sclerosis-Associated Interstitial Lung Disease

(2021) Eleanor Valenzi et al.   Frontiers in Immunology

Insights into origins and specificities of autoantibodies in systemic sclerosis

(2021) Eleni Tiniakou et al.   CURRENT OPINION IN RHEUMATOLOGY

Contribution of monocytes and macrophages to the pathogenesis of systemic sclerosis

(2021) Alain Lescoat et al.   CURRENT OPINION IN RHEUMATOLOGY

Role of JAK/STAT in Interstitial Lung Diseases; Molecular and Cellular Mechanisms

(2021) Paula Montero et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Long-Term Safety and Efficacy of Tocilizumab in Early Systemic Sclerosis–Interstitial Lung Disease: Open Label Extension of a Phase 3 Randomized Controlled Trial

(2021) Dinesh Khanna et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Systemic sclerosis-associated interstitial lung disease

(2020) Apostolos Perelas et al.   Lancet Respiratory Medicine

Crystalline Silica Impairs Efferocytosis Abilities of Human and Mouse Macrophages: Implication for Silica-Associated Systemic Sclerosis

(2020) Alain Lescoat et al.   Frontiers in Immunology

Cytotoxic CD4+ T lymphocytes may induce endothelial cell apoptosis in systemic sclerosis

(2020) Takashi Maehara et al.   JOURNAL OF CLINICAL INVESTIGATION

Combined anti-fibrotic and anti-inflammatory properties of JAK-inhibitors on macrophages in vitro and in vivo: Perspectives for scleroderma-associated interstitial lung disease

(2020) Alain Lescoat et al.   BIOCHEMICAL PHARMACOLOGY

Type I Interferons in the Pathogenesis and Treatment of Autoimmune Diseases

(2020) Jiao Jiang et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Antinuclear Antibodies in Systemic Sclerosis: an Update

(2019) Anna Stochmal et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Janus kinases to jakinibs: from basic insights to clinical practice

(2019) Massimo Gadina et al.   RHEUMATOLOGY

Type I interferon dysregulation in Systemic Sclerosis

(2019) Brian Skaug et al.   CYTOKINE

Nintedanib for Systemic Sclerosis–Associated Interstitial Lung Disease

(2019) Oliver Distler et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interferon regulatory factor 7 (IRF7) represents a link between inflammation and fibrosis in the pathogenesis of systemic sclerosis

(2019) Minghua Wu et al.   ANNALS OF THE RHEUMATIC DISEASES

Global skin gene expression analysis of early diffuse cutaneous systemic sclerosis shows a prominent innate and adaptive inflammatory profile

(2019) Brian Skaug et al.   ANNALS OF THE RHEUMATIC DISEASES

Ruxolitinib in refractory acute and chronic graft-versus-host disease: a multicenter survey study

(2019) Virginia Escamilla Gómez et al.   BONE MARROW TRANSPLANTATION

Targeting interferons as a strategy for systemic sclerosis treatment

(2018) Marzena Ciechomska et al.   IMMUNOLOGY LETTERS

Repression of interferon β-regulated cytokines by the JAK1/2 inhibitor ruxolitinib in inflammatory human macrophages

(2018) Marie Febvre-James et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Mycophenolate Mofetil Treatment of Systemic Sclerosis Reduces Myeloid Cell Numbers and Attenuates the Inflammatory Gene Signature in Skin

(2018) Monique Hinchcliff et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Diagnosis of Idiopathic Pulmonary Fibrosis. An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline

(2018) Ganesh Raghu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Efferocytosis capacities of blood monocyte‐derived macrophages in systemic sclerosis

(2018) Alice Ballerie et al.   IMMUNOLOGY AND CELL BIOLOGY

Systemic sclerosis

(2017) Yoshihide Asano   JOURNAL OF DERMATOLOGY

A novel multi-network approach reveals tissue-specific cellular modulators of fibrosis in systemic sclerosis

(2017) Jaclyn N. Taroni et al.   Genome Medicine

The interferon type I signature is present in systemic sclerosis before overt fibrosis and might contribute to its pathogenesis through high BAFF gene expression and high collagen synthesis

(2015) Zana Brkic et al.   ANNALS OF THE RHEUMATIC DISEASES

Suppression of T Cell Activation and Collagen Accumulation by an Anti-IFNAR1 mAb, Anifrolumab, in Adult Patients with Systemic Sclerosis

(2015) Xiang Guo et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Systems Level Analysis of Systemic Sclerosis Shows a Network of Immune and Profibrotic Pathways Connected with Genetic Polymorphisms

(2015) J. Matthew Mahoney et al.   PLoS Computational Biology

Dissecting the Heterogeneity of Skin Gene Expression Patterns in Systemic Sclerosis

(2015) Shervin Assassi et al.   Arthritis & Rheumatology

A phase I/II study of ofatumumab (GSK1841157) in Japanese and Korean patients with relapsed or refractory B-cell chronic lymphocytic leukemia

(2013) Yoshiaki Ogawa et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Association of Interferon- and Transforming Growth Factor β-Regulated Genes and Macrophage Activation With Systemic Sclerosis-Related Progressive Lung Fibrosis

(2013) Romy B. Christmann et al.   Arthritis & Rheumatology

Correlation of interferon-inducible chemokine plasma levels with disease severity in systemic sclerosis

(2012) Xiaochun Liu et al.   ARTHRITIS AND RHEUMATISM

JAK-2 as a novel mediator of the profibrotic effects of transforming growth factor β in systemic sclerosis

(2012) Clara Dees et al.   ARTHRITIS AND RHEUMATISM

Systemic sclerosis and lupus: Points in an interferon-mediated continuum

(2010) Shervin Assassi et al.   ARTHRITIS AND RHEUMATISM

Macrophage phagocytosis of apoptotic neutrophils is critically regulated by the opposing actions of pro-inflammatory and anti-inflammatory agents: key role for TNF-α

(2008) Sylwia Michlewska et al.   FASEB JOURNAL