Arsenic trioxide inhibits the functions of lung fibroblasts derived from patients with idiopathic pulmonary fibrosis

Esomeprazole attenuates inflammatory and fibrotic response in lung cells through the MAPK/Nrf2/HO1 pathway

(2021) Afshin Ebrahimpour et al.   Journal of Inflammation-London

TGF ‐β as a driver of fibrosis: physiological roles and therapeutic opportunities

(2021) Erine H Budi et al.   JOURNAL OF PATHOLOGY

Pirfenidone: Molecular Mechanisms and Potential Clinical Applications in Lung Disease

(2020) Saleela M Ruwanpura et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Efficacy and safety of nintedanib in patients with advanced idiopathic pulmonary fibrosis

(2020) Luca Richeldi et al.   BMC Pulmonary Medicine

Phase I clinical trial of KML001 monotherapy in patients with advanced solid tumors

(2020) Seokuee Kim et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Activation of Nrf2/AREs-mediated antioxidant signalling, and suppression of profibrotic TGF-β1/Smad3 pathway: a promising therapeutic strategy for hepatic fibrosis — A review

(2020) Yongfang Gong et al.   LIFE SCIENCES

Arsenic trioxide disturbs the LIS1/NDEL1/dynein microtubule dynamic complex by disrupting the CLIP170 zinc finger in head and neck cancer

(2020) Lu Gao et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Mitochondrial Dysfunction in Aged Macrophages and Lung during Primary Streptococcus pneumoniae Infection is Improved with Pirfenidone

(2019) Maria Plataki et al.   Scientific Reports

Bi-directional regulation of TGF-β/Smad pathway by arsenic: A systemic review and meta-analysis of in vivo and in vitro studies

(2019) Jingyuan Dai et al.   LIFE SCIENCES

Arsenic trioxide and curcumin attenuate cisplatin-induced renal fibrosis in rats through targeting Hedgehog signaling

(2019) Abdalkareem Omar Maghmomeh et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Idiopathic Pulmonary Fibrosis

(2018) David J. Lederer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Diagnosis of Idiopathic Pulmonary Fibrosis. An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline

(2018) Ganesh Raghu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Arsenic Trioxide Suppressed Migration and Angiogenesis by Targeting FOXO3a in Gastric Cancer Cells

(2018) Lin Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Arsenic trioxide inhibits the differentiation of fibroblasts to myofibroblasts through nuclear factor erythroid 2-like 2 (NFE2L2) protein and the Smad2/3 pathway

(2018) Lingzhi Zhong et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The role of microRNA-155/liver X receptor pathway in experimental and idiopathic pulmonary fibrosis

(2017) Mariola Kurowska-Stolarska et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Anti-angiogenic effect of arsenic trioxide in lung cancer via inhibition of endothelial cell migration, proliferation and tube formation

(2017) Meng-Hang Yang et al.   Oncology Letters

Novel Mechanisms for the Antifibrotic Action of Nintedanib

(2016) Sunad Rangarajan et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Arsenic Trioxide Induces Apoptosis and Incapacitates Proliferation and Invasive Properties of U87MG Glioblastoma Cells through a Possible NF-κB-Mediated Mechanism

(2016) Seyed H. Ghaffari et al.   Asian Pacific Journal of Cancer Prevention

Arsenic trioxide suppresses cell growth and migration via inhibition of miR-27a in breast cancer cells

(2016) Shunhua Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The role of tyrosine kinases in the pathogenesis of idiopathic pulmonary fibrosis

(2015) Friedrich Grimminger et al.   EUROPEAN RESPIRATORY JOURNAL

Mode of action of nintedanib in the treatment of idiopathic pulmonary fibrosis

(2015) Lutz Wollin et al.   EUROPEAN RESPIRATORY JOURNAL

Inhibition of transforming growth factor beta/SMAD signal by MiR-155 is involved in arsenic trioxide-induced anti-angiogenesis in prostate cancer

(2014) Hui Ji et al.   CANCER SCIENCE

Arsenic trioxide prevents rat pulmonary fibrosis via miR-98 overexpression

(2014) Shu-Yan Gao et al.   LIFE SCIENCES

A Phase 3 Trial of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis

(2014) Talmadge E. King et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy and Safety of Nintedanib in Idiopathic Pulmonary Fibrosis

(2014) Luca Richeldi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Arsenic trioxide inhibits transforming growth factor-β1-induced fibroblast to myofibroblast differentiation in vitro and bleomycin induced lung fibrosis in vivo

(2014) Fayong Luo et al.   RESPIRATORY RESEARCH

Nuclear Factor Erythroid 2-Related Factor 2 Nuclear Translocation Induces Myofibroblastic Dedifferentiation in Idiopathic Pulmonary Fibrosis

(2012) Elise Artaud-Macari et al.   ANTIOXIDANTS & REDOX SIGNALING

Arsenic modulates heme oxygenase-1, interleukin-6, and vascular endothelial growth factor expression in endothelial cells: roles of ROS, NF-κB, and MAPK pathways

(2012) Lisu Wang et al.   ARCHIVES OF TOXICOLOGY

Reactive oxygen species-mediated killing of activated fibroblasts by arsenic trioxide ameliorates fibrosis in a murine model of systemic sclerosis

(2012) Niloufar Kavian et al.   ARTHRITIS AND RHEUMATISM

Arsenic-induced interstitial myocardial fibrosis reveals a new insight into drug-induced long QT syndrome

(2012) Wenfeng Chu et al.   CARDIOVASCULAR RESEARCH

Sulforaphane attenuates hepatic fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-β/Smad signaling

(2011) Chang Joo Oh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Idiopathic pulmonary fibrosis

(2011) Talmadge E King et al.   LANCET

Arsenic trioxide inhibits osteosarcoma cell invasiveness via MAPK signaling pathway

(2010) Ren Tingting et al.   CANCER BIOLOGY & THERAPY

Reactive Oxygen Species Are Not Required for an Arsenic Trioxide-induced Antioxidant Response or Apoptosis

(2009) Alejo A. Morales et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Redox-sensitive regulation of gene expression in human primary macrophages exposed to inorganic arsenic

(2009) Emilie Bourdonnay et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

NRF2 Cysteine Residues Are Critical for Oxidant/Electrophile-Sensing, Kelch-Like ECH-Associated Protein-1-Dependent Ubiquitination-Proteasomal Degradation, and Transcription Activation

(2009) X. He et al.   MOLECULAR PHARMACOLOGY