Disparate Interferon Signaling and Shared Aberrant Basaloid Cells in Single-Cell Profiling of Idiopathic Pulmonary Fibrosis and Systemic Sclerosis-Associated Interstitial Lung Disease

Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis

(2020) Taylor S. Adams et al.   Science Advances

Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis

(2020) Arun C. Habermann et al.   Science Advances

Epithelial Injury and Dysfunction in the Pathogenesis of Idiopathic Pulmonary Fibrosis

(2019) Nichelle I. Winters et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Systemic Sclerosis Pathogenesis and Emerging Therapies, beyond the Fibroblast

(2019) Andrea Sierra-Sepúlveda et al.   Biomed Research International

Evolving insights into the cellular and molecular pathogenesis of fibrosis in systemic sclerosis

(2019) Benjamin Korman   Translational Research

E3 ubiquitin ligases RNF20 and RNF40 are required for DSB repair: evidence for monoubiquitination of histone H2B lysine 120 as a novel axis of DSB signaling and repair

(2019) Clare C. So et al.   MOLECULAR AND CELLULAR BIOLOGY

Nintedanib for Systemic Sclerosis–Associated Interstitial Lung Disease

(2019) Oliver Distler et al.   NEW ENGLAND JOURNAL OF MEDICINE

The FMS-like tyrosine kinase-3 ligand/lung dendritic cell axis contributes to regulation of pulmonary fibrosis

(2019) Meritxell Tort Tarrés et al.   THORAX

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Proliferating SPP1/MERTK-expressing macrophages in idiopathic pulmonary fibrosis

(2019) Christina Morse et al.   EUROPEAN RESPIRATORY JOURNAL

Single-cell analysis reveals fibroblast heterogeneity and myofibroblasts in systemic sclerosis-associated interstitial lung disease

(2019) Eleanor Valenzi et al.   ANNALS OF THE RHEUMATIC DISEASES

Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis

(2019) Richard J Allen et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Shared and distinct mechanisms of fibrosis

(2019) Jörg H. W. Distler et al.   Nature Reviews Rheumatology

GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways

(2019) Elena López-Isac et al.   Nature Communications

Repurposing of gamma interferon via inhalation delivery

(2018) Gerald C. Smaldone   ADVANCED DRUG DELIVERY REVIEWS

Prediction of progression of interstitial lung disease in patients with systemic sclerosis: the SPAR model

(2018) Wanlong Wu et al.   ANNALS OF THE RHEUMATIC DISEASES

Idiopathic pulmonary fibrosis: Epithelial-mesenchymal interactions and emerging therapeutic targets

(2018) Justin C. Hewlett et al.   MATRIX BIOLOGY

Myeloablative Autologous Stem-Cell Transplantation for Severe Scleroderma

(2018) Keith M. Sullivan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Matrix Stiffness: the Conductor of Organ Fibrosis

(2018) Alba Santos et al.   Current Rheumatology Reports

Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis

(2018) Paul A Reyfman et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Dimensionality reduction for visualizing single-cell data using UMAP

(2018) Etienne Becht et al.   NATURE BIOTECHNOLOGY

New insights into the genetics and epigenetics of systemic sclerosis

(2018) Chiara Angiolilli et al.   Nature Reviews Rheumatology

MUC5B Promoter Variant and Rheumatoid Arthritis with Interstitial Lung Disease

(2018) Pierre-Antoine Juge et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Gene Ontology Resource: 20 years and still GOing strong

(2018)   NUCLEIC ACIDS RESEARCH

Systemic sclerosis

(2017) Christopher P Denton et al.   LANCET

Cadmium stimulates myofibroblast differentiation and mouse lung fibrosis

(2017) Xin Hu et al.   TOXICOLOGY

Innate Immunity in Systemic Sclerosis

(2017) Christopher Dowson et al.   Current Rheumatology Reports

Mycophenolate Mofetil Versus Placebo for Systemic Sclerosis-Related Interstitial Lung Disease: An Analysis of Scleroderma Lung Studies I and II

(2017) Elizabeth R. Volkmann et al.   Arthritis & Rheumatology

Association of MicroRNA-618 Expression With Altered Frequency and Activation of Plasmacytoid Dendritic Cells in Patients With Systemic Sclerosis

(2017) Marzia Rossato et al.   Arthritis & Rheumatology

A potential contribution of antimicrobial peptide LL-37 to tissue fibrosis and vasculopathy in systemic sclerosis

(2016) T. Takahashi et al.   BRITISH JOURNAL OF DERMATOLOGY

Ubiquitin E3 ligase FIEL1 regulates fibrotic lung injury through SUMO-E3 ligase PIAS4

(2016) Travis Lear et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Management of interstitial lung disease associated with connective tissue disease

(2016) Stephen C Mathai et al.   BMJ-British Medical Journal

Management of interstitial lung disease associated with connective tissue disease

(2016) Stephen C Mathai et al.   BMJ-British Medical Journal

The interferon type I signature is present in systemic sclerosis before overt fibrosis and might contribute to its pathogenesis through high BAFF gene expression and high collagen synthesis

(2015) Zana Brkic et al.   ANNALS OF THE RHEUMATIC DISEASES

αvβ6 integrin is required for TGFβ1-mediated matrix metalloproteinase2 expression

(2015) Anindita Dutta et al.   BIOCHEMICAL JOURNAL

Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets

(2015) Evan Z. Macosko et al.   CELL

Spatial reconstruction of single-cell gene expression data

(2015) Rahul Satija et al.   NATURE BIOTECHNOLOGY

Predictors of Mortality and Progression in Scleroderma-Associated Interstitial Lung Disease

(2014) Tiffany A. Winstone et al.   CHEST

Autologous Hematopoietic Stem Cell Transplantation vs Intravenous Pulse Cyclophosphamide in Diffuse Cutaneous Systemic Sclerosis

(2014) Jacob M. van Laar et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Transforming growth factor β—at the centre of systemic sclerosis

(2014) Robert Lafyatis   Nature Reviews Rheumatology

Efficacy and Safety of Nintedanib in Idiopathic Pulmonary Fibrosis

(2014) Luca Richeldi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Review: Interstitial Lung Disease Associated With Systemic Sclerosis and Idiopathic Pulmonary Fibrosis: How Similar and Distinct?

(2014) Erica L. Herzog et al.   Arthritis & Rheumatology

The Idiopathic Pulmonary Fibrosis Honeycomb Cyst Contains A Mucocilary Pseudostratified Epithelium

(2013) Max A. Seibold et al.   PLoS One

The MUC5B Variant Is Associated with Idiopathic Pulmonary Fibrosis but Not with Systemic Sclerosis Interstitial Lung Disease in the European Caucasian Population

(2013) Raphael Borie et al.   PLoS One

The Role of Type 1 Interferon in Systemic Sclerosis

(2013) Minghua Wu et al.   Frontiers in Immunology

Delivery and Safety of Inhaled Interferon-γ in Idiopathic Pulmonary Fibrosis

(2012) Keith T. Diaz et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Prednisone, Azathioprine, andN-Acetylcysteine for Pulmonary Fibrosis

(2012)   NEW ENGLAND JOURNAL OF MEDICINE

Autologous non-myeloablative haemopoietic stem-cell transplantation compared with pulse cyclophosphamide once per month for systemic sclerosis (ASSIST): an open-label, randomised phase 2 trial

(2011) Richard K Burt et al.   LANCET

The Unfolded Protein Response: Integrating Stress Signals Through the Stress Sensor IRE1α

(2011) Claudio Hetz et al.   PHYSIOLOGICAL REVIEWS

Lung tissues in patients with systemic sclerosis have gene expression patterns unique to pulmonary fibrosis and pulmonary hypertension

(2010) Eileen Hsu et al.   ARTHRITIS AND RHEUMATISM

Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression

(2010) Fei Liu et al.   JOURNAL OF CELL BIOLOGY

Treatment of Scleroderma-Interstitial Lung Disease With Cyclophosphamide Is Associated With Less Progressive Fibrosis on Serial Thoracic High-Resolution CT Scan Than Placebo

(2009) Jonathan Goldin et al.   CHEST

Effect of interferon gamma-1b on survival in patients with idiopathic pulmonary fibrosis (INSPIRE): a multicentre, randomised, placebo-controlled trial

(2009) Talmadge E King et al.   LANCET

Increased Bronchoalveolar Lavage Fluid CD1c Expressing Dendritic Cells in Idiopathic Pulmonary Fibrosis

(2009) M. Tsoumakidou et al.   RESPIRATION