Systems Level Analysis of Systemic Sclerosis Shows a Network of Immune and Profibrotic Pathways Connected with Genetic Polymorphisms

Experimentally-Derived Fibroblast Gene Signatures Identify Molecular Pathways Associated with Distinct Subsets of Systemic Sclerosis Patients in Three Independent Cohorts

(2015) Michael E. Johnson et al.   PLoS One

Immunochip Analysis Identifies Multiple Susceptibility Loci for Systemic Sclerosis

(2014) Maureen D. Mayes et al.   AMERICAN JOURNAL OF HUMAN GENETICS

High Rhodotorula Sequences in Skin Transcriptome of Patients with Diffuse Systemic Sclerosis

(2014) Sarah T. Arron et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Brief Report: A Regulatory Variant inCCR6Is Associated With Susceptibility to Antitopoisomerase-Positive Systemic Sclerosis

(2013) Eugénie Koumakis et al.   ARTHRITIS AND RHEUMATISM

A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci

(2013) Jose-Ezequiel Martin et al.   HUMAN MOLECULAR GENETICS

SLP-76 Sterile α Motif (SAM) and Individual H5 α Helix Mediate Oligomer Formation for Microclusters and T-cell Activation

(2013) Hebin Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Signatures in Skin Associated with Clinical Improvement during Mycophenolate Treatment in Systemic Sclerosis

(2013) Monique Hinchcliff et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Epstein–Barr Virus Infection Induces Aberrant TLR Activation Pathway and Fibroblast–Myofibroblast Conversion in Scleroderma

(2013) Antonella Farina et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Differential expression and function of human IL-12Rβ2 polymorphic variants

(2013) Roelof A. de Paus et al.   MOLECULAR IMMUNOLOGY

Integrin-modulating therapy prevents fibrosis and autoimmunity in mouse models of scleroderma

(2013) Elizabeth E. Gerber et al.   NATURE

Interspecies Comparison of Human and Murine Scleroderma Reveals IL-13 and CCL2 as Disease Subset-Specific Targets

(2012) Matthew B. Greenblatt et al.   AMERICAN JOURNAL OF PATHOLOGY

Implication ofIL-2/IL-21region in systemic sclerosis genetic susceptibility

(2012) Lina-Marcela Diaz-Gallo et al.   ANNALS OF THE RHEUMATIC DISEASES

Evidence for caveolin-1 as a new susceptibility gene regulating tissue fibrosis in systemic sclerosis

(2012) Mirko Manetti et al.   ANNALS OF THE RHEUMATIC DISEASES

IRF5polymorphism predicts prognosis in patients with systemic sclerosis

(2012) Roozbeh Sharif et al.   ANNALS OF THE RHEUMATIC DISEASES

Identification of CSK as a systemic sclerosis genetic risk factor through Genome Wide Association Study follow-up

(2012) Jose-Ezequiel Martin et al.   HUMAN MOLECULAR GENETICS

Chemokine receptors CCR2 and CX3CR1 regulate skin fibrosis in the mouse model of cytokine-induced systemic sclerosis

(2012) Minako Arai et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Intrinsic Gene Expression Subsets of Diffuse Cutaneous Systemic Sclerosis Are Stable in Serial Skin Biopsies

(2012) Sarah A. Pendergrass et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

LYP inhibits T-cell activation when dissociated from CSK

(2012) Torkel Vang et al.   Nature Chemical Biology

CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation

(2012) Nataly Manjarrez-Orduño et al.   NATURE GENETICS

IMP: a multi-species functional genomics portal for integration, visualization and prediction of protein functions and networks

(2012) Aaron K. Wong et al.   NUCLEIC ACIDS RESEARCH

Systems analysis of primary Sjögren's syndrome pathogenesis in salivary glands identifies shared pathways in human and a mouse model

(2012) Steve Horvath et al.   ARTHRITIS RESEARCH & THERAPY

Association of a non-synonymous functional variant of the ITGAM gene with systemic sclerosis

(2011) F. D. Carmona et al.   ANNALS OF THE RHEUMATIC DISEASES

Novel identification of theIRF7region as an anticentromere autoantibody propensity locus in systemic sclerosis

(2011) F David Carmona et al.   ANNALS OF THE RHEUMATIC DISEASES

The Pathogenesis of Systemic Sclerosis

(2011) Tamiko R. Katsumoto et al.   Annual Review of Pathology-Mechanisms of Disease

Evidence of the contribution of the X chromosome to systemic sclerosis susceptibility: Association with the functional IRAK1 196Phe/532Ser haplotype

(2011) P. Dieudé et al.   ARTHRITIS AND RHEUMATISM

A rare polymorphism in the gene for Toll-like receptor 2 is associated with systemic sclerosis phenotype and increases the production of inflammatory mediators

(2011) J. C. A. Broen et al.   ARTHRITIS AND RHEUMATISM

Association of hepatocyte growth factor promoter polymorphism with severity of interstitial lung disease in Japanese patients with systemic sclerosis

(2011) Kana Hoshino et al.   ARTHRITIS AND RHEUMATISM

Evaluation of genetic association between an ITGAM non-synonymous SNP (rs1143679) and multiple autoimmune diseases

(2011) Juan-Manuel Anaya et al.   AUTOIMMUNITY REVIEWS

Why is PTPN22 a good candidate susceptibility gene for autoimmune disease?

(2011) Garth L. Burn et al.   FEBS LETTERS

A GWAS follow-up study reveals the association of the IL12RB2 gene with systemic sclerosis in Caucasian populations

(2011) Lara Bossini-Castillo et al.   HUMAN MOLECULAR GENETICS

Association Study of ITGAM, ITGAX, and CD58 Autoimmune Risk Loci in Systemic Sclerosis: Results from 2 Large European Caucasian Cohorts

(2011) B. COUSTET et al.   JOURNAL OF RHEUMATOLOGY

g:Profiler—a web server for functional interpretation of gene lists (2011 update)

(2011) Jüri Reimand et al.   NUCLEIC ACIDS RESEARCH

Systemische Sklerose - eine systematische Übersicht

(2011) Opitz et al.   Vasa-European Journal of Vascular Medicine

Identification of Novel Genetic Markers Associated with Clinical Phenotypes of Systemic Sclerosis through a Genome-Wide Association Strategy

(2011) Olga Gorlova et al.   PLoS Genetics

Mouse Genome-Wide Association and Systems Genetics Identify Asxl2 As a Regulator of Bone Mineral Density and Osteoclastogenesis

(2011) Charles R. Farber et al.   PLoS Genetics

Genome-Wide Scan Identifies TNIP1, PSORS1C1, and RHOB as Novel Risk Loci for Systemic Sclerosis

(2011) Yannick Allanore et al.   PLoS Genetics

Analysis of the influence of PTPN22 gene polymorphisms in systemic sclerosis

(2010) L. Diaz-Gallo et al.   ANNALS OF THE RHEUMATIC DISEASES

Association of the TNFAIP3 rs5029939 variant with systemic sclerosis in the European Caucasian population

(2010) P. Dieude et al.   ANNALS OF THE RHEUMATIC DISEASES

A four-gene biomarker predicts skin disease in patients with diffuse cutaneous systemic sclerosis

(2010) G. Farina et al.   ARTHRITIS AND RHEUMATISM

A genetic variation located in the promoter region of the UPAR (CD87) gene is associated with the vascular complications of systemic sclerosis

(2010) Mirko Manetti et al.   ARTHRITIS AND RHEUMATISM

Association of the CD226 Ser307 variant with systemic sclerosis: Evidence of a contribution of costimulation pathways in systemic sclerosis pathogenesis

(2010) P. Dieudé et al.   ARTHRITIS AND RHEUMATISM

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

Allograft inflammatory factor-1 is overexpressed and induces fibroblast chemotaxis in the skin of sclerodermatous GVHD in a murine model

(2010) Aihiro Yamamoto et al.   IMMUNOLOGY LETTERS

Autoimmune-associated PTPN22 R620W Variation Reduces Phosphorylation of Lymphoid Phosphatase on an Inhibitory Tyrosine Residue

(2010) Edoardo Fiorillo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phenotype-Haplotype Correlation of IRF5 in Systemic Sclerosis: Role of 2 Haplotypes in Disease Severity

(2010) P. DIEUDE et al.   JOURNAL OF RHEUMATOLOGY

Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus

(2010) Timothy R D J Radstake et al.   NATURE GENETICS

Network medicine: a network-based approach to human disease

(2010) Albert-László Barabási et al.   NATURE REVIEWS GENETICS

BANK1 functional variants are associated with susceptibility to diffuse systemic sclerosis in Caucasians

(2009) B. Rueda et al.   ANNALS OF THE RHEUMATIC DISEASES

Association of TNFSF4 (OX40L) polymorphisms with susceptibility to systemic sclerosis

(2009) P. Gourh et al.   ANNALS OF THE RHEUMATIC DISEASES

Macrophage Diversity and Polarization in Atherosclerosis

(2009) Alberto Mantovani et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Association between theIRF5rs2004640 functional polymorphism and systemic sclerosis: A new perspective for pulmonary fibrosis

(2009) P. Dieudé et al.   ARTHRITIS AND RHEUMATISM

Weighted gene co-expression network analysis of the peripheral blood from Amyotrophic Lateral Sclerosis patients

(2009) Christiaan GJ Saris et al.   BMC GENOMICS

Alternatively activated macrophages (M2 macrophages) in the skin of patient with localized scleroderma

(2009) Nobuyo Higashi-Kuwata et al.   EXPERIMENTAL DERMATOLOGY

The STAT4 gene influences the genetic predisposition to systemic sclerosis phenotype

(2009) B. Rueda et al.   HUMAN MOLECULAR GENETICS

Clustering and commonalities among autoimmune diseases

(2009) Ian R. Mackay   JOURNAL OF AUTOIMMUNITY

Association of the C8orf13-BLK region with systemic sclerosis in North-American and European populations

(2009) Pravitt Gourh et al.   JOURNAL OF AUTOIMMUNITY

CCL2 and Interleukin-6 Promote Survival of Human CD11b+Peripheral Blood Mononuclear Cells and Induce M2-type Macrophage Polarization

(2009) Hernan Roca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heme Oxygenase-1 Contributes to an Alternative Macrophage Activation Profile Induced by Apoptotic Cell Supernatants

(2009) Nicole Weis et al.   MOLECULAR BIOLOGY OF THE CELL

AIF-1 expression regulates endothelial cell activation, signal transduction, and vasculogenesis

(2008) Ying Tian et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Thy1 Up-Regulates FasL Expression in Lung Myofibroblasts via Src Family Kinases

(2008) Pazit Y. Cohen et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

WGCNA: an R package for weighted correlation network analysis

(2008) Peter Langfelder et al.   BMC BIOINFORMATICS

Structural Basis for the Recognition of c-Src by Its Inactivator Csk

(2008) Nicholas M. Levinson et al.   CELL

Dock10, a novel CZH protein selectively induced by interleukin-4 in human B lymphocytes

(2008) Estefanía Yelo et al.   MOLECULAR IMMUNOLOGY

Molecular Subsets in the Gene Expression Signatures of Scleroderma Skin

(2008) Ausra Milano et al.   PLoS One

Geometric Interpretation of Gene Coexpression Network Analysis

(2008) Steve Horvath et al.   PLoS Computational Biology