Role of JAK/STAT in Interstitial Lung Diseases; Molecular and Cellular Mechanisms
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Title
Role of JAK/STAT in Interstitial Lung Diseases; Molecular and Cellular Mechanisms
Authors
Keywords
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Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 12, Pages 6211
Publisher
MDPI AG
Online
2021-06-09
DOI
10.3390/ijms22126211
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Note: Only part of the references are listed.- Iacta Alea Est: The Inexorable Advance of Tofacitinib in the Treatment of Dermatomyositis-Associated Rapidly Progressive Interstitial Lung Disease. A Case Report
- (2021) Walter Conca et al. Frontiers in Pharmacology
- Effectiveness and safety of ruxolitinib for the treatment of refractory systemic idiopathic juvenile arthritis like associated with interstitial lung disease : a case report
- (2020) Brigitte Bader-Meunier et al. ANNALS OF THE RHEUMATIC DISEASES
- Defining genetic risk factors for scleroderma-associated interstitial lung disease
- (2020) Carmel J. W. Stock et al. CLINICAL RHEUMATOLOGY
- Ionizing radiation modulates vascular endothelial growth factor expression through STAT3 signaling pathway in rat neonatal primary astrocyte cultures
- (2020) Guijuan Zhou et al. Brain and Behavior
- Successful Treatment of Interstitial Lung Disease in STAT3 Gain-of-Function Using JAK Inhibitors
- (2020) Manuel Silva-Carmona et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- JAK Inhibitors: Prospects in Connective Tissue Diseases
- (2020) Hanxiao You et al. CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
- JAK Inhibition as a New Treatment Strategy for Patients with COVID-19
- (2020) Farhad Seif et al. INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
- Alveolar Epithelial Type II Cells as Drivers of Lung Fibrosis in Idiopathic Pulmonary Fibrosis
- (2020) Tanyalak Parimon et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Ruxolitinib in treatment of severe coronavirus disease 2019 (COVID-19): A multicenter, single-blind, randomized controlled trial
- (2020) Yang Cao et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Baricitinib therapy in COVID-19: A pilot study on safety and clinical impact
- (2020) Fabrizio Cantini et al. JOURNAL OF INFECTION
- Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 to Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution
- (2020) Uddalak Bharadwaj et al. PHARMACOLOGICAL REVIEWS
- Pulmonary fibrosis and COVID-19: the potential role for antifibrotic therapy
- (2020) Peter M George et al. Lancet Respiratory Medicine
- The Role of Cytokines including Interleukin-6 in COVID-19 induced Pneumonia and Macrophage Activation Syndrome-Like Disease
- (2020) Dennis McGonagle et al. AUTOIMMUNITY REVIEWS
- Combined anti-fibrotic and anti-inflammatory properties of JAK-inhibitors on macrophages in vitro and in vivo: Perspectives for scleroderma-associated interstitial lung disease
- (2020) Alain Lescoat et al. BIOCHEMICAL PHARMACOLOGY
- The cytokine storm of COVID-19: a spotlight on prevention and protection
- (2020) Lucie Pearce et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Fibroblast-specific IL11 signaling drives chronic inflammation in murine fibrotic lung disease
- (2020) Benjamin Ng et al. FASEB JOURNAL
- A systematic review of pathological findings in COVID-19: a pathophysiological timeline and possible mechanisms of disease progression
- (2020) Samuel B. Polak et al. MODERN PATHOLOGY
- Targeting JAK-STAT Signaling to Control Cytokine Release Syndrome in COVID-19
- (2020) Wei Luo et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- COVID-19: The Potential Treatment of Pulmonary Fibrosis Associated with SARS-CoV-2 Infection
- (2020) Kacper Lechowicz et al. Journal of Clinical Medicine
- Exhaled Biomarkers in Idiopathic Pulmonary Fibrosis—A Six-Month Follow-Up Study in Patients Treated with Pirfenidone
- (2020) Kaja Jaskiewicz et al. Journal of Clinical Medicine
- Interleukin-6 Blocking vs. JAK-STAT Inhibition for Prevention of Lung Injury in Patients with COVID-19
- (2020) Joseph Meletiadis et al. Infectious Diseases and Therapy
- Effect of Total Flavonoids of Oxytropis falcata Bunge on the Expression of p-JAK1-and p-STAT1-Related Proteins in Idiopathic Pulmonary Fibrosis
- (2020) Yan-jun Wang et al. Evidence-based Complementary and Alternative Medicine
- Efficacy of baricitinib in treating rheumatoid arthritis: Modulatory effects on fibrotic and inflammatory biomarkers in a real-life setting
- (2020) Miriana d'Alessandro et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Baricitinib, a drug with potential effect to prevent SARS-COV-2 from entering target cells and control cytokine storm induced by COVID-19
- (2020) Xiuhong Zhang et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Developmental Adaptive Immune Defects Associated with STAT5B Deficiency in Three Young Siblings
- (2020) Corinne L. Foley et al. JOURNAL OF CLINICAL IMMUNOLOGY
- Clinical, Serological, and Histopathological Similarities Between Severe COVID-19 and Acute Exacerbation of Connective Tissue Disease-Associated Interstitial Lung Disease (CTD-ILD)
- (2020) Daniel Gagiannis et al. Frontiers in Immunology
- STAT3 and its targeting inhibitors in osteosarcoma
- (2020) Yun Liu et al. CELL PROLIFERATION
- Emerging cellular and molecular determinants of idiopathic pulmonary fibrosis
- (2020) Thị Hằng Giang Phan et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Interleukin-11 signaling underlies fibrosis, parenchymal dysfunction, and chronic inflammation of the airway
- (2020) Benjamin Ng et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- JAK-STAT Pathway Inhibition and their Implications in COVID-19 Therapy
- (2020) Sairaj Satarker et al. POSTGRADUATE MEDICINE
- The potential involvement of JAK-STAT signaling pathway in the COVID-19 infection assisted by ACE2
- (2020) Jing Luo et al. GENE
- STAT3 Regulates the Onset of Oxidant-Induced Senescence in Lung Fibroblasts
- (2019) David W Waters et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Clinical aspects of STAT3 gain-of-function germline mutations: A Systematic Review
- (2019) Alexandre Fabre et al. Journal of Allergy and Clinical Immunology-In Practice
- Elevation of IL-6 and IL-33 Levels in Serum Associated with Lung Fibrosis and Skeletal Muscle Wasting in a Bleomycin-Induced Lung Injury Mouse Model
- (2019) Jiunn-Min Shieh et al. MEDIATORS OF INFLAMMATION
- FGFR2 Promotes Expression of PD-L1 in Colorectal Cancer via the JAK/STAT3 Signaling Pathway
- (2019) Piao Li et al. JOURNAL OF IMMUNOLOGY
- Cellular Senescence: Aging, Cancer, and Injury
- (2019) Arianna Calcinotto et al. PHYSIOLOGICAL REVIEWS
- Therapeutic Targeting of Fibrotic Epithelial-Mesenchymal Transition–An Outstanding Challenge
- (2019) Attila Fintha et al. Frontiers in Pharmacology
- Increased Pulmonary GM-CSF Causes Alveolar Macrophage Accumulation: Mechanistic Implications for Desquamative Interstitial Pneumonitis
- (2019) Takuji Suzuki et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Comparative phenotypic profiling of the JAK2 inhibitors ruxolitinib, fedratinib, momelotinib, and pacritinib reveals distinct mechanistic signatures
- (2019) Jack W. Singer et al. PLoS One
- Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis
- (2019) Benjamin Ng et al. Science Translational Medicine
- Baricitinib experience on STING-associated vasculopathy with onset in infancy: A representative case from Turkey
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- (2019) Elena Maria Elli et al. Frontiers in Oncology
- Distinct molecular response patterns of activating STAT3 mutations associate with penetrance of lymphoproliferation and autoimmunity
- (2019) Sabine Jägle et al. CLINICAL IMMUNOLOGY
- Endotype–phenotyping may predict a treatment response in progressive fibrosing interstitial lung disease
- (2019) Anna-Maria Hoffmann-Vold et al. EBioMedicine
- JAK-STAT Signaling: A Double-Edged Sword of Immune Regulation and Cancer Progression
- (2019) Katie L. Owen et al. Cancers
- Fibroblast senescence in the pathology of idiopathic pulmonary fibrosis
- (2018) David W Waters et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- STAT3 Gain of Function: A New Kid on the Block in Interstitial Lung Diseases
- (2018) Alexandre Fabre et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Role of the JAK/STAT signaling pathway in regulation of innate immunity in neuroinflammatory diseases
- (2018) Zhaoqi Yan et al. CLINICAL IMMUNOLOGY
- Partial growth hormone insensitivity and dysregulatory immune disease associated with de novo germline activating STAT3 mutations
- (2018) Mariana Gutiérrez et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Idiopathic Pulmonary Fibrosis
- (2018) David J. Lederer et al. NEW ENGLAND JOURNAL OF MEDICINE
- OUP accepted manuscript
- (2018) RHEUMATOLOGY
- JAK2 mediates lung fibrosis, pulmonary vascular remodelling and hypertension in idiopathic pulmonary fibrosis: an experimental study
- (2018) Javier Milara et al. THORAX
- The role of the JAK/STAT signal pathway in rheumatoid arthritis
- (2018) Charles J. Malemud Therapeutic Advances in Musculoskeletal Disease
- Jakinibs for the treatment of immune dysregulation in patients with gain-of-function signal transducer and activator of transcription 1 (STAT1) or STAT3 mutations
- (2018) Lisa R. Forbes et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Investigation of key autophagy-and mitophagy-related proteins and gene expression in BALF cells from patients with IPF and RA-ILD
- (2018) Eirini Vasarmidi et al. Molecular Medicine Reports
- OUP accepted manuscript
- (2018) RHEUMATOLOGY
- OUP accepted manuscript
- (2018) RHEUMATOLOGY
- Bioinformatics analysis of gene expression profile data to screen key genes involved in pulmonary sarcoidosis
- (2017) Hongyan Li et al. GENE
- Transforming growth factor β1 promotes migration and invasion in HepG2 cells: Epithelial‑to‑mesenchymal transition via JAK/STAT3 signaling
- (2017) Xiao‑Long Lin et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Jak Stat signaling and cancer: Opportunities, benefits and side effects of targeted inhibition
- (2017) Bernd Groner et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Both MAPK and STAT3 signal transduction pathways are necessary for IL-6-dependent hepatic stellate cells activation
- (2017) Polina Kagan et al. PLoS One
- IL-13 and idiopathic pulmonary fibrosis: Possible links and new therapeutic strategies
- (2017) Giovanni Passalacqua et al. PULMONARY PHARMACOLOGY & THERAPEUTICS
- Activation of STAT3 integrates common profibrotic pathways to promote fibroblast activation and tissue fibrosis
- (2017) Debomita Chakraborty et al. Nature Communications
- Cellular senescence mediates fibrotic pulmonary disease
- (2017) Marissa J. Schafer et al. Nature Communications
- IL-6 secreted by cancer-associated fibroblasts promotes epithelial-mesenchymal transition and metastasis of gastric cancer via JAK2/STAT3 signaling pathway
- (2017) Xiongyan Wu et al. Oncotarget
- Identification of Jak-STAT signaling involvement in sarcoidosis severity via a novel microRNA-regulated peripheral blood mononuclear cell gene signature
- (2017) Tong Zhou et al. Scientific Reports
- Influences of innate immunity, autophagy, and fibroblast activation in the pathogenesis of lung fibrosis
- (2016) David N. O'Dwyer et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- PDGF-BB induces PRMT1 expression through ERK1/2 dependent STAT1 activation and regulates remodeling in primary human lung fibroblasts
- (2016) Qingzhu Sun et al. CELLULAR SIGNALLING
- STAT-3 contributes to pulmonary fibrosis through epithelial injury and fibroblast-myofibroblast differentiation
- (2016) Mesias Pedroza et al. FASEB JOURNAL
- STAT5B deficiency: Impacts on human growth and immunity
- (2016) Vivian Hwa GROWTH HORMONE & IGF RESEARCH
- STAT mutations as program switchers: turning primary immunodeficiencies into autoimmune diseases
- (2016) Tiziana Lorenzini et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Tofacitinib or adalimumab versus placebo: patient-reported outcomes from a phase 3 study of active rheumatoid arthritis
- (2016) Vibeke Strand et al. RHEUMATOLOGY
- The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention
- (2015) John J. O'Shea et al. Annual Review of Medicine
- The role of STAT3 in autophagy
- (2015) Liangkun You et al. Autophagy
- Epithelial-mesenchymal transition: An emerging target in tissue fibrosis
- (2015) Meirong Li et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- The Fibroblast Growth Factor signaling pathway
- (2015) David M. Ornitz et al. Wiley Interdisciplinary Reviews-Developmental Biology
- Inhibition of casein kinase II reduces TGFβ induced fibroblast activation and ameliorates experimental fibrosis
- (2014) Yun Zhang et al. ANNALS OF THE RHEUMATIC DISEASES
- Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations
- (2014) J. D. Milner et al. BLOOD
- JAK/STAT3 signaling is required for TGF-β-induced epithelial-mesenchymal transition in lung cancer cells
- (2014) RENG-YUN LIU et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Mechanisms of Oncostatin M-Induced Pulmonary Inflammation and Fibrosis
- (2014) A. Mozaffarian et al. JOURNAL OF IMMUNOLOGY
- Blockade of IL-6TransSignaling Attenuates Pulmonary Fibrosis
- (2014) Thanh-Thuy T. Le et al. JOURNAL OF IMMUNOLOGY
- Discovery and Development of Janus Kinase (JAK) Inhibitors for Inflammatory Diseases
- (2014) James D. Clark et al. JOURNAL OF MEDICINAL CHEMISTRY
- PERK-Dependent Activation of JAK1 and STAT3 Contributes to Endoplasmic Reticulum Stress-Induced Inflammation
- (2014) G. P. Meares et al. MOLECULAR AND CELLULAR BIOLOGY
- Respiratory bronchiolitis-interstitial lung disease
- (2014) Alicja Sieminska et al. Orphanet Journal of Rare Diseases
- IPF Fibroblasts Are Desensitized to Type I Collagen Matrix-Induced Cell Death by Suppressing Low Autophagy via Aberrant Akt/mTOR Kinases
- (2014) Richard Seonghun Nho et al. PLoS One
- Effects of matrine on JAK-STAT signaling transduction pathways in bleomycin-induced pulmonary fibrosis
- (2013) X Ma et al. African Journal of Traditional Complementary and Alternative Medicines
- An Official American Thoracic Society/European Respiratory Society Statement: Update of the International Multidisciplinary Classification of the Idiopathic Interstitial Pneumonias
- (2013) William D. Travis et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Roles of STAT3 in Protein Secretion Pathways during the Acute-Phase Response
- (2013) Ayele-Nati N. Ahyi et al. INFECTION AND IMMUNITY
- Pathogenesis pathways of idiopathic pulmonary fibrosis in bleomycin-induced lung injury model in mice
- (2013) Keyun Shi et al. RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
- Microarray profiling reveals suppressed interferon stimulated gene program in fibroblasts from scleroderma-associated interstitial lung disease
- (2013) Gisela E Lindahl et al. RESPIRATORY RESEARCH
- Sorafenib ameliorates bleomycin-induced pulmonary fibrosis: potential roles in the inhibition of epithelial–mesenchymal transition and fibroblast activation
- (2013) Y-L Chen et al. Cell Death & Disease
- Increased Expression of Epidermal Growth Factor Receptor (EGF-R) in Patients with Different Forms of Lung Fibrosis
- (2013) Argyris Tzouvelekis et al. Biomed Research International
- STAT3-Mediated Signaling Dysregulates Lung Fibroblast-Myofibroblast Activation and Differentiation in UIP/IPF
- (2012) Dmitri V. Pechkovsky et al. AMERICAN JOURNAL OF PATHOLOGY
- Insufficient autophagy in idiopathic pulmonary fibrosis
- (2012) Jun Araya et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Tyrosine kinase signaling in fibrotic disorders
- (2012) Christian Beyer et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Oxidative stress and pulmonary fibrosis
- (2012) Paul Cheresh et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis
- (2012) Robert J. J. O'Donoghue et al. EMBO Molecular Medicine
- Targeting the TGFβ signalling pathway in disease
- (2012) Rosemary J. Akhurst et al. NATURE REVIEWS DRUG DISCOVERY
- Autophagy in Idiopathic Pulmonary Fibrosis
- (2012) Avignat S. Patel et al. PLoS One
- Dynamics and non-canonical aspects of JAK/STAT signalling
- (2011) Anne Mohr et al. EUROPEAN JOURNAL OF CELL BIOLOGY
- STAT5b Deficiency: An Unsuspected Cause of Growth Failure, Immunodeficiency, and Severe Pulmonary Disease
- (2011) Kari Nadeau et al. JOURNAL OF PEDIATRICS
- Endoplasmic reticulum stress enhances fibrotic remodeling in the lungs
- (2011) W. E. Lawson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: Results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP-690,550 versus placebo
- (2009) Joel M. Kremer et al. ARTHRITIS AND RHEUMATISM
- Lung alveolar epithelium and interstitial lung disease
- (2009) Harriet Corvol et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Nonspecific Interstitial Pneumonia: Radiologic, Clinical, and Pathologic Considerations
- (2009) Seth J. Kligerman et al. RADIOGRAPHICS
- Tocilizumab: The first interleukin-6-receptor inhibitor
- (2008) Anthony Sebba AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
- Endoplasmic reticulum stress in alveolar epithelial cells is prominent in IPF: association with altered surfactant protein processing and herpesvirus infection
- (2008) William E. Lawson et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Epithelial Endoplasmic Reticulum Stress and Apoptosis in Sporadic Idiopathic Pulmonary Fibrosis
- (2008) Martina Korfei et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Cross talk of signals between EGFR and IL-6R through JAK2/STAT3 mediate epithelial–mesenchymal transition in ovarian carcinomas
- (2008) M Colomiere et al. BRITISH JOURNAL OF CANCER
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