- Home
- Publications
- Publication Search
- Publication Details
Title
Rationale for LDH-targeted cancer immunotherapy
Authors
Keywords
-
Journal
EUROPEAN JOURNAL OF CANCER
Volume 181, Issue -, Pages 166-178
Publisher
Elsevier BV
Online
2022-12-14
DOI
10.1016/j.ejca.2022.11.032
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- High serum LDH and liver metastases are the dominant predictors of primary cancer resistance to anti-PD(L)1 immunotherapy
- (2022) Laurent Dercle et al. EUROPEAN JOURNAL OF CANCER
- Targeting cancer stem cells with a pan-BCL-2 inhibitor in preclinical and clinical settings in patients with gastroesophageal carcinoma
- (2021) Shumei Song et al. GUT
- Second-line nivolumab in relapsed small-cell lung cancer: CheckMate 331☆
- (2021) D.R. Spigel et al. ANNALS OF ONCOLOGY
- Metabolic support of tumour-infiltrating regulatory T cells by lactic acid
- (2021) McLane J. Watson et al. NATURE
- Designed β-Hairpins Inhibit LDH5 Oligomerization and Enzymatic Activity
- (2021) Ferran Nadal-Bufi et al. JOURNAL OF MEDICINAL CHEMISTRY
- Targeting lactate dehydrogenase a improves radiotherapy efficacy in non-small cell lung cancer: from bedside to bench
- (2021) Yang Yang et al. Journal of Translational Medicine
- Phase I expansion study of the first-in-class monocarboxylate transporter 1 (MCT1) inhibitor AZD3965 in patients with diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL).
- (2021) Sarah E. R. Halford et al. JOURNAL OF CLINICAL ONCOLOGY
- Tumor-derived lactate inhibit the efficacy of lenvatinib through regulating PD-L1 expression on neutrophil in hepatocellular carcinoma
- (2021) Haijing Deng et al. Journal for ImmunoTherapy of Cancer
- Macrophages are metabolically heterogeneous within the tumor microenvironment
- (2021) Xenia Geeraerts et al. Cell Reports
- Galloflavin Plus Metformin Treatment Impairs Pancreatic Cancer Cells
- (2020) EDGAR HEINZ UWE WENDT et al. ANTICANCER RESEARCH
- Monocarboxylate transporter 1 blockade with AZD3965 inhibits lipid biosynthesis and increases tumour immune cell infiltration
- (2020) Mounia Beloueche-Babari et al. BRITISH JOURNAL OF CANCER
- Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8+ T cell stemness and antitumor immunity
- (2020) Dalton Hermans et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy
- (2020) Nobu Oshima et al. Cell Reports
- Tumor‐Targeted Inhibition of Monocarboxylate Transporter 1 Improves T‐Cell Immunotherapy of Solid Tumors
- (2020) Tongyi Huang et al. Advanced Healthcare Materials
- Pretreatment Blood Parameters Predict Efficacy from Immunotherapy Agents in Early Phase Clinical Trials
- (2020) Carmen Criscitiello et al. ONCOLOGIST
- Immunotherapy in advanced Non-Small Cell Lung Cancer patients with poor performance status: The role of clinical-pathological variables and inflammatory biomarkers
- (2020) Riccardo Lobefaro et al. LUNG CANCER
- Blockade of Lactate Dehydrogenase-A (LDH-A) Improves Efficacy of Anti-Programmed Cell Death-1 (PD-1) Therapy in Melanoma
- (2019) Saeed Daneshmandi et al. Cancers
- Pretreatment lactate dehydrogenase may predict outcome of advanced non small-cell lung cancer patients treated with immune checkpoint inhibitors: A meta-analysis
- (2019) Zhibo Zhang et al. Cancer Medicine
- The Warburg effect: essential part of metabolic reprogramming and central contributor to cancer progression
- (2019) Peter Vaupel et al. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
- Prognostic Value of Lactate Dehydrogenase in Metastatic Prostate Cancer: A Systematic Review and Meta-analysis
- (2019) Keiichiro Mori et al. Clinical Genitourinary Cancer
- Phenformin as an Anticancer Agent: Challenges and Prospects
- (2019) Rubiño et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Mechanistic basis of L-lactate transport in the SLC16 solute carrier family
- (2019) Patrick D. Bosshart et al. Nature Communications
- Metabolic Control of Dendritic Cell Functions: Digesting Information
- (2019) Stefanie K. Wculek et al. Frontiers in Immunology
- Synthesis and Biological Evaluation of New Glycoconjugated LDH Inhibitors as Anticancer Agents
- (2019) Felicia D’Andrea et al. MOLECULES
- Five-Year Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma
- (2019) James Larkin et al. NEW ENGLAND JOURNAL OF MEDICINE
- Lactate Induces Pro-tumor Reprogramming in Intratumoral Plasmacytoid Dendritic Cells
- (2019) Deblina Raychaudhuri et al. Frontiers in Immunology
- Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy
- (2019) Kathrin Renner et al. Cell Reports
- Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4+ T Cell Metabolic Rewiring
- (2019) Valentina Pucino et al. Cell Metabolism
- Tumor-derived lactate induces M2 macrophage polarization via the activation of the ERK/STAT3 signaling pathway in breast cancer
- (2018) Xianmin Mu et al. CELL CYCLE
- Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy
- (2018) Tina Cascone et al. Cell Metabolism
- Improving immunotherapy outcomes with anti-angiogenic treatments and vice versa
- (2018) Kabir A. Khan et al. Nature Reviews Clinical Oncology
- l-Lactate Transport and Metabolism in Mitochondria of Hep G2 Cells—The Cori Cycle Revisited
- (2018) Salvatore Passarella et al. Frontiers in Oncology
- LDH-A regulates the tumor microenvironment via HIF-signaling and modulates the immune response
- (2018) Inna Serganova et al. PLoS One
- Lactate-mediated acidification of tumor microenvironment induces apoptosis of liver-resident NK cells in colorectal liver metastasis
- (2018) Cathal Harmon et al. Cancer Immunology Research
- Prognostic and predictive role of elevated lactate dehydrogenase in patients with melanoma treated with immunotherapy and BRAF inhibitors
- (2018) Fausto Petrelli et al. MELANOMA RESEARCH
- Prospective validation of a prognostic score for patients in immunotherapy phase I trials: The Gustave Roussy Immune Score (GRIm-Score)
- (2017) Frédéric Bigot et al. EUROPEAN JOURNAL OF CANCER
- Glucose feeds the TCA cycle via circulating lactate
- (2017) Sheng Hui et al. NATURE
- Gpr132 sensing of lactate mediates tumor–macrophage interplay to promote breast cancer metastasis
- (2017) Peiwen Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Trial watch: Immunogenic cell death induction by anticancer chemotherapeutics
- (2017) Abhishek D. Garg et al. OncoImmunology
- Potential Role of Metabolic Intervention in the Management of Advanced Differentiated Thyroid Cancer
- (2017) Sri Harsha Tella et al. Frontiers in Oncology
- Glycolysis inhibition as a cancer treatment and its role in an anti-tumour immune response
- (2016) Kheshwant S. Gill et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- Prognostic significance of serum LDH in small cell lung cancer: A systematic review with meta-analysis
- (2016) Xiuxiu Zhang et al. Cancer Biomarkers
- Exploiting IL-17-producing CD4+ and CD8+ T cells to improve cancer immunotherapy in the clinic
- (2016) Kinga Majchrzak et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells
- (2016) Almut Brand et al. Cell Metabolism
- Rapid and objective CT scan prognostic scoring identifies metastatic patients with long-term clinical benefit on anti-PD-1/-L1 therapy
- (2016) Laurent Dercle et al. EUROPEAN JOURNAL OF CANCER
- Cutting Edge: Critical Role of Glycolysis in Human Plasmacytoid Dendritic Cell Antiviral Responses
- (2016) Gagan Bajwa et al. JOURNAL OF IMMUNOLOGY
- Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition
- (2016) Aaron Boudreau et al. Nature Chemical Biology
- Lactate metabolism is associated with mammalian mitochondria
- (2016) Ying-Jr Chen et al. Nature Chemical Biology
- Prognostic Value of Serum Lactate Dehydrogenase in Renal Cell Carcinoma: A Systematic Review and Meta-Analysis
- (2016) Jie Shen et al. PLoS One
- The Warburg Effect: How Does it Benefit Cancer Cells?
- (2016) Maria V. Liberti et al. TRENDS IN BIOCHEMICAL SCIENCES
- Lactic acidosis switches cancer cells from aerobic glycolysis back to dominant oxidative phosphorylation
- (2016) Hao Wu et al. Oncotarget
- Prognostic Role of Lactate Dehydrogenase Expression in Urologic Cancers: A Systematic Review and Meta-Analysis
- (2016) Yong Zhang et al. Oncology Research and Treatment
- Prognostic role of lactate dehydrogenase in solid tumors: A systematic review and meta-analysis of 76 studies
- (2015) Fausto Petrelli et al. ACTA ONCOLOGICA
- Serum lactate dehydrogenase and survival following cancer diagnosis
- (2015) Wahyu Wulaningsih et al. BRITISH JOURNAL OF CANCER
- Lactate dehydrogenase 5: An old friend and a new hope in the war on cancer
- (2015) Katarzyna Augoff et al. CANCER LETTERS
- Oxamate-mediated inhibition of lactate dehydrogenase induces protective autophagy in gastric cancer cells: Involvement of the Akt–mTOR signaling pathway
- (2015) Zhi Zhao et al. CANCER LETTERS
- Evaluation of the anti-tumor effects of lactate dehydrogenase inhibitor galloflavin in endometrial cancer cells
- (2015) Xiaoyun Han et al. Journal of Hematology & Oncology
- Obesity Drives Th17 Cell Differentiation by Inducing the Lipid Metabolic Kinase, ACC1
- (2015) Yusuke Endo et al. Cell Reports
- Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions
- (2015) Robert Haas et al. PLOS BIOLOGY
- The Monocarboxylate Transporter 4 Is Required for Glycolytic Reprogramming and Inflammatory Response in Macrophages
- (2014) Zheng Tan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Tumor-Secreted Lactic Acid Promotes IL-23/IL-17 Proinflammatory Pathway
- (2014) H. Shime et al. JOURNAL OF IMMUNOLOGY
- Hypoxia and Hypoxia-Inducible Factor-1 Modulate Lipopolysaccharide-Induced Dendritic Cell Activation and Function
- (2014) J. Jantsch et al. JOURNAL OF IMMUNOLOGY
- Functional polarization of tumour-associated macrophages by tumour-derived lactic acid
- (2014) Oscar R. Colegio et al. NATURE
- Metabolic Pathways in Immune Cell Activation and Quiescence
- (2013) Erika L. Pearce et al. IMMUNITY
- Dendritic Cell Reprogramming by Endogenously Produced Lactic Acid
- (2013) A. Nasi et al. JOURNAL OF IMMUNOLOGY
- Tumor-Derived Lactate Modifies Antitumor Immune Response: Effect on Myeloid-Derived Suppressor Cells and NK Cells
- (2013) Z. Husain et al. JOURNAL OF IMMUNOLOGY
- Tumor glycolysis as a target for cancer therapy: progress and prospects
- (2013) Shanmugasundaram Ganapathy-Kanniappan et al. Molecular Cancer
- Lactate dehydrogenase A is overexpressed in pancreatic cancer and promotes the growth of pancreatic cancer cells
- (2013) Yefei Rong et al. TUMOR BIOLOGY
- Galloflavin, a new lactate dehydrogenase inhibitor, induces the death of human breast cancer cells with different glycolytic attitude by affecting distinct signaling pathways
- (2012) F. Farabegoli et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- LDH-C4: a target with therapeutic potential for cancer and contraception
- (2012) G. S. Gupta MOLECULAR AND CELLULAR BIOCHEMISTRY
- Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer
- (2012) Suzanne L. Topalian et al. NEW ENGLAND JOURNAL OF MEDICINE
- LDHA is necessary for the tumorigenicity of esophageal squamous cell carcinoma
- (2012) Feng Yao et al. TUMOR BIOLOGY
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Galloflavin (CAS 568-80-9): A Novel Inhibitor of Lactate Dehydrogenase
- (2011) Marcella Manerba et al. ChemMedChem
- IL-23-dependent and -independent enhancement pathways of IL-17A production by lactic acid
- (2010) Masahiko Yabu et al. INTERNATIONAL IMMUNOLOGY
- Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
- (2010) A. Le et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes
- (2010) A. J. Levine et al. SCIENCE
- Computational analyses of mammalian lactate dehydrogenases: Human, mouse, opossum and platypus LDHs
- (2009) Roger S. Holmes et al. COMPUTATIONAL BIOLOGY AND CHEMISTRY
- Lactic Acid and Acidification Inhibit TNF Secretion and Glycolysis of Human Monocytes
- (2009) K. Dietl et al. JOURNAL OF IMMUNOLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now