Targeting lactate dehydrogenase a improves radiotherapy efficacy in non-small cell lung cancer: from bedside to bench

Pancancer survival analysis of cancer hallmark genes

(2021) Ádám Nagy et al.   Scientific Reports

Cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Molecular Mechanisms of Radiation-Induced Cancer Cell Death: A Primer

(2020) Joseph Sia et al.   Frontiers in Cell and Developmental Biology

Tumor Hypoxia: Impact on Radiation Therapy and Molecular Pathways

(2020) Brita Singers Sørensen et al.   Frontiers in Oncology

Oncometabolites suppress DNA repair by disrupting local chromatin signalling

(2020) Parker L. Sulkowski et al.   NATURE

Radiotherapy treatment for lung cancer: Current status and future directions

(2020) Shalini K. Vinod et al.   RESPIROLOGY

Targeting cancer-cell mitochondria and metabolism to improve radiotherapy response

(2020) Emma McCann et al.   Translational Oncology

Interconnection between Metabolism and Cell Cycle in Cancer

(2019) Philippe Icard et al.   TRENDS IN BIOCHEMICAL SCIENCES

Knockdown of PKM2 enhances radiosensitivity of cervical cancer cells

(2019) Yanzhu Lin et al.   Cancer Cell International

Prognostic Value of Lactate Dehydrogenase Expression in Different Cancers: A Meta-Analysis

(2019) Jiancheng Lv et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Radioresistant Cervical Cancers Are Sensitive to Inhibition of Glycolysis and Redox Metabolism

(2018) Ramachandran Rashmi et al.   CANCER RESEARCH

Role of metabolism in cancer cell radioresistance and radiosensitization methods

(2018) Le Tang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Glucose starvation impairs DNA repair in tumour cells selectively by blocking histone acetylation

(2018) Rena Ampferl et al.   RADIOTHERAPY AND ONCOLOGY

Patterns of locoregional failure in locally advanced non-small cell lung cancer treated with definitive conformal radiotherapy: Results from the Gating 2006 trial

(2018) Emmanuel Jouglar et al.   RADIOTHERAPY AND ONCOLOGY

Association of the Lung Immune Prognostic Index With Immune Checkpoint Inhibitor Outcomes in Patients With Advanced Non–Small Cell Lung Cancer

(2018) Laura Mezquita et al.   JAMA Oncology

Double genetic disruption of lactate dehydrogenase A and B is required to ablate the ‘Warburg effect’ restricting tumor growth to oxidative metabolism

(2018) Maša Ždralević et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

2-Deoxy-D-glucose has distinct and cell line-specific effects on the survival of different cancer cells upon antitumor drug treatment

(2018) Polina Maximchik et al.   FEBS Journal

Targeting glucose and glutamine metabolism combined with radiation therapy in non-small cell lung cancer

(2018) Tineke W.H. Meijer et al.   LUNG CANCER

Lactate dehydrogenase A: A key player in carcinogenesis and potential target in cancer therapy

(2018) Yangbo Feng et al.   Cancer Medicine

ROS and the DNA damage response in cancer

(2018) Upadhyayula Sai Srinivas et al.   Redox Biology

Durvalumab after Chemoradiotherapy in Stage III Non–Small-Cell Lung Cancer

(2017) Scott J. Antonia et al.   NEW ENGLAND JOURNAL OF MEDICINE

GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses

(2017) Zefang Tang et al.   NUCLEIC ACIDS RESEARCH

Tumor LDH-A expression and serum LDH status are two metabolic predictors for triple negative breast cancer brain metastasis

(2017) Tieying Dong et al.   Scientific Reports

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Hypoxia-inducible proteins HIF1α and lactate dehydrogenase LDH5, key markers of anaerobic metabolism, relate with stem cell markers and poor post-radiotherapy outcome in bladder cancer

(2016) Michael I. Koukourakis et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition

(2016) Aaron Boudreau et al.   Nature Chemical Biology

The Warburg Effect: How Does it Benefit Cancer Cells?

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

Targeting pyruvate kinase M2 contributes to radiosensitivity of non-small cell lung cancer cells in vitro and in vivo

(2015) Mao-Bin Meng et al.   CANCER LETTERS

Dichloroacetate alters Warburg metabolism, inhibits cell growth, and increases the X-ray sensitivity of human A549 and H1299 NSC lung cancer cells

(2015) Kah Tan Allen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sensitization of Glioblastoma Cells to Irradiation by Modulating the Glucose Metabolism

(2015) H. Shen et al.   MOLECULAR CANCER THERAPEUTICS

Phosphatidylinositol 3-kinase/Akt signaling as a key mediator of tumor cell responsiveness to radiation

(2015) Mahmoud Toulany et al.   SEMINARS IN CANCER BIOLOGY

Different effects of LDH-A inhibition by oxamate in non-small cell lung cancer cells

(2015) Yang Yang et al.   Oncotarget

Lactate dehydrogenase 5 isoenzyme overexpression defines resistance of prostate cancer to radiotherapy

(2014) M I Koukourakis et al.   BRITISH JOURNAL OF CANCER

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides

(2014) Kıvanç Birsoy et al.   NATURE

AKT-mediated enhanced aerobic glycolysis causes acquired radioresistance by human tumor cells

(2014) Tsutomu Shimura et al.   RADIOTHERAPY AND ONCOLOGY

PI3K/Akt/mTOR pathway inhibitors enhance radiosensitivity in radioresistant prostate cancer cells through inducing apoptosis, reducing autophagy, suppressing NHEJ and HR repair pathways

(2014) L Chang et al.   Cell Death & Disease

Synergistic interaction of novel lactate dehydrogenase inhibitors with gemcitabine against pancreatic cancer cells in hypoxia

(2013) M Maftouh et al.   BRITISH JOURNAL OF CANCER

Lactate dehydrogenase a in cancer: A promising target for diagnosis and therapy

(2013) Ping Miao et al.   IUBMB LIFE

Inhibition of LDH-A by oxamate induces G2/M arrest, apoptosis and increases radiosensitivity in nasopharyngeal carcinoma cells

(2013) XIAOMING ZHAI et al.   ONCOLOGY REPORTS

Online Survival Analysis Software to Assess the Prognostic Value of Biomarkers Using Transcriptomic Data in Non-Small-Cell Lung Cancer

(2013) Balázs Győrffy et al.   PLoS One

Targeting Hypoxia, HIF-1, and Tumor Glucose Metabolism to Improve Radiotherapy Efficacy

(2012) T. W. H. Meijer et al.   CLINICAL CANCER RESEARCH

Radiosensitization by 2-deoxy-D-glucose and 6-aminonicotinamide involves activation of redox sensitive ASK1-JNK/p38MAPK signaling in head and neck cancer cells

(2012) Pradeep Kumar Sharma et al.   FREE RADICAL BIOLOGY AND MEDICINE

Enhanced cytotoxic effect of low doses of metformin combined with ionizing radiation on hepatoma cells via ATP deprivation and inhibition of DNA repair

(2012) JIFANG LIU et al.   ONCOLOGY REPORTS

Overcoming Trastuzumab Resistance in Breast Cancer by Targeting Dysregulated Glucose Metabolism

(2011) Y. Zhao et al.   CANCER RESEARCH

Prognostic and Predictive Role of Lactate Dehydrogenase 5 Expression in Colorectal Cancer Patients Treated with PTK787/ZK 222584 (Vatalanib) Antiangiogenic Therapy

(2011) M. I. Koukourakis et al.   CLINICAL CANCER RESEARCH

Differential effects of the glycolysis inhibitor 2-deoxy-D-glucose on the activity of pro-apoptotic agents in metastatic melanoma cells, and induction of a cytoprotective autophagic response

(2011) Anna Maria Giammarioli et al.   INTERNATIONAL JOURNAL OF CANCER

An Important Role for CDK2 in G1 to S Checkpoint Activation and DNA Damage Response in Human Embryonic Stem Cells

(2011) Irina Neganova et al.   STEM CELLS

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

(2010) A. Le et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumours with PI3K activation are resistant to dietary restriction

(2009) Nada Y. Kalaany et al.   NATURE

Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells

(2009) J. Yun et al.   SCIENCE