Monocarboxylate transporter 1 blockade with AZD3965 inhibits lipid biosynthesis and increases tumour immune cell infiltration

Emerging Concepts for Immune Checkpoint Blockade-Based Combination Therapies

(2018) Roberta Zappasodi et al.   CANCER CELL

Magnetic resonance imaging of cancer metabolism with hyperpolarized 13 C-labeled cell metabolites

(2018) Richard L Hesketh et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Metabolic Symbiosis and Immunomodulation: How Tumor Cell-Derived Lactate May Disturb Innate and Adaptive Immune Responses

(2018) Alexandre Morrot et al.   Frontiers in Oncology

Roles of the immune system in cancer: from tumor initiation to metastatic progression

(2018) Hugo Gonzalez et al.   GENES & DEVELOPMENT

Inhibition of monocarboxyate transporter 1 by AZD3965 as a novel therapeutic approach for diffuse large B-cell lymphoma and Burkitt lymphoma

(2017) Richard A. Noble et al.   HAEMATOLOGICA

Oxygen availability and metabolic reprogramming in cancer

(2017) Hong Xie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic Interactions in the Tumor Microenvironment

(2017) Costas A. Lyssiotis et al.   TRENDS IN CELL BIOLOGY

Pre-clinical pharmacology of AZD3965, a selective inhibitor of MCT1: DLBCL, NHL and Burkitt’s lymphoma anti-tumor activity

(2017) Nicola J. Curtis et al.   Oncotarget

Early IL-6 signalling promotes IL-27 dependent maturation of regulatory T cells in the lungs and resolution of viral immunopathology

(2017) Chloe J. Pyle et al.   PLoS Pathogens

Inhibition of monocarboxyate transporter 1 by AZD3965 as a novel therapeutic approach for diffuse large B-cell lymphoma and Burkitt lymphoma

(2017) Richard A. Noble et al.   HAEMATOLOGICA

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

NK Cells Restrain Spontaneous Antitumor CD8+T Cell Priming through PD-1/PD-L1 Interactions with Dendritic Cells

(2016) Ximena L. Raffo Iraolagoitia et al.   JOURNAL OF IMMUNOLOGY

The BRAF Inhibitor Vemurafenib Activates Mitochondrial Metabolism and Inhibits Hyperpolarized Pyruvate–Lactate Exchange in BRAF-Mutant Human Melanoma Cells

(2016) Teresa Delgado-Goni et al.   MOLECULAR CANCER THERAPEUTICS

Lactate Contribution to the Tumor Microenvironment: Mechanisms, Effects on Immune Cells and Therapeutic Relevance

(2016) Susana Romero-Garcia et al.   Frontiers in Immunology

Acquired resistance to EGFR tyrosine kinase inhibitors alters the metabolism of human head and neck squamous carcinoma cells and xenograft tumours

(2015) M Beloueche-Babari et al.   BRITISH JOURNAL OF CANCER

Functional screening identifies MCT4 as a key regulator of breast cancer cell metabolism and survival

(2015) Franziska Baenke et al.   JOURNAL OF PATHOLOGY

Lactate promotes plasticity gene expression by potentiating NMDA signaling in neurons

(2014) J. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blocking Lactate Export by Inhibiting the Myc Target MCT1 Disables Glycolysis and Glutathione Synthesis

(2013) J. R. Doherty et al.   CANCER RESEARCH

Activity of the Monocarboxylate Transporter 1 Inhibitor AZD3965 in Small Cell Lung Cancer

(2013) R. Polanski et al.   CLINICAL CANCER RESEARCH

Targeting lactate metabolism for cancer therapeutics

(2013) Joanne R. Doherty et al.   JOURNAL OF CLINICAL INVESTIGATION

The SLC16 gene family – Structure, role and regulation in health and disease

(2013) Andrew P. Halestrap   MOLECULAR ASPECTS OF MEDICINE

Comparison of three reference methods for the measurement of intracellular pH using31P MRS in healthy volunteers and patients with lymphoma

(2013) Mihaela Rata et al.   NMR IN BIOMEDICINE

Reciprocal Metabolic Reprogramming through Lactate Shuttle Coordinately Influences Tumor-Stroma Interplay

(2012) T. Fiaschi et al.   CANCER RESEARCH

Histone Deacetylase Inhibition Increases Levels of Choline Kinase   and Phosphocholine Facilitating Noninvasive Imaging in Human Cancers

(2011) M. Beloueche-Babari et al.   CANCER RESEARCH

Exploiting tumor metabolism for non-invasive imaging of the therapeutic activity of molecularly targeted anticancer agents

(2011) Mounia Beloueche-Babari et al.   CELL CYCLE

The Lipogenesis Pathway as a Cancer Target

(2011) Hanley N. Abramson   JOURNAL OF MEDICINAL CHEMISTRY

Tumor imaging using hyperpolarized 13C magnetic resonance spectroscopy

(2011) Kevin M. Brindle et al.   MAGNETIC RESONANCE IN MEDICINE

CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors

(2011) R. Le Floch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Guidelines for the welfare and use of animals in cancer research

(2010) P Workman et al.   BRITISH JOURNAL OF CANCER

Lactate modulates gene expression in human mesenchymal stem cells

(2008) Derek Zieker et al.   LANGENBECKS ARCHIVES OF SURGERY