Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8+ T cell stemness and antitumor immunity
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Title
Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8+ T cell stemness and antitumor immunity
Authors
Keywords
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Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume -, Issue -, Pages 201920413
Publisher
Proceedings of the National Academy of Sciences
Online
2020-03-03
DOI
10.1073/pnas.1920413117
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Note: Only part of the references are listed.- The transcription factor c-Myb regulates CD8+ T cell stemness and antitumor immunity
- (2019) Sanjivan Gautam et al. NATURE IMMUNOLOGY
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- (2018) Wenyun Lu et al. ANTIOXIDANTS & REDOX SIGNALING
- An Integrated View of Immunometabolism
- (2018) Yun Sok Lee et al. CELL
- IL-21 modulates memory and exhaustion phenotype of T-cells in a fatty acid oxidation-dependent manner
- (2018) Romy Loschinski et al. Oncotarget
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- (2018) Jaehong Kim Journal of Immunology Research
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- (2018) Minkyung Song et al. NATURE
- Nuclear lactate dehydrogenase A senses ROS to produce α-hydroxybutyrate for HPV-induced cervical tumor growth
- (2018) Yuan Liu et al. Nature Communications
- Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH)
- (2017) Ganesha Rai et al. JOURNAL OF MEDICINAL CHEMISTRY
- T memory stem cells in health and disease
- (2017) Luca Gattinoni et al. NATURE MEDICINE
- Exhaustion-associated regulatory regions in CD8+tumor-infiltrating T cells
- (2017) Giuliana P. Mognol et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Common Cytokine Receptor γ Chain Family of Cytokines
- (2017) Jian-Xin Lin et al. Cold Spring Harbor Perspectives in Biology
- Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells
- (2017) Jian-Xin Lin et al. Nature Communications
- Generation of clinical-grade CD19-specific CAR-modified CD8+ memory stem cells for the treatment of human B-cell malignancies
- (2016) M. Sabatino et al. BLOOD
- Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming
- (2016) Michael D. Buck et al. CELL
- S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate
- (2016) Petros A. Tyrakis et al. NATURE
- Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism
- (2016) M. Peng et al. SCIENCE
- Mammalian Target of Rapamycin Complex 2 Controls CD8 T Cell Memory Differentiation in a Foxo1-Dependent Manner
- (2016) Lianjun Zhang et al. Cell Reports
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- (2015) Michael D. Buck et al. JOURNAL OF EXPERIMENTAL MEDICINE
- ClustVis: a web tool for visualizing clustering of multivariate data using Principal Component Analysis and heatmap
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- Cell-State-Specific Metabolic Dependency in Hematopoiesis and Leukemogenesis
- (2014) Ying-Hua Wang et al. CELL
- OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand
- (2014) D. A. Patten et al. EMBO JOURNAL
- Memory CD8+ T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development
- (2014) David O’Sullivan et al. IMMUNITY
- Interleukin-21: a double-edged sword with therapeutic potential
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- (2012) Ruoning Wang et al. IMMUNOLOGICAL REVIEWS
- PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+T cells
- (2012) David K. Finlay et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development
- (2011) Gerritje J.W. van der Windt et al. IMMUNITY
- IL-7 and IL-21 are superior to IL-2 and IL-15 in promoting human T cell-mediated rejection of systemic lymphoma in immunodeficient mice
- (2010) J. C. Markley et al. BLOOD
- edgeR: a Bioconductor package for differential expression analysis of digital gene expression data
- (2009) M. D. Robinson et al. BIOINFORMATICS
- Blimp Hovers over T Cell Immunity
- (2009) Raymond M. Welsh IMMUNITY
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- (2008) C. S. Hinrichs et al. BLOOD
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