Article
Biotechnology & Applied Microbiology
Salah Mohamed El Sayed
Summary: Cancer cells prefer glucose metabolism to produce vital biomolecules, causing the Warburg effect of lactate production. The vicious cycle between glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and lactate dehydrogenase (LDH) drives this effect, leading to increased oxidative stress and cancer formation. Targeting GAPDH and LDH, avoiding strong oxidants, and using strong antioxidants can inhibit the Warburg effect.
ONCOTARGETS AND THERAPY
(2023)
Article
Oncology
Nicola Hermann, Lara Valeska Maul, Milad Ameri, Stephan Traidl, Reihane Ziadlou, Karolina Papageorgiou, Isabel Kolm, Mitchell Levesque, Julia-Tatjana Maul, Marie-Charlotte Bruggen
Summary: This study investigated the clinical and biological features of VLD in melanoma patients receiving immunotherapy, revealing a unique immune signature in VLD patients and distinct proteomic profiles in VLD responders. These findings suggest that VLD may have potential implications for treatment response and prognosis in melanoma patients undergoing CPI therapy.
Article
Biophysics
Gopal Varma, Pankaj Seth, Patricia Coutinho de Souza, Cody Callahan, Jocelin Pinto, Manushka Vaidya, Olmo Sonzogni, Vikas Sukhatme, Gerburg M. Wulf, Aaron K. Grant
Summary: The article discusses the role of metabolic pathways in cancer and the selective harm to cancer cells by reversing the Warburg effect through LDH inhibition. Studies on magnetic resonance spectroscopic imaging of LDH inhibition in breast and lung cancer models found that reduction in label exchange between pyruvate and lactate supports the selective harm to cancer cells.
NMR IN BIOMEDICINE
(2021)
Article
Clinical Neurology
Eloi Gine-Serven, Maria Martinez-Ramirez, Ester Boix-Quintana, Eva Davi-Loscos, Nicolau Guanyabens, Virginia Casado, Desiree Muriana, Cristina Torres-Rivas, Benedicto Crespo-Facorro, Javier Labad
Summary: This study found that CSF glucose and LDH levels are associated with early symptoms and phenotypes of psychotic disorders, with lower CSF glucose concentrations being linked to schizophrenia or schizoaffective disorder diagnoses.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Clinical Neurology
Ruwei Ou, Qianqian Wei, Yanbing Hou, Lingyu Zhang, Kuncheng Liu, Junyu Lin, Zheng Jiang, Wei Song, Bei Cao, Huifang Shang
Summary: In patients with Parkinson's disease, poorly controlled diabetes mellitus is an independent risk factor for motor progression, emphasizing the importance of adequate diabetes control in PD patients.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2021)
Article
Pathology
Kelly Offermans, Josien C. A. Jenniskens, Colinda C. J. M. Simons, Iryna Samarska, Gregorio E. Fazzi, Kim M. Smits, Leo J. Schouten, Matty P. Weijenberg, Heike Grabsch, Piet A. van den Brandt
Summary: This study found that CRC patients with Warburg-high subtype had the poorest survival rates, especially for those with TNM stage III CRC and cancers located in the rectum. Further research is needed to confirm the findings and explore the potential clinical utility of Warburg subtypes in CRC.
JOURNAL OF PATHOLOGY CLINICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Xiao-Na Li, San-Qiao Yang, Min Li, Xue-Song Li, Qing Tian, Fan Xiao, Yi-Yun Tang, Xuan Kang, Chun-Yan Wang, Wei Zou, Ping Zhang, Xiao-Qing Tang
Summary: The study revealed that formaldehyde-induced neurotoxicity may involve ferroptosis and the Warburg effect. Inhibition of the Warburg effect can protect neurons from ferroptosis and cell death.
Article
Engineering, Environmental
Maria Martha Barroso Quiroga, Monica Iglesias Junca, Nora Andrea Merino
Summary: Layered double hydroxides (LDH) are anionic clays used as adsorbents, ion exchange materials, and catalysts, with high thermal stability and specific surface areas. LDH synthesized with different combinations showed high removal efficiency of As(III) and As(V) from aqueous solutions, with ZnMgFe removing both species with high efficiency and MgFe showing selectivity for As(V) uptake.
WATER SCIENCE AND TECHNOLOGY
(2021)
Review
Oncology
D. Grahame Hardie
Summary: Otto Warburg published the first paper on the Warburg effect in 1923, revealing the difference in lactate production between tumor tissues and normal tissues in glucose metabolism. However, the mechanisms underlying the Warburg effect are still not fully understood to this day.
ENDOCRINE-RELATED CANCER
(2022)
Article
Energy & Fuels
Qi Li, Tianyi Yang, Shuqing Liao, Luhuan Yang, Xuetang Xu, Fan Wang
Summary: This study discusses the composition effects on the structure and capacitive performance of NiCo layered double hydroxide (NiCo LDH) and regulates the structural diversity of NiCo LDH through alkali conversion. The results show that alkali conversion can enhance the bimetallic synergistic effect and increase the surface content of Ni3+ and Co3+ cations. This evolution enables Ni0.60Co0.40 LDH nanoarrays to exhibit excellent electrochemical performance.
JOURNAL OF ENERGY STORAGE
(2022)
Article
Biochemistry & Molecular Biology
Zhikun Li, Mei Geng, Xiaojian Ye, Yunhan Ji, Yifan Li, Xiangyang Zhang, Wei Xu
Summary: This study reveals that IRF7 is downregulated in osteosarcoma and its higher expression is associated with a better survival prognosis. IRF7 plays critical roles in suppressing aerobic glycolysis in osteosarcoma cells through inhibition of PKM2 expression, making it a potential therapeutic target for osteosarcoma patients.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Energy & Fuels
Samaneh Vahedi, Morteza Saghafi Yazdi, Ahmad Razaghian Arani, Marziyeh Azadfalah
Summary: In this study, LDH-derived Ni-Co-Al oxide (NCL) electrodes with high capacitance stability were successfully fabricated using a hydrothermal method at different pH values. The NCL3 electrode synthesized at pH=8.6 exhibited the best performance at higher current densities compared to an NCL electrode with carbon nanotube additives. The impact of pH rate control on NCL electrodes and the effect of carbonic additives on composite electrodes were comprehensively analyzed using advanced analytical techniques.
JOURNAL OF ENERGY STORAGE
(2021)
Article
Biochemistry & Molecular Biology
Woo Kyung Lee Doolittle, Sunmi Park, Seul Gi Lee, Seonhyang Jeong, Gibbeum Lee, Dongryeol Ryu, Kristina Schoonjans, Johan Auwerx, Jandee Lee, Young Suk Jo
Summary: This study identified a mechanism linking mitochondrial stress response (MSR) with thyroid cancer progression and revealed a novel pathway regulating tumor growth signaling. The findings suggest that MSR could serve as a predictive marker for assessing the aggressiveness of thyroid cancer and as a promising therapeutic target.
Article
Multidisciplinary Sciences
Amit Frenkel, Adi Shiloh, Beatrice Azulay, Victor Novack, Moti Klein, Jacob Dreiher
Summary: This study found that serum lactic dehydrogenase levels were associated with mortality and target organ damage in hospitalized patients with infectious diseases, and the associations were similar in patients with pulmonary and non-pulmonary infections. Among patients with high lactic dehydrogenase levels, the mortality rate was higher in the pulmonary infection group.
Article
Oncology
Kelly Offermans, Josien C. A. Jenniskens, Colinda C. J. M. Simons, Iryna Samarska, Gregorio E. Fazzi, Jaleesa R. M. van der Meer, Kim M. Smits, Leo J. Schouten, Matty P. Weijenberg, Heike Grabsch, Piet A. van den Brandt
Summary: This study investigated the prognostic value of mutational subgroups based on somatic mutations in RAS, BRAF, PIK3CA, MET, and mismatch repair (MMR) status in colorectal cancer (CRC) patients. The results showed that mutational subgroups were associated with survival differences in CRC patients, while Warburg-subtypes did not provide additional prognostic information within these mutational subgroups.
Article
Oncology
Marta Tagliabue, Beth Russell, Charlotte Moss, Rita De Berardinis, Francesco Chu, Jean-Pierre Jeannon, Giacomo Pietrobon, Anna Haire, Enrica Grosso, Harriet Wylie, Stefano Zorzi, Michele Proh, Aina Brunet-Garcia, Augusto Cattaneo, Richard Oakley, Luigi De Benedetto, Asit Arora, Stefano Riccio, Alistair Fry, Roberto Bruschini, William Townley, Gioacchino Giugliano, Georgios Orfaniotis, Marzia Madini, Saoirse Dolly, Ester Borghi, Danila Aprile, Valeria Zurlo, Debora Bibiano, Fabrizio Mastrilli, Susanna Chiocca, Mieke Van Hemelrijck, Sara Gandini, Ricard Simo, Mohssen Ansarin
Summary: This study describes the approach and outcomes from two cancer centres in Europe during the first wave of COVID-19 in patients with head and neck cancer. Results showed that patients with COVID-19 were more likely to be taking ACE inhibitors and experience post-surgical complications, and there were differences in sex and age distribution between Italy and the UK. The preventive measures adopted allowed for continued therapeutic surgical intervention.
Article
Gastroenterology & Hepatology
Jason M. Dunn, Arasteh Reyhani, Aida Santaolalla, Janine Zylstra, Eliza Gimson, Mark Pennington, Cara Baker, Mark Kelly, Mieke Van Hemelrijck, Jesper Lagergren, Sebastian S. Zeki, James A. Gossage, Andrew R. Davies
Summary: This study compared the outcomes of esophagectomy and endoscopic eradication therapy in patients with early esophageal cancer and high-grade dysplasia. The results showed that endoscopic therapy had similar survival rates but lower complication rates, shorter hospital stays, and lower costs compared to surgery.
DISEASES OF THE ESOPHAGUS
(2022)
Article
Oncology
Elke Rammant, Ann Van Hecke, Karel Decaestecker, Maarten Albersen, Steven Joniau, Wouter Everaerts, Femke Jansen, Nihal E. Mohamed, Roos Colman, Mieke Van Hemelrijck, Valerie Fonteyne
Summary: The majority of bladder cancer patients undergoing radical cystectomy have moderate to high supportive care needs, but few utilize or are willing to use supportive care services, with many patients preferring to talk to their physician.
Editorial Material
Oncology
Jonathan L. Moore, Andrew R. Davies, Aida Santaolalla, Mieke van Hemelrijck, Nick Maisey, Jesper Lagergren, James A. Gossage, Mark Kelly, Cara R. Baker
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
J. L. Moore, A. R. Davies, A. Santaolalla, M. Van Hemelrijck, N. Maisey, J. Lagergren, J. A. Gossage, M. Kelly, C. R. Baker
Summary: This study investigated the clinical relevance of the Tumor Location-Modified Lauren Classification (MLC) system in Western patients with gastric adenocarcinoma. The results showed that MLC was an independent prognostic marker in this population, and patients with PND and D tumors had worse survival.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Valenti Gomez, Myria Galazi, Gregory Weitsman, James Monypenny, Fahad Al-Salemee, Paul R. Barber, Kenrick Ng, Richard Beatson, Balint Szokol, Laszlo Orfi, Greg Mullen, Bart Vanhaesebroeck, Simon Chowdhury, Hing Y. Leung, Tony Ng
Summary: This study investigated the response of PTEN wild-type prostate cancer cells to dual PI3K/mTOR inhibitor treatment and found that combination therapy with HER2 or mGluR1 inhibitors can inhibit cell survival and tumor growth, providing a new therapeutic possibility for patients with PTEN wild-type PI3K/AKT-mutant prostate cancer.
MOLECULAR CANCER THERAPEUTICS
(2022)
Article
Oncology
Marieke van Leeuwen, Jacobien M. Kieffer, Teresa E. Young, Neil K. Aaronson, Lonneke V. Van de Poll-Franse
Summary: This study aimed to develop an EORTC QLG questionnaire to comprehensively capture the HRQOL issues relevant to disease-free cancer survivors. Through pretesting and analysis, essential and optional scales were identified, resulting in the QLQ-SURV100 with various scales and items. The availability of this questionnaire will facilitate a standardized assessment of HRQOL for cancer survivors.
JOURNAL OF CANCER SURVIVORSHIP
(2023)
Article
Oncology
Gincy George, Sarah Rudman, Louisa Fleure, Zoe Moon, Hans Garmo, Fidelma Cahill, Louis Fox, Charlotte Moss, Harriet Wylie, Anna Haire, Mieke Van Hemelrijck
Summary: This study investigated the reasons contributing to nonadherence to gonadotropin-releasing hormone (GnRH) agonists in men with advanced prostate cancer through interviews and focus groups. The themes influencing adherence to treatment included side effects, patient belief system, benefits outweighing harm, quality of life over quantity of life, social support, and patient-clinician relationship.
SEMINARS IN ONCOLOGY NURSING
(2022)
Article
Medicine, General & Internal
Csilla Varnai, Claire Palles, Roland Arnold, Helen M. Curley, Karin Purshouse, Vinton W. T. Cheng, Stephen Booth, Naomi A. Campton, Graham P. Collins, Daniel J. Hughes, Austin G. Kulasekararaj, Alvin J. X. Lee, Anna C. Olsson-Brown, Archana Sharma-Oates, Mieke Van Hemelrijck, Lennard Y. W. Lee, Rachel Kerr, Gary Middleton, Jean-Baptiste Cazier
Summary: This study finds no association between recent systemic anticancer treatments and COVID-19 mortality in patients with active cancer, suggesting that cancer treatments do not inferior outcomes. Differences in outcomes among patients with different cancer types were observed.
Review
Oncology
Laudy Chehade, Jad Zeitoun, Dorothy Lombe, Sheeba Irshad, Mieke Van Hemelrijck, Karen Canfell, Richard Sullivan, Deborah Mukherji
Summary: This review examines the efficacy of COVID-19 vaccines in cancer patients and finds that solid tumor patients have lower serologic response rates compared to healthy controls, while patients with hematologic malignancies have the lowest response rates. Patients receiving B-cell depleting therapies have poor serologic responses. Data on cellular response are limited and conflicting. Many questions about vaccination in cancer patients remain unanswered and require further exploration.
ECANCERMEDICALSCIENCE
(2022)
Article
Urology & Nephrology
Edwin M. Chau, Beth Russell, Aida Santaolalla, Mieke Van Hemelrijck, Stuart McCracken, Toby Page, Sidath H. Liyanage, Jonathan Aning, Vincent J. Gnanapragasam, Peter Acher
Summary: This study validates a novel MRI-based nomogram in a multi-centre UK-based cohort, demonstrating its good performance in identifying high-risk individuals with clinically significant prostate cancer. These findings support the use of this risk calculator in the prostate biopsy decision-making process.
JOURNAL OF CLINICAL UROLOGY
(2022)
Article
Oncology
Valeria Manuelli, Fidelma Cahill, Harriet Wylie, Cheryl Gillett, Isabel Correa, Susanne Heck, Alex Rimmer, Anna Haire, Mieke Van Hemelrijck, Sarah Rudman, Claire M. Wells
Summary: This study found that prostate cancer cells have the ability to spontaneously form invadopodia and degrade extracellular matrix, leading to invasion and metastasis in vivo. Circulating tumor cells from patients also exhibited similar characteristics, supporting the role of invadopodia activity in prostate cancer progression.
Article
Oncology
Alessio Cortellini, Ramon Salazar, Alessandra Gennari, Juan Aguilar-Company, Mark Bower, Alexia Bertuzzi, Joan Brunet, Matteo Lambertini, Clara Maluquer, Paolo Pedrazzoli, Alvin JX. Lee, MCarmen Carmona-Garcia, Thomas Newsom-Davis, Mieke Van Hemelrijck, Andrea Plaja, Alberto Zambelli, Carlo Tondini, Daniele Generali, Rossella Bertulli, Nikolaos Diamantis, Uma Mukherjee, Gianpiero Rizzo, Tamara Yu, Federica Zoratto, Riccardo Bruna, Anna Sureda, Clara Martinez-Vila, Luca Cantini, Francesca Mazzoni, Federica Grosso, Alessandro Parisi, Maristella Saponara, Aleix Prat
Summary: This study confirms that a significant proportion of non-advanced cancer patients who recovered from COVID-19 may experience post-COVID-19 syndrome, especially in an unvaccinated population. Some patients may have persistent sequelae up to 12 months, highlighting the importance of dedicated prevention and supportive strategies.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Oncology
David J. Propper, Fangfei Gao, Mark P. Saunders, Debashis Sarker, John A. Hartley, Victoria J. Spanswick, Helen L. Lowe, Louise D. Hackett, Tony T. Ng, Paul R. Barber, Gregory E. Weitsman, Sarah Pearce, Laura White, Andre Lopes, Sharon Forsyth, Daniel Hochhauser
Summary: This study examined the toxicity and efficacy of high-dose pulsed AZD8931 combined with chemotherapy in metastatic colorectal cancer. Results showed acceptable toxicity and some patients had good response to the treatment. Furthermore, a reduction in circulating HER2/3 dimer was observed after treatment.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Shaorong Zhao, Teng Pan, Jinhai Deng, Lixia Cao, Jose M. Vicencio, Jingjing Liu, Guanglin Zhou, Tony Ng, Jin Zhang
Summary: This study reveals the important role of exosomal miR-181b-5p in doxorubicin resistance in breast cancer, and suggests its potential as a prognostic biomarker and therapeutic target for doxorubicin-resistant BC patients.
BRITISH JOURNAL OF CANCER
(2023)