Therapeutic strategies of small molecules in the microbiota–gut–brain axis for alcohol use disorder

Posttraumatic stress as a moderator of the association between HPA-axis functioning and alcohol use disorder among a community sample of women currently experiencing intimate partner violence.

(2022) Silvi C. Goldstein et al.   EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY

New Insights in the Control of Fat Homeostasis: The Role of Neurotensin

(2022) Ilaria Barchetta et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Propionate Ameliorates Alcohol-Induced Liver Injury in Mice via the Gut–Liver Axis: Focus on the Improvement of Intestinal Permeability

(2022) Qi Xu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Involvement of the Dorsal Vagal Complex in Alcohol-Related Behaviors

(2022) Bailey N. Keller et al.   Frontiers in Behavioral Neuroscience

The Influence of Gut Dysbiosis in the Pathogenesis and Management of Ischemic Stroke

(2022) Saravana Babu Chidambaram et al.   Cells

Alcohol-Induced Oxidative Stress and the Role of Antioxidants in Alcohol Use Disorder: A Systematic Review

(2022) Evangelia Eirini Tsermpini et al.   Antioxidants

Role of the ghrelin system in alcohol use disorder and alcohol‐associated liver disease: A narrative review

(2022) Kusum K. Kharbanda et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Neurosteroids (allopregnanolone) and alcohol use disorder: From mechanisms to potential pharmacotherapy

(2022) Eleonora Gatta et al.   PHARMACOLOGY & THERAPEUTICS

Reduced alcohol preference and intake after fecal transplant in patients with alcohol use disorder is transmissible to germ-free mice

(2022) Jennifer T. Wolstenholme et al.   Nature Communications

Prenatal ethanol exposure causes anxiety-like phenotype and alters synaptic nitric oxide and endocannabinoid signaling in dorsal raphe nucleus of adult male rats

(2022) Saida Oubraim et al.   Translational Psychiatry

Comorbidity of Post-Traumatic Stress Disorder and Alcohol Use Disorder: Animal Models and Associated Neurocircuitry

(2022) Bo Zhan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chronic stress and corticosterone exacerbate alcohol-induced tissue injury in the gut-liver-brain axis

(2021) Pradeep K. Shukla et al.   Scientific Reports

Voluntary Binge‐Patterned Alcohol Drinking and Sex‐Specific Influences on Monoamine‐Related Neurochemical Signatures in the Mouse Gut and Brain

(2021) Ella E Bauer et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Neurobiology of alcohol seeking behavior

(2021) Esi Domi et al.   JOURNAL OF NEUROCHEMISTRY

Pharmacological Enhancing Agents Targeting Cognition in Patients with Alcohol-Induced Neurocognitive Disorders: A Systematic Review

(2021) Nicolaj Mistarz et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Gut Microbiota at the Intersection of Alcohol, Brain, and the Liver

(2021) Haripriya Gupta et al.   Journal of Clinical Medicine

Translational Approaches with Antioxidant Phytochemicals against Alcohol-Mediated Oxidative Stress, Gut Dysbiosis, Intestinal Barrier Dysfunction, and Fatty Liver Disease

(2021) Jacob W. Ballway et al.   Antioxidants

The Molecular Basis of Alcohol Use Disorder (AUD). Genetics, Epigenetics, and Nutrition in AUD: An Amazing Triangle

(2021) Agnieszka Siomek-Gorecka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Integrated Analyses of the Gut Microbiota, Intestinal Permeability, and Serum Metabolome Phenotype in Rats with Alcohol Withdrawal Syndrome

(2021) Fan Yang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

The role of glucagon‐like peptide 1 (GLP‐1) in addictive disorders

(2021) Mette Kruse Klausen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Neurobiological correlates of cue-reactivity in alcohol-use disorders: A voxel-wise meta-analysis of fMRI studies

(2021) Jianguang Zeng et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle

(2021) Saravana Babu Chidambaram et al.   PHARMACOLOGY & THERAPEUTICS

Alterations of kynurenine pathway in alcohol use disorder and abstinence: a link with gut microbiota, peripheral inflammation and psychological symptoms

(2021) Sophie Leclercq et al.   Translational Psychiatry

Sex-Specific Effects of Synbiotic Exposure in Mice on Addictive-Like Behavioral Alterations Induced by Chronic Alcohol Intake Are Associated With Changes in Specific Gut Bacterial Taxa and Brain Tryptophan Metabolism

(2021) Nieves Pizarro et al.   Frontiers in Nutrition

Alcohol Use Disorders and the Brain

(2020) Tony Rao et al.   ADDICTION

Microbiota and alcohol use disorder: are psychobiotics a novel therapeutic strategy?

(2020) Alicia Rodriguez-Gonzalez et al.   CURRENT PHARMACEUTICAL DESIGN

The Role of the Central Amygdala in Alcohol Dependence

(2020) Marisa Roberto et al.   Cold Spring Harbor Perspectives in Medicine

Role of Alcohol Drinking in Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis

(2020) Bin Peng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gut Microbiota Dysbiosis Associated With Altered Production of Short Chain Fatty Acids in Children With Neurodevelopmental Disorders

(2020) Katarina Bojović et al.   Frontiers in Cellular and Infection Microbiology

Dopamine D2/3 receptor availability in alcohol use disorder and individuals at high risk: Towards a dimensional approach

(2020) Tobias Gleich et al.   ADDICTION BIOLOGY

The Impact of Appetite-Regulating Neuropeptide Leptin on Alcohol Use, Alcohol Craving and Addictive Behavior: A Systematic Review of Preclinical and Clinical Data

(2020) Patrick Bach et al.   ALCOHOL AND ALCOHOLISM

Alcohol consumption during adolescence alters the hippocampal response to traumatic brain injury

(2020) Rodrigo G. Mira et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Efficacy of pharmacotherapeutics for patients comorbid with alcohol use disorders and depressive symptoms—A bayesian network meta‐analysis

(2020) Jiande Li et al.   CNS Neuroscience & Therapeutics

The Mesolimbic Dopamine Activity Signatures of Relapse to Alcohol-Seeking

(2020) Yu Liu et al.   JOURNAL OF NEUROSCIENCE

Lactobacillus rhamnosus GG and Oat Beta‐Glucan Regulated Fatty Acid Profiles Along the Gut‐Liver‐Brain Axis of Mice Fed with High Fat Diet and the Demonstrated Antioxidant and Anti‐Inflammatory Potentials

(2020) Yu Fung Yau et al.   MOLECULAR NUTRITION & FOOD RESEARCH

A neurotransmitter produced by gut bacteria modulates host sensory behaviour

(2020) Michael P. O’Donnell et al.   NATURE

NADPH oxidase contributes to oxidative damage and mitochondrial impairment induced by acute ethanol treatment in rat hippocampal neurons

(2020) María José Pérez et al.   NEUROPHARMACOLOGY

A Double-Blind, Randomized Placebo-Controlled Trial of Probiotic Lactobacillus casei Shirota in Stable Cirrhotic Patients

(2020) Jane Macnaughtan et al.   Nutrients

Leptin levels in alcohol dependent patients and their relationship with withdrawal and craving

(2020) Sumit Mehta et al.   Asian Journal of Psychiatry

Gut Microbiota-Induced Changes in β-Hydroxybutyrate Metabolism Are Linked to Altered Sociability and Depression in Alcohol Use Disorder

(2020) Sophie Leclercq et al.   Cell Reports

The gut–brain axis in irritable bowel syndrome and inflammatory bowel disease

(2020) Angela Ancona et al.   DIGESTIVE AND LIVER DISEASE

Impacts of fish oil on the gut microbiota of rats with alcoholic liver damage

(2020) Ya-Ling Chen et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice

(2019) Peng Zheng et al.   Science Advances

Alcohol intake enhances glutamatergic transmission from D2 receptor-expressing afferents onto D1 receptor-expressing medium spiny neurons in the dorsomedial striatum

(2019) Jiayi Lu et al.   NEUROPSYCHOPHARMACOLOGY

Fructose Promotes Leaky Gut, Endotoxemia and Liver Fibrosis through CYP 2E1‐Mediated Oxidative and Nitrative Stress

(2019) Young‐Eun Cho et al.   HEPATOLOGY

Ghrelin: From a gut hormone to a potential therapeutic target for alcohol use disorder

(2019) Mehdi Farokhnia et al.   PHYSIOLOGY & BEHAVIOR

Correlations between subunits of GABAA and NMDA receptors after chronic alcohol treatment or withdrawal and the effect of taurine in the hippocampus of rats

(2019) Alana Witt Hansen et al.   ALCOHOL

Long-term consumption of alcohol exacerbates neural lesions by destroying the functional integrity of the blood–brain barrier

(2019) Jiangping Wei et al.   DRUG AND CHEMICAL TOXICOLOGY

Impact of gut microbiota on neurogenesis and neurological diseases during infancy

(2019) Tomás Cerdó et al.   CURRENT OPINION IN PHARMACOLOGY

Stress, Motivation, and the Gut-Brain Axis: A Focus on the Ghrelin System and Alcohol Use Disorder

(2018) Laurel S. Morris et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Apoptosis of enterocytes and nitration of junctional complex proteins promote alcohol-induced gut leakiness and liver injury

(2018) Young-Eun Cho et al.   JOURNAL OF HEPATOLOGY

Preventive effects of indole-3-carbinol against alcohol-induced liver injury in mice via antioxidant, anti-inflammatory, and anti-apoptotic mechanisms: Role of gut-liver-adipose tissue axis

(2018) Youngshim Choi et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Pomegranate prevents binge alcohol-induced gut leakiness and hepatic inflammation by suppressing oxidative and nitrative stress

(2018) Young-Eun Cho et al.   Redox Biology

Interneuronal δ-GABAA receptors regulate binge drinking and are necessary for the behavioral effects of early withdrawal

(2018) Laverne C. Melón et al.   NEUROPSYCHOPHARMACOLOGY

The multiple protective roles and molecular mechanisms of melatonin and its precursor N-acetylserotonin in targeting brain injury and liver damage and in maintaining bone health

(2018) Chengliang Luo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Gut-brain axis and addictive disorders: A review with focus on alcohol and drugs of abuse

(2018) Elisabet Jerlhag   PHARMACOLOGY & THERAPEUTICS

Exogenous ghrelin administration increases alcohol self-administration and modulates brain functional activity in heavy-drinking alcohol-dependent individuals

(2017) M Farokhnia et al.   MOLECULAR PSYCHIATRY

Cytochrome P450-2E1 promotes fast food-mediated hepatic fibrosis

(2017) Mohamed A. Abdelmegeed et al.   Scientific Reports

Protective effect of butyrate against ethanol-induced gastric ulcers in mice by promoting the anti-inflammatory, anti-oxidant and mucosal defense mechanisms

(2016) Jiaming Liu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Communities stimulated with ethanol to perform direct interspecies electron transfer for syntrophic metabolism of propionate and butyrate

(2016) Zhiqiang Zhao et al.   WATER RESEARCH

Aberrant post-translational protein modifications in the pathogenesis of alcohol-induced liver injury

(2016) Natalia A Osna et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Role of defective methylation reactions in ethanol-induced dysregulation of intestinal barrier integrity

(2015) Paul G. Thomes et al.   BIOCHEMICAL PHARMACOLOGY

Fluoxetine Might Alleviate Brain Damage and Hypercortisolemia Related to Chronic Alcohol in Rats*

(2015) Jian Hu et al.   Journal of Studies on Alcohol and Drugs

The effects of chronic alcohol self-administration on serotonin-1A receptor binding in nonhuman primates

(2014) Ansel T. Hillmer et al.   DRUG AND ALCOHOL DEPENDENCE

Increased methylation demand exacerbates ethanol-induced liver injury

(2014) Kusum K. Kharbanda et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Ethanol-Induced Plasticity of GABAA Receptors in the Basolateral Amygdala

(2014) A. Kerstin Lindemeyer et al.   NEUROCHEMICAL RESEARCH

Prebiotic intake reduces the waking cortisol response and alters emotional bias in healthy volunteers

(2014) Kristin Schmidt et al.   PSYCHOPHARMACOLOGY

Gut-brain peptides in corticostriatal-limbic circuitry and alcohol use disorders

(2014) Chelsea A. Vadnie et al.   Frontiers in Neuroscience

Mitochondrial dysfunction and tissue injury by alcohol, high fat, nonalcoholic substances and pathological conditions through post-translational protein modifications

(2014) Byoung-Joon Song et al.   Redox Biology

Blockade of Ethanol-Induced Behavioral Sensitization by Sodium Butyrate: Descriptive Analysis of Gene Regulations in the Striatum

(2013) Rémi Legastelois et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Metagenomic Analyses of Alcohol Induced Pathogenic Alterations in the Intestinal Microbiome and the Effect of Lactobacillus rhamnosus GG Treatment

(2013) Lara Bull-Otterson et al.   PLoS One

Gut Peptide GLP-1 and Its Analogue, Exendin-4, Decrease Alcohol Intake and Reward

(2013) Rozita H. Shirazi et al.   PLoS One

Regulation of the stress response by the gut microbiota: Implications for psychoneuroendocrinology

(2012) Timothy G. Dinan et al.   PSYCHONEUROENDOCRINOLOGY

The glucagon-like peptide 1 analogue Exendin-4 attenuates alcohol mediated behaviors in rodents

(2012) Emil Egecioglu et al.   PSYCHONEUROENDOCRINOLOGY

Involvement of nucleus accumbens dopamine D1 receptors in ethanol drinking, ethanol-induced conditioned place preference, and ethanol-induced psychomotor sensitization in mice

(2012) Amine Bahi et al.   PSYCHOPHARMACOLOGY

Neuropeptide Y Opposes Alcohol Effects on Gamma-Aminobutyric Acid Release in Amygdala and Blocks the Transition to Alcohol Dependence

(2011) Nicholas W. Gilpin et al.   BIOLOGICAL PSYCHIATRY

Post-translational modifications of mitochondrial aldehyde dehydrogenase and biomedical implications

(2011) Byoung-Joon Song et al.   Journal of Proteomics

Increased Ethanol Consumption and Preference in Mice Lacking Neurotensin Receptor Type 2

(2010) Moonnoh R. Lee et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Susceptibility to gut leakiness: a possible mechanism for endotoxaemia in non-alcoholic steatohepatitis

(2010) Ashkan Farhadi et al.   LIVER INTERNATIONAL

GABAergic transmission modulates ethanol excitation of ventral tegmental area dopamine neurons

(2010) J.W. Theile et al.   NEUROSCIENCE

Signalling pathways in alcohol-induced liver inflammation

(2009) Pranoti Mandrekar et al.   JOURNAL OF HEPATOLOGY

Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior to development of alcoholic steatohepatitis in rats

(2008) Ali Keshavarzian et al.   JOURNAL OF HEPATOLOGY