Journal
PSYCHOPHARMACOLOGY
Volume 222, Issue 1, Pages 141-153Publisher
SPRINGER
DOI: 10.1007/s00213-011-2630-8
Keywords
D1 receptor; Ethanol; Reward; Place preference; Behavioral sensitization; SCH-39166; siRNA; Lentivitus
Categories
Funding
- United Arab Emirates University
- Swiss National Science Foundation [3100-059350, 3100AO-100686]
Ask authors/readers for more resources
Dopamine D1 receptor (D1R) signaling has been associated to ethanol consumption and reward in laboratory animals. Here, we hypothesize that this receptor, which is located within the nucleus accumbens (NAc) neurons, modulates alcohol reward mechanisms. To test this hypothesis, we measured alcohol consumption and ethanol-induced psychomotor sensitization and conditioned place preference (CPP) in mice that received bilateral microinjections of small interference RNA (siRNA)-expressing lentiviral vectors (LV-siD1R) producing D1R knock-down. The other group received control (LV-Mock) viral vectors into the NAc. There were no differences in the total fluid consumed and also no differences in the amount of ethanol consumed between groups prior to surgery. However, after surgery, the LV-siD1R group consumed less ethanol than the control group. This difference was not associated to taste neophobia. In addition, results have shown that down-regulation of endogenous D1R using viral-mediated siRNA in the NAc significantly decreased ethanol-induced behavioral sensitization as well as acquisition, but not expression, of ethanol-induced place preference. We conclude that decreased D1R expression into the NAc led to reduced ethanol rewarding properties, thereby leading to lower voluntary ethanol consumption. Together, these findings demonstrate that the D1 receptor pathway within the NAc controls ethanol reward and intake.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available