Stress, Motivation, and the Gut-Brain Axis: A Focus on the Ghrelin System and Alcohol Use Disorder

LEAP2 Is an Endogenous Antagonist of the Ghrelin Receptor

(2018) Xuecai Ge et al.   Cell Metabolism

The novel ghrelin receptor inverse agonist PF-5190457 administered with alcohol: preclinical safety experiments and a phase 1b human laboratory study

(2018) Mary R. Lee et al.   MOLECULAR PSYCHIATRY

From Belly to Brain: Targeting the Ghrelin Receptor in Appetite and Food Intake Regulation

(2017) Ken Howick et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Is Ghrelin Synthesized in the Central Nervous System?

(2017) Agustina Cabral et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exogenous ghrelin administration increases alcohol self-administration and modulates brain functional activity in heavy-drinking alcohol-dependent individuals

(2017) M Farokhnia et al.   MOLECULAR PSYCHIATRY

Ghrelin as a Survival Hormone

(2017) Bharath K. Mani et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Ghrelin stimulation by hypothalamic–pituitary–adrenal axis activation depends on increasing cortisol levels

(2017) I Azzam et al.   Endocrine Connections

The gut in the brain: the effects of bariatric surgery on alcohol consumption

(2016) Ashley N. Blackburn et al.   ADDICTION BIOLOGY

A Significant Role of the Truncated Ghrelin Receptor GHS-R1b in Ghrelin-induced Signaling in Neurons

(2016) Gemma Navarro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ghrelin receptor (GHS-R1A) antagonism alters preference for ethanol and sucrose in a concentration-dependent manner in prairie voles

(2016) J.R. Stevenson et al.   PHYSIOLOGY & BEHAVIOR

Mechanistic relationship between the vagal afferent pathway, central nervous system and peripheral organs in appetite regulation

(2016) Hiroaki Ueno et al.   Journal of Diabetes Investigation

Sub-chronic Ghrelin Receptor Blockade Attenuates Alcohol- and Amphetamine-Induced Locomotor Stimulation in Mice

(2015) Petra Suchankova et al.   ALCOHOL AND ALCOHOLISM

Relationship Between Craving and Ghrelin, Adiponectin, and Resistin Levels in Patients with Alcoholism

(2015) Neslihan Akkişi Kumsar et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

A ghrelin receptor (GHS-R1A) antagonist attenuates the rewarding properties of morphine and increases opioid peptide levels in reward areas in mice

(2015) Jörgen A. Engel et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

GHS-R1A antagonism reduces alcohol but not sucrose preference in prairie voles

(2015) J.R. Stevenson et al.   PHYSIOLOGY & BEHAVIOR

The Effects of Ghrelin Antagonists [D-Lys3]-GHRP-6 or JMV2959 on Ethanol, Water, and Food Intake in C57BL/6J Mice

(2014) Juan L. Gomez et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Ghrelin mimics fasting to enhance human hedonic, orbitofrontal cortex, and hippocampal responses to food

(2014) Anthony P Goldstone et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Intravenous Ghrelin Administration Increases Alcohol Craving in Alcohol-Dependent Heavy Drinkers: A Preliminary Investigation

(2014) Lorenzo Leggio et al.   BIOLOGICAL PSYCHIATRY

Ghrelin alters the stimulatory effect of cocaine on ethanol intake following mesolimbic or systemic administration

(2014) Leah C.S. Cepko et al.   NEUROPHARMACOLOGY

The neural signature of satiation is associated with ghrelin response and triglyceride metabolism

(2014) Xue Sun et al.   PHYSIOLOGY & BEHAVIOR

Anticipation of a psychosocial stressor differentially influences ghrelin, cortisol and food intake among emotional and non-emotional eaters

(2013) Kate Raspopow et al.   APPETITE

Microinjection of ghrelin in the nucleus accumbens core enhances locomotor activity induced by cocaine

(2013) Ju Kyong Jang et al.   BEHAVIOURAL BRAIN RESEARCH

Prefrontal mechanisms of behavioral flexibility, emotion regulation and value updating

(2013) Peter H Rudebeck et al.   NATURE NEUROSCIENCE

Ghrelin amplifies the nicotine-induced dopamine release in the rat striatum

(2013) Miklós Palotai et al.   NEUROCHEMISTRY INTERNATIONAL

Ghrelin knockout mice show decreased voluntary alcohol consumption and reduced ethanol-induced conditioned place preference

(2013) Amine Bahi et al.   PEPTIDES

Ghrelin Receptor (GHS-R1A) Antagonism Suppresses Both Alcohol Consumption and the Alcohol Deprivation Effect in Rats following Long-Term Voluntary Alcohol Consumption

(2013) Petra Suchankova et al.   PLoS One

Fasting-induced increase in plasma ghrelin is blunted by intravenous alcohol administration: A within-subject placebo-controlled study

(2013) Lorenzo Leggio et al.   PSYCHONEUROENDOCRINOLOGY

Ghrelin Levels After a Cold Pressor Stress Test in Obese Women With Binge Eating Disorder

(2013) Marci E. Gluck et al.   PSYCHOSOMATIC MEDICINE

Ghrelin increases the motivation to eat, but does not alter food palatability

(2012) Joost Overduin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Gastric Bypass Surgery Attenuates Ethanol Consumption in Ethanol-Preferring Rats

(2012) Jon F. Davis et al.   BIOLOGICAL PSYCHIATRY

Ghrelin Regulates the Hypothalamic-Pituitary-Adrenal Axis and Restricts Anxiety After Acute Stress

(2012) Sarah J. Spencer et al.   BIOLOGICAL PSYCHIATRY

TOWARD AN ACCOUNT OF CLINICAL ANXIETY PREDICATED ON BASIC, NEURALLY MAPPED MECHANISMS OF PAVLOVIAN FEAR-LEARNING: THE CASE FOR CONDITIONED OVERGENERALIZATION

(2012) Shmuel Lissek   DEPRESSION AND ANXIETY

MECHANISMS IN ENDOCRINOLOGY: Ghrelin: the differences between acyl- and des-acyl ghrelin

(2012) Patric J D Delhanty et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

From prediction error to incentive salience: mesolimbic computation of reward motivation

(2012) Kent C. Berridge   EUROPEAN JOURNAL OF NEUROSCIENCE

Cortisol and ghrelin concentrations following a cold pressor stress test in overweight individuals with and without night eating

(2012) A Geliebter et al.   INTERNATIONAL JOURNAL OF OBESITY

Apo-Ghrelin Receptor Forms Heteromers with DRD2 in Hypothalamic Neurons and Is Essential for Anorexigenic Effects of DRD2 Agonism

(2012) Andras Kern et al.   NEURON

Ghrelin signalling and obesity: At the interface of stress, mood and food reward

(2012) Harriët Schellekens et al.   PHARMACOLOGY & THERAPEUTICS

Altered fear learning across development in both mouse and human

(2012) S. S. Pattwell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A limited role for ghrelin in heroin self-administration and food deprivation-induced reinstatement of heroin seeking in rats

(2011) Tia Maric et al.   ADDICTION BIOLOGY

Ghrelin receptor (GHS-R1A) antagonism suppresses both operant alcohol self-administration and high alcohol consumption in rats

(2011) Sara Landgren et al.   ADDICTION BIOLOGY

Ghrelin system in alcohol-dependent subjects: role of plasma ghrelin levels in alcohol drinking and craving

(2011) Lorenzo Leggio et al.   ADDICTION BIOLOGY

Role of ghrelin in food reward: impact of ghrelin on sucrose self-administration and mesolimbic dopamine and acetylcholine receptor gene expression

(2011) Karolina P. Skibicka et al.   ADDICTION BIOLOGY

Expression of the gene encoding the ghrelin receptor in rats selected for differential alcohol preference

(2011) Sara Landgren et al.   BEHAVIOURAL BRAIN RESEARCH

Ghrelin receptor antagonism attenuates nicotine-induced locomotor stimulation, accumbal dopamine release and conditioned place preference in mice

(2011) Elisabet Jerlhag et al.   DRUG AND ALCOHOL DEPENDENCE

Motivation to obtain preferred foods is enhanced by ghrelin in the ventral tegmental area

(2011) S.J. King et al.   HORMONES AND BEHAVIOR

Ghrelin Modulates Sympathetic Nervous System Activity and Stress Response in Lean and Overweight Men

(2011) Elisabeth Lambert et al.   HYPERTENSION

The role of the central ghrelin system in reward from food and chemical drugs

(2011) Suzanne L. Dickson et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Central administration of ghrelin alters emotional responses in rats: behavioural, electrophysiological and molecular evidence

(2011) C. Hansson et al.   NEUROSCIENCE

Ghrelin directly targets the ventral tegmental area to increase food motivation

(2011) K.P. Skibicka et al.   NEUROSCIENCE

6-Hydroxydopamine lesions of the ventral tegmental area suppress ghrelin's ability to elicit food-reinforced behavior

(2011) Zachary Y. Weinberg et al.   NEUROSCIENCE LETTERS

The association of the appetitive peptide acetylated ghrelin with alcohol craving in early abstinent alcohol dependent individuals

(2011) Anne Koopmann et al.   PSYCHONEUROENDOCRINOLOGY

What and when to “want”? Amygdala-based focusing of incentive salience upon sugar and sex

(2011) Stephen V. Mahler et al.   PSYCHOPHARMACOLOGY

Ghrelin increases intake of rewarding food in rodents

(2010) Emil Egecioglu et al.   ADDICTION BIOLOGY

Glutamatergic regulation of ghrelin-induced activation of the mesolimbic dopamine system

(2010) Elisabet Jerlhag et al.   ADDICTION BIOLOGY

The alcohol-induced locomotor stimulation and accumbal dopamine release is suppressed in ghrelin knockout mice

(2010) Elisabet Jerlhag et al.   ALCOHOL

Ghrelin Receptor Antagonism Decreases Alcohol Consumption and Activation of Perioculomotor Urocortin-Containing Neurons

(2010) Simranjit Kaur et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Emotion, Cognition, and Mental State Representation in Amygdala and Prefrontal Cortex

(2010) C. Daniel Salzman et al.   Annual Review of Neuroscience

Use of hair cortisol analysis to detect hypercortisolism during active drinking phases in alcohol-dependent individuals☆

(2010) Tobias Stalder et al.   BIOLOGICAL PSYCHOLOGY

Neural computations associated with goal-directed choice

(2010) Antonio Rangel et al.   CURRENT OPINION IN NEUROBIOLOGY

Development of anxiety: the role of threat appraisal and fear learning

(2010) Jennifer C. Britton et al.   DEPRESSION AND ANXIETY

GOAT: the master switch for the ghrelin system?

(2010) Amparo Romero et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Psychosocial stressor effects on cortisol and ghrelin in emotional and non-emotional eaters: Influence of anger and shame

(2010) Kate Raspopow et al.   HORMONES AND BEHAVIOR

Effects of ghrelin on psychopathology, sleep and secretion of cortisol and growth hormone in patients with major depression

(2010) Michael Kluge et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Ghrelin receptor antagonism attenuates cocaine- and amphetamine-induced locomotor stimulation, accumbal dopamine release, and conditioned place preference

(2010) Elisabet Jerlhag et al.   PSYCHOPHARMACOLOGY

Increased Perioculomotor Urocortin 1 Immunoreactivity in Genetically Selected Alcohol Preferring Rats

(2009) Irina Fonareva et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Ghrelin Increases the Rewarding Value of High-Fat Diet in an Orexin-Dependent Manner

(2009) Mario Perello et al.   BIOLOGICAL PSYCHIATRY

Appetite control and energy balance regulation in the modern world: reward-driven brain overrides repletion signals

(2009) H Zheng et al.   INTERNATIONAL JOURNAL OF OBESITY

Neural regulation of endocrine and autonomic stress responses

(2009) Yvonne M. Ulrich-Lai et al.   NATURE REVIEWS NEUROSCIENCE

Expression of prepro-ghrelin and related receptor genes in the rat adrenal gland and evidences that ghrelin exerts a potent stimulating effect on corticosterone secretion by cultured rat adrenocortical cells

(2009) Marcin Rucinski et al.   PEPTIDES

Requirement of central ghrelin signaling for alcohol reward

(2009) E. Jerlhag et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Neural Computational Model of Incentive Salience

(2009) Jun Zhang et al.   PLoS Computational Biology

Identification of the Acyltransferase that Octanoylates Ghrelin, an Appetite-Stimulating Peptide Hormone

(2008) Jing Yang et al.   CELL

Ghrelin Modulates Brain Activity in Areas that Control Appetitive Behavior

(2008) Saima Malik et al.   Cell Metabolism

Comparison of the distributions of urocortin-containing and cholinergic neurons in the perioculomotor midbrain of the cat and macaque

(2008) Paul J. May et al.   JOURNAL OF COMPARATIVE NEUROLOGY

The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress

(2008) Michael Lutter et al.   NATURE NEUROSCIENCE

How do you feel — now? The anterior insula and human awareness

(2008) A. D. (Bud) Craig   NATURE REVIEWS NEUROSCIENCE

Enhanced Negative Emotion and Alcohol Craving and Altered Physiological Responses Following Stress and Cue Exposure in Alcohol Dependent Individuals

(2008) Rajita Sinha et al.   NEUROPSYCHOPHARMACOLOGY

Ghrelin octanoylation mediated by an orphan lipid transferase

(2008) J. A. Gutierrez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High Impulsivity Predicts the Switch to Compulsive Cocaine-Taking

(2008) D. Belin et al.   SCIENCE

Changes in leptin, ghrelin, growth hormone and neuropeptide-Y after an acute model of MDMA and methamphetamine exposure in rats

(2007) Firas H. Kobeissy et al.   ADDICTION BIOLOGY

Systemic ghrelin sensitizes cocaine-induced hyperlocomotion in rats

(2007) Paul J. Wellman et al.   REGULATORY PEPTIDES