Gut Microbiota at the Intersection of Alcohol, Brain, and the Liver

Supplementation of a propionate-producing consortium improves markers of insulin resistance in an in vitro model of gut-liver axis

(2020) Racha El Hage et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Microbiota changes and intestinal microbiota transplantation in liver diseases and cirrhosis

(2020) Jasmohan S. Bajaj et al.   JOURNAL OF HEPATOLOGY

Circadian rhythms, Neuroinflammation and Oxidative Stress in the Story of Parkinson’s Disease

(2020) Alexandre Vallée et al.   Cells

Lactobacillus and Pediococcus ameliorate progression of non-alcoholic fatty liver disease through modulation of the gut microbiome

(2020) Na Young Lee et al.   Gut Microbes

Role of Alcohol Drinking in Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis

(2020) Bin Peng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Animal Models for Liver Disease - A Practical Approach for Translational Research

(2020) Yulia A. Nevzorova et al.   JOURNAL OF HEPATOLOGY

Colonic microbiota is associated with inflammation and host epigenomic alterations in inflammatory bowel disease

(2020) F. J. Ryan et al.   Nature Communications

Gut microbiota and obesity: causally linked?

(2020) Patrice D. Cani et al.   Expert Review of Gastroenterology & Hepatology

Microbiota and Fatty Liver Disease—the Known, the Unknown, and the Future

(2020) Sonja Lang et al.   Cell Host & Microbe

New mechanism of neuroinflammation in Alzheimer's disease: The activation of NLRP3 inflammasome mediated by gut microbiota

(2020) Heping Shen et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Alcohol Addiction, Gut Microbiota, and Alcoholism Treatment: A Review

(2020) Shao-Cheng Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Prevention and mitigation of alcohol-induced neuroinflammation by Lactobacillus plantarum by an EGF receptor-dependent mechanism

(2020) Pradeep K. Shukla et al.   NUTRITIONAL NEUROSCIENCE

From intestinal dysbiosis to alcohol-associated liver disease

(2020) Beatriz Garcia Mendes et al.   Clinical and Molecular Hepatology

Alcohol, liver disease and the gut microbiota

(2019) Jasmohan S. Bajaj   Nature Reviews Gastroenterology & Hepatology

A Designer Synbiotic Attenuates Chronic-Binge Ethanol-Induced Gut-Liver Injury in Mice

(2019) Sanjoy Roychowdhury et al.   Nutrients

Gut Microbe to Brain Signaling: What Happens in Vagus…

(2019) Christine Fülling et al.   NEURON

Fecal microbiota from patients with cirrhosis has a low capacity to ferment non‐digestible carbohydrates into short chain fatty acids

(2019) Mingliang Jin et al.   LIVER INTERNATIONAL

Global Liver Disease Burdens and Research Trends: Analysis from a China Perspective

(2019) Jia Xiao et al.   JOURNAL OF HEPATOLOGY

Secondary Bile Acids and Short Chain Fatty Acids in the Colon: A Focus on Colonic Microbiome, Cell Proliferation, Inflammation, and Cancer

(2019) Huawei Zeng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Impaired Autonomic Nervous System-Microbiome Circuit in Hypertension

(2019) Jasenka Zubcevic et al.   CIRCULATION RESEARCH

Diagnosis and Treatment of Alcohol‐Related Liver Diseases: 2019 Practice Guidance from the American Association for the Study of Liver Diseases

(2019) David W. Crabb et al.   HEPATOLOGY

Pathogenesis, Early Diagnosis, and Therapeutic Management of Alcoholic Liver Disease

(2019) Ling-Zu Kong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Randomized, Double-blind, Placebo-controlled Study of a Multispecies Probiotic Mixture in Nonalcoholic Fatty Liver Disease

(2019) Sang Bong Ahn et al.   Scientific Reports

Macronutrient metabolism by the human gut microbiome: major fermentation by-products and their impact on host health

(2019) Kaitlyn Oliphant et al.   Microbiome

Role of Gut Microbiota in Hepatocarcinogenesis

(2019) Haripriya Gupta et al.   Microorganisms

Protective effects of Lactobacillus plantarum against chronic alcohol-induced liver injury in the murine model

(2019) Tony J. Fang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Small talk: microbial metabolites involved in the signaling from microbiota to brain

(2019) Giorgia Caspani et al.   CURRENT OPINION IN PHARMACOLOGY

The gut-liver axis in liver disease: pathophysiological basis for therapy

(2019) Agustín Albillos et al.   JOURNAL OF HEPATOLOGY

Imaging Patterns of Toxic and Metabolic Brain Disorders

(2019) Arthur M. de Oliveira et al.   RADIOGRAPHICS

Short-Chain Fatty Acids Improve Poststroke Recovery via Immunological Mechanisms

(2019) Rebecca Sadler et al.   JOURNAL OF NEUROSCIENCE

The gut-liver-kidney axis: Novel regulator of fatty liver associated chronic kidney disease

(2019) Desh Raj et al.   PHARMACOLOGICAL RESEARCH

Kaempferol alleviates acute alcoholic liver injury in mice by regulating intestinal tight junction proteins and butyrate receptors and transporters

(2019) Jing Chen et al.   TOXICOLOGY

Tryptophan Metabolism by Gut Microbiome and Gut-Brain-Axis: An in silico Analysis

(2019) Harrisham Kaur et al.   Frontiers in Neuroscience

Effects of Alcohol on the Brain in Cirrhosis: Beyond Hepatic Encephalopathy

(2018) Brian C. Davis et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Gut-liver axis alterations in alcoholic liver disease: Are bile acids the answer?

(2018) Jasmohan S. Bajaj et al.   HEPATOLOGY

The circulating microbiome signature and inferred functional metagenomics in alcoholic hepatitis

(2018) Puneet Puri et al.   HEPATOLOGY

The gut-liver axis: impact of a mouse model of small-bowel bacterial overgrowth

(2018) Qingqing Wang et al.   JOURNAL OF SURGICAL RESEARCH

Gut : liver : brain axis: the microbial challenge in the hepatic encephalopathy

(2018) Andrea Mancini et al.   Food & Function

The Vagus Nerve at the Interface of the Microbiota-Gut-Brain Axis

(2018) Bruno Bonaz et al.   Frontiers in Neuroscience

Microbiome–host systems interactions: protective effects of propionate upon the blood–brain barrier

(2018) Lesley Hoyles et al.   Microbiome

Enteric nervous system development: what could possibly go wrong?

(2018) Meenakshi Rao et al.   NATURE REVIEWS NEUROSCIENCE

Gut microbiome correlates with altered striatal dopamine receptor expression in a model of compulsive alcohol seeking

(2018) Kshitij S. Jadhav et al.   NEUROPHARMACOLOGY

A gut-brain neural circuit for nutrient sensory transduction

(2018) Melanie Maya Kaelberer et al.   SCIENCE

Brain GABA levels are reduced in alcoholic liver disease: A proton magnetic resonance spectroscopy study

(2018) Kirsten C. Morley et al.   ADDICTION BIOLOGY

Modulation of neuroinflammation and memory dysfunction using percutaneous vagus nerve stimulation in mice

(2018) William J. Huffman et al.   Brain Stimulation

The gut microbiome: Relationships with disease and opportunities for therapy

(2018) Juliana Durack et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Reduced gut microbiome protects from alcohol-induced neuroinflammation and alters intestinal and brain inflammasome expression

(2018) Patrick P. Lowe et al.   Journal of Neuroinflammation

Mechanisms Underlying Microbial-Mediated Changes in Social Behavior in Mouse Models of Autism Spectrum Disorder

(2018) Martina Sgritta et al.   NEURON

Is treating the gut microbiome the key to achieving better outcomes in cirrhosis?

(2018) Grace Hatton et al.   Expert Review of Gastroenterology & Hepatology

Sensory neuron regulation of gastrointestinal inflammation and bacterial host defence

(2017) N. Y. Lai et al.   JOURNAL OF INTERNAL MEDICINE

Long-term multi-species Lactobacillus and Bifidobacterium dietary supplement enhances memory and changes regional brain metabolites in middle-aged rats

(2017) Caroline O'Hagan et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Clostridium butyricum exerts a neuroprotective effect in a mouse model of traumatic brain injury via the gut-brain axis

(2017) H. Li et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Influence of gut microbiota on neuropsychiatric disorders

(2017) María Carmen Cenit et al.   WORLD JOURNAL OF GASTROENTEROLOGY

The Gut Microbial Metabolite Trimethylamine-N-Oxide Is Present in Human Cerebrospinal Fluid

(2017) Daniele Del Rio et al.   Nutrients

Links of gut microbiota composition with alcohol dependence syndrome and alcoholic liver disease

(2017) Veronika B. Dubinkina et al.   Microbiome

The Human Microbiota in Health and Disease

(2017) Baohong Wang et al.   Engineering

The CircadianClockMutation Promotes Intestinal Dysbiosis

(2016) Robin M. Voigt et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Sodium butyrate exerts neuroprotective effects by restoring the blood-brain barrier in traumatic brain injury mice

(2016) Haixiao Li et al.   BRAIN RESEARCH

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease

(2016) Timothy R. Sampson et al.   CELL

Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism

(2016) Annika Wahlström et al.   Cell Metabolism

Efficacy of Nutritional Therapy for Patients With Cirrhosis and Minimal Hepatic Encephalopathy in a Randomized Trial

(2016) Sudhir Maharshi et al.   Clinical Gastroenterology and Hepatology

Pathogenesis of Alcoholic Liver Disease

(2016) Winston Dunn et al.   Clinics in Liver Disease

Microbe-host interactions: Influence of the gut microbiota on the enteric nervous system

(2016) Niall P. Hyland et al.   DEVELOPMENTAL BIOLOGY

The Effect of Microbiota and the Immune System on the Development and Organization of the Enteric Nervous System

(2016) Yuuki Obata et al.   GASTROENTEROLOGY

Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

(2016) Veit Rothhammer et al.   NATURE MEDICINE

Alcohol: taking a population perspective

(2016) William Gilmore et al.   Nature Reviews Gastroenterology & Hepatology

The role of the gut–brain axis in alcohol use disorders

(2016) Jonathan Gorky et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Bidirectional Communication between Liver and Gut during Alcoholic Liver Disease

(2016) Peter Stärkel et al.   SEMINARS IN LIVER DISEASE

Psychobiotics and the Manipulation of Bacteria–Gut–Brain Signals

(2016) Amar Sarkar et al.   TRENDS IN NEUROSCIENCES

Microbiota-based treatments in alcoholic liver disease

(2016) Hotaik Sung et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Impaired Gut-Liver-Brain Axis in Patients with Cirrhosis

(2016) Vishwadeep Ahluwalia et al.   Scientific Reports

Critical Roles of Kupffer Cells in the Pathogenesis of Alcoholic Liver Disease: From Basic Science to Clinical Trials

(2016) Tao Zeng et al.   Frontiers in Immunology

Circadian rhythms, alcohol and gut interactions

(2015) Christopher B. Forsyth et al.   ALCOHOL

Alcoholic Liver Disease: The Gut Microbiome and Liver Cross Talk

(2015) Phillipp Hartmann et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Faecalibacterium prausnitzii prevents physiological damages in a chronic low-grade inflammation murine model

(2015) Rebeca Martín et al.   BMC MICROBIOLOGY

Gut Emotions - Mechanisms of Action of Probiotics as Novel Therapeutic Targets for Depression and Anxiety Disorders

(2015) Anastasiya Slyepchenko et al.   CNS & Neurological Disorders-Drug Targets

Effects of probiotics (cultured Lactobacillus subtilis/Streptococcus faecium) in the treatment of alcoholic hepatitis

(2015) Sang Hak Han et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Inhibition of sterile danger signals, uric acid and ATP, prevents inflammasome activation and protects from alcoholic steatohepatitis in mice

(2015) Arvin Iracheta-Vellve et al.   JOURNAL OF HEPATOLOGY

The etiology of cirrhosis is a strong determinant of brain reserve: A multimodal magnetic resonance imaging study

(2015) Vishwadeep Ahluwalia et al.   LIVER TRANSPLANTATION

White matter changes in chronic alcoholic liver disease: Hypothesized association and putative biochemical mechanisms

(2015) Leith Hathout et al.   MEDICAL HYPOTHESES

Expression of the short chain fatty acid receptor GPR41/FFAR3 in autonomic and somatic sensory ganglia

(2015) M.K. Nøhr et al.   NEUROSCIENCE

Probing astrocyte metabolism in vivo: proton magnetic resonance spectroscopy in the injured and aging brain

(2015) Janna L. Harris et al.   Frontiers in Aging Neuroscience

The histone deacetylase inhibitor sodium butyrate decreases excessive ethanol intake in dependent animals

(2014) Emmanuelle Simon-O'Brien et al.   ADDICTION BIOLOGY

Colonic inflammation and secondary bile acids in alcoholic cirrhosis

(2014) Genta Kakiyama et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Bile acids permeabilize the blood brain barrier after bile duct ligation in rats via Rac1-dependent mechanisms

(2014) Matthew Quinn et al.   DIGESTIVE AND LIVER DISEASE

Probiotic VSL#3 Reduces Liver Disease Severity and Hospitalization in Patients With Cirrhosis: A Randomized, Controlled Trial

(2014) Radha K. Dhiman et al.   GASTROENTEROLOGY

Interactions Between the Intestinal Microbiome and Liver Diseases

(2014) Bernd Schnabl et al.   GASTROENTEROLOGY

Alterations of the human gut microbiome in liver cirrhosis

(2014) Nan Qin et al.   NATURE

Pleiotropic Roles of Bile Acids in Metabolism

(2013) Thomas Q. de Aguiar Vallim et al.   Cell Metabolism

Toll-Like Receptor 2 Regulates Intestinal Inflammation by Controlling Integrity of the Enteric Nervous System

(2013) Paola Brun et al.   GASTROENTEROLOGY

Deficiency of intestinal mucin-2 ameliorates experimental alcoholic liver disease in mice

(2013) Phillipp Hartmann et al.   HEPATOLOGY

Altered profile of human gut microbiome is associated with cirrhosis and its complications

(2013) Jasmohan S. Bajaj et al.   JOURNAL OF HEPATOLOGY

The liver–brain axis in liver failure: neuroinflammation and encephalopathy

(2013) Roger F. Butterworth   Nature Reviews Gastroenterology & Hepatology

Intestinal microbiota influence the early postnatal development of the enteric nervous system

(2013) J. Collins et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Inflammatory cytokines in depression: Neurobiological mechanisms and therapeutic implications

(2013) J.C. Felger et al.   NEUROSCIENCE

Modulation of the Metabiome by Rifaximin in Patients with Cirrhosis and Minimal Hepatic Encephalopathy

(2013) Jasmohan S. Bajaj et al.   PLoS One

Disruption of the Circadian Clock in Mice Increases Intestinal Permeability and Promotes Alcohol-Induced Hepatic Pathology and Inflammation

(2013) Keith C. Summa et al.   PLoS One

Can Lactobacillus acidophilus improve minimal hepatic encephalopathy? A neurometabolite study using magnetic resonance spectroscopy

(2013) Dina H. Ziada et al.   Arab Journal of Gastroenterology

Colonic microbiome is altered in alcoholism

(2012) Ece A. Mutlu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Psychoactive bacteria Lactobacillus rhamnosus (JB-1) elicits rapid frequency facilitation in vagal afferents

(2012) Azucena Perez-Burgos et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Role of intestinal permeability and inflammation in the biological and behavioral control of alcohol-dependent subjects

(2012) Sophie Leclercq et al.   BRAIN BEHAVIOR AND IMMUNITY

Voices from within: gut microbes and the CNS

(2012) Paul Forsythe et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Temporal changes in innate immune signals in a rat model of alcohol withdrawal in emotional and cardiorespiratory homeostatic nuclei

(2012) Kate Freeman et al.   Journal of Neuroinflammation

A longitudinal systems biology analysis of lactulose withdrawal in hepatic encephalopathy

(2012) Jasmohan S. Bajaj et al.   METABOLIC BRAIN DISEASE

The enteric nervous system and neurogastroenterology

(2012) John B. Furness   Nature Reviews Gastroenterology & Hepatology

The microbiome is essential for normal gut intrinsic primary afferent neuron excitability in the mouse

(2012) K. A. McVey Neufeld et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Linkage of gut microbiome with cognition in hepatic encephalopathy

(2011) Jasmohan S. Bajaj et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets

(2011) Bin Gao et al.   GASTROENTEROLOGY

Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve

(2011) J. A. Bravo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lactobacillus GG treatment ameliorates alcohol-induced intestinal oxidative stress, gut leakiness, and liver injury in a rat model of alcoholic steatohepatitis

(2009) Christopher B. Forsyth et al.   ALCOHOL

Tumor necrosis factor-α mediates hyperglycemia-augmented gut barrier dysfunction in endotoxemia*

(2009) Satoshi Yajima et al.   CRITICAL CARE MEDICINE

Endotoxemia and gut barrier dysfunction in alcoholic liver disease

(2009) Radhakrishna Rao   HEPATOLOGY

Signalling pathways in alcohol-induced liver inflammation

(2009) Pranoti Mandrekar et al.   JOURNAL OF HEPATOLOGY

Critical Role of TLR4 Response in the Activation of Microglia Induced by Ethanol

(2009) S. Fernandez-Lizarbe et al.   JOURNAL OF IMMUNOLOGY

Circulating Cytokines as Biomarkers of Alcohol Abuse and Alcoholism

(2009) Rajeshwara N. Achur et al.   Journal of Neuroimmune Pharmacology

Oxidative Stress and Alcoholic Liver Disease

(2009) Defeng Wu et al.   SEMINARS IN LIVER DISEASE

The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88

(2008) Istvan Hritz et al.   HEPATOLOGY

Thiamine deficiency-related brain dysfunction in chronic liver failure

(2008) Roger F. Butterworth   METABOLIC BRAIN DISEASE