Oral polymicrobial communities: Assembly, function, and impact on diseases

Periodontal Infection Aggravates C1q-Mediated Microglial Activation and Synapse Pruning in Alzheimer’s Mice

(2022) Xiaoxiao Hao et al.   Frontiers in Immunology

Maladaptive innate immune training of myelopoiesis links inflammatory comorbidities

(2022) Xiaofei Li et al.   CELL

Secreted gingipains from Porphyromonas gingivalis increase permeability in human cerebral microvascular endothelial cells through intracellular degradation of tight junction proteins

(2022) Saori Nonaka et al.   NEUROCHEMISTRY INTERNATIONAL

Fusobacterium nucleatum and cancer

(2022) Tamar Alon‐Maimon et al.   PERIODONTOLOGY 2000

Candidate Phyla Radiation, an Underappreciated Division of the Human Microbiome, and Its Impact on Health and Disease

(2022) Sabrina Naud et al.   CLINICAL MICROBIOLOGY REVIEWS

Pathobiont-responsive Th17 cells in gut-mouth axis provoke inflammatory oral disease and are modulated by intestinal microbiome

(2022) Jun-ichi Nagao et al.   Cell Reports

Inflammation-associated nitrate facilitates ectopic colonization of oral bacterium Veillonella parvula in the intestine

(2022) Daniel F. Rojas-Tapias et al.   Nature Microbiology

Comparison of Blood Bacterial Communities in Periodontal Health and Periodontal Disease

(2021) David C. Emery et al.   Frontiers in Cellular and Infection Microbiology

The pathogenic oral–gut–liver axis: new understandings and clinical implications

(2021) Jin Imai et al.   Expert Review of Clinical Immunology

Loss of neutrophil homing to the periodontal tissues modulates the composition and disease potential of the oral microbiota.

(2021) A Hashim et al.   INFECTION AND IMMUNITY

SMDI: An Index for Measuring Subgingival Microbial Dysbiosis

(2021) T. Chen et al.   JOURNAL OF DENTAL RESEARCH

Spatial transcriptomics of planktonic and sessile bacterial populations at single-cell resolution

(2021) Daniel Dar et al.   SCIENCE

Obesity-Related Gut Microbiota Aggravates Alveolar Bone Destruction in Experimental Periodontitis through Elevation of Uric Acid

(2021) Keisuke Sato et al.   mBio

Episymbiotic Saccharibacteria suppresses gingival inflammation and bone loss in mice through host bacterial modulation

(2021) Otari Chipashvili et al.   Cell Host & Microbe

Mechanisms underlying interactions between two abundant oral commensal bacteria

(2021) Dasith Perera et al.   ISME Journal

Ligature induced periodontitis in rats causes gut dysbiosis leading to hepatic injury through SCD1/AMPK signalling pathway

(2021) Tian Xing et al.   LIFE SCIENCES

Phosphorylation of major Porphyromonas gingivalis virulence factors is crucial for their processing and secretion

(2021) Zuzanna Nowakowska et al.   Molecular Oral Microbiology

Ferumoxytol Nanoparticles Target Biofilms Causing Tooth Decay in the Human Mouth

(2021) Yuan Liu et al.   NANO LETTERS

Oral Pathobiont-Induced Changes in Gut Microbiota Aggravate the Pathology of Nonalcoholic Fatty Liver Disease in Mice

(2021) Kyoko Yamazaki et al.   Frontiers in Immunology

Pyruvate secretion by oral streptococci modulates hydrogen peroxide dependent antagonism

(2020) Sylvio Redanz et al.   ISME Journal

Spatial Design of Polymicrobial Oral Biofilm in Its Native Disease State

(2020) D. Kim et al.   JOURNAL OF DENTAL RESEARCH

Magnesium-Dependent Promotion of H2O2 Production Increases Ecological Competitiveness of Oral Commensal Streptococci

(2020) X. Cheng et al.   JOURNAL OF DENTAL RESEARCH

Oral‐lung microbiome interactions in lung diseases

(2020) Manoj J. Mammen et al.   PERIODONTOLOGY 2000

Spatial mapping of polymicrobial communities reveals a precise biogeography associated with human dental caries

(2020) Dongyeop Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spatial Ecology of the Human Tongue Dorsum Microbiome

(2020) Steven A. Wilbert et al.   Cell Reports

The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis

(2020) Sho Kitamoto et al.   CELL

Oral Microbiome Geography: Micron-Scale Habitat and Niche

(2020) Jessica L. Mark Welch et al.   Cell Host & Microbe

Acquisition and Adaptation of Ultra-small Parasitic Reduced Genome Bacteria to Mammalian Hosts

(2020) Jeffrey S. McLean et al.   Cell Reports

Current understanding of periodontal disease pathogenesis and targets for host‐modulation therapy

(2020) George Hajishengallis et al.   PERIODONTOLOGY 2000

F. nucleatum targets lncRNA ENO1-IT1 to promote glycolysis and oncogenesis in colorectal cancer

(2020) Jie Hong et al.   GUT

A cross-species interaction with a symbiotic commensal enables cell-density-dependent growth and in vivo virulence of an oral pathogen

(2020) Anilei Hoare et al.   ISME Journal

Highly multiplexed spatial mapping of microbial communities

(2020) Hao Shi et al.   NATURE

Impact of systemic factors in shaping the periodontal microbiome

(2020) Flavia Teles et al.   PERIODONTOLOGY 2000

An Autoimmunogenic and Proinflammatory Profile Defined by the Gut Microbiota of Patients With Untreated Systemic Lupus Erythematosus

(2020) Bei‐di Chen et al.   Arthritis & Rheumatology

Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors

(2019) Stephen S. Dominy et al.   Science Advances

Spatial, Temporal, and Phylogenetic Scales of Microbial Ecology

(2019) Joshua Ladau et al.   TRENDS IN MICROBIOLOGY

Biogeography of the Oral Microbiome: The Site-Specialist Hypothesis

(2019) Jessica L. Mark Welch et al.   Annual Review of Microbiology

Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer

(2019) Shinichi Yachida et al.   NATURE MEDICINE

Horizontal and Vertical Transfer of Oral Microbial Dysbiosis and Periodontal Disease

(2019) M.A. Payne et al.   JOURNAL OF DENTAL RESEARCH

Porphyromonas gingivalis Tyrosine Phosphatase Php1 Promotes Community Development and Pathogenicity

(2019) Young-Jung Jung et al.   mBio

Fusobacterium nucleatum Caused DNA Damage and Promoted Cell Proliferation by the Ku70/p53 Pathway in Oral Cancer Cells

(2019) Fengxue Geng et al.   DNA AND CELL BIOLOGY

Gingival solitary chemosensory cells are immune sentinels for periodontitis

(2019) Xin Zheng et al.   Nature Communications

Periodontal therapeutics: Current host‐modulation agents and future directions

(2019) Lorne M. Golub et al.   PERIODONTOLOGY 2000

Live and let die: Hydrogen peroxide production by the commensal flora and its role in maintaining a symbiotic microbiome

(2018) Sylvio Redanz et al.   Molecular Oral Microbiology

Commensal orthologs of the human autoantigen Ro60 as triggers of autoimmunity in lupus

(2018) Teri M. Greiling et al.   Science Translational Medicine

Oral Biofilms: Pathogens, Matrix, and Polymicrobial Interactions in Microenvironments

(2018) William H. Bowen et al.   TRENDS IN MICROBIOLOGY

Compositional and Temporal Changes in the Gut Microbiome of Pediatric Ulcerative Colitis Patients Are Linked to Disease Course

(2018) Melanie Schirmer et al.   Cell Host & Microbe

The oral microbiota: dynamic communities and host interactions

(2018) Richard J. Lamont et al.   NATURE REVIEWS MICROBIOLOGY

A dysbiotic microbiome triggers TH17 cells to mediate oral mucosal immunopathology in mice and humans

(2018) Nicolas Dutzan et al.   Science Translational Medicine

Oral Administration of Porphyromonas gingivalis Alters the Gut Microbiome and Serum Metabolome

(2018) Tamotsu Kato et al.   mSphere

Targeting microbial biofilms: current and prospective therapeutic strategies

(2017) Hyun Koo et al.   NATURE REVIEWS MICROBIOLOGY

Ecology of the Oral Microbiome: Beyond Bacteria

(2017) Jonathon L. Baker et al.   TRENDS IN MICROBIOLOGY

Metabolic crosstalk regulates Porphyromonas gingivalis colonization and virulence during oral polymicrobial infection

(2017) Masae Kuboniwa et al.   Nature Microbiology

Fine-tuned production of hydrogen peroxide promotes biofilm formation of Streptococcus parasanguinis by a pathogenic cohabitant Aggregatibacter actinomycetemcomitans

(2016) Dingyu Duan et al.   ENVIRONMENTAL MICROBIOLOGY

Spatial structure, cooperation and competition in biofilms

(2016) Carey D. Nadell et al.   NATURE REVIEWS MICROBIOLOGY

Biogeography of a human oral microbiome at the micron scale

(2016) Jessica L. Mark Welch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dancing with the Stars: How Choreographed Bacterial Interactions Dictate Nososymbiocity and Give Rise to Keystone Pathogens, Accessory Pathogens, and Pathobionts

(2016) George Hajishengallis et al.   TRENDS IN MICROBIOLOGY

A Commensal Bacterium Promotes Virulence of an Opportunistic Pathogen via Cross-Respiration

(2016) Apollo Stacy et al.   mBio

Potential Links between Impaired One-Carbon Metabolism Due to Polymorphisms, Inadequate B-Vitamin Status, and the Development of Alzheimer’s Disease

(2016) Barbara Troesch et al.   Nutrients

Functional signatures of oral dysbiosis during periodontitis progression revealed by microbial metatranscriptome analysis

(2015) Susan Yost et al.   Genome Medicine

Porphyromonas gingivalis Manipulates Complement and TLR Signaling to Uncouple Bacterial Clearance from Inflammation and Promote Dysbiosis

(2014) Tomoki Maekawa et al.   Cell Host & Microbe

The Treatment-Naive Microbiome in New-Onset Crohn’s Disease

(2014) Dirk Gevers et al.   Cell Host & Microbe

Bacterial fight-and-flight responses enhance virulence in a polymicrobial infection

(2014) A. Stacy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Low-Abundance Biofilm Species Orchestrates Inflammatory Periodontal Disease through the Commensal Microbiota and Complement

(2011) George Hajishengallis et al.   Cell Host & Microbe

Hydrogen Peroxide-Dependent DNA Release and Transfer of Antibiotic Resistance Genes in Streptococcus gordonii

(2011) A. Itzek et al.   JOURNAL OF BACTERIOLOGY

Metabolite Cross-Feeding Enhances Virulence in a Model Polymicrobial Infection

(2011) Matthew M. Ramsey et al.   PLoS Pathogens

Structural Dissection andIn VivoEffectiveness of a Peptide Inhibitor ofPorphyromonas gingivalisAdherence toStreptococcus gordonii

(2010) Carlo Amorin Daep et al.   INFECTION AND IMMUNITY

Oral Biofilm Architecture on Natural Teeth

(2010) Vincent Zijnge et al.   PLoS One

Polymicrobial interactions stimulate resistance to host innate immunity through metabolite perception

(2009) M. M. Ramsey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA