Engineering Therapeutics to Detoxify Hemoglobin, Heme, and Iron

Apohemoglobin-haptoglobin complex alleviates iron toxicity in mice with β-thalassemia via scavenging of cell-free hemoglobin and heme

(2022) Carlos J. Munoz et al.   BIOMEDICINE & PHARMACOTHERAPY

Human Plasma and Recombinant Hemopexins: Heme Binding Revisited

(2021) Elena Karnaukhova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Purification and analysis of a protein cocktail capable of scavenging cell‐free hemoglobin, heme, and iron

(2021) Ivan S. Pires et al.   TRANSFUSION

Modular Platform for the Development of Recombinant Hemoglobin Scavenger Biotherapeutics

(2021) Raphael M. Buzzi et al.   MOLECULAR PHARMACEUTICS

Apohemoglobin-haptoglobin complex attenuates the pathobiology of circulating acellular hemoglobin and heme

(2020) Carlos J. Munoz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Poly(ethylene glycol) Surface-Conjugated Apohemoglobin as a Synthetic Heme Scavenger

(2020) Ivan S. Pires et al.   BIOMACROMOLECULES

Tangential flow filtration of haptoglobin

(2020) Ivan S. Pires et al.   BIOTECHNOLOGY PROGRESS

Haptoglobin Therapeutics and Compartmentalization of Cell-Free Hemoglobin Toxicity

(2020) Paul W. Buehler et al.   TRENDS IN MOLECULAR MEDICINE

Anti‐inflammatory effects of haptoglobin on LPS ‐stimulated macrophages: Role of HMGB1 signaling and implications in chronic wound healing

(2020) Paulina Krzyszczyk et al.   WOUND REPAIR AND REGENERATION

Apohemoglobin-haptoglobin complexes attenuate the hypertensive response to low-molecular-weight polymerized hemoglobin

(2020) Donald A. Belcher et al.   Blood Advances

Mechanisms of haemolysis-induced kidney injury

(2019) Kristof Van Avondt et al.   Nature Reviews Nephrology

Novel manufacturing method for producing apohemoglobin and its biophysical properties

(2019) Ivan S. Pires et al.   BIOTECHNOLOGY AND BIOENGINEERING

Serum haptoglobin and hemopexin levels are depleted in pediatric sickle cell disease patients

(2018) Rayra Pereira Santiago et al.   BLOOD CELLS MOLECULES AND DISEASES

Phenotype-specific recombinant haptoglobin polymers co-expressed with C1r-like protein as optimized hemoglobin-binding therapeutics

(2018) Christian A. Schaer et al.   BMC BIOTECHNOLOGY

Mechanisms of Hemolysis During Sepsis

(2018) Katharina Effenberger-Neidnicht et al.   INFLAMMATION

Hemopexin increases the neurotoxicity of hemoglobin when haptoglobin is absent

(2018) Jing Chen-Roetling et al.   JOURNAL OF NEUROCHEMISTRY

Iron overload in patients with rare hereditary hemolytic anemia: Evidence-based suggestion on whom and how to screen

(2018) Stephanie van Straaten et al.   AMERICAN JOURNAL OF HEMATOLOGY

When might transferrin, hemopexin or haptoglobin administration be of benefit following the transfusion of red blood cells?

(2018) Paul W. Buehler et al.   CURRENT OPINION IN HEMATOLOGY

Plasma Gelsolin: Indicator of Inflammation and Its Potential as a Diagnostic Tool and Therapeutic Target

(2018) Ewelina Piktel et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction

(2018) John D. Belcher et al.   PLoS One

Identification of LRP-1 as an endocytosis and recycling receptor for β1-integrin in thyroid cancer cells

(2017) Louis Theret et al.   Oncotarget

On the Mechanism of Human Red Blood Cell Longevity: Roles of Calcium, the Sodium Pump, PIEZO1, and Gardos Channels

(2017) Virgilio L. Lew et al.   Frontiers in Physiology

Haptoglobin Preserves Vascular Nitric Oxide Signaling during Hemolysis

(2016) Christian A. Schaer et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Malaria: Biology and Disease

(2016) Alan F. Cowman et al.   CELL

Red cell DAMPs and inflammation

(2016) Rafaela Mendonça et al.   INFLAMMATION RESEARCH

Haptoglobin increases the vulnerability of CD163-expressing neurons to hemoglobin

(2016) Jing Chen-Roetling et al.   JOURNAL OF NEUROCHEMISTRY

Mechanism of Copper Uptake from Blood Plasma Ceruloplasmin by Mammalian Cells

(2016) Danny Ramos et al.   PLoS One

S-nitroso human serum albumin attenuates pulmonary hypertension, improves right ventricular–arterial coupling, and reduces oxidative stress in a chronic right ventricle volume overload model

(2015) Alessio Rungatscher et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

The pathophysiology of extracellular hemoglobin associated with enhanced oxidative reactions

(2015) Joseph M. Rifkind et al.   Frontiers in Physiology

Hemopexin and haptoglobin: allies against heme toxicity from hemoglobin not contenders

(2015) Ann Smith et al.   Frontiers in Physiology

HMGB1 takes a "Toll" in sickle cell disease

(2014) K. Gupta   BLOOD

The Pathophysiology of Transfusional Iron Overload

(2014) John B. Porter et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Like iron in the blood of the people: the requirement for heme trafficking in iron metabolism

(2014) Tamara Korolnek et al.   Frontiers in Pharmacology

Hemolysis during cardiac surgery is associated with increased intravascular nitric oxide consumption and perioperative kidney and intestinal tissue damage

(2014) Iris C. Vermeulen Windsant et al.   Frontiers in Physiology

Human Hp1-1 and Hp2-2 Phenotype-Specific Haptoglobin Therapeutics Are Both Effective In Vitro and in Guinea Pigs to Attenuate Hemoglobin Toxicity

(2013) Miriam Lipiski et al.   ANTIOXIDANTS & REDOX SIGNALING

Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease

(2013) J. D. Belcher et al.   BLOOD

Iron in Infection and Immunity

(2013) James E. Cassat et al.   Cell Host & Microbe

The Extracellular Chaperone Haptoglobin Prevents Serum Fatty Acid-promoted Amyloid Fibril Formation of β2-Microglobulin, Resistance to Lysosomal Degradation, and Cytotoxicity

(2013) Abdullah Sultan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specific antioxidant properties of human serum albumin

(2013) Myriam Taverna et al.   Annals of Intensive Care

Plasma Clearance of Hemoglobin and Haptoglobin in Mice and Effect of CD163 Gene Targeting Disruption

(2012) Anders Etzerodt et al.   ANTIOXIDANTS & REDOX SIGNALING

Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins

(2012) D. J. Schaer et al.   BLOOD

New perspectives on the vitamin D binding protein

(2012) Rene F. Chun   CELL BIOCHEMISTRY AND FUNCTION

The Heme-Heme Oxygenase System in Wound Healing; Implications for Scar Formation

(2012) Frank A.D.T.G. Wagener et al.   CURRENT DRUG TARGETS

Identification of Hemopexin as an Anti-Inflammatory Factor That Inhibits Synergy of Hemoglobin with HMGB1 in Sterile and Infectious Inflammation

(2012) T. Lin et al.   JOURNAL OF IMMUNOLOGY

Haptoglobin: the hemoglobin detoxifier in plasma

(2012) Abdu I. Alayash et al.   TRENDS IN BIOTECHNOLOGY

Kinetics of iron release from transferrin bound to the transferrin receptor at endosomal pH

(2011) Ashley N. Steere et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The intracellular trafficking pathway of transferrin

(2011) Kristine M. Mayle et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Transfusion of human volunteers with older, stored red blood cells produces extravascular hemolysis and circulating non-transferrin-bound iron

(2011) E. A. Hod et al.   BLOOD

Plasma gelsolin: A general prognostic marker of health

(2011) Nagesh Peddada et al.   MEDICAL HYPOTHESES

Hemolytic anemia after kidney transplantation: a prospective analysis

(2011) Ruth Achkar et al.   TRANSFUSION

Hemoglobin and Cooperativity: Experiments and Theories

(2010) Andrea Bellelli   CURRENT PROTEIN & PEPTIDE SCIENCE

Transferrin therapy ameliorates disease in β-thalassemic mice

(2010) Huihui Li et al.   NATURE MEDICINE

Synthetic and natural iron chelators: therapeutic potential and clinical use

(2009) Heather C Hatcher et al.   Future Medicinal Chemistry

Characterization of high molecular weight multimeric states of human haptoglobin and hemoglobin-based oxygen carriers by high-mass MALDI MS

(2009) Tatiana Pimenova et al.   JOURNAL OF SEPARATION SCIENCE

Hemopexin Prevents Endothelial Damage and Liver Congestion in a Mouse Model of Heme Overload

(2008) Francesca Vinchi et al.   AMERICAN JOURNAL OF PATHOLOGY

Nitrite reductase activity of hemoglobin as a systemic nitric oxide generator mechanism to detoxify plasma hemoglobin produced during hemolysis

(2008) Peter C. Minneci et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Human haptoglobin structure and function - a molecular modelling study

(2008) F. Polticelli et al.   FEBS Journal