Phenotype-specific recombinant haptoglobin polymers co-expressed with C1r-like protein as optimized hemoglobin-binding therapeutics

Haptoglobin Preserves Vascular Nitric Oxide Signaling during Hemolysis

(2016) Christian A. Schaer et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Sustained treatment of sickle cell mice with haptoglobin increases HO-1 and H-ferritin expression and decreases iron deposition in the kidney without improvement in kidney function

(2016) Patricia A. Shi et al.   BRITISH JOURNAL OF HAEMATOLOGY

Recurring exon deletions in the HP (haptoglobin) gene contribute to lower blood cholesterol levels

(2016) Linda M Boettger et al.   NATURE GENETICS

Recurrent mutation at the classical haptoglobin structural polymorphism

(2016) Edward J Hollox et al.   NATURE GENETICS

Spin trapping combined with quantitative mass spectrometry defines free radical redistribution within the oxidized hemoglobin:haptoglobin complex

(2015) Florence Vallelian et al.   FREE RADICAL BIOLOGY AND MEDICINE

Different target specificities of haptoglobin and hemopexin define a sequential protection system against vascular hemoglobin toxicity

(2015) Jeremy W. Deuel et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Risk of Coronary Heart Disease Associated With Glycosylated Hemoglobin of 6.5% or Greater Is Pronounced in the Haptoglobin 2-2 Genotype

(2015) Leah E. Cahill et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Redox properties of human hemoglobin in complex with fractionated dimeric and polymeric human haptoglobin

(2014) Todd L. Mollan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Extracellular Hb Enhances Cardiac Toxicity in Endotoxemic Guinea Pigs: Protective Role of Haptoglobin

(2014) Jin Baek et al.   Toxins

Haptoglobin, hemopexin, and related defense pathways—basic science, clinical perspectives, and drug development

(2014) Dominik J. Schaer et al.   Frontiers in Physiology

Haptoglobin Binding Stabilizes Hemoglobin Ferryl Iron and the Globin Radical on Tyrosine β145

(2013) Chris E. Cooper et al.   ANTIOXIDANTS & REDOX SIGNALING

Human Hp1-1 and Hp2-2 Phenotype-Specific Haptoglobin Therapeutics Are Both Effective In Vitro and in Guinea Pigs to Attenuate Hemoglobin Toxicity

(2013) Miriam Lipiski et al.   ANTIOXIDANTS & REDOX SIGNALING

Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease

(2013) J. D. Belcher et al.   BLOOD

Haptoglobin Genotype Is a Consistent Marker of Coronary Heart Disease Risk Among Individuals With Elevated Glycosylated Hemoglobin

(2013) Leah E. Cahill et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins

(2012) D. J. Schaer et al.   BLOOD

Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy

(2012) Jin Hyen Baek et al.   JOURNAL OF CLINICAL INVESTIGATION

Hemolysis and cell-free hemoglobin drive an intrinsic mechanism for human disease

(2012) Mark T. Gladwin et al.   JOURNAL OF CLINICAL INVESTIGATION

Structure of the haptoglobin–haemoglobin complex

(2012) Christian Brix Folsted Andersen et al.   NATURE

Haptoglobin: the hemoglobin detoxifier in plasma

(2012) Abdu I. Alayash et al.   TRENDS IN BIOTECHNOLOGY

Clearance and Control Mechanisms of Hemoglobin from Cradle to Grave

(2009) Dominik J. Schaer et al.   ANTIOXIDANTS & REDOX SIGNALING

Haptoglobin: Basic and Clinical Aspects

(2009) Andrew P. Levy et al.   ANTIOXIDANTS & REDOX SIGNALING