Glymphatic pathway in sporadic cerebral small vessel diseases: From bench to bedside

MRI EVALUATION OF PERIVASCULAR SPACE ABNORMALITIES IN NEUROMYELITIS OPTICA

(2022) Laura Cacciaguerra et al.   ANNALS OF NEUROLOGY

Glymphatic system dysfunction in patients with cluster headache

(2022) Jinseung Kim et al.   Brain and Behavior

Impaired Glymphatic System Actions in Obstructive Sleep Apnea Adults

(2022) Bhaswati Roy et al.   Frontiers in Neuroscience

Neuroimaging evidence of glymphatic system dysfunction in possible REM sleep behavior disorder and Parkinson’s disease

(2022) Xiaoli Si et al.   npj Parkinsons Disease

Glymphatic dysfunction correlates with severity of small vessel disease and cognitive impairment in cerebral amyloid angiopathy

(2022) Jiajie Xu et al.   EUROPEAN JOURNAL OF NEUROLOGY

Characterization of perivascular space pathology in a rat model of cerebral small vessel disease by in vivo magnetic resonance imaging

(2022) Brittany Monte et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The Association Between Glymphatic System Dysfunction and Cognitive Impairment in Cerebral Small Vessel Disease

(2022) Jie Tang et al.   Frontiers in Aging Neuroscience

Cerebrospinal fluid outflow: a review of the historical and contemporary evidence for arachnoid villi, perineural routes, and dural lymphatics

(2021) Steven T. Proulx   CELLULAR AND MOLECULAR LIFE SCIENCES

Brain blood and cerebrospinal fluid flow dynamics during rhythmic handgrip exercise in young healthy men and women

(2021) Takashi Tarumi et al.   JOURNAL OF PHYSIOLOGY-LONDON

Blood-Brain Barrier Opening with MRI-guided Focused Ultrasound Elicits Meningeal Venous Permeability in Humans with Early Alzheimer Disease

(2021) Rashi I. Mehta et al.   RADIOLOGY

Assessment of the DTI‐ALPS Parameter Along the Perivascular Space in Older Adults at Risk of Dementia

(2021) Christopher E. Steward et al.   JOURNAL OF NEUROIMAGING

Arterial Stiffness and Cardiovascular Risk in Hypertension

(2021) Pierre Boutouyrie et al.   CIRCULATION RESEARCH

Deep white matter hyperintensity is associated with the dilation of perivascular space

(2021) Peiyu Huang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Decreased AQP4 Expression Aggravates ɑ-Synuclein Pathology in Parkinson’s Disease Mice, Possibly via Impaired Glymphatic Clearance

(2021) Huili Cui et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Centrum Semiovale Perivascular Space and Amyloid Deposition in Spontaneous Intracerebral Hemorrhage

(2021) Hsin-Hsi Tsai et al.   STROKE

Peritumoral Brain Edema in Meningiomas May Be Related to Glymphatic Dysfunction

(2021) Cheng Hong Toh et al.   Frontiers in Neuroscience

Direct imaging of glymphatic transport using H217O MRI

(2021) Mohammed S. Alshuhri et al.   JCI Insight

Attenuating vascular stenosis-induced astrogliosis preserves white matter integrity and cognitive function

(2021) Qian Liu et al.   Journal of Neuroinflammation

Glymphatic system dysfunction in patients with juvenile myoclonic epilepsy

(2021) Ho-Joon Lee et al.   JOURNAL OF NEUROLOGY

Glymphatic clearance function in patients with cerebral small vessel disease

(2021) Wenhua Zhang et al.   NEUROIMAGE

Diffusion along perivascular spaces reveals evidence supportive of glymphatic function impairment in Parkinson disease

(2021) Colin D. McKnight et al.   PARKINSONISM & RELATED DISORDERS

Repetitive transcranial magnetic stimulation increases the brain’s drainage efficiency in a mouse model of Alzheimer’s disease

(2021) Yangyang Lin et al.   Acta Neuropathologica Communications

Factors Associated With Dysfunction of Glymphatic System in Patients With Glioma

(2021) Cheng Hong Toh et al.   Frontiers in Oncology

Glymphatic dysfunction in isolated REM sleep behavior disorder

(2021) Dong Ah Lee et al.   ACTA NEUROLOGICA SCANDINAVICA

Glymphatic system impairment in multiple sclerosis: relation with brain damage and disability

(2021) Antonio Carotenuto et al.   BRAIN

Association of Sleep, Neuropsychological Performance, and Gray Matter Volume With Glymphatic Function in Community-Dwelling Older Adults

(2021) Tiing Yee Siow et al.   NEUROLOGY

Current Concepts in Intracranial Interstitial Fluid Transport and the Glymphatic System: Part II—Imaging Techniques and Clinical Applications

(2021) Jesse M. Klostranec et al.   RADIOLOGY

Glymphatic system dysfunction in obstructive sleep apnea evidenced by DTI-ALPS

(2021) Ho-Joon Lee et al.   SLEEP MEDICINE

Digoxin Ameliorates Glymphatic Transport and Cognitive Impairment in a Mouse Model of Chronic Cerebral Hypoperfusion

(2021) Jie Cao et al.   Neuroscience Bulletin

Glymphatic Dysfunction in Patients With Ischemic Stroke

(2021) Cheng Hong Toh et al.   Frontiers in Aging Neuroscience

Peritumoral Brain Edema in Metastases May Be Related to Glymphatic Dysfunction

(2021) Cheng Hong Toh et al.   Frontiers in Oncology

Impairment of the Glymphatic Pathway and Putative Meningeal Lymphatic Vessels in the Aging Human

(2020) Ying Zhou et al.   ANNALS OF NEUROLOGY

Cerebrospinal fluid influx drives acute ischemic tissue swelling

(2020) Humberto Mestre et al.   SCIENCE

Glymphatic System Impairment in Alzheimer’s Disease and Idiopathic Normal Pressure Hydrocephalus

(2020) Benjamin C. Reeves et al.   TRENDS IN MOLECULAR MEDICINE

Cerebrospinal fluid tracer efflux to parasagittal dura in humans

(2020) Geir Ringstad et al.   Nature Communications

Increased Presence of Cerebral Microbleeds Correlates With Ventricular Enlargement and Increased White Matter Hyperintensities in Alzheimer’s Disease

(2020) Takeshi Kuroda et al.   Frontiers in Aging Neuroscience

Intracranial hemodynamic relationships in patients with cerebral small vessel disease

(2020) Gordon W. Blair et al.   NEUROLOGY

Glymphatic System Visualized by Chemical-Exchange-Saturation-Transfer Magnetic Resonance Imaging

(2020) Yuanfeng Chen et al.   ACS Chemical Neuroscience

Impaired glymphatic function and clearance of tau in an Alzheimer’s disease model

(2020) Ian F Harrison et al.   BRAIN

Polyunsaturated fatty acid supplement alleviates depression-incident cognitive dysfunction by protecting the cerebrovascular and glymphatic systems

(2020) Xinghua Liu et al.   BRAIN BEHAVIOR AND IMMUNITY

Concomitant enlargement of perivascular spaces and decrease in glymphatic transport in an animal model of cerebral small vessel disease

(2020) Yang Xue et al.   BRAIN RESEARCH BULLETIN

Evaluation of Glymphatic System Using Diffusion MR Technique in T2DM Cases

(2020) Guangwei Yang et al.   Frontiers in Human Neuroscience

D-Glucose uptake and clearance in the tauopathy Alzheimer’s disease mouse brain detected by on-resonance variable delay multiple pulse MRI

(2020) Lin Chen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Association of cerebrovascular reactivity and Alzheimer pathologic markers with cognitive performance

(2020) Sandeepa Sur et al.   NEUROLOGY

Omega-3 Polyunsaturated Fatty Acids Alleviate Traumatic Brain Injury by Regulating the Glymphatic Pathway in Mice

(2020) Erwei Zhang et al.   Frontiers in Neurology

Noninvasive Characterization of Human Glymphatics and Meningeal Lymphatics in an in vivo Model of Blood–Brain Barrier Leakage

(2020) Chia‐Hung Wu et al.   ANNALS OF NEUROLOGY

Circadian control of brain glymphatic and lymphatic fluid flow

(2020) Lauren M. Hablitz et al.   Nature Communications

A Review of Translational Magnetic Resonance Imaging in Human and Rodent Experimental Models of Small Vessel Disease

(2020) Michael S. Stringer et al.   Translational Stroke Research

Mutant huntingtin is cleared from the brain via active mechanisms in Huntington disease

(2020) Nicholas S. Caron et al.   JOURNAL OF NEUROSCIENCE

Altered glymphatic system in idiopathic normal pressure hydrocephalus

(2020) Yun Jung Bae et al.   PARKINSONISM & RELATED DISORDERS

Immunotherapy with ponezumab for probable cerebral amyloid angiopathy

(2019) Claire Leurent et al.   Annals of Clinical and Translational Neurology

The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans

(2019) Jerrah K. Holth et al.   SCIENCE

Blood-brain barrier impairment and hypoperfusion are linked in cerebral small vessel disease

(2019) Sau May Wong et al.   NEUROLOGY

Dural lymphatics regulate clearance of extracellular tau from the CNS

(2019) Tirth K. Patel et al.   Molecular Neurodegeneration

Microbleeds colocalize with enlarged juxtacortical perivascular spaces in amnestic mild cognitive impairment and early Alzheimer’s disease: A 7 Tesla MRI study

(2019) Willem H Bouvy et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Aquaporin 4 deletion exacerbates brain impairments in a mouse model of chronic sleep disruption

(2019) Rui Zhang et al.   CNS Neuroscience & Therapeutics

Enlarged perivascular spaces and florbetapir uptake in patients with intracerebral hemorrhage

(2019) Nicolas Raposo et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Alcohol promotes waste clearance in the CNS via brain vascular reactivity

(2019) Yiming Cheng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Impaired Glymphatic Transport in Spontaneously Hypertensive Rats

(2019) Kristian Nygaard Mortensen et al.   JOURNAL OF NEUROSCIENCE

Inflammation and cerebral small vessel disease: A systematic review

(2019) Audrey Low et al.   AGEING RESEARCH REVIEWS

Glymphatics visualization after focused ultrasound induced blood‐brain barrier opening in humans

(2019) Ying Meng et al.   ANNALS OF NEUROLOGY

Delayed clearance of cerebrospinal fluid tracer from choroid plexus in idiopathic normal pressure hydrocephalus

(2019) Per Kristian Eide et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Spectral Diffusion Analysis of Intravoxel Incoherent Motion MRI in Cerebral Small Vessel Disease

(2019) Sau May Wong et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep

(2019) Nina E. Fultz et al.   SCIENCE

Association of obstructive sleep apnea and cerebral small vessel disease: a systematic review and meta-analysis

(2019) Yuhong Huang et al.   SLEEP

Possible Empirical Evidence of Glymphatic System on Computed Tomography After Endovascular Perforations

(2019) Eytan Raz et al.   World Neurosurgery

Cerebral Small Vessel Disease (CSVD) – Lessons From the Animal Models

(2019) Muzaimi Mustapha et al.   Frontiers in Physiology

Cerebral amyloid angiopathy and Alzheimer disease — one peptide, two pathways

(2019) Steven M. Greenberg et al.   Nature Reviews Neurology

Vasomotion as a Driving Force for Paravascular Clearance in the Awake Mouse Brain

(2019) Susanne J. van Veluw et al.   NEURON

Impact of obstructive sleep apnea on silent cerebral small vessel disease: a systematic review and meta-analysis

(2019) Anthipa Chokesuwattanaskul et al.   SLEEP MEDICINE

Free water determines diffusion alterations and clinical status in cerebral small vessel disease

(2018) Marco Duering et al.   Alzheimers & Dementia

Cerebrospinal fluid flow increases from newborn to adult stages

(2018) Camille Di Palma et al.   Developmental Neurobiology

Delayed clearance of cerebrospinal fluid tracer from entorhinal cortex in idiopathic normal pressure hydrocephalus: A glymphatic magnetic resonance imaging study

(2018) Per K Eide et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Pericyte degeneration causes white matter dysfunction in the mouse central nervous system

(2018) Axel Montagne et al.   NATURE MEDICINE

Cerebral small vessel disease: from a focal to a global perspective

(2018) Annemieke ter Telgte et al.   Nature Reviews Neurology

Impact of time-of-day on diffusivity measures of brain tissue derived from diffusion tensor imaging

(2018) Cibu Thomas et al.   NEUROIMAGE

Baseline NAWM structural integrity and CBF predict periventricular WMH expansion over time

(2018) Nutta-on Promjunyakul et al.   NEUROLOGY

Cerebral small vessel disease and risk of incident stroke, dementia and depression, and all-cause mortality: A systematic review and meta-analysis

(2018) Sytze P. Rensma et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Voluntary running enhances glymphatic influx in awake behaving, young mice

(2018) Stephanie von Holstein-Rathlou et al.   NEUROSCIENCE LETTERS

Arterial Stiffness Is Associated With Basal Ganglia Enlarged Perivascular Spaces and Cerebral Small Vessel Disease Load

(2018) Iolanda Riba-Llena et al.   STROKE

Blood–brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound

(2018) Nir Lipsman et al.   Nature Communications

Beneficial effects of low alcohol exposure, but adverse effects of high alcohol intake on glymphatic function

(2018) Iben Lundgaard et al.   Scientific Reports

General Anesthesia Inhibits the Activity of the “Glymphatic System”

(2018) Clement Gakuba et al.   Theranostics

Impaired brain glymphatic flow in experimental hepatic encephalopathy

(2018) Anna Hadjihambi et al.   JOURNAL OF HEPATOLOGY

Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease

(2018) Sandro Da Mesquita et al.   NATURE

Non-invasive imaging of CSF-mediated brain clearance pathways via assessment of perivascular fluid movement with diffusion tensor MRI

(2018) Ian F Harrison et al.   eLife

Loss of perivascular aquaporin-4 in idiopathic normal pressure hydrocephalus

(2018) Md Mahdi Hasan-Olive et al.   GLIA

Glymphatic Pathway of Gadolinium-Based Contrast Agents Through the Brain

(2018) Katerina Deike-Hofmann et al.   INVESTIGATIVE RADIOLOGY

Quantitative and qualitative assessment of glymphatic flux using Evans blue albumin

(2018) Michael S. Wolf et al.   JOURNAL OF NEUROSCIENCE METHODS

The glymphatic pathway in neurological disorders

(2018) Martin Kaag Rasmussen et al.   LANCET NEUROLOGY

Gadolinium presence, MRI hyperintensities, and glucose uptake in the hypoperfused rat brain after repeated administrations of gadodiamide

(2018) Francesca Arena et al.   NEURORADIOLOGY

Modeling glymphatic system of the brain using MRI

(2018) Esmaeil Davoodi-Bojd et al.   NEUROIMAGE

Non-invasive MRI of brain clearance pathways using multiple echo time arterial spin labelling: an aquaporin-4 study

(2018) Yolanda Ohene et al.   NEUROIMAGE

Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer’s disease cases

(2017) Toshiaki Taoka et al.   JAPANESE JOURNAL OF RADIOLOGY

Focal Solute Trapping and Global Glymphatic Pathway Impairment in a Murine Model of Multiple Microinfarcts

(2017) Minghuan Wang et al.   JOURNAL OF NEUROSCIENCE

Cortical Spreading Depression Closes Paravascular Space and Impairs Glymphatic Flow: Implications for Migraine Headache

(2017) Aaron J. Schain et al.   JOURNAL OF NEUROSCIENCE

Cerebrovascular function in presymptomatic and symptomatic individuals with hereditary cerebral amyloid angiopathy: a case-control study

(2017) Anna M van Opstal et al.   LANCET NEUROLOGY

White matter hyperintensity reduction and outcomes after minor stroke

(2017) Joanna M. Wardlaw et al.   NEUROLOGY

MRI-visible perivascular spaces in cerebral amyloid angiopathy and hypertensive arteriopathy

(2017) Andreas Charidimou et al.   NEUROLOGY

Continuous theta burst stimulation facilitates the clearance efficiency of the glymphatic pathway in a mouse model of sleep deprivation

(2017) Dong-xu Liu et al.   NEUROSCIENCE LETTERS

Subarachnoid Hemorrhage Severely Impairs Brain Parenchymal Cerebrospinal Fluid Circulation in Nonhuman Primate

(2017) Romain Goulay et al.   STROKE

Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer’s disease cases

(2017) Toshiaki Taoka et al.   Japanese Journal of Radiology

Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice

(2017) Qiaoli Ma et al.   Nature Communications

Association of Perivascular Localization of Aquaporin-4 With Cognition and Alzheimer Disease in Aging Brains

(2017) Douglas M. Zeppenfeld et al.   JAMA Neurology

Voluntary Exercise Promotes Glymphatic Clearance of Amyloid Beta and Reduces the Activation of Astrocytes and Microglia in Aged Mice

(2017) Xiao-fei He et al.   Frontiers in Molecular Neuroscience

Deposition of amyloid β in the walls of human leptomeningeal arteries in relation to perivascular drainage pathways in cerebral amyloid angiopathy

(2016) Abby Keable et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Impairment of the glymphatic system after diabetes

(2016) Quan Jiang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Gray and white matter changes linking cerebral small vessel disease to gait disturbances

(2016) Yeo Jin Kim et al.   NEUROLOGY

Blood–brain barrier leakage is more widespread in patients with cerebral small vessel disease

(2016) C. Eleana Zhang et al.   NEUROLOGY

Mechanism of depression as a risk factor in the development of Alzheimer’s disease: the function of AQP4 and the glymphatic system

(2016) Maosheng Xia et al.   PSYCHOPHARMACOLOGY

Digoxin: The good and the bad

(2016) Oliver J. Ziff et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Cerebral small vessel disease is related to disturbed 24-h activity rhythms: a population-based study

(2015) L. A. Zuurbier et al.   EUROPEAN JOURNAL OF NEUROLOGY

Ultra-fast magnetic resonance encephalography of physiological brain activity – Glymphatic pulsation mechanisms?

(2015) Vesa Kiviniemi et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Circulating biologic markers of endothelial dysfunction in cerebral small vessel disease: A review

(2015) Anna Poggesi et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

(2015) Aleksanteri Aspelund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Effect of Body Posture on Brain Glymphatic Transport

(2015) H. Lee et al.   JOURNAL OF NEUROSCIENCE

Inspiration Is the Major Regulator of Human CSF Flow

(2015) S. Dreha-Kulaczewski et al.   JOURNAL OF NEUROSCIENCE

Deletion of aquaporin-4 in APP/PS1 mice exacerbates brain Aβ accumulation and memory deficits

(2015) Zhiqiang Xu et al.   Molecular Neurodegeneration

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

Vascular risk factors, cerebrovascular reactivity, and the default-mode brain network

(2015) Thaddeus J. Haight et al.   NEUROIMAGE

Impairment of paravascular clearance pathways in the aging brain

(2014) Benjamin T. Kress et al.   ANNALS OF NEUROLOGY

Failure of Perivascular Drainage of β-amyloid in Cerebral Amyloid Angiopathy

(2014) Cheryl A. Hawkes et al.   BRAIN PATHOLOGY

Sleep deprivation impairs memory, tau metabolism, and synaptic integrity of a mouse model of Alzheimer's disease with plaques and tangles

(2014) Antonio Di Meco et al.   NEUROBIOLOGY OF AGING

Impaired Glymphatic Perfusion After Strokes Revealed by Contrast-Enhanced MRI

(2014) Thomas Gaberel et al.   STROKE

Spontaneous white matter damage, cognitive decline and neuroinflammation in middle-aged hypertensive rats: an animal model of early-stage cerebral small vessel disease

(2014) Daniel Kaiser et al.   Acta Neuropathologica Communications

Enlarged Perivascular Spaces and Cerebral Small Vessel Disease

(2013) Gillian M. Potter et al.   International Journal of Stroke

Brain-wide pathway for waste clearance captured by contrast-enhanced MRI

(2013) Jeffrey J. Iliff et al.   JOURNAL OF CLINICAL INVESTIGATION

Cerebral Arterial Pulsation Drives Paravascular CSF-Interstitial Fluid Exchange in the Murine Brain

(2013) J. J. Iliff et al.   JOURNAL OF NEUROSCIENCE

Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging

(2013) Joanna M Wardlaw et al.   LANCET NEUROLOGY

Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration

(2013) Joanna M Wardlaw et al.   LANCET NEUROLOGY

Sleep Drives Metabolite Clearance from the Adult Brain

(2013) L. Xie et al.   SCIENCE

Functional magnetic resonance imaging detection of vascular reactivity in cerebral amyloid angiopathy

(2012) Andrew Dumas et al.   ANNALS OF NEUROLOGY

Cognitive Deficits and Delayed Neuronal Loss in a Mouse Model of Multiple Microinfarcts

(2012) M. Wang et al.   JOURNAL OF NEUROSCIENCE

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

(2011) Berislav V. Zlokovic   NATURE REVIEWS NEUROSCIENCE

Cerebral small vessel endothelial structural changes predate hypertension in stroke-prone spontaneously hypertensive rats: a blinded, controlled immunohistochemical study of 5- to 21-week-old rats

(2011) E. L. Bailey et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges

(2010) Leonardo Pantoni   LANCET NEUROLOGY

Enlarged Perivascular Spaces on MRI Are a Feature of Cerebral Small Vessel Disease

(2010) Fergus N. Doubal et al.   STROKE

Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window

(2009) Anthony Holtmaat et al.   Nature Protocols

Do in vivo Experimental Models Reflect Human Cerebral Small Vessel Disease? a Systematic Review

(2008) Atticus H Hainsworth et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM