Voluntary Exercise Promotes Glymphatic Clearance of Amyloid Beta and Reduces the Activation of Astrocytes and Microglia in Aged Mice

Omega-3 polyunsaturated fatty acids promote amyloid-β clearance from the brain through mediating the function of the glymphatic system

(2017) Huixia Ren et al.   FASEB JOURNAL

Contribution of neuroinflammation and immunity to brain aging and the mitigating effects of physical and cognitive interventions

(2017) Svetlana Di Benedetto et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Neuroprotective Effect of TREM-2 in Aging and Alzheimer’s Disease Model

(2016) Animesh Alexander Raha et al.   JOURNAL OF ALZHEIMERS DISEASE

A Comparative Study Evaluating the Impact of Physical Exercise on Disease Progression in a Mouse Model of Alzheimer’s Disease

(2016) Ewelina Maliszewska-Cyna et al.   JOURNAL OF ALZHEIMERS DISEASE

Age-associated physiological and pathological changes at the blood–brain barrier: A review

(2016) Franciska Erdő et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Deferoxamine inhibits microglial activation, attenuates blood-brain barrier disruption, rescues dendritic damage, and improves spatial memory in a mouse model of microhemorrhages

(2016) Xiao-fei He et al.   JOURNAL OF NEUROCHEMISTRY

Chronic administration of resveratrol prevents morphological changes in prefrontal cortex and hippocampus of aged rats

(2016) Elizabeth Monserrat Hernández-Hernández et al.   SYNAPSE

Exercise-Related Changes of Networks in Aging and Mild Cognitive Impairment Brain

(2016) Pei Huang et al.   Frontiers in Aging Neuroscience

Physical training improves non-spatial memory, locomotor skills and the blood brain barrier in diabetic rats

(2015) Priscylla Nunes de Senna et al.   BRAIN RESEARCH

Exercise suppresses COX-2 pro-inflammatory pathway in vestibular migraine

(2015) Yi-Yen Lee et al.   BRAIN RESEARCH BULLETIN

Establishment and Dysfunction of the Blood-Brain Barrier

(2015) Zhen Zhao et al.   CELL

Voluntary exercise attenuates LPS-induced reductions in neurogenesis and increases microglia expression of a proneurogenic phenotype in aged mice

(2015) Alyssa M. Littlefield et al.   Journal of Neuroinflammation

Immune attack: the role of inflammation in Alzheimer disease

(2015) Frank L. Heppner et al.   NATURE REVIEWS NEUROSCIENCE

Neuroinflammation in the normal aging hippocampus

(2015) R.M. Barrientos et al.   NEUROSCIENCE

Impairment of paravascular clearance pathways in the aging brain

(2014) Benjamin T. Kress et al.   ANNALS OF NEUROLOGY

Analysis of focused ultrasound-induced blood–brain barrier permeability in a mouse model of Alzheimer's disease using two-photon microscopy

(2014) Alison Burgess et al.   JOURNAL OF CONTROLLED RELEASE

Serial propagation of distinct strains of A  prions from Alzheimer's disease patients

(2014) J. C. Watts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hippocampal Neurogenesis Regulates Forgetting During Adulthood and Infancy

(2014) K. G. Akers et al.   SCIENCE

Emerging Concepts about NAIP/NLRC4 Inflammasomes

(2014) Silvia Lucena Lage et al.   Frontiers in Immunology

Interstitial fluid drainage is impaired in ischemic stroke and Alzheimer’s disease mouse models

(2013) Michal Arbel-Ornath et al.   ACTA NEUROPATHOLOGICA

Drug delivery to the brain by focused ultrasound induced blood–brain barrier disruption: Quantitative evaluation of enhanced permeability of cerebral vasculature using two-photon microscopy

(2013) Tam Nhan et al.   JOURNAL OF CONTROLLED RELEASE

Exercise reduces activation of microglia isolated from hippocampus and brain of aged mice

(2013) Rachel A Kohman et al.   Journal of Neuroinflammation

Neuron loss in the 5XFAD mouse model of Alzheimer’s disease correlates with intraneuronal Aβ42 accumulation and Caspase-3 activation

(2013) William A Eimer et al.   Molecular Neurodegeneration

Molecular Mechanisms of Environmental Enrichment: Impairments in Akt/GSK3β, Neurotrophin-3 and CREB Signaling

(2013) Yuan-Shih Hu et al.   PLoS One

Sleep Drives Metabolite Clearance from the Adult Brain

(2013) L. Xie et al.   SCIENCE

Environmental enrichment prevents astroglial pathological changes in the hippocampus of APP transgenic mice, model of Alzheimer's disease

(2012) Juan Beauquis et al.   EXPERIMENTAL NEUROLOGY

Cognitive Deficits and Delayed Neuronal Loss in a Mouse Model of Multiple Microinfarcts

(2012) M. Wang et al.   JOURNAL OF NEUROSCIENCE

Choice-specific sequences in parietal cortex during a virtual-navigation decision task

(2012) Christopher D. Harvey et al.   NATURE

Serial two-photon tomography for automated ex vivo mouse brain imaging

(2012) Timothy Ragan et al.   NATURE METHODS

Dispersible amyloid β-protein oligomers, protofibrils, and fibrils represent diffusible but not soluble aggregates: their role in neurodegeneration in amyloid precursor protein (APP) transgenic mice

(2012) Ajeet Rijal Upadhaya et al.   NEUROBIOLOGY OF AGING

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Microglia: actively surveying and shaping neuronal circuit structure and function

(2012) Hiroaki Wake et al.   TRENDS IN NEUROSCIENCES

Overlapping profiles of Abeta peptides in the Alzheimer's disease and pathological aging brains

(2012) Brenda D Moore et al.   Alzheimers Research & Therapy

Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotype

(2011) Antero Salminen et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Amyloid-β protein modulates the perivascular clearance of neuronal apolipoprotein E in mouse models of Alzheimer’s disease

(2011) Harshvardhan Rolyan et al.   JOURNAL OF NEURAL TRANSMISSION

Potent amyloidogenicity and pathogenicity of Aβ43

(2011) Takashi Saito et al.   NATURE NEUROSCIENCE

Neuroinflammation and Cognitive Aging

(2010) Raymond L. Ownby   Current Psychiatry Reports

Microglial Interactions with Synapses Are Modulated by Visual Experience

(2010) Marie-Ève Tremblay et al.   PLOS BIOLOGY

Physical Activity, Diet, and Risk of Alzheimer Disease

(2009) Nikolaos Scarmeas   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Resting Microglia Directly Monitor the Functional State of Synapses In Vivo and Determine the Fate of Ischemic Terminals

(2009) H. Wake et al.   JOURNAL OF NEUROSCIENCE

Immune Activation in Brain Aging and Neurodegeneration: Too Much or Too Little?

(2009) Kurt M. Lucin et al.   NEURON

Effect of Physical Activity on Cognitive Function in Older Adults at Risk for Alzheimer Disease

(2008) Nicola T. Lautenschlager et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain

(2008) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

Oligomeric and fibrillar species of β-amyloid (Aβ42) both impair mitochondrial function in P301L tau transgenic mice

(2008) Anne Eckert et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid

(2008) Kathryn E Nichol et al.   Journal of Neuroinflammation

Protective effects of NSAIDs on the development of Alzheimer disease

(2008) Steven C. Vlad et al.   NEUROLOGY

Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology

(2008) R. O. Carare et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

In Vivo 2-Photon Calcium Imaging in Layer 2/3 of Mice

(2008) Peyman Golshani et al.   Jove-Journal of Visualized Experiments