Human early syncytiotrophoblasts are highly susceptible to SARS-CoV-2 infection

Acute Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Pregnancy Is Associated with Placental Angiotensin-Converting Enzyme 2 Shedding

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Placental Tissue Destruction and Insufficiency from COVID-19 Causes Stillbirth and Neonatal Death from Hypoxic-Ischemic Injury: A Study of 68 Cases with SARS-CoV-2 Placentitis from 12 Countries

(2022) David A. Schwartz et al.   ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE

Attenuated replication and pathogenicity of SARS-CoV-2 B.1.1.529 Omicron

(2022) Huiping Shuai et al.   NATURE

SARS-CoV-2 Omicron variant replication in human bronchus and lung ex vivo

(2022) Kenrie P. Y. Hui et al.   NATURE

Amniogenesis occurs in two independent waves in primates

(2022) Maria Rostovskaya et al.   Cell Stem Cell

Stem-cell-derived trophoblast organoids model human placental development and susceptibility to emerging pathogens

(2022) Rowan M. Karvas et al.   Cell Stem Cell

Defining the risk of SARS-CoV-2 variants on immune protection

(2022) Marciela M. DeGrace et al.   NATURE

Human organoid models to study SARS-CoV-2 infection

(2022) Yuling Han et al.   NATURE METHODS

SARS-CoV-2 positivity in offspring and timing of mother-to-child transmission: living systematic review and meta-analysis

(2022) John Allotey et al.   BMJ-British Medical Journal

AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells

(2021) Shuai Wang et al.   CELL RESEARCH

MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells

(2021) Xin Yin et al.   Cell Reports

SARS-CoV-2 variants with mutations at the S1/S2 cleavage site are generated in vitro during propagation in TMPRSS2-deficient cells

(2021) Michihito Sasaki et al.   PLoS Pathogens

Human naive epiblast cells possess unrestricted lineage potential

(2021) Ge Guo et al.   Cell Stem Cell

Capturing human trophoblast development with naive pluripotent stem cells in vitro

(2021) Shingo Io et al.   Cell Stem Cell

Fetal and placental infection with SARS‐CoV‐2 in early pregnancy

(2021) María Y. Valdespino‐Vázquez et al.   JOURNAL OF MEDICAL VIROLOGY

Clofazimine broadly inhibits coronaviruses including SARS-CoV-2

(2021) Shuofeng Yuan et al.   NATURE

A standardized definition of placental infection by SARS-CoV-2, a consensus statement from the National Institutes of Health/Eunice Kennedy Shriver National Institute of Child Health and Human Development SARS-CoV-2 Placental Infection Workshop

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Clinical and in Vitro Evidence against Placenta Infection at Term by Severe Acute Respiratory Syndrome Coronavirus 2

(2021) Arthur Colson et al.   AMERICAN JOURNAL OF PATHOLOGY

TMPRSS2 expression dictates the entry route used by SARS‐CoV‐2 to infect host cells

(2021) Jana Koch et al.   EMBO JOURNAL

Postinfection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection

(2021) Chamandi S. Dampalla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses

(2021) Joep Beumer et al.   Nature Communications

BMP-treated human embryonic stem cells transcriptionally resemble amnion cells in the monkey embryo

(2021) Sapna Chhabra et al.   Biology Open

Efficient derivation of human trophoblast stem cells from primed pluripotent stem cells

(2021) Yanxing Wei et al.   Science Advances

Characterization of primary models of human trophoblast

(2021) Megan A. Sheridan et al.   DEVELOPMENT

Single-cell transcriptomic characterization of a gastrulating human embryo

(2021) Richard C. V. Tyser et al.   NATURE

A prenylated dsRNA sensor protects against severe COVID-19

(2021) Arthur Wickenhagen et al.   SCIENCE

SARS-CoV-2 Omicron variant shows less efficient replication and fusion activity when compared with Delta variant in TMPRSS2-expressed cells

(2021) Hanjun Zhao et al.   Emerging Microbes & Infections

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

(2020) Manli Wang et al.   CELL RESEARCH

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Derivation of trophoblast stem cells from naïve human pluripotent stem cells

(2020) Chen Dong et al.   eLife

Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses

(2020) Michael Letko et al.   Nature Microbiology

Visualization of SARS-CoV-2 virus invading the human placenta using electron microscopy

(2020) Gabriela N. Algarroba et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses

(2020) Furong Qi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Second-Trimester Miscarriage in a Pregnant Woman With SARS-CoV-2 Infection

(2020) David Baud et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

SARS-CoV-2 infects human neural progenitor cells and brain organoids

(2020) Bao-Zhong Zhang et al.   CELL RESEARCH

Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease

(2020) Chunlong Ma et al.   CELL RESEARCH

Type I and Type III IFN Restrict SARS-CoV-2 Infection of Human Airway Epithelial Cultures

(2020) Abigail Vanderheiden et al.   JOURNAL OF VIROLOGY

Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing

(2020) Laura Riva et al.   NATURE

Transplacental transmission of SARS-CoV-2 infection

(2020) Alexandre J. Vivanti et al.   Nature Communications

Critical Role of Type III Interferon in Controlling SARS-CoV-2 Infection in Human Intestinal Epithelial Cells

(2020) Megan L. Stanifer et al.   Cell Reports

Does the human placenta express the canonical cell entry mediators for SARS-CoV-2?

(2020) Roger Pique-Regi et al.   eLife

Naive Human Embryonic Stem Cells Can Give Rise to Cells with a Trophoblast-like Transcriptome and Methylome

(2020) Jessica K. Cinkornpumin et al.   Stem Cell Reports

SARS–CoV-2 infection of the placenta

(2020) Hillary Hosier et al.   JOURNAL OF CLINICAL INVESTIGATION

Protective role of ACE2 and its downregulation in SARS-CoV-2 infection leading to Macrophage Activation Syndrome: Therapeutic implications

(2020) Nehla Banu et al.   LIFE SCIENCES

Establishment and differentiation of long-term trophoblast organoid cultures from the human placenta

(2020) Megan A. Sheridan et al.   Nature Protocols

Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease

(2020) Lifeng Fu et al.   Nature Communications

Metallodrug ranitidine bismuth citrate suppresses SARS-CoV-2 replication and relieves virus-associated pneumonia in Syrian hamsters

(2020) Shuofeng Yuan et al.   Nature Microbiology

Viruses harness YxxØ motif to interact with host AP2M1 for replication: A vulnerable broad-spectrum antiviral target

(2020) Shuofeng Yuan et al.   Science Advances

SARS-CoV-2 Entry Factors: ACE2 and TMPRSS2 Are Expressed in Peri-Implantation Embryos and the Maternal–Fetal Interface

(2020) Wei Chen et al.   Engineering

Single-Cell RNA-seq Identifies Cell Subsets in Human Placenta That Highly Expresses Factors Driving Pathogenesis of SARS-CoV-2

(2020) Nancy Ashary et al.   Frontiers in Cell and Developmental Biology

FDA Approval of Remdesivir — A Step in the Right Direction

(2020) Daniel Rubin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Expanded Potential Stem Cell Media as a tool to study human developmental hematopoiesis in vitro

(2019) Adam C. Wilkinson et al.   EXPERIMENTAL HEMATOLOGY

Establishment of porcine and human expanded potential stem cells

(2019) Xuefei Gao et al.   NATURE CELL BIOLOGY

Reconstituting the transcriptome and DNA methylome landscapes of human implantation

(2019) Fan Zhou et al.   NATURE

Controlled modelling of human epiblast and amnion development using stem cells

(2019) Yi Zheng et al.   NATURE

A developmental landscape of 3D-cultured human pre-gastrulation embryos

(2019) Lifeng Xiang et al.   NATURE

Derivation of Human Trophoblast Stem Cells

(2018) Hiroaki Okae et al.   Cell Stem Cell

African and Asian strains of Zika virus differ in their ability to infect and lyse primitive human placental trophoblast

(2018) Megan A. Sheridan et al.   PLoS One

Single-cell RNA-seq reveals the diversity of trophoblast subtypes and patterns of differentiation in the human placenta 

(2018) Yawei Liu et al.   CELL RESEARCH

Self-Renewing Trophoblast Organoids Recapitulate the Developmental Program of the Early Human Placenta

(2018) Sandra Haider et al.   Stem Cell Reports

Congenital Viral Infection: Traversing the Uterine-Placental Interface

(2018) Lenore Pereira   Annual Review of Virology

Trophoblast organoids as a model for maternal–fetal interactions during human placentation

(2018) Margherita Y. Turco et al.   NATURE

Establishment of mouse expanded potential stem cells

(2017) Jian Yang et al.   NATURE

Vulnerability of primitive human placental trophoblast to Zika virus

(2017) Megan A. Sheridan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Outcomes of Congenital Zika Disease Depend on Timing of Infection and Maternal-Fetal Interferon Action

(2017) Jinling Chen et al.   Cell Reports

Type III Interferons Produced by Human Placental Trophoblasts Confer Protection against Zika Virus Infection

(2016) Avraham Bayer et al.   Cell Host & Microbe

Stem cell insights into human trophoblast lineage differentiation

(2016) Teena KJB Gamage et al.   HUMAN REPRODUCTION UPDATE

Diffusion pseudotime robustly reconstructs lineage branching

(2016) Laleh Haghverdi et al.   NATURE METHODS

Human pluripotent stem cells as a model of trophoblast differentiation in both normal development and disease

(2016) Mariko Horii et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

What Is Trophoblast? A Combination of Criteria Define Human First-Trimester Trophoblast

(2016) Cheryl Q.E. Lee et al.   Stem Cell Reports

The placenta: a multifaceted, transient organ

(2015) G. J. Burton et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The Genome Landscape of the African Green Monkey Kidney-Derived Vero Cell Line

(2014) Naoki Osada et al.   DNA RESEARCH

MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-  treatment

(2013) A. H. de Wilde et al.   JOURNAL OF GENERAL VIROLOGY

Complete and unidirectional conversion of human embryonic stem cells to trophoblast by BMP4

(2013) M. Amita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Placental Syncytium Forms a Biophysical Barrier against Pathogen Invasion

(2013) Varvara B. Zeldovich et al.   PLoS Pathogens

Murine Coronavirus Induces Type I Interferon in Oligodendrocytes through Recognition by RIG-I and MDA5

(2010) J. Li et al.   JOURNAL OF VIROLOGY