Viruses harness YxxØ motif to interact with host AP2M1 for replication: A vulnerable broad-spectrum antiviral target

Comparative replication and immune activation profiles of SARS-CoV-2 and SARS-CoV in human lungs: an ex vivo study with implications for the pathogenesis of COVID-19

(2020) Hin Chu et al.   CLINICAL INFECTIOUS DISEASES

Suppression of the SAP18/HDAC1 complex by targeting TRIM56 and Nanog is essential for oncogenic viral FLICE-inhibitory protein-induced acetylation of p65/RelA, NF-κB activation, and promotion of cell invasion and angiogenesis

(2019) Xiangya Ding et al.   CELL DEATH AND DIFFERENTIATION

SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target

(2019) Shuofeng Yuan et al.   Nature Communications

α4β7+ CD4+ Effector/Effector Memory T Cells Differentiate into Productively and Latently Infected Central Memory T Cells by Transforming Growth Factor β1 during HIV-1 Infection

(2018) Ka-Wai Cheung et al.   JOURNAL OF VIROLOGY

Differentiated human airway organoids to assess infectivity of emerging influenza virus

(2018) Jie Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Host Factors Involved in Human Cytomegalovirus Replication, Assembly, and Egress Using a Two-Step Small Interfering RNA Screen

(2018) Dominique McCormick et al.   mBio

The celecoxib derivative kinase inhibitor AR-12 (OSU-03012) inhibits Zika virus via down-regulation of the PI3K/Akt pathway and protects Zika virus-infected A129 mice: A host-targeting treatment strategy

(2018) Jasper Fuk-Woo Chan et al.   ANTIVIRAL RESEARCH

A tricyclic pyrrolobenzodiazepine produced byKlebsiella oxytocais associated with cytotoxicity in antibiotic-associated hemorrhagic colitis

(2017) Herman Tse et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects

(2017) Elena Bekerman et al.   JOURNAL OF CLINICAL INVESTIGATION

Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus

(2017) Jie Zhou et al.   Science Advances

Zika Virus

(2016) Didier Musso et al.   CLINICAL MICROBIOLOGY REVIEWS

Regulation of clathrin-mediated endocytosis by hierarchical allosteric activation of AP2

(2016) Zuzana Kadlecova et al.   JOURNAL OF CELL BIOLOGY

Human Induced Pluripotent Cell-Derived Sensory Neurons for Fate Commitment of Bone Marrow-Derived Schwann Cells: Implications for Remyelination Therapy

(2016) Sa Cai et al.   Stem Cells Translational Medicine

Middle East Respiratory Syndrome Coronavirus: Another Zoonotic Betacoronavirus Causing SARS-Like Disease

(2015) Jasper F. W. Chan et al.   CLINICAL MICROBIOLOGY REVIEWS

AP-2-Associated Protein Kinase 1 and Cyclin G-Associated Kinase Regulate Hepatitis C Virus Entry and Are Potential Drug Targets

(2015) Gregory Neveu et al.   JOURNAL OF VIROLOGY

Influenza Virus-Host Interactome Screen as a Platform for Antiviral Drug Development

(2014) Tokiko Watanabe et al.   Cell Host & Microbe

An siRNA Screen of Membrane Trafficking Genes Highlights Pathways Common to HIV-1 and M-PMV Virus Assembly and Release

(2014) Xiaoyun Wen et al.   PLoS One

The K526R substitution in viral protein PB2 enhances the effects of E627K on influenza virus replication

(2014) Wenjun Song et al.   Nature Communications

The emergence of influenza A H7N9 in human beings 16 years after influenza A H5N1: a tale of two cities

(2013) Kelvin KW To et al.   LANCET INFECTIOUS DISEASES

Tollip, an Intracellular Trafficking Protein, Is a Novel Modulator of the Transforming Growth Factor-β Signaling Pathway

(2012) Lu Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signaling Mechanisms Controlling Cell Fate and Embryonic Patterning

(2012) N. Perrimon et al.   Cold Spring Harbor Perspectives in Biology

Identification and Targeting of an Interaction between a Tyrosine Motif within Hepatitis C Virus Core Protein and AP2M1 Essential for Viral Assembly

(2012) Gregory Neveu et al.   PLoS Pathogens

Molecular Determinants and Dynamics of Hepatitis C Virus Secretion

(2012) Kelly E. Coller et al.   PLoS Pathogens

A Large-Scale Conformational Change Couples Membrane Recruitment to Cargo Binding in the AP2 Clathrin Adaptor Complex

(2010) Lauren P. Jackson et al.   CELL

Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication

(2010) Alexander Karlas et al.   NATURE

Lead Finder: An Approach To Improve Accuracy of Protein−Ligand Docking, Binding Energy Estimation, and Virtual Screening

(2008) Oleg V. Stroganov et al.   Journal of Chemical Information and Modeling

Delayed antiviral plus immunomodulator treatment still reduces mortality in mice infected by high inoculum of influenza A/H5N1 virus

(2008) B.-J. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA