Stem-cell-derived trophoblast organoids model human placental development and susceptibility to emerging pathogens

Cell trajectory modeling identifies a primitive trophoblast state defined by BCAM enrichment

(2022) Matthew J. Shannon et al.   DEVELOPMENT

Decidual immune response following COVID-19 during pregnancy varies by timing of maternal SARS-CoV-2 infection

(2022) Lillian J. Juttukonda et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

SARS-CoV-2 entry into human airway organoids is serine protease-mediated and facilitated by the multibasic cleavage site

(2021) Anna Z Mykytyn et al.   eLife

COVID-19 Infection and Hypertensive Disorders of Pregnancy

(2021) Joshua I. Rosenbloom et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Human naive epiblast cells possess unrestricted lineage potential

(2021) Ge Guo et al.   Cell Stem Cell

Capturing human trophoblast development with naive pluripotent stem cells in vitro

(2021) Shingo Io et al.   Cell Stem Cell

Integrated analysis of multimodal single-cell data

(2021) Yuhan Hao et al.   CELL

Probing the signaling requirements for naive human pluripotency by high-throughput chemical screening

(2021) Shafqat A. Khan et al.   Cell Reports

Characterization of primary models of human trophoblast

(2021) Megan A. Sheridan et al.   DEVELOPMENT

Diverse epigenetic mechanisms maintain parental imprints within the embryonic and extraembryonic lineages

(2021) Daniel Andergassen et al.   DEVELOPMENTAL CELL

The X chromosome dosage compensation program during the development of cynomolgus monkeys

(2021) Ikuhiro Okamoto et al.   SCIENCE

Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records

(2020) Huijun Chen et al.   LANCET

A new coronavirus associated with human respiratory disease in China

(2020) Fan Wu et al.   NATURE

Derivation of trophoblast stem cells from naïve human pluripotent stem cells

(2020) Chen Dong et al.   eLife

An Analysis of 38 Pregnant Women with COVID-19, Their Newborn Infants, and Maternal-Fetal Transmission of SARS-CoV-2: Maternal Coronavirus Infections and Pregnancy Outcomes

(2020) David A. Schwartz   ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Infection of bat and human intestinal organoids by SARS-CoV-2

(2020) Jie Zhou et al.   NATURE MEDICINE

SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

(2020) Waradon Sungnak et al.   NATURE MEDICINE

SARS-CoV-2 productively infects human gut enterocytes

(2020) Mart M. Lamers et al.   SCIENCE

SARS‐CoV2 and pregnancy: An invisible enemy?

(2020) Sonam Verma et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Neutralizing Antibody and Soluble ACE2 Inhibition of a Replication-Competent VSV-SARS-CoV-2 and a Clinical Isolate of SARS-CoV-2

(2020) James Brett Case et al.   Cell Host & Microbe

A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids

(2020) Liuliu Yang et al.   Cell Stem Cell

Overcoming Autocrine FGF Signaling-Induced Heterogeneity in Naive Human ESCs Enables Modeling of Random X Chromosome Inactivation

(2020) Chenrui An et al.   Cell Stem Cell

Placental SARS‐CoV‐2 in a Pregnant Woman with Mild COVID‐19 Disease

(2020) Albert L. Hsu et al.   JOURNAL OF MEDICAL VIROLOGY

SARS-CoV-2 can infect the placenta and is not associated with specific placental histopathology: a series of 19 placentas from COVID-19-positive mothers

(2020) Jonathon L. Hecht et al.   MODERN PATHOLOGY

Transplacental transmission of SARS-CoV-2 infection

(2020) Alexandre J. Vivanti et al.   Nature Communications

Expression of SARS-CoV-2 receptor ACE2 and the protease TMPRSS2 suggests susceptibility of the human embryo in the first trimester

(2020) Bailey A. T. Weatherbee et al.   Open Biology

Naive Human Embryonic Stem Cells Can Give Rise to Cells with a Trophoblast-like Transcriptome and Methylome

(2020) Jessica K. Cinkornpumin et al.   Stem Cell Reports

SARS-CoV-2 infects the brain choroid plexus and disrupts the blood-CSF-barrier in human brain organoids

(2020) Laura Pellegrini et al.   Cell Stem Cell

Histopathology of Third Trimester Placenta from SARS-CoV-2-Positive Women

(2020) Mai He et al.   Fetal and Pediatric Pathology

Reprogramming roadmap reveals route to human induced trophoblast stem cells

(2020) Xiaodong Liu et al.   NATURE

Establishment and differentiation of long-term trophoblast organoid cultures from the human placenta

(2020) Megan A. Sheridan et al.   Nature Protocols

Single cell census of human kidney organoids shows reproducibility and diminished off-target cells after transplantation

(2019) Ayshwarya Subramanian et al.   Nature Communications

A developmental landscape of 3D-cultured human pre-gastrulation embryos

(2019) Lifeng Xiang et al.   NATURE

Derivation of Human Trophoblast Stem Cells

(2018) Hiroaki Okae et al.   Cell Stem Cell

Single-cell RNA-seq reveals the diversity of trophoblast subtypes and patterns of differentiation in the human placenta 

(2018) Yawei Liu et al.   CELL RESEARCH

Self-Renewing Trophoblast Organoids Recapitulate the Developmental Program of the Early Human Placenta

(2018) Sandra Haider et al.   Stem Cell Reports

Trophoblast organoids as a model for maternal–fetal interactions during human placentation

(2018) Margherita Y. Turco et al.   NATURE

Inhibition of autophagy limits vertical transmission of Zika virus in pregnant mice

(2017) Bin Cao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Vulnerability of primitive human placental trophoblast to Zika virus

(2017) Megan A. Sheridan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Primary Human Placental Trophoblasts are Permissive for Zika Virus (ZIKV) Replication

(2017) Kjersti M. Aagaard et al.   Scientific Reports

Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal Demise

(2016) Jonathan J. Miner et al.   CELL

Naive Human Pluripotent Cells Feature a Methylation Landscape Devoid of Blastocyst or Germline Memory

(2016) William A. Pastor et al.   Cell Stem Cell

Molecular Criteria for Defining the Naive Human Pluripotent State

(2016) Thorold W. Theunissen et al.   Cell Stem Cell

Zika Virus Infection in Pregnant Women in Rio de Janeiro

(2016) Patrícia Brasil et al.   NEW ENGLAND JOURNAL OF MEDICINE

destiny: diffusion maps for large-scale single-cell data in R

(2015) Philipp Angerer et al.   BIOINFORMATICS

OVO-like 1 regulates progenitor cell fate in human trophoblast development

(2015) Stephen J. Renaud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Derivation of consensus inactivation status for X-linked genes from genome-wide studies

(2015) Bradley P. Balaton et al.   Biology of Sex Differences

Systematic Identification of Culture Conditions for Induction and Maintenance of Naive Human Pluripotency

(2014) Thorold W. Theunissen et al.   Cell Stem Cell

The Human Placenta Project: Placental structure, development, and function in real time

(2014) A.E. Guttmacher et al.   PLACENTA

Implication of Human Endogenous Retrovirus Envelope Proteins in Placental Functions

(2014) Adjimon Lokossou et al.   Viruses-Basel

Patterns of placental development evaluated by X chromosome inactivation profiling provide a basis to evaluate the origin of epigenetic variation

(2012) M.S. Peñaherrera et al.   HUMAN REPRODUCTION

The primate-specific microRNA gene cluster (C19MC) is imprinted in the placenta

(2010) M. Noguer-Dance et al.   HUMAN MOLECULAR GENETICS

First-Trimester Determination of Complications of Late Pregnancy

(2010) Gordon C. S. Smith   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

High-resolution DNA analysis of human embryonic stem cell lines reveals culture-induced copy number changes and loss of heterozygosity

(2010) Elisa Närvä et al.   NATURE BIOTECHNOLOGY

Random X Inactivation and Extensive Mosaicism in Human Placenta Revealed by Analysis of Allele-Specific Gene Expression along the X Chromosome

(2010) Joana Carvalho Moreira de Mello et al.   PLoS One