Human naive epiblast cells possess unrestricted lineage potential

Evaluating totipotency using criteria of increasing stringency

(2021) Eszter Posfai et al.   NATURE CELL BIOLOGY

Derivation of trophoblast stem cells from naïve human pluripotent stem cells

(2020) Chen Dong et al.   eLife

Toward Guidelines for Research on Human Embryo Models Formed from Stem Cells

(2020) Insoo Hyun et al.   Stem Cell Reports

Naive Human Embryonic Stem Cells Can Give Rise to Cells with a Trophoblast-like Transcriptome and Methylome

(2020) Jessica K. Cinkornpumin et al.   Stem Cell Reports

Capacitation of human naïve pluripotent stem cells for multi-lineage differentiation

(2019) Maria Rostovskaya et al.   DEVELOPMENT

The Cell-Surface Marker Sushi Containing Domain 2 Facilitates Establishment of Human Naive Pluripotent Stem Cells

(2019) Nicholas Bredenkamp et al.   Stem Cell Reports

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Establishment of porcine and human expanded potential stem cells

(2019) Xuefei Gao et al.   NATURE CELL BIOLOGY

Controlled modelling of human epiblast and amnion development using stem cells

(2019) Yi Zheng et al.   NATURE

In vitro culture of cynomolgus monkey embryos beyond early gastrulation

(2019) Huaixiao Ma et al.   SCIENCE

Recent insights into the naïve state of human pluripotency and its applications

(2019) Chen Dong et al.   EXPERIMENTAL CELL RESEARCH

A developmental landscape of 3D-cultured human pre-gastrulation embryos

(2019) Lifeng Xiang et al.   NATURE

Wnt Inhibition Facilitates RNA-Mediated Reprogramming of Human Somatic Cells to Naive Pluripotency

(2019) Nicholas Bredenkamp et al.   Stem Cell Reports

Derivation of Human Trophoblast Stem Cells

(2018) Hiroaki Okae et al.   Cell Stem Cell

Integrated analysis of single-cell embryo data yields a unified transcriptome signature for the human pre-implantation epiblast

(2018) Giuliano G. Stirparo et al.   DEVELOPMENT

Blastocyst-like structures generated solely from stem cells

(2018) Nicolas C. Rivron et al.   NATURE

TFAP2C regulates transcription in human naive pluripotency by opening enhancers

(2018) William A. Pastor et al.   NATURE CELL BIOLOGY

Genetic Control of Early Cell Lineages in the Mammalian Embryo

(2018) Janet Rossant   Annual Review of Genetics

Single cell transcriptome analysis of human, marmoset and mouse embryos reveals common and divergent features of preimplantation development

(2018) Thorsten Boroviak et al.   DEVELOPMENT

BMP4 plays a role in apoptosis during human preimplantation development

(2018) C. De Paepe et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Massively parallel digital transcriptional profiling of single cells

(2017) Grace X. Y. Zheng et al.   Nature Communications

Position- and Hippo signaling-dependent plasticity during lineage segregation in the early mouse embryo

(2017) Eszter Posfai et al.   eLife

Single-Cell RNA-Seq Reveals Lineage and X Chromosome Dynamics in Human Preimplantation Embryos

(2016) Sophie Petropoulos et al.   CELL

Self-organization of the in vitro attached human embryo

(2016) Alessia Deglincerti et al.   NATURE

A developmental coordinate of pluripotency among mice, monkeys and humans

(2016) Tomonori Nakamura et al.   NATURE

Self-organization of the human embryo in the absence of maternal tissues

(2016) Marta N. Shahbazi et al.   NATURE CELL BIOLOGY

Comparison of syncytiotrophoblast generated from human embryonic stem cells and from term placentas

(2016) Shinichiro Yabe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Asynchronous fate decisions by single cells collectively ensure consistent lineage composition in the mouse blastocyst

(2016) Néstor Saiz et al.   Nature Communications

Naive Pluripotent Stem Cells Derived Directly from Isolated Cells of the Human Inner Cell Mass

(2016) Ge Guo et al.   Stem Cell Reports

What Is Trophoblast? A Combination of Criteria Define Human First-Trimester Trophoblast

(2016) Cheryl Q.E. Lee et al.   Stem Cell Reports

Defining the three cell lineages of the human blastocyst by single-cell RNA-seq

(2015) P. Blakeley et al.   DEVELOPMENT

Transcription factor AP-2  induces early Cdx2 expression and represses HIPPO signaling to specify the trophectoderm lineage

(2015) Z. Cao et al.   DEVELOPMENT

Resetting Transcription Factor Control Circuitry toward Ground-State Pluripotency in Human

(2014) Yasuhiro Takashima et al.   CELL

Systematic Identification of Culture Conditions for Induction and Maintenance of Naive Human Pluripotency

(2014) Thorold W. Theunissen et al.   Cell Stem Cell

Mouse and human blastocyst-derived stem cells: vive les differences

(2014) J. Rossant   DEVELOPMENT

The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification

(2014) Thorsten Boroviak et al.   NATURE CELL BIOLOGY

Differentiation of trophoblast cells from human embryonic stem cells: to be or not to be?

(2014) R Michael Roberts et al.   REPRODUCTION

Defining an essential transcription factor program for naive pluripotency

(2014) S.- J. Dunn et al.   SCIENCE

Epigenetic memory of the first cell fate decision prevents complete ES cell reprogramming into trophoblast

(2014) Francesco Cambuli et al.   Nature Communications

Context-Dependent Wiring of Sox2 Regulatory Networks for Self-Renewal of Embryonic and Trophoblast Stem Cells

(2013) Kenjiro Adachi et al.   MOLECULAR CELL

Complete and unidirectional conversion of human embryonic stem cells to trophoblast by BMP4

(2013) M. Amita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Transcription factor AP-2  is a core regulator of tight junction biogenesis and cavity formation during mouse early embryogenesis

(2012) I. Choi et al.   DEVELOPMENT

Analysis of human embryos from zygote to blastocyst reveals distinct gene expression patterns relative to the mouse

(2012) Kathy K. Niakan et al.   DEVELOPMENTAL BIOLOGY

Human trophectoderm cells are not yet committed

(2012) C. De Paepe et al.   HUMAN REPRODUCTION

Tracking the progression of the human inner cell mass during embryonic stem cell derivation

(2012) Thomas O'Leary et al.   NATURE BIOTECHNOLOGY

BRACHYURY and CDX2 Mediate BMP-Induced Differentiation of Human and Mouse Pluripotent Stem Cells into Embryonic and Extraembryonic Lineages

(2011) Andreia S. Bernardo et al.   Cell Stem Cell

Human hypoblast formation is not dependent on FGF signalling

(2011) Mila Roode et al.   DEVELOPMENTAL BIOLOGY

Chemically defined conditions for human iPSC derivation and culture

(2011) Guokai Chen et al.   NATURE METHODS

The Transcription Factor TCFAP2C/AP-2  Cooperates with CDX2 To Maintain Trophectoderm Formation

(2010) P. Kuckenberg et al.   MOLECULAR AND CELLULAR BIOLOGY

Differential expression analysis for sequence count data

(2010) Simon Anders et al.   GENOME BIOLOGY

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Klf4 reverts developmentally programmed restriction of ground state pluripotency

(2009) G. Guo et al.   DEVELOPMENT

The C-terminal Region of Laminin β Chains Modulates the Integrin Binding Affinities of Laminins

(2009) Yukimasa Taniguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Validated germline-competent embryonic stem cell lines from nonobese diabetic mice

(2009) Jennifer Nichols et al.   NATURE MEDICINE

Distinct sequential cell behaviours direct primitive endoderm formation in the mouse blastocyst

(2008) B. Plusa et al.   DEVELOPMENT

The ground state of embryonic stem cell self-renewal

(2008) Qi-Long Ying et al.   NATURE

Epigenetic restriction of embryonic cell lineage fate by methylation of Elf5

(2008) Ray Kit Ng et al.   NATURE CELL BIOLOGY