NLR-regulated pathways in cancer: opportunities and obstacles for therapeutic interventions

Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer

(2015) Si Ming Man et al.   CELL

The NLRP1 inflammasomes

(2015) Joseph Chavarría-Smith et al.   IMMUNOLOGICAL REVIEWS

Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling

(2015) Christina Antonopoulos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The NLRP1 Inflammasome Attenuates Colitis and Colitis-Associated Tumorigenesis

(2015) Tere M. Williams et al.   JOURNAL OF IMMUNOLOGY

Role of Genetic Alterations in theNLRP3andCARD8Genes in Health and Disease

(2015) G. V. Paramel et al.   MEDIATORS OF INFLAMMATION

The receptor NLRP3 is a transcriptional regulator of TH2 differentiation

(2015) Mélanie Bruchard et al.   NATURE IMMUNOLOGY

The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection

(2015) Si Ming Man et al.   NATURE IMMUNOLOGY

Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt

(2015) Justin E Wilson et al.   NATURE MEDICINE

AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3

(2015) Adam Denes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Assembly-driven activation of the AIM2 foreign-dsDNA sensor provides a polymerization template for downstream ASC

(2015) Seamus R. Morrone et al.   Nature Communications

IL-1β microenvironment promotes proliferation, migration, and invasion of human glioma cells

(2014) K. Fathima Hurmath et al.   CELL BIOLOGY INTERNATIONAL

Lack of Absent in Melanoma 2 (AIM2) expression in tumor cells is closely associated with poor survival in colorectal cancer patients

(2014) Susanne Dihlmann et al.   INTERNATIONAL JOURNAL OF CANCER

Nuclear Factor E2-related Factor-2 (Nrf2) Is Required for NLRP3 and AIM2 Inflammasome Activation

(2014) Changcheng Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Mitochondrial Protein NLRX1 Controls the Balance between Extrinsic and Intrinsic Apoptosis

(2014) Fraser Soares et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Microtubule-associated Protein EB1 Links AIM2 Inflammasomes with Autophagy-dependent Secretion

(2014) Li-Jie Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Molecular Chaperone HSP70 Binds to and Stabilizes NOD2, an Important Protein Involved in Crohn Disease

(2014) Vishnu Mohanan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NAIP and Ipaf Control Legionella pneumophila Replication in Human Cells

(2014) M. Vinzing et al.   JOURNAL OF IMMUNOLOGY

Protective Role for Caspase-11 during Acute Experimental Murine Colitis

(2014) Katarzyna Oficjalska et al.   JOURNAL OF IMMUNOLOGY

Critical role for the AIM2 inflammasome during acute CNS bacterial infection

(2014) Richa Hanamsagar et al.   JOURNAL OF NEUROCHEMISTRY

Interleukin-1-induced changes in the glioblastoma secretome suggest its role in tumor progression

(2014) Leonid Tarassishin et al.   Journal of Proteomics

ASC deficiency suppresses proliferation and prevents medulloblastoma incidence

(2014) E R W Knight et al.   ONCOGENE

Aberrant Expression of Interleukin-1β and Inflammasome Activation in Human Malignant Gliomas

(2014) Leonid Tarassishin et al.   PLoS One

Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex

(2014) S. M. Man et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CARD8 is a negative regulator for NLRP3 inflammasome, but mutant NLRP3 in cryopyrin-associated periodic syndromes escapes the restriction

(2014) Sayaka Ito et al.   ARTHRITIS RESEARCH & THERAPY

Amyloid-β induces NLRP1-dependent neuronal pyroptosis in models of Alzheimer’s disease

(2014) M-S Tan et al.   Cell Death & Disease

Dual Engagement of the NLRP3 and AIM2 Inflammasomes by Plasmodium-Derived Hemozoin and DNA during Malaria

(2014) Parisa Kalantari et al.   Cell Reports

Mitochondrial ROS potentiates indirect activation of the AIM2 inflammasome

(2014) Deborah D. Crane et al.   Frontiers in Microbiology

Nod-Like Receptors: Key Molecular Switches in the Conundrum of Cancer

(2014) Andrew Kent et al.   Frontiers in Immunology

Non-Inflammasome Forming NLRs in Inflammation and Tumorigenesis

(2014) Irving Coy Allen   Frontiers in Immunology

Targeting Apoptosis Pathways for New Cancer Therapeutics

(2013) Longchuan Bai et al.   Annual Review of Medicine

AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC

(2013) V Sagulenko et al.   CELL DEATH AND DIFFERENTIATION

Role of Nlrp6 and Nlrp12 in the maintenance of intestinal homeostasis

(2013) Grace Y. Chen   EUROPEAN JOURNAL OF IMMUNOLOGY

Activation of NLRP3 and AIM2 Inflammasomes by Porphyromonas gingivalis Infection

(2013) Eunjoo Park et al.   INFECTION AND IMMUNITY

NLRP1 Is an Inflammasome Sensor for Toxoplasma gondii

(2013) Sarah E. Ewald et al.   INFECTION AND IMMUNITY

Structure of the Absent in Melanoma 2 (AIM2) Pyrin Domain Provides Insights into the Mechanisms of AIM2 Autoinhibition and Inflammasome Assembly

(2013) Tengchuan Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of IL-1  in the Early Tumor Cell-Induced Angiogenic Response

(2013) Y. Carmi et al.   JOURNAL OF IMMUNOLOGY

Deregulation of the NLRP3 inflammasome in hepatic parenchymal cells during liver cancer progression

(2013) Qing Wei et al.   LABORATORY INVESTIGATION

AIM2, an IFN-Inducible Cytosolic DNA Sensor, in the Development of Benign Prostate Hyperplasia and Prostate Cancer

(2013) Larissa Ponomareva et al.   MOLECULAR CANCER RESEARCH

Mycoplasma hyorhinis Activates the NLRP3 Inflammasome and Promotes Migration and Invasion of Gastric Cancer Cells

(2013) Yongfen Xu et al.   PLoS One

Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer

(2013) B. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Salmonella exploits NLRP12-dependent innate immune signaling to suppress host defenses during infection

(2013) M. H. Zaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human NAIP and mouse NAIP1 recognize bacterial type III secretion needle protein for inflammasome activation

(2013) J. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of NLRC4 Reveals Its Autoinhibition Mechanism

(2013) Z. Hu et al.   SCIENCE

Direct Proteolytic Cleavage of NLRP1B Is Necessary and Sufficient for Inflammasome Activation by Anthrax Lethal Factor

(2013) Joseph Chavarría-Smith et al.   PLoS Pathogens

Functions of NOD-Like Receptors in Human Diseases

(2013) Yifei Zhong et al.   Frontiers in Immunology

Roles of NOD1 (NLRC1) and NOD2 (NLRC2) in innate immunity and inflammatory diseases

(2012) Ricardo G. Correa et al.   BIOSCIENCE REPORTS

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

Nanovector delivery of siRNA for cancer therapy

(2012) H Shen et al.   CANCER GENE THERAPY

AIM2/ASC triggers caspase-8-dependent apoptosis in Francisella-infected caspase-1-deficient macrophages

(2012) R Pierini et al.   CELL DEATH AND DIFFERENTIATION

Epidermal growth factor receptor

(2012) Monika E. Hegi et al.   CURRENT OPINION IN NEUROLOGY

Current status of inflammasome blockers as anti-inflammatory drugs

(2012) Gloria López-Castejón et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Structure and Functional Characterization of the RNA-Binding Element of the NLRX1 Innate Immune Modulator

(2012) Minsun Hong et al.   IMMUNITY

NLRX1 Has a Tail to Tell

(2012) Tsan Sam Xiao et al.   IMMUNITY

Sensing of Commensal Organisms by the Intracellular Sensor NOD1 Mediates Experimental Pancreatitis

(2012) Yoshihisa Tsuji et al.   IMMUNITY

NLRP1 Inflammasome Activation Induces Pyroptosis of Hematopoietic Progenitor Cells

(2012) Seth L. Masters et al.   IMMUNITY

NLRP12 Suppresses Colon Inflammation and Tumorigenesis through the Negative Regulation of Noncanonical NF-κB Signaling

(2012) Irving C. Allen et al.   IMMUNITY

The Mitochondrial Proteins NLRX1 and TUFM Form a Complex that Regulates Type I Interferon and Autophagy

(2012) Yu Lei et al.   IMMUNITY

NLRX1 does not inhibit MAVS-dependent antiviral signalling

(2012) Fraser Soares et al.   Innate Immunity

Critical role of AIM2 in Mycobacterium tuberculosis infection

(2012) H. Saiga et al.   INTERNATIONAL IMMUNOLOGY

Pathogen Sensing by Nucleotide-binding Oligomerization Domain-containing Protein 2 (NOD2) Is Mediated by Direct Binding to Muramyl Dipeptide and ATP

(2012) Jinyao Mo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autolytic Proteolysis within the Function to Find Domain (FIIND) Is Required for NLRP1 Inflammasome Activity

(2012) Joshua N. Finger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NLRP1-Dependent Pyroptosis Leads to Acute Lung Injury and Morbidity in Mice

(2012) M. Kovarova et al.   JOURNAL OF IMMUNOLOGY

Apoptosis inhibition or inflammation: the role of NAIP protein expression in Hodgkin and non-Hodgkin lymphomas compared to non-neoplastic lymph node

(2012) Safoura Mazrouei et al.   Journal of Inflammation-London

Dual Role of Apoptosis-Associated Speck-Like Protein Containing a CARD (ASC) in Tumorigenesis of Human Melanoma

(2012) Weimin Liu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens

(2012) Paras K. Anand et al.   NATURE

Phosphorylation of NLRC4 is critical for inflammasome activation

(2012) Yan Qu et al.   NATURE

Inflammasomes in carcinogenesis and anticancer immune responses

(2012) Laurence Zitvogel et al.   NATURE IMMUNOLOGY

Inflammasome polymorphisms confer susceptibility to sporadic malignant melanoma

(2012) Deepti Verma et al.   Pigment Cell & Melanoma Research

NLRP1 polymorphisms in patients with asbestos-associated mesothelioma

(2012) Alessandra Pontillo et al.   Infectious Agents and Cancer

NALP1/NLRP1 Genetic Variants are Associated With Alzheimer Disease

(2011) Alessandra Pontillo et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases

(2011) Beckley K. Davis et al.   Annual Review of Immunology

NLRP1 gene polymorphism influences gene transcription and is a risk factor for rheumatoid arthritis in Han Chinese

(2011) Jiangdong Sui et al.   ARTHRITIS AND RHEUMATISM

Integrity of ATP binding site is essential for effective inhibition of the intrinsic apoptosis pathway by NAIP

(2011) Sarvenaz Karimpour et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The NOD-Like Receptor NLRP12 Attenuates Colon Inflammation and Tumorigenesis

(2011) Md. Hasan Zaki et al.   CANCER CELL

Increased Survival of Glioblastoma Patients Who Respond to Antiangiogenic Therapy with Elevated Blood Perfusion

(2011) A. G. Sorensen et al.   CANCER RESEARCH

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

(2011) Eran Elinav et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The inflammasomes in health and disease: from genetics to molecular mechanisms of autoinflammation and beyond

(2011) Cristina Conforti-Andreoni et al.   Cellular & Molecular Immunology

The brain tumor microenvironment

(2011) Nikki A. Charles et al.   GLIA

Role of NOD1/CARD4 and NOD2/CARD15 gene polymorphisms in cancer etiology

(2011) Anton G. Kutikhin   HUMAN IMMUNOLOGY

NLRX1 Negatively Regulates TLR-Induced NF-κB Signaling by Targeting TRAF6 and IKK

(2011) Xiaojun Xia et al.   IMMUNITY

NLRX1 Protein Attenuates Inflammatory Responses to Infection by Interfering with the RIG-I-MAVS and TRAF6-NF-κB Signaling Pathways

(2011) Irving C. Allen et al.   IMMUNITY

A Functional Role for Nlrp6 in Intestinal Inflammation and Tumorigenesis

(2011) G. Y. Chen et al.   JOURNAL OF IMMUNOLOGY

The NLRP12 Pyrin Domain: Structure, Dynamics, and Functional Insights

(2011) Anderson S. Pinheiro et al.   JOURNAL OF MOLECULAR BIOLOGY

Differential Roles for the Interferon-Inducible IFI16 and AIM2 Innate Immune Sensors for Cytosolic DNA in Cellular Senescence of Human Fibroblasts

(2011) X. Duan et al.   MOLECULAR CANCER RESEARCH

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

(2011) Yue Zhao et al.   NATURE

NLR functions beyond pathogen recognition

(2011) Thomas A Kufer et al.   NATURE IMMUNOLOGY

Absent in Melanoma 2 (AIM2) is an important mediator of interferon-dependent and -independent HLA-DRA and HLA-DRB gene expression in colorectal cancers

(2011) J Lee et al.   ONCOGENE

Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury

(2011) S. Normand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of a Viral NLR Homolog that Inhibits the Inflammasome

(2011) S. M. Gregory et al.   SCIENCE

NLRP3 inflammasomes link inflammation and metabolic disease

(2011) Dominic De Nardo et al.   TRENDS IN IMMUNOLOGY

The Inflammasome Component Nlrp3 Impairs Antitumor Vaccine by Enhancing the Accumulation of Tumor-Associated Myeloid-Derived Suppressor Cells

(2010) H. W. van Deventer et al.   CANCER RESEARCH

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Listeria monocytogenes Triggers AIM2-Mediated Pyroptosis upon Infrequent Bacteriolysis in the Macrophage Cytosol

(2010) John-Demian Sauer et al.   Cell Host & Microbe

Expression of inhibitor of apoptosis family proteins in human oral squamous cell carcinogenesis

(2010) Yuk-Kwan Chen et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

The NLRP3 Inflammasome Protects against Loss of Epithelial Integrity and Mortality during Experimental Colitis

(2010) Md. Hasan Zaki et al.   IMMUNITY

Neuronal apoptosis inhibitory protein, NAIP, is an inhibitor of procaspase-9

(2010) Jamshid Davoodi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Caspase Recruitment Domain-containing Protein 8 (CARD8) Negatively Regulates NOD2-mediated Signaling

(2010) Oliver von Kampen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer

(2010) Irving C. Allen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense againstSalmonella

(2010) Petr Broz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-18 Production Downstream of the Nlrp3 Inflammasome Confers Protection against Colorectal Tumor Formation

(2010) M. H. Zaki et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Cytosolic Bacterial DNA Activates the Inflammasome via Aim2

(2010) S. E. Warren et al.   JOURNAL OF IMMUNOLOGY

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

(2010) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

The AIM2 inflammasome is critical for innate immunity to Francisella tularensis

(2010) Teresa Fernandes-Alnemri et al.   NATURE IMMUNOLOGY

Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria

(2010) Edward A Miao et al.   NATURE IMMUNOLOGY

IL-1 pathways in inflammation and human diseases

(2010) Cem Gabay et al.   Nature Reviews Rheumatology

Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4

(2010) B. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How the Noninflammasome NLRs Function in the Innate Immune System

(2010) J. P. Y. Ting et al.   SCIENCE

Induction of neuronal apoptosis inhibitory protein expression in response to androgen deprivation in prostate cancer

(2009) Helen H.L. Chiu et al.   CANCER LETTERS

Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability

(2009) F. Colotta et al.   CARCINOGENESIS

The innate immune molecule, NOD1, regulates direct killing ofHelicobacter pyloriby antimicrobial peptides

(2009) Alexandra Grubman et al.   CELLULAR MICROBIOLOGY

Cellular Inhibitors of Apoptosis cIAP1 and cIAP2 Are Required for Innate Immunity Signaling by the Pattern Recognition Receptors NOD1 and NOD2

(2009) Mathieu J.M. Bertrand et al.   IMMUNITY

Cellular and molecular pathways linking inflammation and cancer

(2009) Chiara Porta et al.   IMMUNOBIOLOGY

Restoration of absent in melanoma 2 (AIM2) induces G2/M cell cycle arrest and promotes invasion of colorectal cancer cells

(2009) Georgios Patsos et al.   INTERNATIONAL JOURNAL OF CANCER

Therapeutic Neutralization of the NLRP1 Inflammasome Reduces the Innate Immune Response and Improves Histopathology after Traumatic Brain Injury

(2009) Juan Pablo de Rivero Vaccari et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Mechanism and Repertoire of ASC-Mediated Gene Expression

(2009) M. Hasegawa et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Nucleotide-Binding Oligomerization Domain 1-Dependent Responses Account for Murine Resistance against Trypanosoma cruzi Infection

(2009) G. K. Silva et al.   JOURNAL OF IMMUNOLOGY

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

The Patched dependence receptor triggers apoptosis through a DRAL–caspase-9 complex

(2009) Frédéric Mille et al.   NATURE CELL BIOLOGY

The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

(2009) Luigi Franchi et al.   NATURE IMMUNOLOGY

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

(2009) François Ghiringhelli et al.   NATURE MEDICINE

Gene polymorphisms in the NALP3 inflammasome are associated with interleukin-1 production and severe inflammation: Relation to common inflammatory diseases?

(2008) Deepti Verma et al.   ARTHRITIS AND RHEUMATISM

Combination of SMN2 copy number and NAIP deletion predicts disease severity in spinal muscular atrophy

(2008) Mohd Shamshudin Watihayati et al.   BRAIN & DEVELOPMENT

The Innate Immune Receptor Nod1 Protects the Intestine from Inflammation-Induced Tumorigenesis

(2008) G. Y. Chen et al.   CANCER RESEARCH

Active Caspase-1 Is a Regulator of Unconventional Protein Secretion

(2008) Martin Keller et al.   CELL

NLR, the nucleotide-binding domain leucine-rich repeat containing gene family

(2008) Zhengmao Ye et al.   CURRENT OPINION IN IMMUNOLOGY

NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-κB and JNK pathways by inducing reactive oxygen species production

(2008) Ivan Tattoli et al.   EMBO REPORTS

The Cytosolic Sensors Nod1 and Nod2 Are Critical for Bacterial Recognition and Host Defense after Exposure to Toll-like Receptor Ligands

(2008) Yun-Gi Kim et al.   IMMUNITY

The NLR Gene Family: A Standard Nomenclature

(2008) Jenny P.-Y. Ting et al.   IMMUNITY

NLRX1 is a regulator of mitochondrial antiviral immunity

(2008) Chris B. Moore et al.   NATURE

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

Reprogrammed viruses as cancer therapeutics: targeted, armed and shielded

(2008) Roberto Cattaneo et al.   NATURE REVIEWS MICROBIOLOGY

A NOD2-NALP1 complex mediates caspase-1-dependent IL-1  secretion in response to Bacillus anthracis infection and muramyl dipeptide

(2008) L.-C. Hsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA