Article
Immunology
Leying Zhang, Yuanjing Li, Zhenyang Zhao, Jiabao Cai, Shuxin Zhao, Ling Yang
Summary: This study found that the expression of NLR family in the maternal thymus is changed during pregnancy stages, which may be related to the modulation of maternal thymic immune responses and beneficial for normal pregnancy in sheep.
Article
Biochemistry & Molecular Biology
Ying Li, Rujun Jin, Lan Li, Ji Suk Choi, Jonghwa Kim, Hyeon Jeong Yoon, Jong Hwan Park, Kyung Chul Yoon
Summary: This study investigated the effects of blue light exposure on NOD2 expression and autophagy in mice ocular surface. The findings suggest that blue light exposure activates NOD2, leading to impaired autophagy and corneal epithelial apoptosis. NOD2-KO mice showed lower levels of autophagic impairment and epithelial damage after blue light exposure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Shaowei Huang, Jinrong He, Yanping Chen, Xiaojing Wang, Yanyang Li, Yulin Su, Ruyan Wen, Xiuling Li, Guanghua Yang, Shuang Luo, Lian Zhou, Xia Luo
Summary: This study found that Huangqin decoction can regulate the intestinal flora of ulcerative colitis mice, mainly by inhibiting the NOD2-dependent pathway.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Integrative & Complementary Medicine
Chen Song, Ding Yi-hang, Shi Song-sheng, Tu Xian-kun
Summary: The study found that Schisandrin B can attenuate early brain injury caused by subarachnoid hemorrhage in rats, possibly by inhibiting neuroinflammation, neuronal apoptosis, and the NLRP3 inflammatory signaling pathway.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Wan-Yang Li, Fan Yang, Ji-Hua Chen, Guo-Feng Ren
Summary: The study explored the anti-inflammatory effects of beta-caryophyllene on MSU crystal-induced acute gouty arthritis. Beta-caryophyllene significantly reduced inflammation in the ankle joints and decreased serum cytokine levels in gouty arthritis rats. Furthermore, it inhibited the expressions of inflammatory markers in the synovial tissue.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Cuiping Zheng, Zongsi Zhu, Shanshan Weng, Qikai Zhang, Yixiao Fu, Xiaoping Cai, Zhen Liu, Yuejian Shi
Summary: This study found that NOD2 promotes cell apoptosis and reduces drug resistance in chronic lymphocytic leukemia (CLL) by inhibiting the NF-kappa B signaling pathway.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Plant Sciences
Xiaohui Zhao, Zhengqiang Chen, Qian Wu, Yazhen Cai, Yu Zhang, Ruizhen Zhao, Jiaoling Yan, Xin Qian, Jia Li, Min Zhu, Lizhou Hong, Jincheng Xing, Nasr Ullah Khan, Yinghua Ji, Peijun Wu, Changjun Huang, Xin Shun Ding, Hui Zhang, Xiaorong Tao
Summary: Studies have shown that the nucleotide-binding domain Sw-5b NLR alone can activate downstream defense signaling in tomato, leading to elicitor-independent cell death. Self-association of the Sw-5b NB domain is crucial for activating cell death signaling, while mutations can compromise this function. These findings suggest a potential mechanism for the activation of defense signaling in plant cells.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Biochemistry & Molecular Biology
Liang Zheng, Hongbiao Xu, Fufu Zheng, Yuanhui Lai, Jie Li, Weiming Lv, Zuojun Hu, Wenjian Wang
Summary: It has been found that interventions against lipid abnormalities or inflammatory reactions during different stages of atherosclerosis may yield different results. These findings can help improve therapeutic strategies for atherosclerosis and emphasize the importance of a healthy lifestyle as a preventive measure.
LIPIDS IN HEALTH AND DISEASE
(2022)
Article
Medicine, Research & Experimental
Yuanyuan Li, Zhongyan Wang
Summary: IL-32 plays a pro-inflammatory role in myocardial ischemia-reperfusion injury and induces oxidative stress, inflammation, and apoptosis via the NOD2/NOX2/MAPK signaling pathway.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
News Item
Biophysics
Piotr E. Marszalek
Summary: In this article, Singh, Rief, and Zoldak provide an exquisitely detailed study of the nanomechanical aspects of the allosteric mechanism in the Hsp70 chaperone DnaK.
BIOPHYSICAL JOURNAL
(2022)
Article
Nanoscience & Nanotechnology
Guowei Shen, Shichang Yan, Siyuan Shen, Feng Liang, Shouyun Xiao, Yunpeng Zhang, Yongtao Zhang, Huimin Ding
Summary: This study found that curculigoside has the potential to aid cartilage restoration in osteoarthritis patients by inhibiting the NLRP3 pathway.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2023)
Article
Immunology
Yu-Wei Chang, Ling-Chien Hung, Yu-Cheng Chen, Wen-Hung Wang, Chun-Yu Lin, Hsin-Han Tzeng, Jau-Ling Suen, Yen-Hsu Chen
Summary: Insulin may reduce inflammation by regulating the NLRP3 inflammasome, as demonstrated in in vivo models, providing evidence for its potential immunomodulatory role in anti-inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Urology & Nephrology
Moxuan Feng, Yani Yu, Yueqi Chen, Xiaoqian Yang, Baoshuang Li, Wei Jiang
Summary: Hepatitis B virus-associated glomerulonephritis (HBV-GN) is a main type of secondary glomerular diseases, and podocyte injury is an important pathogenic mechanism of HBV-GN, participating in the occurrence and development of HBV-GN. However, the specific mechanism of podocyte injury remains to be studied.
Article
Multidisciplinary Sciences
Amanda J. Russell, Paul E. Gray, John B. Ziegler, Yae Jean Kim, Sandy Smith, William A. Sewell, Christopher C. Goodnow
Summary: The study analyzed the function of SAMD9L protein, which is encoded by an interferon-induced gene and plays a role in controlling virus replication. Mutations in SAMD9L were found to be associated with an interferon-induced translational repressor, and truncating mutations resulted in exaggerated translational repression.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Xue-Qin Tang, Ruo-Yi Liao, Li-Jun Zheng, Ling-Ling Yang, Zhi-Lin Ma, Chan Yi, Jin Liu, Jin-Can Liu, Yi-Jin Kuang, Hua-An Cai, Liang Huang
Summary: In this study, aerobic exercise was found to have a protective effect on a mouse model of post-stroke depression (PSD), and it was discovered that aerobic exercise is involved in PSD through the serotonin (5-HT) signaling pathway and the protein irisin. Aerobic exercise inhibits the activation of the nuclear factor kappa B (NF-kappa B)/nucleotide-binding oligomerization domain--like receptor protein 3 (NLRP3) inflammasome, reduces mitochondrial damage, and alleviates PSD.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Ladan Nekoohesh, Shahrbano Rostami, Mohsen Nikbakht, Saeed Mohammadi, Davood Babakhani, Kamran Alimoghaddam, Mohammad H. Ghahremani, Bahram Chahardouli
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2020)
Article
Pharmacology & Pharmacy
Niloufar Maghsoudni, Reza Baradaran Eftekhari, Alireza Naderi Sohi, Parisa Norouzi, Hamid Akbari, Mohammad Hossein Ghahremani, Masoud Soleimani, Mohsen Amini, Flamed Samadi, Farid Abedin Dorkoosh
JOURNAL OF DRUG TARGETING
(2020)
Article
Cardiac & Cardiovascular Systems
Somayeh Keshtkar, Maryam Kaviani, Zahra Jabbarpour, Ismail H. Al-Abdullah, Mahdokht H. Aghdaei, Saman Nikeghbalian, Alireza Shamsaeefar, Bita Geramizadeh, Negar Azarpira, Mohammad H. Ghahremani
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2020)
Article
Nanoscience & Nanotechnology
Mohammad Reza Sepand, Sheyda Ranjbar, Ivan M. Kempson, Mostafa Akbariani, Willis Collins Akeyo Muganda, Mareike Mueller, Mohammad Hossein Ghahremani, Mohammad Raoufi
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2020)
Article
Cell & Tissue Engineering
Somayeh Keshtkar, Maryam Kaviani, Zahra Jabbarpour, Fatemeh Sabet Sarvestani, Mohammad Hossein Ghahremani, Elaheh Esfandiari, Mahdokht Hossein Aghdaei, Saman Nikeghbalian, Alireza Shamsaeefar, Bita Geramizadeh, Negar Azarpira
STEM CELLS INTERNATIONAL
(2020)
Article
Biotechnology & Applied Microbiology
Sara Kasirzadeh, Mohammad Hossein Ghahremani, Neda Setayesh, Fereshteh Jeivad, Amir Shadboorestan, Ali Taheri, Abbas Beh-Pajooh, Armin Azadkhah Shalmani, Alireza Ebadollahi-Natanzi, Alamgir Khan, Samin Sabzevari, Omid Sabzevari
Summary: This study evaluated the effects of beta S on biomarkers of inflammation and liver function in septic rats, showing that beta S can effectively reduce inflammation and increase liver GSH content, potentially through inhibition of the NF-kappa B signaling pathway.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Materials Science, Biomaterials
Maryam Zohri, Ehsan Arefian, Hamid Akbari Javar, Taraneh Gazori, Seyed Hamid Aghaee-Bakhtiari, Mojtaba Taheri, Yousef Fatahi, Amir Azadi, Mohammad Reza Khoshayand, Mohammad Hossein Ghahremani
Summary: By optimizing the Chi/Alg nanoparticles as a non-viral vector using a D-optimal design, the researchers successfully prepared well-shaped nanoparticles for gene delivery. Through toxicity and transfection studies, it was found that the optimized Chi/Alg/S nanoparticles exhibited no toxicity and slightly lower transfection efficiency compared to commercial reagents Lipofectamine and PEI.
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Medicine, Research & Experimental
Fatemeh Mahmoudian, Mostafa Akbariqomi, Reza Heidaril, Mohammad H. Ghahremani, Nader Roshan, Mandi Adabi, Moloud Absalan, Fatemeh Karimi, Samira Bahrami, Samaneh Fathi, Gholamreza Tavoosidana
Summary: The study aimed to design an optimized biosensor to detect the KRAS G12D mutation in plasma using padlock probe-based hyperbranched rolling circle amplification. The results showed the biosensor has a low detection limit and linear response in detecting KRAS point mutations in liquid state reactions.
BIOMARKERS IN MEDICINE
(2021)
Article
Neurosciences
Yazdan Hasani Nourian, Abbas Beh-Pajooh, Mehdi Aliomrani, Mohsen Amini, Mohammad A. Sahraian, Rohollah Hosseini, Saeid Mohammadi, Mohammad H. Ghahremani
Summary: The study examined the correlation of DNA methylation changes in APOE and ACKR3 genes in MS patients with blood concentrations of arsenic, cadmium, and lead. Results showed hypomethylation of the ACKR3 gene and hypermethylation of the APOE gene in MS patients, along with significantly higher levels of arsenic and cadmium in the patient group compared to controls. These findings suggest that epigenetic changes and exposure to heavy metals, especially arsenic, may play a role in the pathogenesis of MS.
Article
Medicine, General & Internal
Paria Sharafi-Badr, Sepideh Karoobi, Hamid Reza Monsef-Esfahani, Mohammad Hossein Ghahremani, Hamid-Reza Adhami
Summary: This study investigated the in vitro cytotoxic properties of different parts of Ornithogalum bungei on various human cancer cell lines. The results showed that the plant exhibited significant inhibitory effects on different cancer cell lines.
IRANIAN JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Elnaz Shaabani, Maryam Sharifiaghdam, Joris Lammens, Herlinde De Keersmaecker, Chris Vervaet, Thomas De Beer, Elahe Motevaseli, Mohammad Hossein Ghahremani, Parvin Mansouri, Stefaan De Smedt, Koen Raemdonck, Reza Faridi-Majidi, Kevin Braeckmans, Juan C. Fraire
Summary: Impaired wound healing in people with diabetes is caused by multiple factors, with lack of new blood vessel formation being one of the most important. Stabilization of HIF-1 alpha by downregulating PHD-2 can upregulate pro-angiogenic factors, improving diabetic wound healing. Gold nanoparticles loaded with siRNA and coated with a Poly L-arginine outer layer showed enhanced endosomal escape and transfection efficiency compared to other formulations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Amir Shadboorestan, Parastoo Tarighi, Mahsa Koosha, Homa Faghihi, Mohammad Hossein Ghahremani, Hamed Montazeri
Summary: Liraglutide may stimulate the growth of MDA-MB-231 breast cancer cells and potentially lead to drug resistance and epithelial-mesenchymal transition. Caution should be exercised when using liraglutide in patients with a history of triple negative breast cancer.
Article
Cell Biology
Samaneh Sharif, Mohammad Hossein Ghahremani, Masoud Soleimani
Summary: The study demonstrated that the delivery of miR-124 through indirect means via hAD-MSCs significantly reduced the proliferation of NB cells and induced their differentiation. This suggests the potential use of exosomes derived from hAD-MSCs as a novel stem cell-based therapy for NB cancer.
Article
Pharmacology & Pharmacy
Vahideh Montazeri, Mohammad Hossein Ghahremani, Hamed Montazeri, Mandana Hasanzad, Majid Safavi, Mohsen Ayati, Mohammad Chehrazi, Baharak Arefi Moghaddam, Seyed Nasser Ostad
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH
(2020)
Article
Chemistry, Analytical
Fateme Karimi, Elnaz Shaabani, Immaculada Martinez-Rovira, Ibraheem Yousef, Mohammad Hossein Ghahremani, Sharmin Kharrazi
Summary: Curcumin-coated gold nanoparticles effectively decrease DNA damage caused by H2O2 treatment, with pre-treatment showing more effectiveness in preventing lipid peroxidation than post-treatment. Analysis of the CH2(asym) to CH3(asym) ratio provides insights into lipid peroxidation levels in cells and the interaction of nanoparticles with the plasma membrane.
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)