Recent Advances in Cancer Vaccines: Challenges, Achievements, and Futuristic Prospects

Granulocyte macrophage colony-stimulating factor has come of age: from a vaccine adjuvant to antiviral immunotherapy

(2021) Maria Petrina et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Cancer Vaccines: Antigen Selection Strategy

(2021) Yue Zhao et al.   Vaccines

mRNA vaccine for cancer immunotherapy

(2021) Lei Miao et al.   Molecular Cancer

Integrase-Defective Lentiviral Vector Is an Efficient Vaccine Platform for Cancer Immunotherapy

(2021) Valeria Morante et al.   Viruses-Basel

Manganese salts function as potent adjuvants

(2021) Rui Zhang et al.   Cellular & Molecular Immunology

mRNA therapeutics in cancer immunotherapy

(2021) Jan D. Beck et al.   Molecular Cancer

Cancer Vaccines, Adjuvants, and Delivery Systems

(2021) Samantha J. Paston et al.   Frontiers in Immunology

New generation of DNA-based immunotherapy induces a potent immune response and increases the survival in different tumor models

(2021) Alessandra Lopes et al.   Journal for ImmunoTherapy of Cancer

Prophylactic Cancer Vaccines Engineered to Elicit Specific Adaptive Immune Response

(2021) Davis W. Crews et al.   Frontiers in Oncology

An Overview of Nanocarrier-Based Adjuvants for Vaccine Delivery

(2021) Kailash C. Petkar et al.   Pharmaceutics

Combining Cancer Vaccines with Immunotherapy: Establishing a New Immunological Approach

(2021) Chang-Gon Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

STING Agonist Combined to a Protein-Based Cancer Vaccine Potentiates Peripheral and Intra-Tumoral T Cell Immunity

(2021) Matteo Rossi et al.   Frontiers in Immunology

A Neoantigen-Based Peptide Vaccine for Patients With Advanced Pancreatic Cancer Refractory to Standard Treatment

(2021) Zheling Chen et al.   Frontiers in Immunology

A Guide to Nucleic Acid Vaccines in the Prevention and Treatment of Infectious Diseases and Cancers: From Basic Principles to Current Applications

(2021) Furong Qin et al.   Frontiers in Cell and Developmental Biology

Cancer Vaccines: Promising Therapeutics or an Unattainable Dream

(2021) Howard Donninger et al.   Vaccines

Nucleic acid-based biosensors: analytical devices for prevention, diagnosis and treatment of diseases

(2021) Laura Carvajal Barbosa et al.   Vitae

Opportunities and Challenges in the Delivery of mRNA-Based Vaccines

(2020) Abishek Wadhwa et al.   Pharmaceutics

Revisiting the role of CD4+ T cells in cancer immunotherapy—new insights into old paradigms

(2020) Rong En Tay et al.   CANCER GENE THERAPY

Polyanhydride nanoparticles stabilize pancreatic cancer antigen MUC4β

(2020) Luman Liu et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

An RNA vaccine drives immunity in checkpoint-inhibitor-treated melanoma

(2020) Ugur Sahin et al.   NATURE

Recent progress in the design of DNA vaccines against tuberculosis

(2020) Youssof Sefidi-Heris et al.   DRUG DISCOVERY TODAY

Strategies in DNA vaccine for melanoma cancer

(2020) Tayebeh Rezaei et al.   Pigment Cell & Melanoma Research

Emerging Concepts and Technologies in Vaccine Development

(2020) Morgan Brisse et al.   Frontiers in Immunology

The Emergence of Natural Killer Cells as a Major Target in Cancer Immunotherapy

(2019) Fernando Souza-Fonseca-Guimaraes et al.   TRENDS IN IMMUNOLOGY

A Synthetic DNA, Multi-Neoantigen Vaccine Drives Predominately MHC Class I CD8+ T-cell Responses, Impacting Tumor Challenge

(2019) Elizabeth K. Duperret et al.   Cancer Immunology Research

Synergistic STING activation by PC7A nanovaccine and ionizing radiation improves cancer immunotherapy

(2019) Min Luo et al.   JOURNAL OF CONTROLLED RELEASE

Cancer DNA vaccines: current preclinical and clinical developments and future perspectives

(2019) Alessandra Lopes et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Current RNA-based Therapeutics in Clinical Trials

(2019) Ling-Yan Zhou et al.   CURRENT GENE THERAPY

Novel biomimetic reconstituted built-in adjuvanted Hepatitis B vaccine for transcutaneous immunization

(2019) Monika Kaurav et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Tumor neoantigens: from basic research to clinical applications

(2019) Tao Jiang et al.   Journal of Hematology & Oncology

Neoantigen vaccine: an emerging tumor immunotherapy

(2019) Miao Peng et al.   Molecular Cancer

A trans-amplifying RNA vaccine strategy for induction of potent protective immunity

(2019) Tim Beissert et al.   MOLECULAR THERAPY

Codelivery of mRNA with α-Galactosylceramide Using a New Lipopolyplex Formulation Induces a Strong Antitumor Response upon Intravenous Administration

(2019) Maria L. Guevara et al.   ACS Omega

Peptide-Based Vaccines: Current Progress and Future Challenges

(2019) Ryan J. Malonis et al.   CHEMICAL REVIEWS

Intranasal Administration of miR-146a Agomir Rescued the Pathological Process and Cognitive Impairment in an AD Mouse Model

(2019) Hui Mai et al.   Molecular Therapy-Nucleic Acids

Designable Immune Therapeutical Vaccine System Based on DNA Supramolecular Hydrogels

(2018) Yu Shao et al.   ACS Applied Materials & Interfaces

Tailoring inorganic nanoadjuvants towards next-generation vaccines

(2018) Xia Li et al.   CHEMICAL SOCIETY REVIEWS

Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses

(2018) Chenguang Wang et al.   IMMUNITY

The Immune Landscape of Cancer

(2018) Vésteinn Thorsson et al.   IMMUNITY

Cytokines in the Treatment of Cancer

(2018) Kevin C. Conlon et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Immune Checkpoint Blockade: The New Frontier in Cancer Treatment

(2018) Jeffrey M. Clarke et al.   Targeted Oncology

YAP Is Essential for Treg-Mediated Suppression of Antitumor Immunity

(2018) Xuhao Ni et al.   Cancer Discovery

M7824, a novel bifunctional anti-PD-L1/TGFβ Trap fusion protein, promotes anti-tumor efficacy as monotherapy and in combination with vaccine

(2018) Karin M. Knudson et al.   OncoImmunology

Computational prediction of vaccine potential epitopes and 3-dimensional structure of XAGE-1b for non-small cell lung cancer immunotherapy

(2018) Mohammad M. Tarek et al.   Biomedical Journal

The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery

(2018) Yun Xia et al.   CELL

Targeting STING with cyclic di-GMP greatly augmented immune responses of glycopeptide cancer vaccines

(2018) Jun-Jun Wu et al.   CHEMICAL COMMUNICATIONS

CD8+ cytotoxic T lymphocytes in cancer immunotherapy: A review

(2018) Bagher Farhood et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Biomaterials for vaccine-based cancer immunotherapy

(2018) Rui Zhang et al.   JOURNAL OF CONTROLLED RELEASE

Antigen discovery and specification of immunodominance hierarchies for MHCII-restricted epitopes

(2018) Daniel B. Graham et al.   NATURE MEDICINE

Physical activation of innate immunity by spiky particles

(2018) Ji Wang et al.   Nature Nanotechnology

Combined adjuvant-delivery system for new generation vaccine antigens: alliance has its own advantage

(2018) Monika Kaurav et al.   Artificial Cells Nanomedicine and Biotechnology

High Therapeutic Efficacy of a New Survivin LSP-Cancer Vaccine Containing CD4+ and CD8+ T-Cell Epitopes

(2018) Fanny Onodi et al.   Frontiers in Oncology

Revised Overall Survival Analysis of a Phase II, Randomized, Double-Blind, Controlled Study of PROSTVAC in Men With Metastatic Castration-Resistant Prostate Cancer

(2017) Philip W. Kantoff et al.   JOURNAL OF CLINICAL ONCOLOGY

Effects of gold nanoparticle-based vaccine size on lymph node delivery and cytotoxic T-lymphocyte responses

(2017) Sukmo Kang et al.   JOURNAL OF CONTROLLED RELEASE

Elements of cancer immunity and the cancer–immune set point

(2017) Daniel S. Chen et al.   NATURE

A STING-activating nanovaccine for cancer immunotherapy

(2017) Min Luo et al.   Nature Nanotechnology

Is It Possible to Develop Cancer Vaccines to Neoantigens, What Are the Major Challenges, and How Can These Be Overcome?

(2017) Olivera J. Finn et al.   Cold Spring Harbor Perspectives in Biology

Interferon-γ derived from cytotoxic lymphocytes directly enhances their motility and cytotoxicity

(2017) Purnima Bhat et al.   Cell Death & Disease

Signalling strength determines proapoptotic functions of STING

(2017) Muhammet F. Gulen et al.   Nature Communications

The revival of cancer vaccines — The eminent need to activate humoral immunity

(2017) Elisabeth J. M. Huijbers et al.   Human Vaccines & Immunotherapeutics

Cancer prevention from the perspective of global cancer burden patterns

(2017) Hiroki Nagai et al.   Journal of Thoracic Disease

Blinatumomab bridges the gap between leukemia and immunity

(2017) Takahiro Yamazaki et al.   OncoImmunology

Trial watch: Immunogenic cell death induction by anticancer chemotherapeutics

(2017) Abhishek D. Garg et al.   OncoImmunology

Microdosed Lipid-Coated 67Ga-Magnetite Enhances Antigen-Specific Immunity by Image Tracked Delivery of Antigen and CpG to Lymph Nodes

(2016) Ane Ruiz-de-Angulo et al.   ACS Nano

Strategies to genetically engineer T cells for cancer immunotherapy

(2016) Timothy T. Spear et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Immunotherapy against cancer-related viruses

(2016) Haruko Tashiro et al.   CELL RESEARCH

Micro- and nanoparticulates for DNA vaccine delivery

(2016) Eric Farris et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Nanoparticulate mediated transcutaneous immunization: Myth or reality

(2016) Monika Kaurav et al.   Nanomedicine-Nanotechnology Biology and Medicine

DNA vaccines to attack cancer: Strategies for improving immunogenicity and efficacy

(2016) Angeliki Tiptiri-Kourpeti et al.   PHARMACOLOGY & THERAPEUTICS

Novel ISCOMs from Quillaja brasiliensis saponins induce mucosal and systemic antibody production, T-cell responses and improved antigen uptake

(2016) Samuel Paulo Cibulski et al.   VACCINE

Nanomaterial-based vaccine adjuvants

(2016) Bingbing Sun et al.   Journal of Materials Chemistry B

Chemotherapy and immunotherapy: A close interplay to fight cancer?

(2016) Aurélie Hanoteau et al.   OncoImmunology

Lipopeptide-Coated Iron Oxide Nanoparticles as Potential Glycoconjugate-Based Synthetic Anticancer Vaccines

(2015) Suttipun Sungsuwan et al.   ACS Applied Materials & Interfaces

Polyelectrolyte Multilayers Assembled Entirely from Immune Signals on Gold Nanoparticle Templates Promote Antigen-Specific T Cell Response

(2015) Peipei Zhang et al.   ACS Nano

Antigen-Loaded Upconversion Nanoparticles for Dendritic Cell Stimulation, Tracking, and Vaccination in Dendritic Cell-Based Immunotherapy

(2015) Jian Xiang et al.   ACS Nano

Manganese Is Essential for Neuronal Health

(2015) Kyle J. Horning et al.   Annual Review of Nutrition

Novel Cell-Penetrating Peptide-Based Vaccine Induces Robust CD4+ and CD8+ T Cell-Mediated Antitumor Immunity

(2015) M. Derouazi et al.   CANCER RESEARCH

Cancer Neoantigens and Applications for Immunotherapy

(2015) A. Desrichard et al.   CLINICAL CANCER RESEARCH

Nanoparticulate STING agonists are potent lymph node–targeted vaccine adjuvants

(2015) Melissa C. Hanson et al.   JOURNAL OF CLINICAL INVESTIGATION

Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes

(2015) Norbert Pardi et al.   JOURNAL OF CONTROLLED RELEASE

Combination cancer immunotherapy and new immunomodulatory targets

(2015) Kathleen M. Mahoney et al.   NATURE REVIEWS DRUG DISCOVERY

Oncolytic viruses: a new class of immunotherapy drugs

(2015) Howard L. Kaufman et al.   NATURE REVIEWS DRUG DISCOVERY

A 9-Valent HPV Vaccine against Infection and Intraepithelial Neoplasia in Women

(2015) Elmar A. Joura et al.   NEW ENGLAND JOURNAL OF MEDICINE

Poly(I:C) as cancer vaccine adjuvant: Knocking on the door of medical breakthroughs

(2015) Rachid Ammi et al.   PHARMACOLOGY & THERAPEUTICS

An Ebola whole-virus vaccine is protective in nonhuman primates

(2015) A. Marzi et al.   SCIENCE

In situ vaccine, immunological memory and cancer cure

(2015) Kangla Tsung et al.   Human Vaccines & Immunotherapeutics

Classification of current anticancer immunotherapies

(2015) Lorenzo Galluzzi et al.   Oncotarget

Adoptive Immunotherapy for Cancer or Viruses

(2014) Marcela V. Maus et al.   Annual Review of Immunology

Adenovirus-Based Vaccines for Fighting Infectious Diseases and Cancer: Progress in the Field

(2014) Dragomira Majhen et al.   HUMAN GENE THERAPY

Cancer vaccine adjuvants – recent clinical progress and future perspectives

(2014) Abid H. Banday et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Characterization of the Antibody Response against NeuGcGM3 Ganglioside Elicited in Non-Small Cell Lung Cancer Patients Immunized with an Anti-Idiotype Antibody

(2014) A. M. Hernandez et al.   JOURNAL OF IMMUNOLOGY

Ultra-pH-Sensitive Nanoprobe Library with Broad pH Tunability and Fluorescence Emissions

(2014) Xinpeng Ma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing

(2014) Mahesh Yadav et al.   NATURE

Structure-based programming of lymph-node targeting in molecular vaccines

(2014) Haipeng Liu et al.   NATURE

Therapeutic vaccines for cancer: an overview of clinical trials

(2014) Ignacio Melero et al.   Nature Reviews Clinical Oncology

Combined Stimulation of IL-2 and 4-1BB Receptors Augments the Antitumor Activity of E7 DNA Vaccines by Increasing Ag-Specific CTL Responses

(2014) Ha Kim et al.   PLoS One

Unleashing the potential of NOD- and Toll-like agonists as vaccine adjuvants

(2014) C. Maisonneuve et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo Gold Nanoparticle Delivery of Peptide Vaccine Induces Anti-Tumor Immune Response in Prophylactic and Therapeutic Tumor Models

(2014) Joao Paulo Mattos Almeida et al.   Small

Mucosal vaccination against tuberculosis using Ag85A-loaded immunostimulating complexes

(2014) Swati Pabreja et al.   Artificial Cells Nanomedicine and Biotechnology

STING Ligand c-di-GMP Improves Cancer Vaccination against Metastatic Breast Cancer

(2014) D. Chandra et al.   Cancer Immunology Research

The Dendritic Cell Lineage: Ontogeny and Function of Dendritic Cells and Their Subsets in the Steady State and the Inflamed Setting

(2013) Miriam Merad et al.   Annual Review of Immunology

TGF-β Activation and Function in Immunity

(2013) Mark A. Travis et al.   Annual Review of Immunology

A liposome-based antigen delivery system using pH-sensitive fusogenic polymers for cancer immunotherapy

(2013) Eiji Yuba et al.   BIOMATERIALS

Agonistic CD40 Antibodies and Cancer Therapy

(2013) R. H. Vonderheide et al.   CLINICAL CANCER RESEARCH

Dendritic-Cell-Based Therapeutic Cancer Vaccines

(2013) Karolina Palucka et al.   IMMUNITY

Multifunctional nanoparticles co-delivering Trp2 peptide and CpG adjuvant induce potent cytotoxic T-lymphocyte response against melanoma and its lung metastasis

(2013) Zhenghong Xu et al.   JOURNAL OF CONTROLLED RELEASE

Aluminum hydroxide nanoparticles show a stronger vaccine adjuvant activity than traditional aluminum hydroxide microparticles

(2013) Xinran Li et al.   JOURNAL OF CONTROLLED RELEASE

Mouse, but not Human STING, Binds and Signals in Response to the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid

(2013) J. Conlon et al.   JOURNAL OF IMMUNOLOGY

Emerging Research and Clinical Development Trends of Liposome and Lipid Nanoparticle Drug Delivery Systems

(2013) John C. Kraft et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Oral Vaccination With Adeno-associated Virus Vectors Expressing the Neu Oncogene Inhibits the Growth of Murine Breast Cancer

(2013) Jason C Steel et al.   MOLECULAR THERAPY

Adoptive cell therapy: Honing that killer instinct

(2013) Courtney Humphries   NATURE

Heat-shock protein peptide complex–96 vaccination for recurrent glioblastoma: a phase II, single-arm trial

(2013) Orin Bloch et al.   NEURO-ONCOLOGY

Xenogeneic Human p53 DNA Vaccination by Electroporation Breaks Immune Tolerance to Control Murine Tumors Expressing Mouse p53

(2013) Ruey-Shyang Soong et al.   PLoS One

Boosting anticancer vaccines

(2013) Alessia Ricupito et al.   OncoImmunology

Vaccination of biliary tract cancer patients with four peptides derived from cancer-testis antigens

(2013) Atsushi Aruga   OncoImmunology

Breaking tumor-induced immunosuppression with 5′-triphosphate siRNA silencing TGFβ and activating RIG-I

(2013) Max Schnurr et al.   OncoImmunology

Peptide-based anticancer vaccines

(2013) Yared Hailemichael et al.   OncoImmunology

Cancer vaccines

(2013) Kavitha Yaddanapudi et al.   OncoImmunology

DNA fusion-gene vaccination in patients with prostate cancer induces high-frequency CD8+ T-cell responses and increases PSA doubling time

(2012) Lindsey Chudley et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Fully Synthetic Self-Adjuvanting Thioether-Conjugated GlycopeptideLipopeptide Antitumor Vaccines for the Induction of Complement-Dependent Cytotoxicity against Tumor Cells

(2012) Hui Cai et al.   CHEMISTRY-A EUROPEAN JOURNAL

Improving T cell responses to modified peptides in tumor vaccines

(2012) Jonathan D. Buhrman et al.   IMMUNOLOGIC RESEARCH

Antibody-Antigen-Adjuvant Conjugates Enable Co-Delivery of Antigen and Adjuvant to Dendritic Cells in Cis but Only Have Partial Targeting Specificity

(2012) Martin Kreutz et al.   PLoS One

Betting on improved cancer immunotherapy by doubling down on CD134 and CD137 co-stimulation

(2012) Adam J. Adler et al.   OncoImmunology

Human papillomavirus 16 E7 protein inhibits interferon-γ-mediated enhancement of keratinocyte antigen processing and T-cell lysis

(2011) Fang Zhou et al.   FEBS Journal

Immunological mechanisms of vaccination

(2011) Bali Pulendran et al.   NATURE IMMUNOLOGY

Cancer immunotherapy – revisited

(2011) W. Joost Lesterhuis et al.   NATURE REVIEWS DRUG DISCOVERY

Contributions of humoral and cellular immunity to vaccine-induced protection in humans

(2011) Ian J. Amanna et al.   VIROLOGY

Paradigm shifting vaccines: prophylactic vaccines against latent varicella-zoster virus infection and against HPV-associated cancer

(2011) Ian H Frazer et al.   Current Opinion in Virology

Enhancing immune responses to tumor-associated antigens

(2010) Jack P. Higgins et al.   CANCER BIOLOGY & THERAPY

Therapeutic Targeting of TLR9 Inhibits Cell Growth and Induces Apoptosis in Neuroblastoma

(2010) C. Brignole et al.   CANCER RESEARCH

Biodistribution and toxicity of engineered gold nanoparticles: a review of in vitro and in vivo studies

(2010) Nikolai Khlebtsov et al.   CHEMICAL SOCIETY REVIEWS

Use of attenuated paramyxoviruses for cancer therapy

(2010) Patrycja J Lech et al.   Expert Review of Vaccines

Anti-idiotype antibody response after vaccination correlates with better overall survival in follicular lymphoma

(2009) W. Z. Ai et al.   BLOOD

A virosomal formulated Her-2/neu multi-peptide vaccine induces Her-2/neu-specific immune responses in patients with metastatic breast cancer: a phase I study

(2009) Ursula Wiedermann et al.   BREAST CANCER RESEARCH AND TREATMENT

Effect of Granulocyte/Macrophage Colony-Stimulating Factor on Circulating CD8+ and CD4+ T-Cell Responses to a Multipeptide Melanoma Vaccine: Outcome of a Multicenter Randomized Trial

(2009) C. L. Slingluff et al.   CLINICAL CANCER RESEARCH

Oligo-branched peptides for tumor targeting: from magic bullets to magic forks

(2009) Chiara Falciani et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Engineered adenovirus serotypes for overcoming anti-vector immunity

(2009) Sridhar Dharmapuri et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

IFN-  Enhances Peptide Vaccine-Induced CD8+ T Cell Numbers, Effector Function, and Antitumor Activity

(2009) A. G. Sikora et al.   JOURNAL OF IMMUNOLOGY

Decreased Incidence of Hepatocellular Carcinoma in Hepatitis B Vaccinees: A 20-Year Follow-up Study

(2009) Mei-Hwei Chang et al.   JNCI-Journal of the National Cancer Institute

Vaccination against HPV-16 Oncoproteins for Vulvar Intraepithelial Neoplasia

(2009) Gemma G. Kenter et al.   NEW ENGLAND JOURNAL OF MEDICINE

Heat-shock proteins as powerful weapons in vaccine development

(2008) Azam Bolhassani et al.   Expert Review of Vaccines

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE