Tailoring inorganic nanoadjuvants towards next-generation vaccines

Synergistic effects of stellated fibrous mesoporous silica and synthetic dsRNA analogues for cancer immunotherapy

(2018) Xiupeng Wang et al.   CHEMICAL COMMUNICATIONS

Nanoporous microstructures mediate osteogenesis by modulating the osteo-immune response of macrophages

(2017) Zetao Chen et al.   Nanoscale

Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection

(2017) Justin Eyquem et al.   NATURE

Hollow ZnO Nanospheres Enhance Anticancer Immunity by Promoting CD4+ and CD8+ T Cell Populations In Vivo

(2017) Xiupeng Wang et al.   Small

Hollow boron nitride nanospheres as boron reservoir for prostate cancer treatment

(2017) Xia Li et al.   Nature Communications

Understanding the Effect of Surface Chemistry of Mesoporous Silica Nanorods on Their Vaccine Adjuvant Potency

(2017) Yannan Yang et al.   Advanced Healthcare Materials

The shape and size of hydroxyapatite particles dictate inflammatory responses following implantation

(2017) Filipa Lebre et al.   Scientific Reports

Hierarchically porous, and Cu- and Zn-containing γ-AlOOH mesostrands as adjuvants for cancer immunotherapy

(2017) Xia Li et al.   Scientific Reports

One-Shot Immunomodulatory Nanodiamond Agents for Cancer Immunotherapy

(2016) Yu Zhang et al.   ADVANCED MATERIALS

The effect of surface modification of mesoporous silica micro-rod scaffold on immune cell activation and infiltration

(2016) Weiwei Aileen Li et al.   BIOMATERIALS

Rod-shaped and fluorine-substituted hydroxyapatite free of molecular immunopotentiators stimulates anti-cancer immunity in vivo

(2016) Xiupeng Wang et al.   CHEMICAL COMMUNICATIONS

Rod-shaped and substituted hydroxyapatite nanoparticles stimulating type 1 and 2 cytokine secretion

(2016) Xiupeng Wang et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

DNA–inorganic hybrid nanovaccine for cancer immunotherapy

(2016) Guizhi Zhu et al.   Nanoscale

Hollow Structure Improved Anti-Cancer Immunity of Mesoporous Silica Nanospheres In Vivo

(2016) Xiupeng Wang et al.   Small

Optimization of physiological properties of hydroxyapatite as a vaccine adjuvant

(2016) Masayuki Hayashi et al.   VACCINE

Radionuclide-embedded gold nanoparticles for enhanced dendritic cell-based cancer immunotherapy, sensitive and quantitative tracking of dendritic cells with PET and Cerenkov luminescence

(2016) Sang Bong Lee et al.   NPG Asia Materials

Comprehensive Mechanism Analysis of Mesoporous-Silica-Nanoparticle-Induced Cancer Immunotherapy

(2016) Xiupeng Wang et al.   Advanced Healthcare Materials

Stimulation of In Vivo Antitumor Immunity with Hollow Mesoporous Silica Nanospheres

(2015) Xiupeng Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Magnesium Sulfate Induced Toxicity in Vitro in AGS Gastric Adenocarcinoma Cells and in Vivo in Mouse Gastric Mucosa

(2015) Xulong Zhang et al.   Asian Pacific Journal of Cancer Prevention

Binding of CpG oligodeoxynucleotides to mesoporous silica nanoparticles for enhancing delivery efficiency

(2015) Cuilian Tao et al.   MICROPOROUS AND MESOPOROUS MATERIALS

Genomic correlates of response to CTLA-4 blockade in metastatic melanoma

(2015) E. M. Van Allen et al.   SCIENCE

Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer

(2015) N. A. Rizvi et al.   SCIENCE

The future of immune checkpoint therapy

(2015) P. Sharma et al.   SCIENCE

Live attenuated vaccines: Historical successes and current challenges

(2015) Philip D. Minor   VIROLOGY

Porous Silicon Microparticle Potentiates Anti-Tumor Immunity by Enhancing Cross-Presentation and Inducing Type I Interferon Response

(2015) Xiaojun Xia et al.   Cell Reports

Hollow-Structured Mesoporous Materials: Chemical Synthesis, Functionalization and Applications

(2014) Yongsheng Li et al.   ADVANCED MATERIALS

Multimodal luminescent-magnetic boron nitride nanotubes@NaGdF4:Eu structures for cancer therapy

(2014) Xia Li et al.   CHEMICAL COMMUNICATIONS

Challenges and responses in human vaccine development

(2014) Stefan HE Kaufmann et al.   CURRENT OPINION IN IMMUNOLOGY

Mesoporous silica nanoparticles for enhancing the delivery efficiency of immunostimulatory DNA drugs

(2014) Cuilian Tao et al.   DALTON TRANSACTIONS

Th1 cytokine-based immunotherapy for cancer

(2014) Hong-Mei Xu   Hepatobiliary & Pancreatic Diseases International

Immunity induced by a broad class of inorganic crystalline materials is directly controlled by their chemistry

(2014) Gareth R. Williams et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Adjuvants Aluminum Hydroxide and MF59 Induce Monocyte and Granulocyte Chemoattractants and Enhance Monocyte Differentiation toward Dendritic Cells

(2014) A. Seubert et al.   JOURNAL OF IMMUNOLOGY

Mesoporous silica particles potentiate antigen-specific T-cell responses

(2014) Natalia Kupferschmidt et al.   Nanomedicine

Injectable, spontaneously assembling, inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy

(2014) Jaeyun Kim et al.   NATURE BIOTECHNOLOGY

Therapeutic vaccines for cancer: an overview of clinical trials

(2014) Ignacio Melero et al.   Nature Reviews Clinical Oncology

Clinical translation of an ultrasmall inorganic optical-PET imaging nanoparticle probe

(2014) E. Phillips et al.   Science Translational Medicine

In vivo Gold Nanoparticle Delivery of Peptide Vaccine Induces Anti-Tumor Immune Response in Prophylactic and Therapeutic Tumor Models

(2014) Joao Paulo Mattos Almeida et al.   Small

ZnO nanoparticles induced adjuvant effect via toll-like receptors and Src signaling in Balb/c mice

(2014) Ruchi Roy et al.   TOXICOLOGY LETTERS

Cancer immunotherapy: nanodelivery approaches for immune cell targeting and tracking

(2014) João Conniot et al.   Frontiers in Chemistry

Gold Nanoparticles as a Vaccine Platform: Influence of Size and Shape on Immunological Responses in Vitro and in Vivo

(2013) Kenichi Niikura et al.   ACS Nano

Engineering an Effective Immune Adjuvant by Designed Control of Shape and Crystallinity of Aluminum Oxyhydroxide Nanoparticles

(2013) Bingbing Sun et al.   ACS Nano

Particle-size-dependent toxicity and immunogenic activity of mesoporous silica-based adjuvants for tumor immunotherapy

(2013) Xiupeng Wang et al.   Acta Biomaterialia

In Vivo Bio-Safety Evaluations and Diagnostic/Therapeutic Applications of Chemically Designed Mesoporous Silica Nanoparticles

(2013) Yu Chen et al.   ADVANCED MATERIALS

The enhanced immune response of hepatitis B virus DNA vaccine using SiO2@LDH nanoparticles as an adjuvant

(2013) Jin Wang et al.   BIOMATERIALS

Boron nitride nanotubes functionalized with mesoporous silica for intracellular delivery of chemotherapy drugs

(2013) Xia Li et al.   CHEMICAL COMMUNICATIONS

Modern Subunit Vaccines: Development, Components, and Research Opportunities

(2013) Peter Michael Moyle et al.   ChemMedChem

Zinc oxide nanoparticles provide an adjuvant effect to ovalbumin via a Th2 response in Balb/c mice

(2013) Ruchi Roy et al.   INTERNATIONAL IMMUNOLOGY

Particle platforms for cancer immunotherapy

(2013) Rita Serda   International Journal of Nanomedicine

Pore size-dependent immunogenic activity of mesoporous silica-based adjuvants in cancer immunotherapy

(2013) Xiupeng Wang et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Comparison of the adjuvant activity of aluminum hydroxide and calcium phosphate on the antibody response towardsBothrops aspersnake venom

(2013) Hidekel Olmedo et al.   Journal of Immunotoxicology

Passive Tumor Targeting of Renal-Clearable Luminescent Gold Nanoparticles: Long Tumor Retention and Fast Normal Tissue Clearance

(2013) Jinbin Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Just-in-time vaccines: Biomineralized calcium phosphate core-immunogen shell nanoparticles induce long-lasting CD8+ T cell responses in mice

(2013) Weibin Zhou et al.   Nanomedicine-Nanotechnology Biology and Medicine

Key roles of adjuvants in modern vaccines

(2013) Steven G Reed et al.   NATURE MEDICINE

Rapid formation of plasma protein corona critically affects nanoparticle pathophysiology

(2013) Stefan Tenzer et al.   Nature Nanotechnology

Immunomodulation and T Helper TH1/TH2 Response Polarization by CeO2 and TiO2 Nanoparticles

(2013) Brian C. Schanen et al.   PLoS One

A phase I study on combined therapy with proton-beam radiotherapy and in situ tumor vaccination for locally advanced recurrent hepatocellular carcinoma

(2013) Masato Abei et al.   Radiation Oncology

Solution to Vaccine Mystery Starts to Crystallize

(2013) M. Leslie   SCIENCE

Cancer Nanomedicine: From Drug Delivery to Imaging

(2013) E. K.-H. Chow et al.   Science Translational Medicine

Mesoporous Silica Nanoparticles Act as a Self-Adjuvant for Ovalbumin Model Antigen in Mice

(2013) Donna Mahony et al.   Small

Protein coated microcrystals formulated with model antigens and modified with calcium phosphate exhibit enhanced phagocytosis and immunogenicity

(2013) Sarah Jones et al.   VACCINE

Simple synthesis route of mesoporous AlOOH nanofibers to enhance immune responses

(2013) Xiupeng Wang et al.   RSC Advances

Zn- and Mg- Containing Tricalcium Phosphates-Based Adjuvants for Cancer Immunotherapy

(2013) Xiupeng Wang et al.   Scientific Reports

Mesoporous Silica-Calcium Phosphate-Tuberculin Purified Protein Derivative Composites as an Effective Adjuvant for Cancer Immunotherapy

(2013) Xia Li et al.   Advanced Healthcare Materials

Multifunctional Mesoporous Silica Nanoparticles for Cancer-Targeted and Controlled Drug Delivery

(2012) Quan Zhang et al.   ADVANCED FUNCTIONAL MATERIALS

Multivalent Porous Silicon Nanoparticles Enhance the Immune Activation Potency of Agonistic CD40 Antibody

(2012) Luo Gu et al.   ADVANCED MATERIALS

Imageable Antigen-Presenting Gold Nanoparticle Vaccines for Effective Cancer Immunotherapy In Vivo

(2012) In-Hyun Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Functionalized mesoporous silica materials for controlled drug delivery

(2012) Piaoping Yang et al.   CHEMICAL SOCIETY REVIEWS

Inactivated virus vaccines from chemistry to prophylaxis: merits, risks and challenges

(2012) Iris Delrue et al.   Expert Review of Vaccines

Iron oxide nanoparticles as a clinically acceptable delivery platform for a recombinant blood-stage human malaria vaccine

(2012) Kae Pusic et al.   FASEB JOURNAL

Alum increases antigen uptake, reduces antigen degradation and sustains antigen presentation by DCs in vitro

(2012) Tirth R. Ghimire et al.   IMMUNOLOGY LETTERS

Enhanced mucosal and systemic immune responses obtained by porous silica nanoparticles used as an oral vaccine adjuvant: Effect of silica architecture on immunological properties

(2012) Tianyi Wang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Nanoparticle Hydrophobicity Dictates Immune Response

(2012) Daniel F. Moyano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Surface-Engineered Gold Nanorods: Promising DNA Vaccine Adjuvant for HIV-1 Treatment

(2012) Ligeng Xu et al.   NANO LETTERS

Adjuvanticity and toxicity of cobalt oxide nanoparticles as an alternative vaccine adjuvant

(2012) Wan-Seob Cho et al.   Nanomedicine

Identification of a boron nitride nanosphere-binding peptide for the intracellular delivery of CpG oligodeoxynucleotides

(2012) Huijie Zhang et al.   Nanoscale

Synthetic mast-cell granules as adjuvants to promote and polarize immunity in lymph nodes

(2012) Ashley L. St. John et al.   NATURE MATERIALS

Combination delivery of TGF-β inhibitor and IL-2 by nanoscale liposomal polymeric gels enhances tumour immunotherapy

(2012) Jason Park et al.   NATURE MATERIALS

Adjuvant Properties of Mesoporous Silica Particles Tune the Development of Effector T Cells

(2012) Helen Vallhov et al.   Small

Immunization of mice by Hollow Mesoporous Silica Nanoparticles as carriers of Porcine Circovirus Type 2 ORF2 Protein

(2012) Hui-Chen Guo et al.   Virology Journal

Zinc and Regulation of Inflammatory Cytokines: Implications for Cardiometabolic Disease

(2012) Meika Foster et al.   Nutrients

Polyvalent Immunostimulatory Nanoagents with Self-Assembled CpG Oligonucleotide-Conjugated Gold Nanoparticles

(2011) Min Wei et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The use of a gold nanoparticle-based adjuvant to improve the therapeutic efficacy of hNgR-Fc protein immunization in spinal cord-injured rats

(2011) Yong-Tang Wang et al.   BIOMATERIALS

Silica Crystals and Aluminum Salts Regulate the Production of Prostaglandin in Macrophages via NALP3 Inflammasome-Independent Mechanisms

(2011) Etsushi Kuroda et al.   IMMUNITY

Understanding controlled drug release from mesoporous silicates: Theory and experiment

(2011) T. Ukmar et al.   JOURNAL OF CONTROLLED RELEASE

Basic Calcium Phosphate Crystals Induce Monocyte/Macrophage IL-1  Secretion through the NLRP3 Inflammasome In Vitro

(2011) B. Pazar et al.   JOURNAL OF IMMUNOLOGY

DNA released from dying host cells mediates aluminum adjuvant activity

(2011) Thomas Marichal et al.   NATURE MEDICINE

Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity

(2011) Tracy L Flach et al.   NATURE MEDICINE

A multifunctional core–shell nanoparticle for dendritic cell-based cancer immunotherapy

(2011) Nam-Hyuk Cho et al.   Nature Nanotechnology

Alpha-alumina nanoparticles induce efficient autophagy-dependent cross-presentation and potent antitumour response

(2011) Haiyan Li et al.   Nature Nanotechnology

NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy

(2011) C. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion

(2011) R. D. Schreiber et al.   SCIENCE

Efficient internalization of silica-coated iron oxide nanoparticles of different sizes by primary human macrophages and dendritic cells

(2011) Andrea Kunzmann et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The effect of surface modification of amorphous silica particles on NLRP3 inflammasome mediated IL-1β production, ROS production and endosomal rupture

(2010) Tomohiro Morishige et al.   BIOMATERIALS

The use of calcium phosphate nanoparticles encapsulating Toll-like receptor ligands and the antigen hemagglutinin to induce dendritic cell maturation and T cell activation

(2010) Viktoriya Sokolova et al.   BIOMATERIALS

The use of layered double hydroxides as DNA vaccine delivery vector for enhancement of anti-melanoma immune response

(2010) Ang Li et al.   BIOMATERIALS

Designing CD8+ T cell vaccines: it's not rocket science (yet)

(2010) Jonathan W Yewdell   CURRENT OPINION IN IMMUNOLOGY

Relationship between the size of nanoparticles and their adjuvant activity: Data from a study with an improved experimental design

(2010) Xinran Li et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Nano-microparticles as immune adjuvants: correlating particle sizes and the resultant immune responses

(2010) Moses O Oyewumi et al.   Expert Review of Vaccines

Overview of the immune response

(2010) David D. Chaplin   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mesoporous bioactive glass coatings on stainless steel for enhanced cell activity, cytoskeletal organization and AsMg immobilization

(2010) Xiupeng Wang et al.   JOURNAL OF MATERIALS CHEMISTRY

Cerium oxide nanoparticles protect gastrointestinal epithelium from radiation-induced damage by reduction of reactive oxygen species and upregulation of superoxide dismutase 2

(2010) Jimmie Colon et al.   Nanomedicine-Nanotechnology Biology and Medicine

Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1  and IL-1 

(2010) A. S. Yazdi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunological parameters related to the adjuvant effect of the ordered mesoporous silica SBA-15

(2010) Luciana V. Carvalho et al.   VACCINE

Exposure to Titanium Dioxide Nanomaterials Provokes Inflammation of an in Vitro Human Immune Construct

(2009) Brian C. Schanen et al.   ACS Nano

Ascorbate–apatite composite and ascorbate–FGF-2–apatite composite layers formed on external fixation rods and their effects on cell activity in vitro

(2009) Xiupeng Wang et al.   Acta Biomaterialia

Proinflammatory and osteoclastogenic effects of beta-tricalciumphosphate and hydroxyapatite particles on human mononuclear cells in vitro

(2009) Tobias Lange et al.   BIOMATERIALS

The effect of Gd@C82(OH)22 nanoparticles on the release of Th1/Th2 cytokines and induction of TNF-α mediated cellular immunity

(2009) Ying Liu et al.   BIOMATERIALS

Signalling pathways involved in the activation of dendritic cells by layered double hydroxide nanoparticles

(2009) Ang Li et al.   BIOMATERIALS

The effect of the shape of mesoporous silica nanoparticles on cellular uptake and cell function

(2009) Xinglu Huang et al.   BIOMATERIALS

The path to a successful vaccine adjuvant – ‘The long and winding road’

(2009) Derek T. O’Hagan et al.   DRUG DISCOVERY TODAY

Vaccine adjuvants: scientific challenges and strategic initiatives

(2009) Ali M Harandi et al.   Expert Review of Vaccines

Adjuvant effect of zinc oxide on Th2 but not Th1 immune responses in mice

(2009) Misa Matsumura et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Adsorption and release of BMP-2 on nanocrystalline apatite-coated and uncoated hydroxyapatite/β-tricalcium phosphate porous ceramics

(2009) Hélène Autefage et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Natural Killer T Cells: An Unconventional T-Cell Subset with Diverse Effector and Regulatory Functions

(2009) Anna Balato et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The Influences of Cell Type and ZnO Nanoparticle Size on Immune Cell Cytotoxicity and Cytokine Induction

(2009) Cory Hanley et al.   Nanoscale Research Letters

Materials engineering for immunomodulation

(2009) Jeffrey A. Hubbell et al.   NATURE

Anti-inflammatory Properties of Cerium Oxide Nanoparticles

(2009) Suzanne M. Hirst et al.   Small

Efficient internalization of mesoporous silica particles of different sizes by primary human macrophages without impairment of macrophage clearance of apoptotic or antibody-opsonized target cells

(2009) Erika Witasp et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Calcium phosphate nanoparticle prepared with foot and mouth disease virus P1-3CD gene construct protects mice and guinea pigs against the challenge virus

(2009) Dechamma Hosur Joyappa et al.   VETERINARY MICROBIOLOGY

PEGylated Gold Nanoparticles Conjugated to Monoclonal F19 Antibodies as Targeted Labeling Agents for Human Pancreatic Carcinoma Tissue

(2008) Wolfgang Eck et al.   ACS Nano

One-pot synthesis of magnetic and mesoporous bioactive glass composites and their sustained drug release property

(2008) Xia Li et al.   ACTA MATERIALIA

Biological applications of gold nanoparticles

(2008) Ralph A. Sperling et al.   CHEMICAL SOCIETY REVIEWS

Nanoparticles target distinct dendritic cell populations according to their size

(2008) Vania Manolova et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Alum adjuvanticity: Unraveling a century old mystery

(2008) Ennio De Gregorio et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells

(2008) Mirjam Kool et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Effect of coprecipitation temperature on the properties and activity of fibroblast growth factor-2 apatite composite layer

(2008) Xia Li et al.   Materials Science & Engineering C-Materials for Biological Applications

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

(2008) Stephanie C. Eisenbarth et al.   NATURE

Quantum Dots for Tracking Dendritic Cells and Priming an Immune Response In Vitro and In Vivo

(2008) Debasish Sen et al.   PLoS One

Antigen kinetics determines immune reactivity

(2008) Pål Johansen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE

In vitro and in vivo effects of zinc on cytokine signalling in human T cells

(2007) Audrey Varin et al.   EXPERIMENTAL GERONTOLOGY