Targeting STING with cyclic di-GMP greatly augmented immune responses of glycopeptide cancer vaccines

Biopolymers codelivering engineered T cells and STING agonists can eliminate heterogeneous tumors

(2017) Tyrel T. Smith et al.   JOURNAL OF CLINICAL INVESTIGATION

Synthesis of All Possible Canonical (3′–5′-Linked) Cyclic Dinucleotides and Evaluation of Riboswitch Interactions and Immune-Stimulatory Effects

(2017) Changhao Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer

(2017) Ugur Sahin et al.   NATURE

An immunogenic personal neoantigen vaccine for patients with melanoma

(2017) Patrick A. Ott et al.   NATURE

IgG Antibody Response Elicited by a Fully Synthetic Two-Component Carbohydrate-Based Cancer Vaccine Candidate with α-Galactosylceramide as Built-in Adjuvant

(2017) Xu-Guang Yin et al.   ORGANIC LETTERS

cGAS is essential for the antitumor effect of immune checkpoint blockade

(2017) Hua Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Glycopeptides as Posttranslationally Modified Neoantigens in Leukemia

(2017) Stacy A. Malaker et al.   Cancer Immunology Research

Fully synthetic self-adjuvanting MUC1-fibroblast stimulating lipopeptide 1 conjugates as potential cancer vaccines

(2016) Yonghui Liu et al.   CHEMICAL COMMUNICATIONS

Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma

(2016) Avery D. Posey et al.   IMMUNITY

Mucin architecture behind the immune response: design, evaluation and conformational analysis of an antitumor vaccine derived from an unnatural MUC1 fragment

(2016) Nuria Martínez-Sáez et al.   Chemical Science

Peptide-based synthetic vaccines

(2016) Mariusz Skwarczynski et al.   Chemical Science

STING activator c-di-GMP enhances the anti-tumor effects of peptide vaccines in melanoma-bearing mice

(2015) Zili Wang et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Linear synthesis and immunological properties of a fully synthetic vaccine candidate containing a sialylated MUC1 glycopeptide

(2015) Pamela Thompson et al.   CHEMICAL COMMUNICATIONS

A fully synthetic self-adjuvanting globo H-Based vaccine elicited strong T cell-mediated antitumor immunity

(2015) Zhifang Zhou et al.   Chemical Science

Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

(2015) Leticia Corrales et al.   Cell Reports

Synthetic Multivalent Glycopeptide-Lipopeptide Antitumor Vaccines: Impact of the Cluster Effect on the Killing of Tumor Cells

(2014) Hui Cai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Immune and Anticancer Responses Elicited by Fully Synthetic Aberrantly Glycosylated MUC1 Tripartite Vaccines Modified by a TLR2 or TLR9 Agonist

(2014) Abu-Baker M. Abdel-Aal et al.   CHEMBIOCHEM

Synthesis and immunological evaluation of self-adjuvanting MUC1-macrophage activating lipopeptide 2 conjugate vaccine candidates

(2014) David M. McDonald et al.   CHEMICAL COMMUNICATIONS

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

(2014) Liufu Deng et al.   IMMUNITY

A self-adjuvanting vaccine induces cytotoxic T lymphocytes that suppress allergy

(2014) Regan J Anderson et al.   Nature Chemical Biology

A semisynthetic carbohydrate-lipid vaccine that protects against S. pneumoniae in mice

(2014) Marco Cavallari et al.   Nature Chemical Biology

Synthesis and evaluation of monophosphoryl lipid A derivatives as fully synthetic self-adjuvanting glycoconjugate cancer vaccine carriers

(2014) Zhifang Zhou et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

STING Ligand c-di-GMP Improves Cancer Vaccination against Metastatic Breast Cancer

(2014) D. Chandra et al.   Cancer Immunology Research

Anticancer Flavonoids Are Mouse-Selective STING Agonists

(2013) Sujeong Kim et al.   ACS Chemical Biology

Novel c-di-GMP recognition modes of the mouse innate immune adaptor protein STING

(2013) Ko-Hsin Chin et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Self-Adjuvanting Synthetic Antitumor Vaccines from MUC1 Glycopeptides Conjugated to T-Cell Epitopes from Tetanus Toxoid

(2013) Hui Cai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The development of synthetic antitumour vaccines from mucin glycopeptide antigens

(2013) Nikola Gaidzik et al.   CHEMICAL SOCIETY REVIEWS

Synthesis of Biotinylated c-di-Gmp And c-di-Amp using Click Conjugation

(2013) Barbara L. Gaffney et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Variation of the Glycosylation Pattern in MUC1 Glycopeptide BSA Vaccines and Its Influence on the Immune Response

(2012) Hui Cai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fully Synthetic Self-Adjuvanting Thioether-Conjugated GlycopeptideLipopeptide Antitumor Vaccines for the Induction of Complement-Dependent Cytotoxicity against Tumor Cells

(2012) Hui Cai et al.   CHEMISTRY-A EUROPEAN JOURNAL

The structural basis for the sensing and binding of cyclic di-GMP by STING

(2012) Yi-He Huang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Carbohydrate-Monophosphoryl Lipid A Conjugates Are Fully Synthetic Self-Adjuvanting Cancer Vaccines Eliciting Robust Immune Responses in the Mouse

(2011) Qianli Wang et al.   ACS Chemical Biology

Synthesis of Tn/T Antigen MUC1 Glycopeptide BSA Conjugates and Their Evaluation as Vaccines

(2011) Hui Cai et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

STING is a direct innate immune sensor of cyclic di-GMP

(2011) Dara L. Burdette et al.   NATURE

Immune recognition of tumor-associated mucin MUC1 is achieved by a fully synthetic aberrantly glycosylated MUC1 tripartite vaccine

(2011) V. Lakshminarayanan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fully Synthetic Vaccines Consisting of Tumor-Associated MUC1 Glycopeptides and a Lipopeptide Ligand of the Toll-like Receptor 2

(2010) Anton Kaiser et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

One-Flask Syntheses of c-di-GMP and the [Rp,Rp] and [Rp,Sp] Thiophosphate Analogues

(2010) Barbara L. Gaffney et al.   ORGANIC LETTERS

Transient Pretreatment With Glucocorticoid Ablates Innate Toxicity of Systemically Delivered Adenoviral Vectors Without Reducing Efficacy

(2009) Sergey S Seregin et al.   MOLECULAR THERAPY

CD4 T cells: fates, functions, and faults

(2008) J. Zhu et al.   BLOOD

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE