Roles of extracellular vesicles associated non-coding RNAs in Diabetes Mellitus

Exosomal lncRNA TUG1 from cancer-associated fibroblasts promotes liver cancer cell migration, invasion, and glycolysis by regulating the miR-524-5p/SIX1 axis

(2022) Le Lu et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Exosomal MALAT1 Derived from High Glucose-Treated Macrophages Up-Regulates Resistin Expression via miR-150-5p Downregulation

(2022) Kou-Gi Shyu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sorting and packaging of RNA into extracellular vesicles shape intracellular transcript levels

(2022) Tina O’Grady et al.   BMC BIOLOGY

Uptake, functionality, and re-release of extracellular vesicle-encapsulated cargo

(2022) Killian O’Brien et al.   Cell Reports

Characterization of lncRNA Profiles of Plasma-Derived Exosomes From Type 1 Diabetes Mellitus

(2022) Haipeng Pang et al.   Frontiers in Endocrinology

Exosomal RNA Expression Profiles and Their Prediction Performance in Patients With Gestational Diabetes Mellitus and Macrosomia

(2022) Yingdi Yuan et al.   Frontiers in Endocrinology

Long Noncoding RNA GAS5 Contained in Exosomes Derived from Human Adipose Stem Cells Promotes Repair and Modulates Inflammation in a Chronic Dermal Wound Healing Model

(2022) Rekha S. Patel et al.   Biology-Basel

Translating extracellular vesicle packaging into therapeutic applications

(2022) Dilara C. Ozkocak et al.   Frontiers in Immunology

MiR-690, an exosomal-derived miRNA from M2-polarized macrophages, improves insulin sensitivity in obese mice

(2021) Wei Ying et al.   Cell Metabolism

Expression of miRNA-29 in Pancreatic β Cells Promotes Inflammation and Diabetes via TRAF3

(2021) Yi Sun et al.   Cell Reports

Genomic instability-derived plasma extracellular vesicle-microRNA signature as a minimally invasive predictor of risk and unfavorable prognosis in breast cancer

(2021) Siqi Bao et al.   JOURNAL OF NANOBIOTECHNOLOGY

Crosstalk between Macrophages and Pancreatic β-Cells in Islet Development, Homeostasis and Disease

(2021) Cristina Cosentino et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Long Non-Coding RNAs as Key Modulators of Pancreatic β-Cell Mass and Function

(2021) Livia López–Noriega et al.   Frontiers in Endocrinology

Extracellular Vesicles as Biomarkers and Therapeutic Tools: From Pre-Clinical to Clinical Applications

(2021) Maria Chiara Ciferri et al.   Biology-Basel

M1 macrophage-derived exosomes impair beta cell insulin secretion via miR-212-5p by targeting SIRT2 and inhibiting Akt/GSK-3β/β-catenin pathway in mice

(2021) Bin Qian et al.   DIABETOLOGIA

Circular RNAs as microRNA sponges: evidence and controversies

(2021) Morten T. Jarlstad Olesen et al.   Essays in Biochemistry

Circulating miRNAs miR-574-5p and miR-3135b are potential metabolic regulators for serum lipids and blood glucose in gestational diabetes mellitus

(2021) Fuyan Wang et al.   GYNECOLOGICAL ENDOCRINOLOGY

Crosstalk between Metabolic Disorders and Immune Cells

(2021) Shinichi Saitoh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular vesicle-associated miRNAs are an adaptive response to gestational diabetes mellitus

(2021) Soumyalekshmi Nair et al.   Journal of Translational Medicine

A comprehensive integrated post-GWAS analysis of Type 1 diabetes reveals enhancer-based immune dysregulation

(2021) Seung-Soo Kim et al.   PLoS One

HOXA5–miR-574-5p axis promotes adipogenesis and alleviates insulin resistance

(2021) Yuying Li et al.   Molecular Therapy-Nucleic Acids

Extracellular Vesicles in Immune System Regulation and Type 1 Diabetes: Cell-to-Cell Communication Mediators, Disease Biomarkers, and Promising Therapeutic Tools

(2021) Giuseppina Emanuela Grieco et al.   Frontiers in Immunology

HIF-Overexpression and Pro-Inflammatory Priming in Human Mesenchymal Stromal Cells Improves the Healing Properties of Extracellular Vesicles in Experimental Crohn’s Disease

(2021) Marta Gómez-Ferrer et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MicroRNA sequence codes for small extracellular vesicle release and cellular retention

(2021) Ruben Garcia-Martin et al.   NATURE

A putative long noncoding RNA-encoded micropeptide maintains cellular homeostasis in pancreatic β cells

(2021) Mark Li et al.   Molecular Therapy-Nucleic Acids

Time for a paradigm shift in treating type 1 diabetes mellitus: coupling inflammation to islet regeneration

(2020) Nadia Cobo-Vuilleumier et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Pancreatic β cell microRNA-26a alleviates type 2 diabetes by improving peripheral insulin sensitivity and preserving β cell function

(2020) Haixia Xu et al.   PLOS BIOLOGY

RNA delivery by extracellular vesicles in mammalian cells and its applications

(2020) Killian O’Brien et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The T1D-associated lncRNA Lnc13 modulates human pancreatic β cell inflammation by allele-specific stabilization of STAT1 mRNA

(2020) Itziar Gonzalez-Moro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miR-210 in Exosomes Derived from Macrophages under High Glucose Promotes Mouse Diabetic Obesity Pathogenesis by Suppressing NDUFA4 Expression

(2020) Feng Tian et al.   Journal of Diabetes Research

A micropeptide encoded by lncRNA MIR155HG suppresses autoimmune inflammation via modulating antigen presentation

(2020) Liman Niu et al.   Science Advances

The Long and Short of It: The Emerging Roles of Non-Coding RNA in Small Extracellular Vesicles

(2020) Agata Abramowicz et al.   Cancers

Extracellular Vesicles Derived Human-miRNAs Modulate the Immune System in Type 1 Diabetes

(2020) Tine Tesovnik et al.   Frontiers in Cell and Developmental Biology

LncRNA MALAT1 induces the dysfunction of β cells via reducing the histone acetylation of the PDX-1 promoter in type 1 diabetes

(2020) Haixia Ding et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Characterizing Extracellular Vesicles and Their Diverse RNA Contents

(2020) Eren M. Veziroglu et al.   Frontiers in Genetics

Paracrine regulation of insulin secretion

(2020) Mark O. Huising   DIABETOLOGIA

miRNA-16-5p inhibits the apoptosis of high glucose-induced pancreatic β cells via targeting CXCL10: potential biomarkers in type 1 diabetes mellitus

(2020) Xiaoyan Gao et al.   Endokrynologia Polska

Elevated Circulating LINC-P21 Serves as a Diagnostic Biomarker of Type 2 Diabetes Mellitus and Regulates Pancreatic β-cell Function by Sponging miR-766-3p to Upregulate NR3C2

(2020) Zhibin Cao et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Molecular and Functional Diversity of Distinct Subpopulations of the Stressed Insulin-Secreting Cell's Vesiculome

(2020) Khem Raj Giri et al.   Frontiers in Immunology

Effect of diabetes on exosomal miRNA profile in patients with obesity

(2020) Hyoshik Kim et al.   BMJ Open Diabetes Research & Care

Delivery of muscle-derived exosomal miRNAs induced by HIIT improves insulin sensitivity through down-regulation of hepatic FoxO1 in mice

(2020) Carlos Castaño et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emerging Roles of Exosomes in T1DM

(2020) Haipeng Pang et al.   Frontiers in Immunology

RNA packaging into extracellular vesicles: An orchestra of RNA‐binding proteins?

(2020) Fabrizio Fabbiano et al.   Journal of Extracellular Vesicles

The biogenesis, biology and characterization of circular RNAs

(2019) Lasse S. Kristensen et al.   NATURE REVIEWS GENETICS

Exosomes and Their Noncoding RNA Cargo Are Emerging as New Modulators for Diabetes Mellitus

(2019) Wenguang Chang et al.   Cells

Profiling of RNAs from Human Islet-Derived Exosomes in a Model of Type 1 Diabetes

(2019) Preethi Krishnan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Circular RNA expression profiles in extracellular vesicles from the plasma of patients with pancreatic ductal adenocarcinoma

(2019) Qingqing Li et al.   FEBS Open Bio

miR-10b and miR-223-3p in serum microvesicles signal progression from prediabetes to type 2 diabetes

(2019) M. Parrizas et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Mechanism of recipient cell-dependent differences in exosome uptake

(2018) Sayo Horibe et al.   BMC CANCER

Circulating LncRNAs Analysis in Patients with Type 2 Diabetes Reveals Novel Genes Influencing Glucose Metabolism and Islet β-Cell Function

(2018) Yuting Ruan et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Elevated Medium-Chain Acylcarnitines Are Associated With Gestational Diabetes Mellitus and Early Progression to Type 2 Diabetes and Induce Pancreatic β-Cell Dysfunction

(2018) Battsetseg Batchuluun et al.   DIABETES

Beta cell extracellular vesicle miR-21-5p cargo is increased in response to inflammatory cytokines and serves as a biomarker of type 1 diabetes

(2018) Alexander J. Lakhter et al.   DIABETOLOGIA

Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes: A prospective study in children

(2018) Ezio Bonifacio et al.   PLOS MEDICINE

Lymphocyte-Derived Exosomal MicroRNAs Promote Pancreatic β Cell Death and May Contribute to Type 1 Diabetes Development

(2018) Claudiane Guay et al.   Cell Metabolism

Transient PAX8 Expression in Islets During Pregnancy Correlates With β-Cell Survival, Revealing a Novel Candidate Gene in Gestational Diabetes Mellitus

(2018) Alejandro Martin-Montalvo et al.   DIABETES

Understanding extracellular vesicle diversity – current status

(2018) David W. Greening et al.   Expert Review of Proteomics

Progression from islet autoimmunity to clinical type 1 diabetes is influenced by genetic factors: results from the prospective TEDDY study

(2018) Andreas Beyerlein et al.   JOURNAL OF MEDICAL GENETICS

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

(2018) Mathilde Mathieu et al.   NATURE CELL BIOLOGY

Obesity-associated exosomal miRNAs modulate glucose and lipid metabolism in mice

(2018) Carlos Castaño et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diverse Long RNAs Are Differentially Sorted into Extracellular Vesicles Secreted by Colorectal Cancer Cells

(2018) Scott A. Hinger et al.   Cell Reports

Selective Export into Extracellular Vesicles and Function of tRNA Fragments during T Cell Activation

(2018) Ni-Ting Chiou et al.   Cell Reports

Adipose-derived circulating miRNAs regulate gene expression in other tissues

(2017) Thomas Thomou et al.   NATURE

Genetics of type 1 diabetes

(2017) Maria J Redondo et al.   PEDIATRIC DIABETES

RNA in extracellular vesicles

(2017) Kyoung Mi Kim et al.   Wiley Interdisciplinary Reviews-RNA

MicroRNAs 106b and 222 Improve Hyperglycemia in a Mouse Model of Insulin-Deficient Diabetes via Pancreatic β-Cell Proliferation

(2017) Sohei Tsukita et al.   EBioMedicine

Plasma-derived exosome characterization reveals a distinct microRNA signature in long duration Type 1 diabetes

(2017) Marta Garcia-Contreras et al.   Scientific Reports

Exosomal microRNA signatures in multiple sclerosis reflect disease status

(2017) Saeideh Ebrahimkhani et al.   Scientific Reports

Circulating long noncoding RNAs as novel biomarkers of human diseases

(2016) Xiaoying Jiang et al.   Biomarkers in Medicine

Introduction to Extracellular Vesicles: Biogenesis, RNA Cargo Selection, Content, Release, and Uptake

(2016) Erik R. Abels et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Primary Human and Rat β-Cells Release the Intracellular Autoantigens GAD65, IA-2, and Proinsulin in Exosomes Together With Cytokine-Induced Enhancers of Immunity

(2016) Chiara Cianciaruso et al.   DIABETES

Exosome-like vesicles released from lipid-induced insulin-resistant muscles modulate gene expression and proliferation of beta recipient cells in mice

(2016) Audrey Jalabert et al.   DIABETOLOGIA

The RNA-Binding Protein SYNCRIP Is a Component of the Hepatocyte Exosomal Machinery Controlling MicroRNA Sorting

(2016) Laura Santangelo et al.   Cell Reports

Circular RNAs are down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes

(2016) Yongchao Dou et al.   Scientific Reports

Horizontal transfer of exosomal microRNAs transduce apoptotic signals between pancreatic beta-cells

(2015) Claudiane Guay et al.   Cell Communication and Signaling

Downregulation of lncRNA TUG1 Affects Apoptosis and Insulin Secretion in Mouse Pancreatic β Cells

(2015) Dan-dan Yin et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Large oncosomes contain distinct protein cargo and represent a separate functional class of tumor-derived extracellular vesicles

(2015) Valentina R. Minciacchi et al.   Oncotarget

Islet amyloid with macrophage migration correlates with augmented β-cell deficits in type 2 diabetic patients

(2014) Kosuke Kamata et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Most People With Long-Duration Type 1 Diabetes in a Large Population-Based Study Are Insulin Microsecretors

(2014) Richard A. Oram et al.   DIABETES CARE

Plasma Exosome MicroRNA Profiling Unravels a New Potential Modulator of Adiponectin Pathway in Diabetes: Effect of Glycemic Control

(2014) Donato Santovito et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

MicroRNA-29b Modulates Innate and Antigen-Specific Immune Responses in Mouse Models of Autoimmunity

(2014) Apolline Salama et al.   PLoS One

Exosome Uptake Depends on ERK1/2-Heat Shock Protein 27 Signaling and Lipid Raft-mediated Endocytosis Negatively Regulated by Caveolin-1

(2013) Katrin J. Svensson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

(2013) Carolina Villarroya-Beltri et al.   Nature Communications

Diabetes Mellitus and the β Cell: The Last Ten Years

(2012) Frances M. Ashcroft et al.   CELL

Tumor-exosomes and leukocyte activation: an ambivalent crosstalk

(2012) Daniela Zech et al.   Cell Communication and Signaling

Human β Cell Transcriptome Analysis Uncovers lncRNAs That Are Tissue-Specific, Dynamically Regulated, and Abnormally Expressed in Type 2 Diabetes

(2012) Ignasi Morán et al.   Cell Metabolism

Circulating Levels of MicroRNA from Children with Newly Diagnosed Type 1 Diabetes and Healthy Controls: Evidence That miR-25 Associates to Residual Beta-Cell Function and Glycaemic Control during Disease Progression

(2012) Lotte B. Nielsen et al.   Experimental Diabetes Research

Toward tailored exosomes: The exosomal tetraspanin web contributes to target cell selection

(2012) Sanyukta Rana et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Lin28/let-7 Axis Regulates Glucose Metabolism

(2011) Hao Zhu et al.   CELL

ANRIL, a long, noncoding RNA, is an unexpected major hotspot in GWAS

(2010) Eric Pasmant et al.   FASEB JOURNAL

A comprehensive definition for metabolic syndrome

(2009) P. L. Huang   Disease Models & Mechanisms

The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes

(2009) Chris Wallace et al.   NATURE GENETICS