Exosomes and Their Noncoding RNA Cargo Are Emerging as New Modulators for Diabetes Mellitus

Exploiting Exosomes in Cancer Liquid Biopsies and Drug Delivery

(2019) Coy Austin Fitts et al.   Advanced Healthcare Materials

Exosome secreted from adipose-derived stem cells attenuates diabetic nephropathy by promoting autophagy flux and inhibiting apoptosis in podocyte

(2019) Juan Jin et al.   Stem Cell Research & Therapy

Temperature- and rigidity-mediated rapid transport of lipid nanovesicles in hydrogels

(2019) Miaorong Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosomes are the novel players involved in the beneficial effects of exercise on type 2 diabetes

(2019) Gaohua Li et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Noninvasive diagnosis of recurrent autoimmune type 1 diabetes after islet cell transplantation

(2019) Laxminarayana Korutla et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Bone Marrow Mesenchymal Stem Cells-Derived Exosomal MiR-29b-3p Regulates Aging-Associated Insulin Resistance

(2019) Tian Su et al.   ACS Nano

Extracellular Vesicles: Exosomes and Microvesicles, Integrators of Homeostasis

(2019) Philip D. Stahl et al.   PHYSIOLOGY

Human pancreatic cancer cell exosomes, but not human normal cell exosomes, act as an initiator in cell transformation

(2019) Karoliina Stefanius et al.   eLife

Exosomes

(2019) D. Michiel Pegtel et al.   Annual Review of Biochemistry

Exosomal miRNA in chemoresistance, immune evasion, metastasis and progression of cancer

(2019) Bhagyashri Kulkarni et al.   DRUG DISCOVERY TODAY

Highly Efficient Exosome Isolation and Protein Analysis by an Integrated Nanomaterial-Based Platform

(2018) Xiaoni Fang et al.   ANALYTICAL CHEMISTRY

Circulating LncRNAs Analysis in Patients with Type 2 Diabetes Reveals Novel Genes Influencing Glucose Metabolism and Islet β-Cell Function

(2018) Yuting Ruan et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Potential Value of Urinary Exosome-Derived let-7c-5p in the Diagnosis and Progression of Type II Diabetic Nephropathy

(2018) Weite Li et al.   Clinical Laboratory

Injury Factors Alter miRNAs Profiles of Exosomes Derived from Islets and Circulation

(2018) QI FU et al.   DIABETES

IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045

(2018) N.H. Cho et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Beta cell extracellular vesicle miR-21-5p cargo is increased in response to inflammatory cytokines and serves as a biomarker of type 1 diabetes

(2018) Alexander J. Lakhter et al.   DIABETOLOGIA

Extracellular vesicle-mimetic nanovesicles transport LncRNA-H19 as competing endogenous RNA for the treatment of diabetic wounds

(2018) Shi-Cong Tao et al.   DRUG DELIVERY

Insulin resistance adipocyte-derived exosomes aggravate atherosclerosis by increasing vasa vasorum angiogenesis in diabetic ApoE −/− mice

(2018) Feng Wang et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Screening of circular RNAs and validation of circANKRD36 associated with inflammation in patients with type 2 diabetes mellitus

(2018) Yuan Fang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Biogenesis and function of ESCRT-dependent extracellular vesicles

(2018) Thomas Juan et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Circular RNAs as novel regulators of β-cell functions in normal and disease conditions

(2018) Lisa Stoll et al.   Molecular Metabolism

Human Mesenchymal Stem Cell Derived Exosomes Alleviate Type 2 Diabetes Mellitus by Reversing Peripheral Insulin Resistance and Relieving β-Cell Destruction

(2018) Yaoxiang Sun et al.   ACS Nano

Adipocyte-Derived Exosomes Carrying Sonic Hedgehog Mediate M1 Macrophage Polarization-Induced Insulin Resistance via Ptch and PI3K Pathways

(2018) Ming Song et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Human Placental Exosomes in Gestational Diabetes Mellitus Carry a Specific Set of miRNAs Associated with Skeletal Muscle Insulin Sensitivity

(2018) Soumyalekshmi Nair et al.   CLINICAL SCIENCE

Extracellular histones are the ligands for the uptake of exosomes and hydroxyapatite-nanoparticles by tumor cells via syndecan-4

(2018) Josiah Ochieng et al.   FEBS LETTERS

Immunomodulatory effects of mesenchymal stem cell-derived exosomes on experimental type-1 autoimmune diabetes

(2018) Shahrzad Nojehdehi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

An enriched environment prevents diabetes-induced cognitive impairment in rats by enhancing exosomal miR-146a secretion from endogenous bone marrow-derived mesenchymal stem cells

(2018) Kenta Kubota et al.   PLoS One

ANRIL: A lncRNA at the CDKN2A/B Locus With Roles in Cancer and Metabolic Disease

(2018) Yahui Kong et al.   Frontiers in Endocrinology

Lymphocyte-Derived Exosomal MicroRNAs Promote Pancreatic β Cell Death and May Contribute to Type 1 Diabetes Development

(2018) Claudiane Guay et al.   Cell Metabolism

Circulating Exosomal miR-20b-5p is Elevated in Type 2 Diabetes and Could Impair Insulin Action in Human Skeletal Muscle

(2018) Mutsumi Katayama et al.   DIABETES

Separation of virus-like particles and extracellular vesicles by flow-through and heparin affinity chromatography

(2018) Katrin Reiter et al.   JOURNAL OF CHROMATOGRAPHY A

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

(2018) Mathilde Mathieu et al.   NATURE CELL BIOLOGY

Obesity-associated exosomal miRNAs modulate glucose and lipid metabolism in mice

(2018) Carlos Castaño et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell- and tissue-specific epigenetic changes associated with chronic inflammation in insulin resistance and type 2 diabetes mellitus

(2018) Velosha Naidoo et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Molecular lipid species in urinary exosomes as potential prostate cancer biomarkers

(2017) Tore Skotland et al.   EUROPEAN JOURNAL OF CANCER

Extracellular vesicles in food: Experimental evidence of their secretion in grape fruits

(2017) Pedro Pérez-Bermúdez et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Non-coding RNAs and Berberine: A new mechanism of its anti-diabetic activities

(2017) Wenguang Chang   EUROPEAN JOURNAL OF PHARMACOLOGY

Tiny RNAs and their voyage via extracellular vesicles: Secretion of bacterial small RNA and eukaryotic microRNA

(2017) Ji-Woong Choi et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

LncRNA MALAT1 is dysregulated in diabetic nephropathy and involved in high glucose-induced podocyte injury via its interplay with β-catenin

(2017) Mengsi Hu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Role of exosomal proteins in cancer diagnosis

(2017) Weihua Li et al.   Molecular Cancer

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

(2017) Sushrut Kamerkar et al.   NATURE

Insulin action and resistance in obesity and type 2 diabetes

(2017) Michael P Czech   NATURE MEDICINE

Adult-onset autoimmune diabetes: current knowledge and implications for management

(2017) Raffaella Buzzetti et al.   Nature Reviews Endocrinology

Isolation and characterization of urinary extracellular vesicles: implications for biomarker discovery

(2017) Michael L. Merchant et al.   Nature Reviews Nephrology

Bariatric Surgery Is Accompanied by Changes in Extracellular Vesicle-Associated and Plasma Fatty Acid Binding Protein 4

(2017) Justyna K. Witczak et al.   OBESITY SURGERY

Extracellular vesicle-mediated cell–cell communication in haematological neoplasms

(2017) Junko H. Ohyashiki et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Broad role for YBX1 in defining the small noncoding RNA composition of exosomes

(2017) Matthew J. Shurtleff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipids in exosomes: Current knowledge and the way forward

(2017) Tore Skotland et al.   PROGRESS IN LIPID RESEARCH

Cell-cell communication in diabetic retinopathy

(2017) Sayon Roy et al.   VISION RESEARCH

Umbilical cord extracts improve diabetic abnormalities in bone marrow-derived mesenchymal stem cells and increase their therapeutic effects on diabetic nephropathy

(2017) Kanna Nagaishi et al.   Scientific Reports

Progress in Exosome Isolation Techniques

(2017) Pin Li et al.   Theranostics

Urinary Exosomal MicroRNA Profiling in Incipient Type 2 Diabetic Kidney Disease

(2017) Yijun Xie et al.   Journal of Diabetes Research

MicroRNAs 106b and 222 Improve Hyperglycemia in a Mouse Model of Insulin-Deficient Diabetes via Pancreatic β-Cell Proliferation

(2017) Sohei Tsukita et al.   EBioMedicine

Exosomes derived from pancreatic cancer cells induce insulin resistance in C2C12 myotube cells through the PI3K/Akt/FoxO1 pathway

(2017) Lantian Wang et al.   Scientific Reports

Pathology of Human Coronary and Carotid Artery Atherosclerosis and Vascular Calcification in Diabetes MellitusHighlights

(2016) Kazuyuki Yahagi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Type 1 diabetes associated autoimmunity

(2016) George J. Kahaly et al.   AUTOIMMUNITY REVIEWS

Clinical verification of a novel urinary microRNA panal: 133b, -342 and -30 as biomarkers for diabetic nephropathy identified by bioinformatics analysis

(2016) Sanaa Eissa et al.   BIOMEDICINE & PHARMACOTHERAPY

Long Noncoding RNA-Sox2OT Knockdown Alleviates Diabetes Mellitus-Induced Retinal Ganglion Cell (RGC) injury

(2016) Chao-Peng Li et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Hsp20-Mediated Activation of Exosome Biogenesis in Cardiomyocytes Improves Cardiac Function and Angiogenesis in Diabetic Mice

(2016) Xiaohong Wang et al.   DIABETES

Primary Human and Rat β-Cells Release the Intracellular Autoantigens GAD65, IA-2, and Proinsulin in Exosomes Together With Cytokine-Induced Enhancers of Immunity

(2016) Chiara Cianciaruso et al.   DIABETES

Rebranding asymptomatic type 1 diabetes: the case for autoimmune beta cell disorder as a pathological and diagnostic entity

(2016) Ezio Bonifacio et al.   DIABETOLOGIA

Effect of exosome isolation methods on physicochemical properties of exosomes and clearance of exosomes from the blood circulation

(2016) Takuma Yamashita et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Neutral Ceramidase Secreted Via Exosome Protects Against Palmitate-Induced Apoptosis in INS-1 Cells

(2016) S. Tang et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

ESCRT-III and Vps4: a dynamic multipurpose tool for membrane budding and scission

(2016) Manuel Alonso Y Adell et al.   FEBS Journal

Mesenchymal stem cell and derived exosome as small RNA carrier and Immunomodulator to improve islet transplantation

(2016) Di Wen et al.   JOURNAL OF CONTROLLED RELEASE

Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells

(2016) Myung Soo Kim et al.   Nanomedicine-Nanotechnology Biology and Medicine

The potential of endurance exercise-derived exosomes to treat metabolic diseases

(2016) Adeel Safdar et al.   Nature Reviews Endocrinology

The Influence of Ionizing Radiation on Exosome Composition, Secretion and Intercellular Communication

(2016) Karol Jelonek et al.   PROTEIN AND PEPTIDE LETTERS

Urinary Exosomal microRNA-451-5p Is a Potential Early Biomarker of Diabetic Nephropathy in Rats

(2016) Aradhana Mohan et al.   PLoS One

Associated autoimmune diseases in children and adolescents with type 1 diabetes mellitus (T1DM)

(2015) Kostas Kakleas et al.   AUTOIMMUNITY REVIEWS

Are Obesity-Related Insulin Resistance and Type 2 Diabetes Autoimmune Diseases?

(2015) Sue Tsai et al.   DIABETES

Exosome Adherence and Internalization by Hepatic Stellate Cells Triggers Sphingosine 1-Phosphate-dependent Migration

(2015) Ruisi Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

The circular RNA Cdr1as, via miR-7 and its targets, regulates insulin transcription and secretion in islet cells

(2015) Huanyu Xu et al.   Scientific Reports

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Epigenetic Regulation of the DLK1-MEG3 MicroRNA Cluster in Human Type 2 Diabetic Islets

(2014) Vasumathi Kameswaran et al.   Cell Metabolism

New Insight Into Early Events in Type 1 Diabetes: Role for Islet Stem Cell Exosomes

(2014) M. L. Lukic et al.   DIABETES

The global implications of diabetes and cancer

(2014) Yuankai Shi et al.   LANCET

The H19/let-7 double-negative feedback loop contributes to glucose metabolism in muscle cells

(2014) Yuan Gao et al.   NUCLEIC ACIDS RESEARCH

MicroRNA-223 coordinates cholesterol homeostasis

(2014) Kasey C. Vickers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autocrine role of interleukin-13 on skeletal muscle glucose metabolism in type 2 diabetic patients involves microRNA let-7

(2013) Lake Q. Jiang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Cell-Cell Communication between Malaria-Infected Red Blood Cells via Exosome-like Vesicles

(2013) Neta Regev-Rudzki et al.   CELL

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity

(2013) H. C. Christianson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diabetes Mellitus and the β Cell: The Last Ten Years

(2012) Frances M. Ashcroft et al.   CELL

miR-107: a Toll-like receptor-regulated miRNA dysregulated in obesity and type II diabetes

(2012) N. H. Foley et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks

(2012) Deepali Malhotra et al.   NATURE IMMUNOLOGY

MVB vesicle formation: ESCRT-dependent, ESCRT-independent and everything in between

(2011) Markus Babst   CURRENT OPINION IN CELL BIOLOGY

The Tetraspanin CD63 Regulates ESCRT-Independent and -Dependent Endosomal Sorting during Melanogenesis

(2011) Guillaume van Niel et al.   DEVELOPMENTAL CELL

Insulinoma-Released Exosomes or Microparticles Are Immunostimulatory and Can Activate Autoreactive T Cells Spontaneously Developed in Nonobese Diabetic Mice

(2011) H. Sheng et al.   JOURNAL OF IMMUNOLOGY

Autonomous versus dendritic cell-dependent contributions of medullary thymic epithelial cells to central tolerance

(2011) Ludger Klein et al.   TRENDS IN IMMUNOLOGY

Microenvironmental pH Is a Key Factor for Exosome Traffic in Tumor Cells

(2009) Isabella Parolini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY