Journal
BIOMARKERS IN MEDICINE
Volume 10, Issue 7, Pages 757-769Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/bmm-2016-0039
Keywords
circulating lncRNAs; common diseases; diagnosis; long noncoding RNAs; prognosis
Categories
Funding
- National Science Foundation of China [31100834]
- International Cooperation Founds of Shaanxi Province [2012KW-32-02]
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Long noncoding RNAs (lncRNAs) are a kind of noncoding RNAs which are longer than similar to 200 nucleotides, lacking of protein-encoding capacity and are implicated in the pathogenesis of various diseases. Recently, it was demonstrated that lncRNAs could be released into the circulation and be stable in blood. Circulating lncRNAs have been reported to have potential in distinguishing patients from healthy individuals. Therefore, the detection of circulating lncRNAs may be valuable for improving the diagnosis and prognosis of various diseases. This review summarized the current understanding of circulating lncRNAs as novel biomarkers of various human diseases, such as cancer, cardiovascular diseases, nervous system diseases and other diseases, which highlighted the significance of circulating lncRNAs as novel diagnostic and prognostic biomarkers of human diseases.
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