Paracrine regulation of insulin secretion

The Role of α-Cells in Islet Function and Glucose Homeostasis in Health and Type 2 Diabetes

(2020) Patrick Gilon   JOURNAL OF MOLECULAR BIOLOGY

Paracrine signaling in islet function and survival

(2020) Sean M. Hartig et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

In the rat pancreas, somatostatin tonically inhibits glucagon secretion and is required for glucose‐induced inhibition of glucagon secretion

(2020) Stella F.S. Xu et al.   Acta Physiologica

Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes

(2020) Muhmmad Omar-Hmeadi et al.   Nature Communications

Serotonin Regulates Adult β-Cell Mass by Stimulating Perinatal β-Cell Proliferation

(2019) Joon Ho Moon et al.   DIABETES

The Pericyte of the Pancreatic Islet Regulates Capillary Diameter and Local Blood Flow

(2018) Joana Almaça et al.   Cell Metabolism

The somatostatin-secreting pancreatic δ-cell in health and disease

(2018) Patrik Rorsman et al.   Nature Reviews Endocrinology

Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men

(2018) Patrik Rorsman et al.   PHYSIOLOGICAL REVIEWS

α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes

(2018) Marcela Brissova et al.   Cell Reports

Somatostatin is Only Partly Required for the Glucagonostatic Effect of Glucose but is Necessary for the Glucagonostatic Effect of KATPChannel Blockers

(2018) Bao-Khanh Lai et al.   DIABETES

The Difference δ-Cells Make in Glucose Control

(2018) Mark O. Huising et al.   PHYSIOLOGY

Insulin Secretion Depends on Intra-islet Glucagon Signaling

(2018) Berit Svendsen et al.   Cell Reports

δ-cells and β-cells are electrically coupled and regulate α-cell activity via somatostatin

(2017) L. J. B. Briant et al.   JOURNAL OF PHYSIOLOGY-LONDON

Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets

(2016) Alice E. Adriaenssens et al.   DIABETOLOGIA

Single-cell transcriptomes identify human islet cell signatures and reveal cell-type–specific expression changes in type 2 diabetes

(2016) Nathan Lawlor et al.   GENOME RESEARCH

Glucagon secretion from pancreatic α-cells

(2016) Linford Briant et al.   UPSALA JOURNAL OF MEDICAL SCIENCES

Human Beta Cells Produce and Release Serotonin to Inhibit Glucagon Secretion from Alpha Cells

(2016) Joana Almaça et al.   Cell Reports

Comprehensive alpha, beta and delta cell transcriptomes reveal that ghrelin selectively activates delta cells and promotes somatostatin release from pancreatic islets

(2016) Michael R. DiGruccio et al.   Molecular Metabolism

Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion

(2015) Talitha van der Meulen et al.   NATURE MEDICINE

Altered serotonin (5-HT) 1D and 2A receptor expression may contribute to defective insulin and glucagon secretion in human type 2 diabetes

(2015) H. Bennet et al.   PEPTIDES

The transcriptional landscape of mouse beta cells compared to human beta cells reveals notable species differences in long non-coding RNA and protein-coding gene expression

(2014) Christopher Benner et al.   BMC GENOMICS

Islet Microenvironment, Modulated by Vascular Endothelial Growth Factor-A Signaling, Promotes β Cell Regeneration

(2014) Marcela Brissova et al.   Cell Metabolism

Neurotransmitter control of islet hormone pulsatility

(2014) E. Gylfe et al.   DIABETES OBESITY & METABOLISM

Somatostatin Receptor Type 2 Antagonism Improves Glucagon Counterregulation in Biobreeding Diabetic Rats

(2013) Negar Karimian et al.   DIABETES

Amelioration of Hypoglycemia Via Somatostatin Receptor Type 2 Antagonism in Recurrently Hypoglycemic Diabetic Rats

(2013) J. T. Y. Yue et al.   DIABETES

Cell-type, allelic, and genetic signatures in the human pancreatic beta cell transcriptome

(2013) A. C. Nica et al.   GENOME RESEARCH

A local glucagon-like peptide 1 (GLP-1) system in human pancreatic islets

(2012) P. Marchetti et al.   DIABETOLOGIA

Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover

(2012) Roger H. Unger et al.   JOURNAL OF CLINICAL INVESTIGATION

Isolated mouse islets respond to glucose with an initial peak of glucagon release followed by pulses of insulin and somatostatin in antisynchrony with glucagon

(2011) Bo Hellman et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Alpha cells secrete acetylcholine as a non-neuronal paracrine signal priming beta cell function in humans

(2011) Rayner Rodriguez-Diaz et al.   NATURE MEDICINE

Serotonin regulates pancreatic beta cell mass during pregnancy

(2010) Hail Kim et al.   NATURE MEDICINE

Paracrinology of islets and the paracrinopathy of diabetes

(2010) R. H. Unger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CRFR1 is expressed on pancreatic   cells, promotes   cell proliferation, and potentiates insulin secretion in a glucose-dependent manner

(2009) M. O. Huising et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA