Article
Pharmacology & Pharmacy
Jianping Xiao, Deguang Wang
Summary: The contribution of long noncoding RNA-GAS5 in the pathogenesis of systemic lupus erythematosus (SLE) was investigated. It was found that the expression of GAS5 was significantly decreased in peripheral monocytes of SLE patients compared to healthy individuals. GAS5 was shown to inhibit monocyte proliferation and promote apoptosis. The study also revealed the involvement of GAS5 in the TLR4-mediated inflammatory process through the MAPK signaling pathway.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Article
Medicine, Research & Experimental
Yuqian Guo, Guoxing Li, Lei Gao, Xiaocheng Cheng, Liyou Wang, Yuhong Qin, Dongying Zhang
Summary: In the mouse model of renal fibrosis induced by unilateral ureteric obstruction, deficiency in lncRNA Gas5 exacerbates renal fibrosis, leading to more severe fibrosis and collagen deposition in the obstructed kidney.
Article
Genetics & Heredity
Yaru Kong, Bo Han, Li Zhang, Qingqing Liu, Guanlin Zheng, Keying Guo, Qing Chen, Zhongmei Chen
Summary: In this study, the researchers investigated the role of lncRNA NONHSAT177112.1 in inflammatory injury of human cardiomyocytes induced by lipopolysaccharide. Results showed that NONHSAT177112.1 is expressed in the nucleus and cytoplasm, with dynamic expression patterns during LPS stimulation. Knocking down NONHSAT177112.1 reversed the promotion effect of LPS on inflammatory injury, while overexpression had the opposite effects.
Article
Chemistry, Multidisciplinary
Marwa M. Esawy, Amir Abd-elhameed, Ahmed F. Gomaa, Shereen A. Baioumy, Moataz A. ElKot, Mohammed A. Hegab, Ahmed S. Alazzouni, Felwa A. Thagfan, Rewaida Abdel-Gaber, Mohamed A. Dkhil, Marwa A. Shabana
Summary: This study investigated the roles of LncRNA-GAS5 and S-catenin in predicting asymptomatic organ damage (AOD) in hypertensive nondiabetic patients. It found that decreased LncRNA-GAS5 expression and elevated S-catenin levels were associated with AOD in hypertensive patients. LncRNA-GAS5 expression was a better diagnostic predictor of AOD than S-catenin.
Article
Biotechnology & Applied Microbiology
Jing Zhang, Shiquan Li, Xiaona Zhang, Chao Li, Jiantao Zhang, Wenli Zhou
Summary: This study revealed that HLA-F-AS1 promotes migration, invasion, and EMT of CRC cells by competitively binding to miR-375 and inversely regulating its expression pattern. Moreover, PFN1 was identified as a direct target of miR-375, positively modulated by HLA-F-AS1, and affecting macrophage polarization. The overexpression of HLA-F-AS1 repressed miR-375 and promoted PFN1 expression pattern, further stimulating CRC cell proliferation and migration through macrophage interactions.
CANCER GENE THERAPY
(2021)
Article
Medicine, Research & Experimental
Liu Kai-xin, Cheng Cheng, Li Rui, Shi Zheng-wei, Tan Wen-wen, Xu Peng
Summary: Long noncoding RNAs (lncRNAs) play crucial roles in cancer, with MAGI2-AS3 being a widely expressed lncRNA associated with cancer development and prognosis. Dysregulation of MAGI2-AS3 can affect cancer cell behaviors and treatment responses, making it a potential biomarker and therapeutic target for cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Physiology
Ying-Ying Zhang, Rui-Zhi Tan, Ying Yu, Yang-Yang Niu, Chen Yu
Summary: The study highlights the important role of the long noncoding RNA GAS5 in kidney disease, particularly in renal fibrosis. GAS5 interacts with miR-142-5p, participating in a competing endogenous RNA network that modulates extracellular matrix formation and cell apoptosis via the Smad3 pathway. Overexpression of GAS5 effectively blocks renal fibrosis, suggesting its potential as a novel and precision therapeutic target for alleviating kidney fibrosis.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Changhao Chen, Hanhao Zheng, Yuming Luo, Yao Kong, Mingjie An, Yuting Li, Wang He, Bowen Gao, Yue Zhao, Hao Huang, Jian Huang, Tianxin Lin
Summary: This study reveals that SUMOylation is a crucial mechanism promoting lymphatic metastasis in bladder cancer, by regulating the ELNAT1/UBC9/SOX18 axis to enhance lymphangiogenesis and LN metastasis. Blocking tumor cell SUMOylation could be a promising therapeutic strategy for LN metastatic BCa.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Multidisciplinary Sciences
Omar A. Alfituri, Enock M. Mararo, Pieter C. Steketee, Liam J. Morrison, Neil A. Mabbott
Summary: The study found that although increasing the local abundance of macrophages in the skin through colony stimulating factor 1 (CSF1) injection did not affect susceptibility to T. brucei infection, bacterial LPS-stimulation in the skin significantly reduced disease susceptibility to intradermal trypanosome infection. This implies that enhancing the ability of dermal macrophages to eliminate injected T. brucei parasites may help reduce the transmission of African trypanosomes in the future.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Litao Yan, Gejun Liu, Xing Wu
Summary: This study found that exosomal lncRNA H19 derived from UMSCs acts as a competing endogenous RNA to enhance osteochondral activity in chondrocytes by sequestering miR-29b-3p. Injection of exosomes overexpressing H19 promoted sustained cartilage repair, highlighting its potential for developing strategies against cartilage defects.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Ehsaneh Azaryan, Samira Karbasi, Mansoore Saharkhiz, Mohammad Yahya Hanafi-Bojd, Asghar Zarban, Fariba Emadian Razavi, Mohsen Naseri
Summary: The study aimed to investigate the effects of human milk exosomes (HM-Exos) on lipopolysaccharide (LPS)-exposed human dental pulp stem cells (HDPSCs) in terms of viability, migration, and inflammatory responses. The results showed that HM-Exos could promote migration and proliferation of LPS-exposed HDPSCs and reduce the expression of inflammatory cytokines. These findings suggest that HM-Exos could be a promising candidate for pulpitis therapy.
Article
Cell Biology
Lirong Peng, Banglun Pan, Xiaoxia Zhang, Zengbin Wang, Jiacheng Qiu, Xiaoqian Wang, Nanhong Tang
Summary: Recent studies suggest that lipopolysaccharide (LPS) of intestinal bacteria plays a critical role in immune escape of hepatocellular carcinoma (HCC) through METTL14/MIR155HG/PD-L1 axis regulation. This study provides new insight into understanding the complex immune microenvironment of HCC.
CELL BIOLOGY AND TOXICOLOGY
(2022)
Article
Pharmacology & Pharmacy
Qing Zhao, Meng-Fei Sheng, Yao-Yun Wang, Xing-Yu Wang, Wei-Yi Liu, Yuan-Yuan Zhang, Tiao-Ying Ke, Shu Chen, Gao-Zong Pang, Liang Yong, Zhan Ding, Yu-Jun Shen, Yu-Xian Shen, Wei Shao
Summary: Our study revealed that silencing of LPS-induced lncRNA Gm26917 protects against LPS-induced liver injury by regulating the TLR4/NF-kappa B signaling pathway in macrophages.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Rheumatology
Rajan Bhandari, Heetaek Yang, Noelle N. Kosarek, Avi E. Smith, Jonathan A. Garlick, Monique Hinchcliff, Michael L. Whitfield, Patricia A. Pioli
Summary: This study demonstrates that dermal fibroblasts from SSc patients activate macrophages through exosomes. The findings suggest that there is cross-talk between macrophages and fibroblasts in SSc skin, resulting in mutual activation, inflammation, and extracellular matrix deposition.
Article
Physiology
Fengxiang Zhang, Xigang Luo, Yi Wang, Lingling Ma, Dapeng Sun
Summary: The study found that the expression levels of lncRNA PMS2L2 and miR-21 are downregulated in patients with acute kidney injury (AKI), and they are positively correlated. PMS2L2 regulates the expression of miR-21 by decreasing its methylation level, and inhibits LPS-induced apoptosis of podocytes, indicating its important anti-inflammatory role in sepsis.
KIDNEY & BLOOD PRESSURE RESEARCH
(2023)
Article
Endocrinology & Metabolism
Ghattas El Bassit, Rekha S. Patel, Gay Carter, Vyshakh Shibu, Achintya A. Patel, Shijie Song, Michel Murr, Denise R. Cooper, Paula C. Bickford, Niketa A. Patel
Article
Immunology
Niketa A. Patel, Lauren Daly Moss, Jea-Young Lee, Naoki Tajiri, Sandra Acosta, Charles Hudson, Sajan Parag, Denise R. Cooper, Cesario V. Borlongan, Paula C. Bickford
JOURNAL OF NEUROINFLAMMATION
(2018)
Article
Dermatology
Denise R. Cooper, Chunyan Wang, Rehka Patel, Andrea Trujillo, Niketa A. Patel, Jamie Prather, Lisa J. Gould, Mack H. Wu
ADVANCES IN WOUND CARE
(2018)
Article
Biochemistry & Molecular Biology
Ashley Lui, Robert Sparks, Rekha Patel, Niketa A. Patel
Summary: This study identified a novel sortilin splice variant related to glucose metabolism, whose presence may be associated with insulin resistance in adipocytes. This finding provides a new potential target for the management of type 2 diabetes and metabolic syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Deena Bader, Rekha S. Patel, Ashley Lui, Chetna Thawani, Rea Rupani, Gitanjali Vidyarthi, Niketa A. Patel
Summary: The study suggests that lithium chloride may promote adipogenesis and increase oxidative stress by affecting the alternative splicing of PKC δ I, potentially contributing to the development of metabolic disorders such as obesity.
MOLECULAR AND CELLULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lauren D. Moss, Derek Sode, Rekha Patel, Ashley Lui, Charles Hudson, Niketa A. Patel, Paula C. Bickford
Summary: The study demonstrates the efficacy of human adipose-derived stem cell exosomes in treating traumatic brain injury, extending the therapeutic window through intranasal delivery in mice. Treatment with exosomes containing MALAT1 significantly improved motor and cognitive function in mice, reduced cortical damage, and decreased MHCII+ staining of microglial cells. The findings suggest a promising therapeutic approach with exosomes and highlight the role of MALAT1 in promoting recovery.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Ashley Lui, Rekha S. Patel, Meredith Krause-Hauch, Robert P. Sparks, Niketa A. Patel
Summary: This study reveals the presence of a truncated sortilin variant (Sort_T) in diabetic adipose tissue, which is significantly upregulated. The association between Sort_T and GLUT4, as well as its impact on glucose uptake in adipocytes, is confirmed through various experiments and analyses. Furthermore, it is found that glucagon-like peptide-1 (GLP1) hormone regulates the alternative splicing of Sort_T. Targeted antisense oligonucleotide treatment reduces Sort_T levels and improves glucose uptake in diabetic adipocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Rekha S. Patel, Rea Rupani, Sabrina Impreso, Ashley Lui, Niketa A. Patel
Summary: The study revealed a significant increase in PKC delta VIII expression in ovarian cancer cells, indicating its potential role in promoting cellular survival and migration. Additionally, the association of PKC delta VIII with Bcl2 and Bcl-xL was demonstrated, suggesting its involvement in regulating apoptosis. The findings suggest that PKC delta VIII could be a promising target for therapeutic development in combating ovarian cancer progression.
Article
Biochemistry & Molecular Biology
Yan Shi, Sajan Parag, Rekha Patel, Ashley Lui, Michel Murr, Jianfeng Cai, Niketa A. Patel
CELL CHEMICAL BIOLOGY
(2019)
Article
Medicine, General & Internal
Gay Carter, Branko Miladinovic, Achintya A. Patel, Lauren Deland, Stephen Mastorides, Niketa A. Patel