Cholesterol: An important actor on the cancer immune scene

Involvement of LDL and ox-LDL in Cancer Development and Its Therapeutical Potential

(2022) Chang-Feng Deng et al.   Frontiers in Oncology

Protein Farnesylation on Nasopharyngeal Carcinoma, Molecular Background and Its Potential as a Therapeutic Target

(2022) Eiji Kobayashi et al.   Cancers

Cholesterol Synthesis Is Important for Breast Cancer Cell Tumor Sphere Formation and Invasion

(2022) Hee Yeon Kim et al.   Biomedicines

Coexistence of inhibitory and activating killer-cell immunoglobulin-like receptors to the same cognate HLA-C2 and Bw4 ligands confer breast cancer risk

(2021) Elham Ashouri et al.   Scientific Reports

The Role of Macrophages in Cancer Development and Therapy

(2021) Ewa Cendrowicz et al.   Cancers

Role of Cholesterol and Lipid Rafts in Cancer Signaling: A Promising Therapeutic Opportunity?

(2021) Rosa Vona et al.   Frontiers in Cell and Developmental Biology

Chemotherapy: a double-edged sword in cancer treatment

(2021) Nafiseh Behranvand et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Influence of cholesterol on cancer progression and therapy

(2021) Shyamananda Singh Mayengbam et al.   Translational Oncology

Cholesterol Metabolism as a Potential Therapeutic Target and a Prognostic Biomarker for Cancer Immunotherapy

(2021) Huixian Zhang et al.   OncoTargets and Therapy

Cholesterol Metabolic Reprogramming in Cancer and Its Pharmacological Modulation as Therapeutic Strategy

(2021) Isabella Giacomini et al.   Frontiers in Oncology

The cholesterol pathway: impact on immunity and cancer

(2021) Ryan J. King et al.   TRENDS IN IMMUNOLOGY

Mechanistic Insights Delineating the Role of Cholesterol in Epithelial Mesenchymal Transition and Drug Resistance in Cancer

(2021) Naaziyah Abdulla et al.   Frontiers in Cell and Developmental Biology

Association Between Genetically Proxied Inhibition of HMG-CoA Reductase and Epithelial Ovarian Cancer

(2020) James Yarmolinsky et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Assessment of acyl-CoA cholesterol acyltransferase (ACAT-1) role in ovarian cancer progression—An in vitro study

(2020) Vijayalakshmi N. Ayyagari et al.   PLoS One

Lipid profile and risk of ovarian tumours: a meta-analysis

(2020) Justina Ucheojor Onwuka et al.   BMC CANCER

mTOR signaling pathway and mTOR inhibitors in cancer: progress and challenges

(2020) Zhilin Zou et al.   Cell and Bioscience

Myeloid-Derived Suppressor Cells in Tumors: From Mechanisms to Antigen Specificity and Microenvironmental Regulation

(2020) Yuhui Yang et al.   Frontiers in Immunology

Cholesterol metabolism in drug‑resistant cancer (Review)

(2020) Aiwen Yan et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Disturbances in Cholesterol Homeostasis and Non-alcoholic Fatty Liver Diseases

(2020) Pooja Malhotra et al.   Frontiers in Medicine

Cholesterol and Its Metabolites in Tumor Growth: Therapeutic Potential of Statins in Cancer Treatment

(2019) Adele Chimento et al.   Frontiers in Endocrinology

Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death

(2019) Javier Garcia-Bermudez et al.   NATURE

Membrane Cholesterol Efflux Drives Tumor-Associated Macrophage Reprogramming and Tumor Progression

(2019) Pieter Goossens et al.   Cell Metabolism

Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment

(2019) Xingzhe Ma et al.   Cell Metabolism

Dendritic Cells and Cancer: From Biology to Therapeutic Intervention

(2019) Wylie et al.   Cancers

Increased Cholesterol Biosynthesis Is a Key Characteristic of Breast Cancer Stem Cells Influencing Patient Outcome

(2019) Sidse Ehmsen et al.   Cell Reports

Clinical relevance of cholesterol homeostasis genes in colorectal cancer

(2019) Bhoomika Sharma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Lipid order and charge protect killer T cells from accidental death

(2019) Jesse A. Rudd-Schmidt et al.   Nature Communications

Retrospective on Cholesterol Homeostasis: The Central Role of Scap

(2018) Michael S. Brown et al.   Annual Review of Biochemistry

Lysosomal acid lipase promotes cholesterol ester metabolism and drives clear cell renal cell carcinoma progression

(2018) Jun Wang et al.   CELL PROLIFERATION

Prognostic role of serum total cholesterol and high-density lipoprotein cholesterol in cancer survivors: A systematic review and meta-analysis

(2018) Pingting Zhou et al.   CLINICA CHIMICA ACTA

High cholesterol in lipid rafts reduces the sensitivity to EGFR-TKI therapy in non-small cell lung cancer

(2018) Qiufang Chen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Lipophilic statins limit cancer cell growth and survival, via involvement of Akt signaling

(2018) Colin H. Beckwitt et al.   PLoS One

Molecular Pathways Underlying Cholesterol Homeostasis

(2018) Milessa Silva Afonso et al.   Nutrients

Association between body mass index and breast cancer risk: evidence based on a dose–response meta-analysis

(2018) Kang Liu et al.   Cancer Management and Research

ATP citrate lyase (ACLY) inhibitors: An anti-cancer strategy at the crossroads of glucose and lipid metabolism

(2018) Carlotta Granchi   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Total Serum Cholesterol and Pancreatic Cancer: A Nested Case–Control Study

(2018) William Chang-Yuen Chen et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Statin therapy in the treatment of active cancer: A systematic review and meta-analysis of randomized controlled trials

(2018) Mohammed A. M. Farooqi et al.   PLoS One

Interlink between cholesterol & cell cycle in prostate carcinoma

(2017) NimaiChand Chandra et al.   INDIAN JOURNAL OF MEDICAL RESEARCH

Pro-inflammation NF-κB signaling triggers a positive feedback via enhancing cholesterol accumulation in liver cancer cells

(2017) Mingyan He et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Cholesterol Levels in Patients with Chronic Lymphocytic Leukemia

(2017) Irfan Yavasoglu et al.   JOURNAL OF THE NATIONAL MEDICAL ASSOCIATION

Role of the PDZ-scaffold protein NHERF1/EBP50 in cancer biology: from signaling regulation to clinical relevance

(2017) J Vaquero et al.   ONCOGENE

Serum cholesterol and risk of high-grade prostate cancer: results from the REDUCE study

(2017) Juzar Jamnagerwalla et al.   PROSTATE CANCER AND PROSTATIC DISEASES

Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex

(2017) Brian M. Castellano et al.   SCIENCE

The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells

(2017) Amy E. Baek et al.   Nature Communications

Atorvastatin downregulates co-inhibitory receptor expression by targeting Ras-activated mTOR signalling

(2017) Isobel Okoye et al.   Oncotarget

Extracellular Acidic pH Activates the Sterol Regulatory Element-Binding Protein 2 to Promote Tumor Progression

(2017) Ayano Kondo et al.   Cell Reports

Statin use and survival in colorectal cancer: Results from a population-based cohort study and an updated systematic review and meta-analysis

(2016) Ronan T. Gray et al.   Cancer Epidemiology

Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling

(2016) Pengxiang Huang et al.   CELL

A Cholesterol-Based Allostery Model of T Cell Receptor Phosphorylation

(2016) Mahima Swamy et al.   IMMUNITY

Systematic review and meta-analysis suggest that dietary cholesterol intake increases risk of breast cancer

(2016) Changkun Li et al.   NUTRITION RESEARCH

Abrogating cholesterol esterification suppresses growth and metastasis of pancreatic cancer

(2016) J Li et al.   ONCOGENE

Wnt signaling in cancer

(2016) T Zhan et al.   ONCOGENE

24-Hydroxycholesterol participates in pancreatic neuroendocrine tumor development

(2016) Matias Soncini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ROS-mediated activation of STAT-3/VEGF signaling is involved in the 27-hydroxycholesterol-induced angiogenesis in human breast cancer cells

(2016) Dongmei Zhu et al.   TOXICOLOGY LETTERS

Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling

(2016) Giovanni Luchetti et al.   eLife

Cholesterol Levels in Blood and the Risk of Prostate Cancer: A Meta-analysis of 14 Prospective Studies

(2015) L. YuPeng et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Statin use and mortality in cancer patients: Systematic review and meta-analysis of observational studies

(2015) Shanliang Zhong et al.   CANCER TREATMENT REVIEWS

A link between hypercholesterolemia and chronic lymphocytic leukemia

(2015) Signy Chow et al.   LEUKEMIA & LYMPHOMA

Statin-Based Palliative Therapy for Hepatocellular Carcinoma

(2015) Joni Yu-Hsuan Shao et al.   MEDICINE

The cholesterol metabolite 27-hydroxycholesterol regulates p53 activity and increases cell proliferation via MDM2 in breast cancer cells

(2015) Shaneabbas Raza et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

SREBP maintains lipid biosynthesis and viability of cancer cells under lipid- and oxygen-deprived conditions and defines a gene signature associated with poor survival in glioblastoma multiforme

(2015) C A Lewis et al.   ONCOGENE

Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP

(2015) S J H Ricoult et al.   ONCOGENE

Cholesterol uptake disruption, in association with chemotherapy, is a promising combined metabolic therapy for pancreatic adenocarcinoma

(2015) Fabienne Guillaumond et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The HDL receptor SR-BI is associated with human prostate cancer progression and plays a possible role in establishing androgen independence

(2015) David Schörghofer et al.   Reproductive Biology and Endocrinology

Association between cholesterol intake and pancreatic cancer risk: Evidence from a meta-analysis

(2015) Hongqiang Chen et al.   Scientific Reports

The Science of Fatty Acids and Inflammation

(2015) Kevin L Fritsche   Advances in Nutrition

M-CSF from Cancer Cells Induces Fatty Acid Synthase and PPARβ/δ Activation in Tumor Myeloid Cells, Leading to Tumor Progression

(2015) Jonghanne Park et al.   Cell Reports

Cholesterol-induced mammary tumorigenesis is enhanced by adiponectin deficiency: role of LDL receptor upregulation

(2015) Jing Liu et al.   Oncotarget

Cholesteryl Ester Accumulation Induced by PTEN Loss and PI3K/AKT Activation Underlies Human Prostate Cancer Aggressiveness

(2014) Shuhua Yue et al.   Cell Metabolism

Oxidized Lipids Block Antigen Cross-Presentation by Dendritic Cells in Cancer

(2014) W. Cao et al.   JOURNAL OF IMMUNOLOGY

LDL-cholesterol signaling induces breast cancer proliferation and invasion

(2014) Catarina Rodrigues dos Santos et al.   Lipids in Health and Disease

Lipid levels in serum and cancerous tissues of colorectal cancer patients

(2014) Xin Zhang   WORLD JOURNAL OF GASTROENTEROLOGY

Cholesterol selectively activates canonical Wnt signalling over non-canonical Wnt signalling

(2014) Ren Sheng et al.   Nature Communications

The oxysterol–CXCR2 axis plays a key role in the recruitment of tumor-promoting neutrophils

(2013) Laura Raccosta et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sterol regulatory element–binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity

(2013) Yoko Kidani et al.   NATURE IMMUNOLOGY

27-Hydroxycholesterol Links Hypercholesterolemia and Breast Cancer Pathophysiology

(2013) E. R. Nelson et al.   SCIENCE

Cholesterol and the risk of grade-specific prostate cancer incidence: evidence from two large prospective cohort studies with up to 37 years' follow up

(2012) Kashif Shafique et al.   BMC CANCER

Protein farnesylation and disease

(2012) Giuseppe Novelli et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Impact of Circulating Cholesterol Levels on Growth and Intratumoral Androgen Concentration of Prostate Tumors

(2012) Elahe A. Mostaghel et al.   PLoS One

Cholesterol modulates cell signaling and protein networking by specifically interacting with PDZ domain-containing scaffold proteins

(2012) Ren Sheng et al.   Nature Communications

Cholesterol-Dependent Degradation of Squalene Monooxygenase, a Control Point in Cholesterol Synthesis beyond HMG-CoA Reductase

(2011) Saloni Gill et al.   Cell Metabolism

Simvastatin inhibits cancer cell growth by inducing apoptosis correlated to activation of Bax and down-regulation of BCL-2 gene expression

(2011) CARMINE SPAMPANATO et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Total Cholesterol and Cancer Risk in a Large Prospective Study in Korea

(2011) Cari M. Kitahara et al.   JOURNAL OF CLINICAL ONCOLOGY

Statin Prescriptions and Breast Cancer Recurrence Risk: A Danish Nationwide Prospective Cohort Study

(2011) T. P. Ahern et al.   JNCI-Journal of the National Cancer Institute

Simvastatin inhibits cell growth and induces apoptosis and G0/G1 cell cycle arrest in hepatic cancer cells

(2010) Relja   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Lipid accumulation and dendritic cell dysfunction in cancer

(2010) Donna L Herber et al.   NATURE MEDICINE

Wnt signal transduction pathways

(2010) Yuko Komiya et al.   Organogenesis

High ACAT1 expression in estrogen receptor negative basal-like breast cancer cells is associated with LDL-induced proliferation

(2009) Caryl J. Antalis et al.   BREAST CANCER RESEARCH AND TREATMENT

Dissection of the Endogenous Cellular Pathways of PCSK9-induced Low Density Lipoprotein Receptor Degradation

(2009) Steve Poirier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor-mediated liver X receptor-α activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses

(2009) Eduardo J Villablanca et al.   NATURE MEDICINE

Androgen-independent prostate cancer cells acquire the complete steroidogenic potential of synthesizing testosterone from cholesterol

(2008) Paulette R. Dillard et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY