Cholesterol Synthesis Is Important for Breast Cancer Cell Tumor Sphere Formation and Invasion

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Lovastatin Inhibits EMT and Metastasis of Triple-Negative Breast Cancer Stem Cells Through Dysregulation of Cytoskeleton-Associated Proteins

(2021) Chanjuan Zheng et al.   Frontiers in Oncology

O-GlcNAcylation of Sox2 at threonine 258 regulates the self-renewal and early cell fate of embryonic stem cells

(2021) Dong Keon Kim et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis

(2021) Madeleine Dorsch et al.   Cell Reports

Regulation of mRNA export through API5 and nuclear FGF2 interaction

(2020) Seoung Min Bong et al.   NUCLEIC ACIDS RESEARCH

Cancer cells undergoing epigenetic transition show short-term resistance and are transformed into cells with medium-term resistance by drug treatment

(2020) Shiv Poojan et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Circulating Tumor Cells in Metastatic Breast Cancer: From Genome Instability to Metastasis

(2020) Ekaterina Ivanova et al.   Frontiers in Molecular Biosciences

ATP Production Relies on Fatty Acid Oxidation Rather than Glycolysis in Pancreatic Ductal Adenocarcinoma

(2020) Jae-Seon Lee et al.   Cancers

The lingering mysteries of metastatic recurrence in breast cancer

(2020) Alessandra I. Riggio et al.   BRITISH JOURNAL OF CANCER

A Novel Long Non‐Coding RNA lnc030 Maintains Breast Cancer Stem Cell Stemness by Stabilizing SQLE mRNA and Increasing Cholesterol Synthesis

(2020) Yilu Qin et al.   Advanced Science

Targeting Ovarian Cancer Cells Overexpressing CD44 with Immunoliposomes Encapsulating Glycosylated Paclitaxel

(2019) Apriliana Cahya Khayrani et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Increased Cholesterol Biosynthesis Is a Key Characteristic of Breast Cancer Stem Cells Influencing Patient Outcome

(2019) Sidse Ehmsen et al.   Cell Reports

Differentially Expressed microRNAs in MIA PaCa-2 and PANC-1 Pancreas Ductal Adenocarcinoma Cell Lines are Involved in Cancer Stem Cell Regulation

(2019) Shen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Identification of new cancer stem cell markers and signaling pathways in HER‑2‑positive breast cancer by transcriptome sequencing

(2019) Lu Feng et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Breast cancer lung metastasis: Molecular biology and therapeutic implications

(2018) Liting Jin et al.   CANCER BIOLOGY & THERAPY

SREBP-2 aggravates breast cancer associated osteolysis by promoting osteoclastogenesis and breast cancer metastasis

(2018) Zhiwei Jie et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Statins attenuate outgrowth of breast cancer metastases

(2018) Colin H. Beckwitt et al.   BRITISH JOURNAL OF CANCER

Loss-of-function screens of druggable targetome against cancer stem–like cells

(2017) Mee Song et al.   FASEB JOURNAL

20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years

(2017) Hongchao Pan et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Contribution of Cholesterol and Its Metabolites to the Pathophysiology of Breast Cancer

(2016) Amy E. Baek et al.   Hormones & Cancer

Alendronate, a double-edged sword acting in the mevalonate pathway

(2015) PAOLA MAURA TRICARICO et al.   Molecular Medicine Reports

Statin-induced inhibition of breast cancer proliferation and invasion involves attenuation of iron transport: intermediacy of nitric oxide and antioxidant defence mechanisms

(2014) Anantha Koteswararao Kanugula et al.   FEBS Journal

Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility

(2014) M. Yu et al.   SCIENCE

27-Hydroxycholesterol Links Hypercholesterolemia and Breast Cancer Pathophysiology

(2013) E. R. Nelson et al.   SCIENCE

Obesity and Risk of Recurrence or Death After Adjuvant Endocrine Therapy With Letrozole or Tamoxifen in the Breast International Group 1-98 Trial

(2012) Marianne Ewertz et al.   JOURNAL OF CLINICAL ONCOLOGY

Relationship of CD44+CD24-/low breast cancer stem cells and axillary lymph node metastasis

(2012) Wei Wei et al.   Journal of Translational Medicine

Mevalonate Metabolism Regulates Basal Breast Cancer Stem Cells and Is a Potential Therapeutic Target

(2012) Christophe Ginestier et al.   STEM CELLS

Role of Cholesterol in the Development and Progression of Breast Cancer

(2011) Gemma Llaverias et al.   AMERICAN JOURNAL OF PATHOLOGY

Simvastatin Prevents Skeletal Metastasis of Breast Cancer by an Antagonistic Interplay between p53 and CD44

(2011) Chandi Charan Mandal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Perspective on Cancer Cell Metastasis

(2011) C. L. Chaffer et al.   SCIENCE

Effect of Body Mass Index on Recurrences in Tamoxifen and Anastrozole Treated Women: An Exploratory Analysis From the ATAC Trial

(2010) Ivana Sestak et al.   JOURNAL OF CLINICAL ONCOLOGY

Effect of Obesity on Prognosis After Early-Stage Breast Cancer

(2010) Marianne Ewertz et al.   JOURNAL OF CLINICAL ONCOLOGY

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL